Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | protein-tyrosine kinase | 0.1486 | 0.5 | 0.5 |
Onchocerca volvulus | 0.1486 | 0.5 | 0.5 | |
Onchocerca volvulus | 0.1486 | 0.5 | 0.5 | |
Loa Loa (eye worm) | TK/FER protein kinase | 0.1486 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.1486 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.1486 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.1486 | 0.5 | 0.5 |
Onchocerca volvulus | 0.1486 | 0.5 | 0.5 | |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.1486 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.1486 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.1486 | 0.5 | 0.5 |
Brugia malayi | hypothetical protein | 0.1486 | 0.5 | 0.5 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.1486 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.1486 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.1486 | 0.5 | 0.5 |
Brugia malayi | SH2 domain containing protein | 0.1486 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase ABL1 | 0.1486 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.1486 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1486 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK protein kinase | 0.1486 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.1486 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.1486 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.1486 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.1486 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine kinase | 0.1486 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Srms | 0.1486 | 0.5 | 0.5 |
Echinococcus multilocularis | c src tyrosine kinase | 0.1486 | 0.5 | 0.5 |
Onchocerca volvulus | 0.1486 | 0.5 | 0.5 | |
Echinococcus multilocularis | tyrosine protein kinase shark | 0.1486 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.1486 | 0.5 | 0.5 |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.1486 | 0.5 | 0.5 |
Brugia malayi | SH2 domain containing protein | 0.1486 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.1486 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.1486 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.1486 | 0.5 | 0.5 |
Onchocerca volvulus | 0.1486 | 0.5 | 0.5 | |
Loa Loa (eye worm) | TK/FER protein kinase | 0.1486 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.1486 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Srms | 0.1486 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine kinase | 0.1486 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.1486 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.1486 | 0.5 | 0.5 |
Loa Loa (eye worm) | SRC-1 | 0.1486 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase ABL1 | 0.1486 | 0.5 | 0.5 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.1486 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase shark | 0.1486 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.1486 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.1486 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.1486 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Blk | 0.1486 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine kinase | 0.1486 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.1486 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.1486 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.1486 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.1486 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.1486 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.1486 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Blk | 0.1486 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/ABL protein kinase | 0.1486 | 0.5 | 0.5 |
Brugia malayi | SRC-1 | 0.1486 | 0.5 | 0.5 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.1486 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fps85D | 0.1486 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.1486 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.1486 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.1486 | 0.5 | 0.5 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.1486 | 0.5 | 0.5 |
Echinococcus granulosus | c src tyrosine kinase | 0.1486 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.1486 | 0.5 | 0.5 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.1486 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fps85D | 0.1486 | 0.5 | 0.5 |
Onchocerca volvulus | 0.1486 | 0.5 | 0.5 | |
Loa Loa (eye worm) | TK/FER protein kinase | 0.1486 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine kinase|tyrosine protein kinase Fyn | 0.1486 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.1486 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.1486 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 38 uM | Inhibition of Pseudomonas sp. AK1 BBOX assessed as hydroxylation of GBB to L-carnitine measured for 60 sec in presence of 2OG and Fe2+ by 1H NMR assay | ChEMBL. | No reference |
IC50 (binding) | = 160 uM | Inhibition of Pseudomonas sp. AK1 BBOX using GBBF as substrate after 10 mins in presence of 2OG and Fe2+ using TBS-protected fluorescein probe by fluoride release assay | ChEMBL. | No reference |
Inhibition (binding) | Inhibition of 2OG binding to Pseudomonas sp. AK1 BBOX at 25 uM in presence of Mn2+ by 1H NMR GBB/2OG dual reporter displacement assay | ChEMBL. | No reference | |
Inhibition (binding) | Inhibition of GBB binding to Pseudomonas sp. AK1 BBOX at 25 uM in presence of Mn2+ by 1H NMR GBB/2OG dual reporter displacement assay | ChEMBL. | No reference | |
Kd (binding) | = 101 uM | Binding affinity to Pseudomonas sp. AK1 BBOX by intrinsic tryptophan fluorescence quenching assay | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.