Detailed information for compound 1768163

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 270.712 | Formula: C12H15ClN2O3
  • H donors: 2 H acceptors: 4 LogP: -1.97 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC1CN(Cc2ccncc2)CC(=C1)C(=O)O.Cl
  • InChi: 1S/C12H14N2O3.ClH/c15-11-5-10(12(16)17)7-14(8-11)6-9-1-3-13-4-2-9;/h1-5,11,15H,6-8H2,(H,16,17);1H
  • InChiKey: KVESZKSKEGBBMB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis epidermal growth factor receptor 0.0396 0.98 1
Trichomonas vaginalis CMGC family protein kinase 0.038 0.9396 0.5
Schistosoma mansoni ephrin receptor 0.008 0.1678 0.1712
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0025 0.0278 0.0275
Echinococcus multilocularis roundabout 2 0.0025 0.0278 0.0284
Schistosoma mansoni nephrin 0.0025 0.0278 0.0284
Schistosoma mansoni tyrosine kinase 0.0236 0.5689 0.5805
Echinococcus granulosus tyrosine protein kinase shark 0.0014 0.0009 0.0009
Echinococcus granulosus tyrosine protein kinase Fyn 0.005 0.0924 0.0943
Brugia malayi Protein kinase domain containing protein 0.0014 0.0009 0.0005
Brugia malayi Protein kinase domain containing protein 0.0014 0.0009 0.0005
Schistosoma mansoni serine/threonine protein kinase 0.0014 0.0006 0.0006
Onchocerca volvulus 0.0033 0.0496 0.0556
Echinococcus granulosus tyrosine protein kinase Src64B 0.005 0.0924 0.0943
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0088 0.1891 0.2013
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0088 0.1891 0.2013
Schistosoma mansoni roundabout 0.0022 0.0212 0.0216
Schistosoma mansoni septate junction protein 0.0022 0.0212 0.0216
Loa Loa (eye worm) hypothetical protein 0.0022 0.0212 0.0208
Echinococcus granulosus tyrosine protein kinase HCK 0.0042 0.0716 0.0731
Echinococcus multilocularis lamin 0.0031 0.0444 0.0453
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.007 0.0066
Loa Loa (eye worm) TK/FER protein kinase 0.0014 0.0009 0.0005
Loa Loa (eye worm) TK/FER protein kinase 0.0014 0.0009 0.0005
Loa Loa (eye worm) TK/FER protein kinase 0.0014 0.0009 0.0005
Schistosoma mansoni cell adhesion molecule 0.0025 0.0278 0.0284
Loa Loa (eye worm) hypothetical protein 0.0015 0.0012 0.0009
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0088 0.1891 0.1888
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.007 0.0066
Echinococcus multilocularis tyrosine protein kinase Fgr 0.005 0.0924 0.0943
Echinococcus multilocularis mitogen activated protein kinase 14 0.0088 0.1891 0.193
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0444 0.044
Brugia malayi Protein kinase domain containing protein 0.0014 0.0009 0.0005
Echinococcus multilocularis roundabout 2 0.0025 0.0278 0.0284
Echinococcus granulosus roundabout 2 0.0025 0.0278 0.0284
Schistosoma mansoni cell adhesion molecule 0.0025 0.0278 0.0284
Schistosoma mansoni cell adhesion molecule 0.0014 0.0004 0.0004
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0256 0.62 0.6326
Schistosoma mansoni nephrin 0.006 0.117 0.1194
Echinococcus multilocularis tyrosine protein kinase Fyn 0.005 0.0924 0.0943
Echinococcus granulosus c src tyrosine kinase 0.0018 0.0111 0.0113
Schistosoma mansoni serine/threonine protein kinase 0.038 0.9396 0.9587
Trichomonas vaginalis CMGC family protein kinase 0.038 0.9396 0.5
Brugia malayi Protein kinase domain containing protein 0.0014 0.0009 0.0005
Echinococcus granulosus ephrin type A receptor 4 A 0.008 0.1678 0.1712
Loa Loa (eye worm) hypothetical protein 0.0048 0.0872 0.0869
