Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.4505 | 1 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.4429 | 0.9706 | 0.9706 |
Giardia lamblia | Hypothetical protein | 0.2659 | 0.2852 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.2659 | 0.2852 | 0.5 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.4505 | 1 | 1 |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.2659 | 0.2852 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.4505 | 1 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.4429 | 0.9706 | 0.9706 |
Loa Loa (eye worm) | hypothetical protein | 0.4429 | 0.9706 | 0.9604 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.2659 | 0.2852 | 0.5 |
Schistosoma mansoni | 6-phosphofructokinase | 0.4505 | 1 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.4505 | 1 | 1 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.4429 | 0.9706 | 0.9706 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.4505 | 1 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.2659 | 0.2852 | 0.5 |
Onchocerca volvulus | 0.4505 | 1 | 0.5 | |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.4505 | 1 | 1 |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.4429 | 0.9706 | 0.9706 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 94 uM | Inhibition of Pseudomonas sp. AK1 BBOX assessed as hydroxylation of GBB to L-carnitine measured for 60 sec in presence of 2OG and Fe2+ by 1H NMR assay | ChEMBL. | No reference |
IC50 (binding) | > 1000 uM | Inhibition of Pseudomonas sp. AK1 BBOX using GBBF as substrate after 10 mins in presence of 2OG and Fe2+ using TBS-protected fluorescein probe by fluoride release assay | ChEMBL. | No reference |
Inhibition (binding) | Inhibition of GBB binding to Pseudomonas sp. AK1 BBOX at 25 uM in presence of Mn2+ by 1H NMR GBB/2OG dual reporter displacement assay | ChEMBL. | No reference | |
Inhibition (binding) | Inhibition of 2OG binding to Pseudomonas sp. AK1 BBOX at 25 uM in presence of Mn2+ by 1H NMR GBB/2OG dual reporter displacement assay | ChEMBL. | No reference | |
Kd (binding) | = 103 uM | Binding affinity to Pseudomonas sp. AK1 BBOX by intrinsic tryptophan fluorescence quenching assay | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.