TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 412.309 | Formula: C18H29BN2O6S
H donors: 4 H acceptors: 6 LogP: -1.22 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: OB(CCCCC(C1CCN(CC1)S(=O)(=O)c1ccc(cc1)C)(C(=O)O)N)O
InChi: 1S/C18H29BN2O6S/c1-14-4-6-16(7-5-14)28(26,27)21-12-8-15(9-13-21)18(20,17(22)23)10-2-3-11-19(24)25/h4-7,15,24-25H,2-3,8-13,20H2,1H3,(H,22,23)
InChiKey: CSADLHWLKFKYNY-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	arginase 1	Starlite/ChEMBL	References
Homo sapiens	arginase 2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis		Get druggable targets OG5_128245	All targets in OG5_128245
Leishmania donovani	arginase	Get druggable targets OG5_128245	All targets in OG5_128245
Plasmodium falciparum	arginase	Get druggable targets OG5_128245	All targets in OG5_128245
Echinococcus multilocularis	arginase 2, mitochondrial	Get druggable targets OG5_128245	All targets in OG5_128245
Plasmodium knowlesi	arginase, putative	Get druggable targets OG5_128245	All targets in OG5_128245
Plasmodium yoelii	arginase	Get druggable targets OG5_128245	All targets in OG5_128245
Leishmania infantum	arginase	Get druggable targets OG5_128245	All targets in OG5_128245
Schistosoma mansoni	arginase	Get druggable targets OG5_128245	All targets in OG5_128245
Leishmania braziliensis	arginase	Get druggable targets OG5_128245	All targets in OG5_128245
Echinococcus granulosus	arginase 2 mitochondrial	Get druggable targets OG5_128245	All targets in OG5_128245
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_128245	All targets in OG5_128245
Plasmodium berghei	arginase	Get druggable targets OG5_128245	All targets in OG5_128245
Echinococcus granulosus	3'partial\|arginase 2 mitochondrial	Get druggable targets OG5_128245	All targets in OG5_128245
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_128245	All targets in OG5_128245
Candida albicans	likely arginase similar to S. cerevisiae CAR1 (YPL111W) involved in arginine catabolism to ornithine	Get druggable targets OG5_128245	All targets in OG5_128245
Candida albicans	likely arginase similar to S. cerevisiae CAR1 (YPL111W) involved in arginine catabolism to ornithine	Get druggable targets OG5_128245	All targets in OG5_128245
Trichomonas vaginalis	Arginase, putative	Get druggable targets OG5_128245	All targets in OG5_128245
Leishmania mexicana	arginase	Get druggable targets OG5_128245	All targets in OG5_128245
Schistosoma japonicum	ko:K01476 arginase [EC3.5.3.1], putative	Get druggable targets OG5_128245	All targets in OG5_128245
Leishmania major	arginase	Get druggable targets OG5_128245	All targets in OG5_128245
Entamoeba histolytica	Arginase, putative	Get druggable targets OG5_128245	All targets in OG5_128245
Plasmodium vivax	arginase, putative	Get druggable targets OG5_128245	All targets in OG5_128245
Plasmodium yoelii	arginase	Get druggable targets OG5_128245	All targets in OG5_128245

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0286	0.3364	0.9088
Onchocerca volvulus		0.0286	0.3364	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0286	0.3364	0.336
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0286	0.3364	0.336
Leishmania major	GTP-binding protein, putative	0.0022	0.0113	0.0064
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0286	0.3364	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0094	0.0997	0.189
Onchocerca volvulus		0.0286	0.3364	1
Echinococcus granulosus	3'partial\|arginase 2 mitochondrial	0.0414	0.4925	1
Trypanosoma cruzi	agmatinase, putative	0.0151	0.1694	1
Leishmania major	agmatinase-like protein	0.0151	0.1694	0.333
Brugia malayi	putative neuropeptide receptor NPR1	0.0286	0.3364	1
Schistosoma mansoni	ap endonuclease	0.0019	0.0082	0.0002
Echinococcus granulosus	7tm_1 domain containing protein	0.0286	0.3364	0.6826
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0094	0.0997	0.189
Trichomonas vaginalis	CAMK family protein kinase	0.0096	0.103	0.1958
Echinococcus granulosus	7TM GPCR rhodopsin	0.0286	0.3364	0.6826
Echinococcus multilocularis	dro:myosuppressin receptor	0.0286	0.3364	0.336
Brugia malayi	G-protein coupled receptor	0.0286	0.3364	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0286	0.3364	0.336