Echinococcus granulosus roundabout 2 0.007 0.1445 0.1475
Echinococcus multilocularis cpg binding protein 0.0035 0.0545 0.0556
Echinococcus granulosus tyrosine protein kinase Fyn 0.005 0.0924 0.0943
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0014 0.0009 0.0009
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.038 0.9396 1
Entamoeba histolytica protein kinase, putative 0.0042 0.0716 1
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0014 0.0009 0.0122
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0025 0.0278 0.0284
Echinococcus granulosus defective proboscis extension response 0.0046 0.0806 0.0822
Trichomonas vaginalis CMGC family protein kinase 0.038 0.9396 0.5
Brugia malayi Immunoglobulin I-set domain containing protein 0.0129 0.2949 0.2947
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0246 0.5954 0.6075
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0117 0.2651 0.2705
Echinococcus granulosus mitogen activated protein kinase 11 0.0088 0.1891 0.193
Brugia malayi protein-tyrosine kinase 0.0046 0.0821 0.0818
Schistosoma mansoni tyrosine kinase 0.0117 0.2651 0.2705
Loa Loa (eye worm) hypothetical protein 0.0031 0.0429 0.0425
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.038 0.9396 1
Loa Loa (eye worm) TK/FER protein kinase 0.0014 0.0009 0.0005
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.038 0.9396 1
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0018 0.0111 0.0113
Brugia malayi Immunoglobulin I-set domain containing protein 0.0022 0.0212 0.0208
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0029 0.0374 0.0371
Schistosoma mansoni tyrosine kinase 0.005 0.0924 0.0943
Echinococcus multilocularis mitogen activated protein kinase 11 0.0088 0.1891 0.193
Brugia malayi Immunoglobulin I-set domain containing protein 0.0018 0.01 0.0096
Brugia malayi Prion-like- 0.0022 0.0212 0.0208
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0117 0.2651 0.2705
Plasmodium vivax protein kinase, putative 0.0016 0.0043 0.5
Loa Loa (eye worm) hypothetical protein 0.0022 0.0212 0.0208
Echinococcus granulosus neuroglian 0.0025 0.0278 0.0284
Echinococcus multilocularis mitogen activated protein kinase 0.038 0.9396 0.9587
Echinococcus granulosus lachesin 0.0022 0.0212 0.0216
Brugia malayi Fibronectin type III domain containing protein 0.0048 0.0872 0.0869
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0088 0.1891 0.2013
Schistosoma mansoni neuroglian 0.0025 0.0278 0.0284
Onchocerca volvulus 0.0014 0.0009 0.0006
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0015 0.0027 0.0028
Schistosoma mansoni lamin 0.0031 0.0444 0.0453
Loa Loa (eye worm) hypothetical protein 0.0035 0.0542 0.0538
Brugia malayi Immunoglobulin I-set domain containing protein 0.0025 0.0278 0.0275
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0022 0.0212 0.0216
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0046 0.0806 0.0822
Echinococcus multilocularis transfer RNA-Phe 0.0014 0.0004 0.0004
Loa Loa (eye worm) CAMK protein kinase 0.0018 0.01 0.0096
Schistosoma mansoni cell adhesion molecule 0.0014 0.0004 0.0004
Loa Loa (eye worm) TK/FER protein kinase 0.0014 0.0009 0.0005
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0444 0.044
Schistosoma mansoni tyrosine kinase 0.0014 0.0009 0.0009
Echinococcus multilocularis twitchin 0.0015 0.0033 0.0034
Echinococcus granulosus tyrosine kinase 0.0014 0.0009 0.0009
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0046 0.0806 0.0822
