Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | Starlite/ChEMBL | References |
Homo sapiens | nuclear receptor subfamily 3, group C, member 2 | Starlite/ChEMBL | References |
Homo sapiens | androgen receptor | Starlite/ChEMBL | References |
Homo sapiens | progesterone receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0685 | 1 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0681 | 0.9883 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0685 | 1 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.0681 | 0.9883 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0681 | 0.9883 | 1 |
Onchocerca volvulus | 0.0339 | 0 | 0.5 | |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0681 | 0.9883 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0685 | 1 | 0.5 |
Brugia malayi | dihydrofolate reductase family protein | 0.0681 | 0.9883 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0681 | 0.9883 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0685 | 1 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0681 | 0.9883 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0681 | 0.9883 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.0681 | 0.9883 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.0681 | 0.9883 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0685 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 92 nM | Displacement of [3H]-Aldosterone from human MR expressed in 293 cells after 16 hrs by scintillation counting | ChEMBL. | 23958516 |
IC50 (binding) | = 3200 nM | Displacement of [3H]-Progesterone from human PR expressed in 293 cells after 16 hrs by scintillation counting | ChEMBL. | 23958516 |
IC50 (binding) | = 5000 nM | Displacement of [3H]-Dexamethasone human GR expressed in 293 cells after 16 hrs by scintillation counting | ChEMBL. | 23958516 |
IC50 (binding) | > 10000 nM | Displacement of [3H]-Testosterone from human AR expressed in 293 cells after 16 hrs by scintillation counting | ChEMBL. | 23958516 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.