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0286	0.3364	0.336
Schistosoma mansoni	intermediate filament proteins	0.0027	0.0177	0.0196
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0286	0.3364	0.6777
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0286	0.3364	0.9088
Brugia malayi	hypothetical protein	0.0286	0.3364	1
Trichomonas vaginalis	CAMK family protein kinase	0.0096	0.103	0.1958
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0019	0.0082	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0286	0.3364	0.6777
Trichomonas vaginalis	CAMK family protein kinase	0.0096	0.103	0.1958
Echinococcus granulosus	sex peptide receptor	0.0286	0.3364	0.6826
Loa Loa (eye worm)	neuropeptide F receptor	0.0286	0.3364	0.9088
Plasmodium vivax	arginase, putative	0.0414	0.4925	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0094	0.0997	0.2015
Echinococcus granulosus	neuropeptide FF receptor 2	0.0286	0.3364	0.6826
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0286	0.3364	0.6826
Echinococcus granulosus	hypothetical protein	0.0286	0.3364	0.6826
Echinococcus granulosus	dna polymerase kappa	0.0019	0.0082	0.0154
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0094	0.0997	0.189
Echinococcus granulosus	neuropeptides capa receptor	0.0286	0.3364	0.6826
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0006	0.0016
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.0082	0.0174
Echinococcus granulosus	neuropeptide Y receptor	0.0286	0.3364	0.6826
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0286	0.3364	0.336
Schistosoma mansoni	neuropeptide F-like receptor	0.0286	0.3364	0.6777
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0082	0.0432
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0022	0.0113	0.0062
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0019	0.0082	0.0006
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0286	0.3364	0.6777
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0094	0.0997	0.0992
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0286	0.3364	0.336
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0286	0.3364	0.336
Loa Loa (eye worm)	hypothetical protein	0.0286	0.3364	0.9088
Schistosoma mansoni	opsin-like receptor	0.0286	0.3364	0.6777
Loa Loa (eye worm)	hypothetical protein	0.0286	0.3364	0.9088
Loa Loa (eye worm)	hypothetical protein	0.0286	0.3364	0.9088
Schistosoma mansoni	ap endonuclease	0.0019	0.0082	0.0002
Brugia malayi	G protein-coupled receptor F59B2.13	0.0286	0.3364	1
Echinococcus granulosus	somatostatin receptor	0.0286	0.3364	0.6826
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0286	0.3364	1
Echinococcus granulosus	allatostatin A receptor	0.0286	0.3364	0.6826
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0286	0.3364	0.336
Echinococcus granulosus	arginase 2 mitochondrial	0.0414	0.4925	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0082	0.0432
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0286	0.3364	0.336
Schistosoma mansoni	ran	0.0022	0.0113	0.0064
Trichomonas vaginalis	Arginase, putative	0.0414	0.4925	1
Trichomonas vaginalis	importin beta-1, putative	0.0024	0.014	0.012
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0286	0.3364	0.6777
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0082	0.0432
Brugia malayi	G protein-coupled receptor	0.0286	0.3364	1
Loa Loa (eye worm)	hypothetical protein	0.0286	0.3364	0.9088
Echinococcus granulosus	g protein coupled receptor	0.0286	0.3364	0.6826
Loa Loa (eye worm)	hypothetical protein	0.0286	0.3364	0.9088
Schistosoma mansoni	adenoreceptor	0.0286	0.3364	0.6777
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0286	0.3364	0.6777
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0286	0.3364	0.336
Schistosoma mansoni	opsin-like receptor	0.0286	0.3364	0.6777
Loa Loa (eye worm)	hypothetical protein	0.0286	0.3364	0.9088
Entamoeba histolytica	hypothetical protein	0.0024	0.014	0.012
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0286	0.3364	0.336
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0286	0.3364	0.6777
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0022	0.0113	0.2408
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0286	0.3364	1