Brugia malayi intermediate filament protein 0.0031 0.0444 0.044
Loa Loa (eye worm) hypothetical protein 0.0048 0.0872 0.0869
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0022 0.0212 0.0235
Brugia malayi Protein kinase domain containing protein 0.0253 0.6133 0.6132
Loa Loa (eye worm) TK protein kinase 0.0042 0.0716 0.0713
Schistosoma mansoni tyrosine kinase 0.0246 0.5954 0.6075
Loa Loa (eye worm) hypothetical protein 0.0069 0.1413 0.141
Brugia malayi Furin-like cysteine rich region family protein 0.0396 0.98 0.98
Brugia malayi Tyrosine-protein kinase abl-1 0.0018 0.0111 0.0108
Echinococcus multilocularis peroxidasin 0.0022 0.0212 0.0216
Echinococcus multilocularis titin 0.0018 0.01 0.0102
Trichomonas vaginalis CMGC family protein kinase 0.038 0.9396 0.5
Echinococcus granulosus mitogen activated protein kinase 3 0.038 0.9396 0.9587
Echinococcus granulosus tyrosine protein kinase Fyn 0.005 0.0924 0.0943
Loa Loa (eye worm) TK/ABL protein kinase 0.0014 0.0009 0.0005
Echinococcus multilocularis tyrosine protein kinase otk 0.0022 0.0212 0.0216
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0256 0.62 0.6326
Schistosoma mansoni hemicentin 0.0014 0.0004 0.0004
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0056 0.108 0.1102
Loa Loa (eye worm) hypothetical protein 0.0019 0.012 0.0117
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0025 0.0278 0.0284
Brugia malayi Immunoglobulin I-set domain containing protein 0.0022 0.0212 0.0208
Loa Loa (eye worm) hypothetical protein 0.0022 0.0212 0.0208
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0015 0.0027 0.0028
Brugia malayi plexin A 0.0022 0.0208 0.0205
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0025 0.0278 0.0284
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.005 0.0924 0.0943
Echinococcus multilocularis mitogen activated protein kinase 11 0.0088 0.1891 0.193
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.005 0.0924 0.0943
Loa Loa (eye worm) hypothetical protein 0.0022 0.0212 0.0208
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.038 0.9396 1
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.005 0.0924 0.0943
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0036 0.0556 0.0568
Echinococcus granulosus cpg binding protein 0.0035 0.0545 0.0556
Schistosoma mansoni myosin-binding protein-related 0.0014 0.0004 0.0004
Echinococcus multilocularis insulin receptor 0.0253 0.6133 0.6258
Brugia malayi P38 map kinase family protein 2 0.0088 0.1891 0.1888
Schistosoma mansoni septate junction protein 0.0022 0.0212 0.0216
Echinococcus multilocularis tyrosine protein kinase shark 0.0014 0.0009 0.0009
Brugia malayi Immunoglobulin I-set domain containing protein 0.0025 0.0278 0.0275
Brugia malayi CXXC zinc finger family protein 0.0033 0.0496 0.0492
Schistosoma mansoni tyrosine kinase 0.0236 0.5689 0.5805
Echinococcus multilocularis tyrosine protein kinase Abl 0.0018 0.0111 0.0113
Echinococcus multilocularis lachesin 0.0022 0.0212 0.0216
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0014 0.0004 0.0004
Echinococcus granulosus titin 0.0018 0.01 0.0102
Onchocerca volvulus 0.0014 0.0009 0.0006
Onchocerca volvulus 0.0014 0.0009 0.0006
Loa Loa (eye worm) TK/FER protein kinase 0.0014 0.0009 0.0005
Schistosoma mansoni plexin 0.0019 0.012 0.0123
Echinococcus multilocularis Immunoglobulin 0.0046 0.0806 0.0822
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0022 0.0212 0.0208
