Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.4505 | 1 | 1 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.4429 | 0.9706 | 0.9706 |
Loa Loa (eye worm) | hypothetical protein | 0.4429 | 0.9706 | 0.9604 |
Schistosoma mansoni | 6-phosphofructokinase | 0.4505 | 1 | 0.5 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.2659 | 0.2852 | 0.5 |
Onchocerca volvulus | 0.4505 | 1 | 0.5 | |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.4505 | 1 | 1 |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.4429 | 0.9706 | 0.9706 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.4505 | 1 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.2659 | 0.2852 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.2659 | 0.2852 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.4429 | 0.9706 | 0.9706 |
Mycobacterium ulcerans | hypothetical protein | 0.2659 | 0.2852 | 0.5 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.4505 | 1 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.4429 | 0.9706 | 0.9706 |
Loa Loa (eye worm) | hypothetical protein | 0.4505 | 1 | 1 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.4505 | 1 | 1 |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.2659 | 0.2852 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 26 uM | Inhibition of Pseudomonas sp. AK1 BBOX assessed as hydroxylation of GBB to L-carnitine measured for 60 sec in presence of 2OG and Fe2+ by 1H NMR assay | ChEMBL. | No reference |
IC50 (binding) | = 125 uM | Inhibition of Pseudomonas sp. AK1 BBOX using GBBF as substrate after 10 mins in presence of 2OG and Fe2+ using TBS-protected fluorescein probe by fluoride release assay | ChEMBL. | No reference |
Inhibition (binding) | Inhibition of GBB binding to Pseudomonas sp. AK1 BBOX at 25 uM in presence of Mn2+ by 1H NMR GBB/2OG dual reporter displacement assay | ChEMBL. | No reference | |
Inhibition (binding) | Inhibition of 2OG binding to Pseudomonas sp. AK1 BBOX at 25 uM in presence of Mn2+ by 1H NMR GBB/2OG dual reporter displacement assay | ChEMBL. | No reference | |
Kd (binding) | = 55 uM | Binding affinity to Pseudomonas sp. AK1 BBOX by intrinsic tryptophan fluorescence quenching assay | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.