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0286	0.3364	0.6777
Loa Loa (eye worm)	G-protein coupled receptor	0.0286	0.3364	0.9088
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0286	0.3364	0.336
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0094	0.0997	0.2015
Trypanosoma cruzi	polo-like protein kinase, putative	0.0096	0.103	0.5878
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0096	0.103	0.1958
Echinococcus multilocularis	geminin	0.0173	0.1969	0.1964
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0286	0.3364	0.6777
Loa Loa (eye worm)	TYRA-2 protein	0.0286	0.3364	0.9088
Echinococcus multilocularis	dna polymerase kappa	0.0019	0.0082	0.0076
Loa Loa (eye worm)	hypothetical protein	0.0286	0.3364	0.9088
Echinococcus multilocularis	neuropeptide Y receptor	0.0286	0.3364	0.336
Echinococcus granulosus	neuropeptide s receptor	0.0286	0.3364	0.6826
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0094	0.0997	0.2694
Schistosoma mansoni	hypothetical protein	0.0286	0.3364	0.6777
Brugia malayi	serine/threonine-protein kinase plk-2	0.0096	0.103	0.3012
Brugia malayi	hypothetical protein	0.0286	0.3364	1
Echinococcus granulosus	orexin receptor type 2	0.0286	0.3364	0.6826
Echinococcus multilocularis	musashi	0.0027	0.0177	0.0171
Echinococcus multilocularis	g protein coupled receptor	0.0286	0.3364	0.336
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0286	0.3364	0.6826
Loa Loa (eye worm)	hypothetical protein	0.0286	0.3364	0.9088
Onchocerca volvulus		0.0286	0.3364	1
Loa Loa (eye worm)	hypothetical protein	0.0286	0.3364	0.9088
Schistosoma mansoni	biogenic amine receptor	0.0286	0.3364	0.6777
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0286	0.3364	0.6777
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0286	0.3364	0.336
Echinococcus multilocularis	fmrfamide receptor	0.0286	0.3364	0.336
Echinococcus multilocularis	lamin dm0	0.0027	0.0177	0.0171
Echinococcus granulosus	snurportin 1	0.0314	0.3701	0.7512
Echinococcus granulosus	importin subunit beta 1	0.0029	0.0208	0.0411
Echinococcus granulosus	neuropeptide receptor	0.0286	0.3364	0.6826
Schistosoma mansoni	amine GPCR	0.0286	0.3364	0.6777
Loa Loa (eye worm)	hypothetical protein	0.0286	0.3364	0.9088
Loa Loa (eye worm)	hypothetical protein	0.0286	0.3364	0.9088
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0286	0.3364	0.6826
Brugia malayi	hypothetical protein	0.0286	0.3364	1
Brugia malayi	sulfakinin receptor protein	0.0286	0.3364	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0286	0.3364	0.6826
Schistosoma mansoni	serine/threonine protein kinase	0.0096	0.103	0.1958
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0019	0.0082	0.0009
Loa Loa (eye worm)	G-protein coupled receptor	0.0286	0.3364	0.9088
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0022	0.0113	0.0193
Plasmodium falciparum	importin beta, putative	0.0029	0.0208	0.0259
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0286	0.3364	0.6777
Trypanosoma brucei	agmatinase, putative	0.0151	0.1694	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0286	0.3364	0.336
Echinococcus multilocularis	sex peptide receptor	0.0286	0.3364	0.336
Brugia malayi	Importin beta-1 subunit	0.0029	0.0208	0.0552
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0286	0.3364	0.336
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0019	0.0082	0.0002
Onchocerca volvulus		0.0286	0.3364	1
Loa Loa (eye worm)	hypothetical protein	0.0286	0.3364	0.9088
Echinococcus multilocularis	g-protein coupled receptor	0.0286	0.3364	0.336
Schistosoma mansoni	myosin xvIII	0.0286	0.3364	0.6777
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0286	0.3364	0.6826
Giardia lamblia	Kinase, PLK	0.0096	0.103	1
Echinococcus granulosus	g protein coupled receptor	0.0286	0.3364	0.6826
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0022	0.0113	0.0304
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0286	0.3364	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0286	0.3364	0.6826
Loa Loa (eye worm)	hypothetical protein	0.0286	0.3364	0.9088
Onchocerca volvulus		0.0286	0.3364	1
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0022	0.0113	0.0617