Loa Loa (eye worm) hypothetical protein 0.0025 0.0278 0.0275
Schistosoma mansoni serine/threonine protein kinase 0.0015 0.0033 0.0034
Loa Loa (eye worm) hypothetical protein 0.0068 0.1378 0.1375
Echinococcus multilocularis mitogen activated protein kinase 14 0.0088 0.1891 0.193
Brugia malayi Immunoglobulin I-set domain containing protein 0.0022 0.0212 0.0208
Echinococcus multilocularis mitogen activated protein kinase 3 0.038 0.9396 0.9587
Onchocerca volvulus 0.0069 0.1413 0.1592
Echinococcus multilocularis neuroglian 0.0057 0.1104 0.1126
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0014 0.0009 0.0009
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0046 0.0821 0.0838
Echinococcus multilocularis tyrosine protein kinase Blk 0.0046 0.0821 0.0838
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0018 0.0111 0.0113
Schistosoma mansoni tyrosine kinase 0.0253 0.6133 0.6258
Loa Loa (eye worm) TK/FER protein kinase 0.0014 0.0009 0.0005
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0018 0.01 0.0096
Brugia malayi Immunoglobulin I-set domain containing protein 0.0022 0.0212 0.0208
Echinococcus granulosus fibroblast growth factor receptor 4 0.0117 0.2651 0.2705
Echinococcus multilocularis tyrosine protein kinase Src64B 0.005 0.0924 0.0943
Brugia malayi MAP kinase sur-1 0.038 0.9396 0.9396
Echinococcus granulosus nephrin 0.0014 0.0004 0.0004
Echinococcus granulosus lamin dm0 0.0031 0.0444 0.0453
Schistosoma mansoni cell adhesion molecule 0.0022 0.0212 0.0216
Loa Loa (eye worm) TK protein kinase 0.0129 0.2949 0.2947
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0046 0.0806 0.0822
Echinococcus granulosus plexin a4 0.0022 0.0208 0.0213
Loa Loa (eye worm) TK protein kinase 0.0046 0.0821 0.0818
Brugia malayi Protein kinase domain containing protein 0.0088 0.1893 0.1891
Echinococcus multilocularis c src tyrosine kinase 0.0018 0.0111 0.0113
Echinococcus granulosus epidermal growth factor receptor 0.0396 0.98 1
Schistosoma mansoni tyrosine kinase 0.0253 0.6133 0.6258
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0022 0.0212 0.0208
Loa Loa (eye worm) plexin A 0.0022 0.0208 0.0205
Onchocerca volvulus 0.0031 0.0444 0.0497
Brugia malayi Immunoglobulin I-set domain containing protein 0.0022 0.0212 0.0208
Echinococcus granulosus tyrosine protein kinase ABL1 0.0014 0.0009 0.0009
Schistosoma mansoni tyrosine kinase 0.0236 0.5689 0.5805
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.038 0.9396 1
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.038 0.9396 1
Echinococcus multilocularis lamin dm0 0.0031 0.0444 0.0453
Echinococcus multilocularis neuroglian 0.0025 0.0278 0.0284
Echinococcus granulosus tyrosine protein kinase Blk 0.0046 0.0821 0.0838
Echinococcus multilocularis hemicentin 1 0.0022 0.0212 0.0216
Schistosoma mansoni serine/threonine protein kinase 0.0018 0.01 0.0102
Schistosoma mansoni titin 0.0022 0.0212 0.0216
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0022 0.0202 0.0206
Schistosoma mansoni titin 0.0018 0.01 0.0102
Echinococcus granulosus lamin 0.0031 0.0444 0.0453
Echinococcus granulosus peroxidasin 0.0022 0.0212 0.0216
Schistosoma mansoni intermediate filament proteins 0.0031 0.0444 0.0453
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0071 0.1457 0.1486
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0444 0.044
Loa Loa (eye worm) TK/ROR protein kinase 0.0022 0.0202 0.0198
Echinococcus granulosus neuroglian 0.0057 0.1104 0.1126
