Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | aldo-keto reductase, putative | 0.1691 | 0.4852 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.1691 | 0.4852 | 0.4727 |
Giardia lamblia | Aldose reductase | 0.1691 | 0.4852 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.1691 | 0.4852 | 0.4727 |
Mycobacterium leprae | Conserved hypothetical protein | 0.1201 | 0.297 | 0.5922 |
Leishmania major | prostaglandin f2-alpha synthase/D-arabinose dehydrogenase | 0.1691 | 0.4852 | 1 |
Plasmodium falciparum | aldehyde reductase, putative | 0.049 | 0.0236 | 0.5 |
Echinococcus multilocularis | aldo keto reductase | 0.1691 | 0.4852 | 0.4727 |
Plasmodium falciparum | aldo-keto reductase, putative | 0.049 | 0.0236 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.1691 | 0.4852 | 1 |
Mycobacterium leprae | PROBABLE OXIDOREDUCTASE | 0.1691 | 0.4852 | 1 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.303 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.1691 | 0.4852 | 1 |
Schistosoma mansoni | P2X receptor subunit | 0.303 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.1691 | 0.4852 | 0.4727 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.1691 | 0.4852 | 0.4727 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.1691 | 0.4852 | 0.4727 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.1691 | 0.4852 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.1691 | 0.4852 | 0.4727 |
Onchocerca volvulus | 0.1691 | 0.4852 | 1 | |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.1691 | 0.4852 | 1 |
Schistosoma mansoni | pol-related | 0.1691 | 0.4852 | 0.4852 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.1691 | 0.4852 | 1 |
Schistosoma mansoni | P2X receptor subunit | 0.303 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.1691 | 0.4852 | 0.4727 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.1691 | 0.4852 | 1 |
Mycobacterium ulcerans | oxidoreductase | 0.1691 | 0.4852 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.1691 | 0.4852 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.1691 | 0.4852 | 1 |
Onchocerca volvulus | 0.1691 | 0.4852 | 1 | |
Schistosoma mansoni | aldo-keto reductase | 0.1691 | 0.4852 | 0.4852 |
Trypanosoma brucei | prostaglandin f synthase | 0.1691 | 0.4852 | 1 |
Echinococcus multilocularis | aldehyde reductase | 0.1201 | 0.297 | 0.28 |
Leishmania major | aldo-keto reductase-like protein | 0.1691 | 0.4852 | 1 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.303 | 1 | 1 |
Schistosoma mansoni | P2X receptor subunit | 0.303 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.1691 | 0.4852 | 0.4727 |
Leishmania major | aldehyde reductase, putative,oxidoreductase, putative | 0.1691 | 0.4852 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.1691 | 0.4852 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.1691 | 0.4852 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.1691 | 0.4852 | 0.4727 |
Loa Loa (eye worm) | hypothetical protein | 0.1691 | 0.4852 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.1691 | 0.4852 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.1691 | 0.4852 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.1691 | 0.4852 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.1691 | 0.4852 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.1691 | 0.4852 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.1691 | 0.4852 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.1691 | 0.4852 | 0.4727 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.1691 | 0.4852 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.1691 | 0.4852 | 0.4727 |
Loa Loa (eye worm) | oxidoreductase | 0.1691 | 0.4852 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.1691 | 0.4852 | 0.4727 |
Onchocerca volvulus | 0.1691 | 0.4852 | 1 | |
Echinococcus granulosus | p2X purinoceptor 4 | 0.303 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.1691 | 0.4852 | 1 |
Giardia lamblia | Aldose reductase | 0.1691 | 0.4852 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.1691 | 0.4852 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.1691 | 0.4852 | 1 |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.1691 | 0.4852 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.1691 | 0.4852 | 0.4727 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.1691 | 0.4852 | 1 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.303 | 1 | 1 |
Echinococcus granulosus | aldehyde reductase | 0.1201 | 0.297 | 0.28 |
Echinococcus multilocularis | aldo keto reductase | 0.1691 | 0.4852 | 0.4727 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.1691 | 0.4852 | 0.4727 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.1691 | 0.4852 | 0.4727 |
Schistosoma mansoni | P2X receptor subunit | 0.303 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.1691 | 0.4852 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.1691 | 0.4852 | 0.4727 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.1691 | 0.4852 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.1691 | 0.4852 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.1691 | 0.4852 | 0.4727 |
Plasmodium vivax | oxidoreductase, aldo/keto reductase domain containing protein | 0.049 | 0.0236 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.1691 | 0.4852 | 0.4727 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.1691 | 0.4852 | 0.4727 |
Echinococcus granulosus | hypothetical protein | 0.1691 | 0.4852 | 0.4727 |
Leishmania major | prostaglandin f synthase, putative | 0.1691 | 0.4852 | 1 |
Plasmodium vivax | aldehyde reductase, putative | 0.049 | 0.0236 | 0.5 |
Trypanosoma cruzi | aldo-keto reductase | 0.1691 | 0.4852 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.1691 | 0.4852 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.1691 | 0.4852 | 0.4727 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.303 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.1691 | 0.4852 | 0.4727 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.1691 | 0.4852 | 1 |
Schistosoma mansoni | aldo-keto reductase | 0.1691 | 0.4852 | 0.4852 |
Onchocerca volvulus | 0.1691 | 0.4852 | 1 | |
Toxoplasma gondii | aldose reductase, putative | 0.1691 | 0.4852 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.1691 | 0.4852 | 0.4727 |
Echinococcus multilocularis | aldo keto reductase | 0.1691 | 0.4852 | 0.4727 |
Entamoeba histolytica | aldose reductase, putative | 0.1691 | 0.4852 | 1 |
Schistosoma mansoni | potassium channel beta | 0.049 | 0.0236 | 0.0236 |
Onchocerca volvulus | 0.1691 | 0.4852 | 1 | |
Trypanosoma brucei | aldo-keto reductase, putative | 0.1691 | 0.4852 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.1691 | 0.4852 | 0.4727 |
Onchocerca volvulus | 0.1691 | 0.4852 | 1 | |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.1691 | 0.4852 | 0.4727 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.1691 | 0.4852 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.1691 | 0.4852 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 2.72 uM | Transcriptional activation activity on human Peroxisome proliferator activated receptor alpha expressed in CHO-K1 cells | ChEMBL. | 12951082 |
EC50 (binding) | = 16.1 uM | Transcriptional activation activity on human T279M-mutant Peroxisome proliferator activated receptor alpha expressed in CHO-K1 cells | ChEMBL. | 12951082 |
EC50 (binding) | = 33.4 uM | Transcriptional activation activity on human I272F-mutant Peroxisome proliferator activated receptor alpha expressed in CHO-K1 cells | ChEMBL. | 12951082 |
Ratio (binding) | = 5.92 | Ratio of transcriptional activation of T279M mutant compared to wild type PPAR-GAL4 chimeric receptors in CHO-K1 cells | ChEMBL. | 12951082 |
Ratio (binding) | = 12.3 | Ratio of transcriptional activation of I272F mutant compared to wild type PPAR-GAL4 chimeric receptors in CHO-K1 cells | ChEMBL. | 12951082 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.