Schistosoma mansoni	hypothetical protein	0.0286	0.3364	0.6777
Trichomonas vaginalis	CAMK family protein kinase	0.0096	0.103	0.1958
Loa Loa (eye worm)	hypothetical protein	0.0286	0.3364	0.9088
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0286	0.3364	0.6826
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0286	0.3364	1
Trypanosoma brucei	DNA polymerase eta, putative	0.0019	0.0082	0.0432
Echinococcus multilocularis	allatostatin A receptor	0.0286	0.3364	0.336
Schistosoma mansoni	amine GPCR	0.0286	0.3364	0.6777
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0019	0.0082	0.022
Onchocerca volvulus		0.0286	0.3364	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0082	0.0432
Echinococcus granulosus	biogenic amine 5HT receptor	0.0286	0.3364	0.6826
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0082	0.0432
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0082	0.0432
Brugia malayi	RE15519p	0.0286	0.3364	1
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0019	0.0082	0.0155
Loa Loa (eye worm)	hypothetical protein	0.0286	0.3364	0.9088
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0024	0.014	0.0361
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0096	0.103	0.1958
Schistosoma mansoni	neuropeptide receptor	0.0286	0.3364	0.6777
Onchocerca volvulus		0.0286	0.3364	1
Schistosoma mansoni	kinase	0.0049	0.0448	0.0757
Echinococcus multilocularis	g protein coupled receptor	0.0286	0.3364	0.336
Loa Loa (eye worm)	hypothetical protein	0.0286	0.3364	0.9088
Schistosoma mansoni	hypothetical protein	0.0173	0.1969	0.3896
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0286	0.3364	0.6777
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0019	0.0082	0.5
Echinococcus multilocularis	neuropeptide receptor	0.0286	0.3364	0.336
Echinococcus granulosus	G protein coupled receptor 139	0.0286	0.3364	0.6826
Schistosoma mansoni	biogenic amine receptor	0.0286	0.3364	0.6777
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0286	0.3364	0.6777
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0286	0.3364	0.6777
Loa Loa (eye worm)	hypothetical protein	0.0286	0.3364	0.9088
Brugia malayi	Serotonin receptor	0.0286	0.3364	1
Echinococcus multilocularis	g protein coupled receptor	0.0286	0.3364	0.336
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0286	0.3364	1
Schistosoma mansoni	amine GPCR	0.0286	0.3364	0.6777
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0082	0.0432
Loa Loa (eye worm)	hypothetical protein	0.0286	0.3364	0.9088
Schistosoma mansoni	importin beta-1	0.0029	0.0208	0.0261
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0019	0.0082	0.0076
Loa Loa (eye worm)	hypothetical protein	0.0286	0.3364	0.9088
Schistosoma mansoni	hypothetical protein	0.0173	0.1969	0.3896
Schistosoma mansoni	histamine h1 receptor	0.0286	0.3364	0.6777
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0286	0.3364	0.6777
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0286	0.3364	0.336
Loa Loa (eye worm)	hypothetical protein	0.0286	0.3364	0.9088
Brugia malayi	Dopamine receptor	0.0286	0.3364	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0286	0.3364	0.6777
Echinococcus granulosus	neuropeptide receptor A26	0.0286	0.3364	0.6826
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0096	0.103	0.2677
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0286	0.3364	0.336
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0019	0.0082	0.0076
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0019	0.0082	1
Leishmania major	importin beta-1 subunit, putative	0.0024	0.014	0.012
Echinococcus granulosus	rhodopsin orphan GPCR	0.0286	0.3364	0.6826
Brugia malayi	Intermediate filament tail domain containing protein	0.0027	0.0177	0.0458
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0286	0.3364	0.6826
Echinococcus multilocularis	G protein coupled receptor 139	0.0286	0.3364	0.336
Schistosoma mansoni	amine GPCR	0.0286	0.3364	0.6777
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0286	0.3364	0.336
Brugia malayi	exodeoxyribonuclease III family protein	0.0019	0.0082	0.0176
Loa Loa (eye worm)	hypothetical protein	0.0286	0.3364	0.9088
Echinococcus multilocularis	arginase 2, mitochondrial	0.0414	0.4925	0.4922
