Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Tumor necrosis factor receptor superfamily member 6 | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 5.65 | Inhibition of Fas-mediated cell death in oxygen and glucose deprived rat H9c2 cells treated 30 mins before oxygen and glucose deprivation measured after 6 hrs by DAPI staining | ChEMBL. | 23916254 |
Inhibition (binding) | = 30.86 % | Inhibition of Fas-mediated cell death in oxygen and glucose deprived rat H9c2 cells at 10 uM treated 30 mins before oxygen and glucose deprivation measured after 6 hrs by DAPI staining | ChEMBL. | 23916254 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.