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.038 0.9396 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.108 0.1077
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.005 0.0924 0.0943
Echinococcus granulosus tyrosine kinase 0.0046 0.0821 0.0838
Loa Loa (eye worm) SRC-1 0.005 0.0924 0.092
Plasmodium falciparum protein kinase, putative 0.0014 0 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0014 0.0009 0.0005
Loa Loa (eye worm) hypothetical protein 0.0015 0.0012 0.0009
Loa Loa (eye worm) hypothetical protein 0.0046 0.0806 0.0802
Onchocerca volvulus 0.0019 0.012 0.0132
Loa Loa (eye worm) TK/EGFR protein kinase 0.0396 0.98 0.98
Loa Loa (eye worm) hypothetical protein 0.0022 0.0212 0.0208
Trypanosoma brucei protein kinase, putative 0.038 0.9396 1
Echinococcus multilocularis tyrosine protein kinase Srms 0.0046 0.0821 0.0838
Echinococcus granulosus mitogen activated protein kinase 0.038 0.9396 0.9587
Echinococcus granulosus insulin receptor 0.0253 0.6133 0.6258
Echinococcus multilocularis tyrosine kinase 0.0014 0.0009 0.0009
Brugia malayi Protein kinase domain containing protein 0.0014 0.0009 0.0005
Echinococcus multilocularis tyrosine protein kinase HCK 0.0042 0.0716 0.0731
Loa Loa (eye worm) hypothetical protein 0.0015 0.0027 0.0024
Onchocerca volvulus 0.0018 0.01 0.0109
Loa Loa (eye worm) hypothetical protein 0.0014 0.0009 0.0005
Echinococcus granulosus tyrosine protein kinase Srms 0.0014 0.0009 0.0009
Brugia malayi SH2 domain containing protein 0.0014 0.0009 0.0005
Echinococcus granulosus titin 0.0018 0.01 0.0102
Schistosoma mansoni cell adhesion molecule 0.0059 0.1147 0.1171
Echinococcus multilocularis musashi 0.0031 0.0444 0.0453
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0117 0.2651 0.2705
Brugia malayi ephrin receptor 1 precursor 0.0043 0.074 0.0737
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0496 0.0492
Echinococcus granulosus epidermal growth factor receptor 0.0246 0.5954 0.6075
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.038 0.9396 1
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0404 1 1
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0025 0.0278 0.0284
Echinococcus granulosus Immunoglobulin 0.0046 0.0806 0.0822
Schistosoma mansoni cpg binding protein 0.0033 0.0496 0.0506
Loa Loa (eye worm) TK/EPH protein kinase 0.0099 0.2165 0.2162
Schistosoma mansoni tyrosine kinase 0.0396 0.98 1
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.005 0.0924 0.0943
Brugia malayi protein unc-22 0.0018 0.01 0.0096
Brugia malayi SRC-1 0.005 0.0924 0.092
Brugia malayi Peroxidasin 0.0022 0.0212 0.0208
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0025 0.0278 0.0284
Schistosoma mansoni hypothetical protein 0.0014 0.0004 0.0004
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0018 0.0111 0.0113
Echinococcus multilocularis 0.0119 0.2689 0.2743
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0022 0.0202 0.0206
Echinococcus granulosus contactin 0.0025 0.0278 0.0284
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0046 0.0821 0.0838
Brugia malayi hypothetical protein 0.0048 0.0872 0.0869
Echinococcus multilocularis tyrosine protein kinase Src42A 0.005 0.0924 0.0943
Schistosoma mansoni tyrosine kinase 0.0014 0.0009 0.0009
Brugia malayi Plexin repeat family protein 0.0019 0.012 0.0117
Echinococcus granulosus tyrosine protein kinase Src42A 0.005 0.0924 0.0943
Echinococcus granulosus tyrosine protein kinase Lyn 0.0054 0.102 0.1041
Loa Loa (eye worm) hypothetical protein 0.0022 0.0212 0.0208