Loa Loa (eye worm)	hypothetical protein	0.0286	0.3364	0.9088
Brugia malayi	hypothetical protein	0.0286	0.3364	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0094	0.0997	0.0992
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0286	0.3364	0.9088
Schistosoma mansoni	neuropeptide F-like receptor	0.0286	0.3364	0.6777
Brugia malayi	larval opioid receptor	0.0286	0.3364	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0286	0.3364	0.6777
Schistosoma mansoni	neuropeptide f receptor 76f	0.0286	0.3364	0.6777
Leishmania major	arginase	0.0414	0.4925	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0286	0.3364	0.6826
Brugia malayi	Melatonin receptor type 1A	0.0286	0.3364	1
Loa Loa (eye worm)	hypothetical protein	0.0286	0.3364	0.9088
Schistosoma mansoni	lamin	0.0027	0.0177	0.0196
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0286	0.3364	0.336
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0286	0.3364	0.9088
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0082	0.0432
Onchocerca volvulus		0.0286	0.3364	1
Loa Loa (eye worm)	hypothetical protein	0.0286	0.3364	0.9088
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0286	0.3364	0.6777
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0171	0.0461
Onchocerca volvulus		0.0286	0.3364	1
Loa Loa (eye worm)	hypothetical protein	0.0286	0.3364	0.9088
Schistosoma mansoni	lamin	0.0027	0.0177	0.0196
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0286	0.3364	0.6777
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0286	0.3364	0.6777
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0286	0.3364	0.6777
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0082	0.0432
Echinococcus granulosus	neuropeptides capa receptor	0.0286	0.3364	0.6826
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0082	0.0432
Schistosoma mansoni	biogenic amine receptor	0.0286	0.3364	0.6777
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0096	0.103	0.2782
Loa Loa (eye worm)	hypothetical protein	0.0286	0.3364	0.9088
Loa Loa (eye worm)	hypothetical protein	0.0286	0.3364	0.9088
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0096	0.103	0.1024
Loa Loa (eye worm)	hypothetical protein	0.0286	0.3364	0.9088
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0286	0.3364	0.336
Echinococcus multilocularis	neuropeptide receptor A26	0.0286	0.3364	0.336
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0286	0.3364	0.6777
Trichomonas vaginalis	CAMK family protein kinase	0.0048	0.0432	0.0725
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0082	0.0002
Echinococcus granulosus	rhodopsin orphan GPCR	0.0286	0.3364	0.6826
Loa Loa (eye worm)	hypothetical protein	0.0286	0.3364	0.9088
Echinococcus granulosus	neuropeptide receptor	0.0286	0.3364	0.6826
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0024	0.014	0.012
Echinococcus multilocularis	dna polymerase eta	0.0019	0.0082	0.0076
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0286	0.3364	0.336
Entamoeba histolytica	Arginase, putative	0.0414	0.4925	1
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0022	0.0113	0.0328
Loa Loa (eye worm)	hypothetical protein	0.0286	0.3364	0.9088
Trypanosoma brucei	importin beta-1 subunit, putative	0.0029	0.0208	0.1182
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0082	0.0432
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0286	0.3364	0.6826
Schistosoma mansoni	arginase	0.0414	0.4925	1
Echinococcus granulosus	g-protein coupled receptor	0.0286	0.3364	0.6826
Schistosoma mansoni	opsin-like receptor	0.0286	0.3364	0.6777
Echinococcus multilocularis	serotonin receptor	0.0286	0.3364	0.336
Echinococcus multilocularis	serotonin receptor	0.0286	0.3364	0.336
Onchocerca volvulus		0.0286	0.3364	1
Echinococcus multilocularis	snurportin 1	0.0314	0.3701	0.3697
Echinococcus multilocularis	importin subunit beta 1	0.0029	0.0208	0.0202
Schistosoma mansoni	neuropeptide receptor	0.0286	0.3364	0.6777
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0019	0.0082	0.0223
Onchocerca volvulus		0.0286	0.3364	1
Echinococcus multilocularis	neuropeptide s receptor	0.0286	0.3364	0.336
Trichomonas vaginalis	CAMK family protein kinase	0.0096	0.103	0.1958
Loa Loa (eye worm)	hypothetical protein	0.0286	0.3364	0.9088
