Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0733 | 0.0733 |
Onchocerca volvulus | 0.0045 | 0.0733 | 0.14 | |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0142 | 0.3538 | 0.3538 |
Echinococcus multilocularis | hypothetical protein | 0.0045 | 0.0733 | 0.0733 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0437 | 0.0437 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0437 | 0.0437 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.071 | 0.071 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0042 | 0.0637 | 1 |
Loa Loa (eye worm) | beta-lactamase | 0.0035 | 0.0437 | 0.0437 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0038 | 0.0536 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0437 | 0.0437 |
Brugia malayi | Inhibitor of Apoptosis domain containing protein | 0.0065 | 0.1315 | 0.1315 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0035 | 0.0437 | 0.0437 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0025 | 0.0153 | 0.2853 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.0437 | 0.687 |
Brugia malayi | hypothetical protein | 0.0045 | 0.0733 | 0.0733 |
Leishmania major | 0.0366 | 1 | 1 | |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.0366 | 1 | 1 |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.0366 | 1 | 1 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0366 | 1 | 1 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0366 | 1 | 1 |
Brugia malayi | Inhibitor of Apoptosis domain containing protein | 0.0065 | 0.1315 | 0.1315 |
Trypanosoma cruzi | sedoheptulose-1,7-bisphosphatase, putative | 0.0136 | 0.336 | 0.3056 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0437 | 0.687 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0437 | 0.0437 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0044 | 0.071 | 0.071 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0035 | 0.0437 | 0.5 |
Mycobacterium ulcerans | lipase LipD | 0.0035 | 0.0437 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0437 | 0.0437 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0035 | 0.0437 | 0.0437 |
Mycobacterium ulcerans | beta-lactamase | 0.0035 | 0.0437 | 0.5 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0035 | 0.0437 | 0.0437 |
Trichomonas vaginalis | esterase, putative | 0.0035 | 0.0437 | 0.687 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0038 | 0.0536 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0437 | 0.0437 |
Echinococcus multilocularis | plexin a4 | 0.0128 | 0.3124 | 0.3124 |
Schistosoma mansoni | inhibitor of apoptosis protein | 0.0065 | 0.1315 | 0.1315 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.071 | 0.071 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0437 | 0.687 |
Onchocerca volvulus | Deterin homolog | 0.0065 | 0.1315 | 0.4148 |
Echinococcus multilocularis | semaphorin 5B | 0.0045 | 0.0733 | 0.0733 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.1315 | 0.1315 |
Echinococcus granulosus | plexin a4 | 0.0128 | 0.3124 | 0.3124 |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.0366 | 1 | 1 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0038 | 0.0536 | 0.5 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0042 | 0.0637 | 0.0208 |
Brugia malayi | Sema domain containing protein | 0.0045 | 0.0733 | 0.0733 |
Entamoeba histolytica | tyrosin kinase, putative | 0.0025 | 0.0153 | 0.2853 |
Toxoplasma gondii | fructose-bisphospatase I | 0.0136 | 0.336 | 0.3056 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.071 | 0.071 |
Loa Loa (eye worm) | plexin A | 0.0128 | 0.3124 | 0.3124 |
Trypanosoma brucei | sedoheptulose-1,7-bisphosphatase | 0.0136 | 0.336 | 0.3056 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.071 | 0.071 |
Schistosoma mansoni | inhibitor of apoptosis (iap) domain family member | 0.0065 | 0.1315 | 0.1315 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0437 | 0.0437 |
Schistosoma mansoni | semaphorin 5-related | 0.0045 | 0.0733 | 0.0733 |
Schistosoma mansoni | hypothetical protein | 0.0063 | 0.1247 | 0.1247 |
Schistosoma mansoni | plexin | 0.0063 | 0.1247 | 0.1247 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0035 | 0.0437 | 0.0437 |
Toxoplasma gondii | fructose-bisphospatase II | 0.0366 | 1 | 1 |
Brugia malayi | Plexin repeat family protein | 0.0108 | 0.2552 | 0.2552 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.0437 | 0.687 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0223 | 0.5876 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0437 | 0.0437 |
Schistosoma mansoni | plexin | 0.0108 | 0.2552 | 0.2552 |
Loa Loa (eye worm) | acetyltransferase | 0.0142 | 0.3538 | 0.3538 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0042 | 0.0637 | 1 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0142 | 0.3538 | 0.3538 |
Trypanosoma cruzi | sedoheptulose-1,7-bisphosphatase, putative | 0.0136 | 0.336 | 0.3056 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0042 | 0.0637 | 0.0637 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.071 | 0.071 |
Schistosoma mansoni | hypothetical protein | 0.0045 | 0.0733 | 0.0733 |
Echinococcus granulosus | semaphorin 1A | 0.0045 | 0.0733 | 0.0733 |
Mycobacterium leprae | Probable lipase LipE | 0.0035 | 0.0437 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0733 | 0.0733 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0437 | 0.0437 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.0366 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0733 | 0.0733 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.1315 | 0.1315 |
Echinococcus granulosus | inhibitor of apoptosis protein | 0.0065 | 0.1315 | 0.1315 |
Mycobacterium leprae | conserved hypothetical protein | 0.0035 | 0.0437 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0733 | 0.0733 |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.0366 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0035 | 0.0437 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.071 | 0.071 |
Brugia malayi | plexin A | 0.0128 | 0.3124 | 0.3124 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0733 | 0.0733 |
Echinococcus multilocularis | inhibitor of apoptosis protein | 0.0065 | 0.1315 | 0.1315 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0142 | 0.3538 | 0.3538 |
Echinococcus granulosus | baculoviral IAP repeat containing protein | 0.0065 | 0.1315 | 0.1315 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.1247 | 0.1247 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0733 | 0.0733 |
Brugia malayi | beta-lactamase | 0.0035 | 0.0437 | 0.0437 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0042 | 0.0637 | 0.0208 |
Onchocerca volvulus | 0.0065 | 0.1315 | 0.4148 | |
Onchocerca volvulus | 0.0108 | 0.2552 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0045 | 0.0733 | 0.0733 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0437 | 0.0437 |
Echinococcus granulosus | semaphorin 5B | 0.0045 | 0.0733 | 0.0733 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0138 | 0.3422 | 0.3422 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0437 | 0.687 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0035 | 0.0437 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.2552 | 0.2552 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.071 | 0.071 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0044 | 0.071 | 0.071 |
Brugia malayi | Sema domain containing protein | 0.0045 | 0.0733 | 0.0733 |
Echinococcus multilocularis | baculoviral IAP repeat containing protein | 0.0065 | 0.1315 | 0.1315 |
Toxoplasma gondii | sedoheptulose-1,7-bisphosphatase | 0.0136 | 0.336 | 0.3056 |
Loa Loa (eye worm) | sema domain-containing protein | 0.0045 | 0.0733 | 0.0733 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0042 | 0.0637 | 1 |
Brugia malayi | hypothetical protein | 0.0045 | 0.0733 | 0.0733 |
Schistosoma mansoni | hypothetical protein | 0.0065 | 0.1315 | 0.1315 |
Loa Loa (eye worm) | sema domain-containing protein | 0.0045 | 0.0733 | 0.0733 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 70.8 % | Cytotoxicity against human MCF7 cells assessed as cell viability after by MTT assay | ChEMBL. | 23886811 |
Activity (binding) | = 87.6 % | Antagonist activity at recombinant human XIAP BIR3-domain assessed as recovery of caspase-9 recovery at 1 uM after 1 hr by spectrofluorimetry | ChEMBL. | 23886811 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.