Onchocerca volvulus 0.0014 0.0009 0.0006
Onchocerca volvulus Tyrosine kinase homolog 0.0359 0.8856 1
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.038 0.9396 0.9396
Echinococcus granulosus roundabout 2 0.0025 0.0278 0.0284
Schistosoma mansoni tyrosine kinase 0.0018 0.0111 0.0113
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0014 0.0009 0.0009
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0022 0.0212 0.0216
Loa Loa (eye worm) hypothetical protein 0.0068 0.1378 0.1375
Onchocerca volvulus 0.0014 0.0009 0.0006
Loa Loa (eye worm) hypothetical protein 0.0046 0.0806 0.0802
Schistosoma mansoni cpg binding protein 0.0035 0.0545 0.0556
Echinococcus granulosus twitchin 0.0061 0.12 0.1224
Echinococcus granulosus tyrosine protein kinase Src42A 0.0036 0.0556 0.0568
Loa Loa (eye worm) TK/FER protein kinase 0.0014 0.0009 0.0005
Onchocerca volvulus 0.0014 0.0009 0.0006
Brugia malayi Immunoglobulin I-set domain containing protein 0.0025 0.0278 0.0275
Echinococcus granulosus intermediate filament protein 0.0031 0.0444 0.0453
Loa Loa (eye worm) hypothetical protein 0.0046 0.0806 0.0802
Echinococcus multilocularis hemicentin 1 0.0022 0.0212 0.0216
Echinococcus multilocularis epidermal growth factor receptor 0.0246 0.5954 0.6075
Echinococcus multilocularis tyrosine protein kinase Fyn 0.005 0.0924 0.0943
Schistosoma mansoni cpg binding protein 0.0035 0.0545 0.0556
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0025 0.0278 0.0284
Echinococcus multilocularis roundabout 2 0.007 0.1445 0.1475
Echinococcus multilocularis Immunoglobulin 0.0046 0.0806 0.0822
Schistosoma mansoni tyrosine kinase 0.0033 0.0477 0.0486
Loa Loa (eye worm) TK/FER protein kinase 0.0014 0.0009 0.0005
Giardia lamblia Kinase, CMGC MAPK 0.038 0.9396 0.5
Loa Loa (eye worm) hypothetical protein 0.0022 0.0212 0.0208
Brugia malayi Immunoglobulin I-set domain containing protein 0.0022 0.0212 0.0208
Schistosoma mansoni lamin 0.0031 0.0444 0.0453
Schistosoma mansoni titin 0.0014 0.0004 0.0004
Brugia malayi hypothetical protein 0.0014 0.0009 0.0005
Echinococcus granulosus tyrosine protein kinase otk 0.0022 0.0212 0.0216
Brugia malayi SH2 domain containing protein 0.0014 0.0009 0.0005
Loa Loa (eye worm) TK/INSR protein kinase 0.0253 0.6133 0.6132
Brugia malayi Immunoglobulin I-set domain containing protein 0.0048 0.0872 0.0869
Schistosoma mansoni vesicular amine transporter 0.0046 0.0806 0.0822
Onchocerca volvulus 0.0031 0.0444 0.0497
Loa Loa (eye worm) hypothetical protein 0.0078 0.1628 0.1625
Schistosoma mansoni tyrosine kinase 0.0246 0.5954 0.6075
Loa Loa (eye worm) hypothetical protein 0.0031 0.0444 0.044
Onchocerca volvulus 0.0338 0.8293 0.9364
Schistosoma mansoni tyrosine kinase 0.0018 0.0111 0.0113
Echinococcus multilocularis tyrosine protein kinase Fyn 0.005 0.0924 0.0943
Loa Loa (eye worm) hypothetical protein 0.0048 0.0872 0.0869
Echinococcus multilocularis plexin a4 0.0022 0.0208 0.0213
Toxoplasma gondii histone lysine methyltransferase SET1 0.0063 0.1263 0.1344
Echinococcus multilocularis ephrin type A receptor 4 A 0.008 0.1678 0.1712
Schistosoma mansoni tyrosine kinase 0.005 0.0924 0.0943
Echinococcus granulosus mitogen activated protein kinase 14 0.0088 0.1891 0.193
Echinococcus granulosus hemicentin 1 0.0022 0.0212 0.0216
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0088 0.1891 0.2013

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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