Echinococcus granulosus	intermediate filament protein	0.0027	0.0177	0.0347
Loa Loa (eye worm)	intermediate filament protein	0.0027	0.0177	0.0477
Schistosoma mansoni	neuropeptide receptor	0.0286	0.3364	0.6777
Plasmodium vivax	importin-beta 2, putative	0.0029	0.0208	0.0259
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0022	0.0113	0.0193
Trichomonas vaginalis	ran, putative	0.0022	0.0113	0.0064
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0094	0.0997	0.2914
Toxoplasma gondii	HEAT repeat-containing protein	0.0029	0.0208	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0286	0.3364	0.6826
Loa Loa (eye worm)	hypothetical protein	0.0286	0.3364	0.9088
Echinococcus granulosus	dro:myosuppressin receptor	0.0286	0.3364	0.6826
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0314	0.3701	1
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0286	0.3364	1
Loa Loa (eye worm)	hypothetical protein	0.0286	0.3364	0.9088
Echinococcus granulosus	tm gpcr rhodopsin	0.0286	0.3364	0.6826
Echinococcus multilocularis	neuropeptide Y receptor	0.0286	0.3364	0.336
Loa Loa (eye worm)	hypothetical protein	0.0286	0.3364	0.9088
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0024	0.014	0.012
Loa Loa (eye worm)	hypothetical protein	0.0286	0.3364	0.9088
Brugia malayi	hypothetical protein	0.0286	0.3364	1
Trichomonas vaginalis	conserved hypothetical protein	0.0414	0.4925	1
Echinococcus granulosus	g protein coupled receptor	0.0286	0.3364	0.6826
Brugia malayi	G-protein coupled receptor	0.0286	0.3364	1
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0082	0.0437
Trypanosoma cruzi	arginase, putative	0.0151	0.1694	1
Onchocerca volvulus		0.0286	0.3364	1
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0286	0.3364	0.336
Echinococcus multilocularis	neuropeptides capa receptor	0.0286	0.3364	0.336
Trichomonas vaginalis	CAMK family protein kinase	0.0096	0.103	0.1958
Echinococcus multilocularis	neuropeptide receptor	0.0286	0.3364	0.336
Loa Loa (eye worm)	hypothetical protein	0.0286	0.3364	0.9088
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0014	0.0024	0.0064
Echinococcus multilocularis	somatostatin receptor	0.0286	0.3364	0.336
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0022	0.0113	0.0062
Brugia malayi	hypothetical protein	0.0286	0.3364	1
Brugia malayi	hypothetical protein	0.0286	0.3364	1
Trypanosoma brucei	unspecified product	0.0019	0.0082	0.0432
Onchocerca volvulus		0.0286	0.3364	1
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.0082	0.0174
Plasmodium falciparum	arginase	0.0414	0.4925	1
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0286	0.3364	0.6777
Brugia malayi	RNA, U transporter 1	0.0084	0.0874	0.2545
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0286	0.3364	0.336
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0082	0.022
Brugia malayi	neuropeptide F receptor	0.0286	0.3364	1
Trichomonas vaginalis	CAMK family protein kinase	0.0096	0.103	0.1958
Brugia malayi	Serotonin receptor	0.0286	0.3364	1
Schistosoma mansoni	ran	0.0022	0.0113	0.0064
Echinococcus multilocularis	lamin	0.0027	0.0177	0.0171
Onchocerca volvulus		0.0286	0.3364	1
Brugia malayi	follicle stimulating hormone receptor	0.0286	0.3364	1
Echinococcus granulosus	serotonin receptor	0.0286	0.3364	0.6826
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0019	0.0082	0.0002
Brugia malayi	putative neuropeptide receptor	0.0286	0.3364	1
Echinococcus granulosus	lamin	0.0027	0.0177	0.0347
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0019	0.0082	0.0154
Loa Loa (eye worm)	hypothetical protein	0.0286	0.3364	0.9088
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0286	0.3364	0.9088
Trichomonas vaginalis	CAMK family protein kinase	0.0048	0.0432	0.0725
Schistosoma mansoni	amine GPCR	0.0286	0.3364	0.6777
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0177	0.0477
Brugia malayi	hypothetical protein	0.0286	0.3364	1
Loa Loa (eye worm)	hypothetical protein	0.0286	0.3364	0.9088
Schistosoma mansoni	hypothetical protein	0.0286	0.3364	0.6777
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0082	0.0006
Echinococcus multilocularis	orexin receptor type 2	0.0286	0.3364	0.336
Loa Loa (eye worm)	hypothetical protein	0.0286	0.3364	0.9088
Echinococcus granulosus	dna polymerase eta	0.0019	0.0082	0.0154
Loa Loa (eye worm)	hypothetical protein	0.0286	0.3364	0.9088
Echinococcus granulosus	rhodopsin orphan GPCR	0.0286	0.3364	0.6826
Brugia malayi	intermediate filament protein	0.0027	0.0177	0.0458
Trypanosoma cruzi	polo-like protein kinase, putative	0.0096	0.103	0.5878
Loa Loa (eye worm)	hypothetical protein	0.0286	0.3364	0.9088
Brugia malayi	hypothetical protein	0.0286	0.3364	1
Loa Loa (eye worm)	hypothetical protein	0.0286	0.3364	0.9088
Brugia malayi	AKH receptor	0.0286	0.3364	1
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0096	0.103	0.2081
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0286	0.3364	0.336
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0027	0.0177	0.0477
Brugia malayi	Dopamine receptor protein 2	0.0286	0.3364	1
Loa Loa (eye worm)	hypothetical protein	0.0286	0.3364	0.9088
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0286	0.3364	0.6777
Echinococcus granulosus	tm gpcr rhodopsin	0.0286	0.3364	0.6826
Schistosoma mansoni	growth hormone secretagogue receptor	0.0286	0.3364	0.6777
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0286	0.3364	0.336
Echinococcus multilocularis	fmrfamide receptor	0.0286	0.3364	0.336
Brugia malayi	GnHR receptor homolog	0.0286	0.3364	1
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0022	0.0113	0.0217
Schistosoma mansoni	neuropeptide receptor	0.0286	0.3364	0.6777
Brugia malayi	hypothetical protein	0.0286	0.3364	1
Entamoeba histolytica	Ran family GTPase	0.0022	0.0113	0.0064
Echinococcus granulosus	fmrfamide receptor	0.0286	0.3364	0.6826
Trypanosoma brucei	importin beta-1 subunit, putative	0.0029	0.0208	0.1182
Trypanosoma brucei	polo-like protein kinase	0.0096	0.103	0.6056
Loa Loa (eye worm)	hypothetical protein	0.0286	0.3364	0.9088
Echinococcus granulosus	rhodopsin orphan GPCR	0.0286	0.3364	0.6826
Schistosoma mansoni	hypothetical protein	0.0286	0.3364	0.6777
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0022	0.0113	0.0107
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0082	0.0432
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0286	0.3364	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0208	0.0562
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0022	0.0113	0.0267
Brugia malayi	neuropeptide F receptor	0.0286	0.3364	1
Brugia malayi	Dopamine receptor protein 1	0.0286	0.3364	1
Echinococcus granulosus	lamin dm0	0.0027	0.0177	0.0347
Onchocerca volvulus		0.0286	0.3364	1
Onchocerca volvulus		0.0286	0.3364	1
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0019	0.0082	1
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0082	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0286	0.3364	0.9088
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0286	0.3364	0.6826
Loa Loa (eye worm)	melatonin receptor type 1A	0.0286	0.3364	0.9088
Echinococcus granulosus	geminin	0.0173	0.1969	0.399
Onchocerca volvulus		0.0286	0.3364	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0286	0.3364	0.6777
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0286	0.3364	0.6777
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0286	0.3364	0.6826
Trypanosoma cruzi	arginase, putative	0.0151	0.1694	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0286	0.3364	0.9088
Echinococcus granulosus	rhodopsin orphan GPCR	0.0286	0.3364	0.6826
Trichomonas vaginalis	conserved hypothetical protein	0.0414	0.4925	1
Schistosoma mansoni	hypothetical protein	0.0314	0.3701	0.7474
Echinococcus granulosus	neuropeptide Y receptor	0.0286	0.3364	0.6826
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0082	0.0432
Trypanosoma cruzi	agmatinase, putative	0.0151	0.1694	1
Echinococcus multilocularis		0.0414	0.4925	0.4922
Brugia malayi	ORL1-like opioid receptor	0.0286	0.3364	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 4650 nM	Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assay	ChEMBL.	23886684
IC50 (binding)	= 6650 nM	Inhibition of human arginase-1 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assay	ChEMBL.	23886684

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2419000

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1767935