Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | protein kinase, putative | 0.0118 | 0.7698 | 1 |
Trypanosoma brucei | STE/STE11 serine/threonine-protein kinase, putative | 0.0076 | 0.2055 | 0.0223 |
Entamoeba histolytica | protein kinase, putative | 0.0118 | 0.7698 | 0.7799 |
Loa Loa (eye worm) | AUR protein kinase | 0.0118 | 0.7698 | 0.7265 |
Entamoeba histolytica | protein kinase, putative | 0.0075 | 0.1926 | 0.1951 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0076 | 0.2055 | 0.2081 |
Echinococcus multilocularis | aurora kinase A | 0.0118 | 0.7698 | 0.7265 |
Entamoeba histolytica | hypothetical protein | 0.0075 | 0.1926 | 0.1951 |
Echinococcus multilocularis | serine:threonine protein kinase 12 B | 0.0118 | 0.7698 | 0.7265 |
Entamoeba histolytica | serine/threonine protein kinase 6, putative | 0.0118 | 0.7698 | 0.7799 |
Entamoeba histolytica | serine/threonine kinase, putative | 0.0075 | 0.1926 | 0.1951 |
Entamoeba histolytica | protein tyrosine kinase domain-containing protein | 0.0075 | 0.1926 | 0.1951 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0075 | 0.1926 | 0.1951 |
Onchocerca volvulus | 0.0134 | 0.9871 | 1 | |
Entamoeba histolytica | protein tyrosine kinase domain-containing protein | 0.0075 | 0.1926 | 0.1951 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0075 | 0.1926 | 0.1951 |
Echinococcus multilocularis | tyrosine kinase | 0.0134 | 0.9871 | 1 |
Echinococcus granulosus | tyrosine kinase | 0.0134 | 0.9871 | 0.984 |
Entamoeba histolytica | serine/threonine- protein kinase 6 , putative | 0.0118 | 0.7698 | 0.7799 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0075 | 0.1926 | 0.1951 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0134 | 0.9871 | 0.984 |
Entamoeba histolytica | protein kinase, putative | 0.0075 | 0.1926 | 0.1951 |
Echinococcus granulosus | tyrosine protein kinase ABL1 | 0.0134 | 0.9871 | 0.984 |
Entamoeba histolytica | tyrosine kinase, putative | 0.0075 | 0.1926 | 0.1951 |
Entamoeba histolytica | serine/threonine kinase, putative | 0.0075 | 0.1926 | 0.1951 |
Brugia malayi | SRC-1 | 0.0134 | 0.9871 | 1 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0134 | 0.9871 | 0.984 |
Brugia malayi | Protein kinase domain containing protein | 0.0134 | 0.9871 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0134 | 0.9871 | 1 |
Entamoeba histolytica | serine/threonine kinase, putative | 0.0075 | 0.1926 | 0.1951 |
Echinococcus multilocularis | tyrosine protein kinase Fps85D | 0.0134 | 0.9871 | 1 |
Entamoeba histolytica | tyrosine kinase, putative | 0.0075 | 0.1926 | 0.1951 |
Echinococcus granulosus | serine:threonine protein kinase 12 B | 0.0118 | 0.7698 | 0.7149 |
Plasmodium falciparum | serine/threonine protein kinase, putative | 0.0118 | 0.7698 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0075 | 0.1926 | 0.1951 |
Entamoeba histolytica | protein tyrosine kinase domain-containing protein | 0.0075 | 0.1926 | 0.1951 |
Echinococcus multilocularis | tyrosine protein kinase shark | 0.0134 | 0.9871 | 1 |
Plasmodium falciparum | protein kinase, putative | 0.0076 | 0.2055 | 0.0223 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0118 | 0.7698 | 0.7799 |
Entamoeba histolytica | hypothetical protein | 0.0075 | 0.1926 | 0.1951 |
Entamoeba histolytica | protein kinase, putative | 0.0075 | 0.1926 | 0.1951 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0107 | 0.6261 | 0.5457 |
Entamoeba histolytica | tyrosine kinase, putative | 0.0075 | 0.1926 | 0.1951 |
Brugia malayi | Protein kinase domain containing protein | 0.0134 | 0.9871 | 1 |
Entamoeba histolytica | protein tyrosine kinase domain-containing protein | 0.0075 | 0.1926 | 0.1951 |
Entamoeba histolytica | protein kinase, putative | 0.0075 | 0.1926 | 0.1951 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0075 | 0.1926 | 0.1951 |
Entamoeba histolytica | protein tyrosine kinase domain-containing protein | 0.0075 | 0.1926 | 0.1951 |
Toxoplasma gondii | calcium dependent protein kinase CDPK8 | 0.0076 | 0.2055 | 0.0223 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0134 | 0.9871 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0075 | 0.1926 | 0.1951 |
Entamoeba histolytica | protein kinase, putative | 0.0075 | 0.1926 | 0.1951 |
Entamoeba histolytica | ankyrin repeat protein | 0.0075 | 0.1926 | 0.1951 |
Entamoeba histolytica | tyrosine kinase, putative | 0.0075 | 0.1926 | 0.1951 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.0134 | 0.9871 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0075 | 0.1926 | 0.1951 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0075 | 0.1926 | 0.1951 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0075 | 0.1926 | 0.1951 |
Echinococcus multilocularis | c src tyrosine kinase | 0.0134 | 0.9871 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0075 | 0.1926 | 0.1951 |
Entamoeba histolytica | hypothetical protein | 0.0075 | 0.1926 | 0.1951 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0075 | 0.1926 | 0.1951 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0075 | 0.1926 | 0.1951 |
Onchocerca volvulus | 0.0134 | 0.9871 | 1 | |
Entamoeba histolytica | protein kinase, putative | 0.0075 | 0.1926 | 0.1951 |
Entamoeba histolytica | leucine-rich repeat domain-containing protein | 0.0075 | 0.1926 | 0.1951 |
Entamoeba histolytica | tyrosine kinase, putative | 0.0075 | 0.1926 | 0.1951 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0134 | 0.9871 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0134 | 0.9871 | 1 |
Entamoeba histolytica | protein tyrosine kinase domain-containing protein | 0.0075 | 0.1926 | 0.1951 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0075 | 0.1926 | 0.1951 |
Schistosoma mansoni | tyrosine kinase | 0.0134 | 0.9871 | 1 |
Entamoeba histolytica | tyrosine kinase, putative | 0.0075 | 0.1926 | 0.1951 |
Entamoeba histolytica | serine/threonine kinase, putative | 0.0075 | 0.1926 | 0.1951 |
Echinococcus multilocularis | activin receptor type | 0.0076 | 0.2055 | 0.0162 |
Giardia lamblia | Aurora kinase | 0.0118 | 0.7698 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0075 | 0.1926 | 0.1951 |
Entamoeba histolytica | hypothetical protein | 0.0075 | 0.1926 | 0.1951 |
Entamoeba histolytica | protein tyrosine kinase domain-containing protein | 0.0075 | 0.1926 | 0.1951 |
Entamoeba histolytica | tyrosine kinase, putative | 0.0075 | 0.1926 | 0.1951 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.0134 | 0.9871 | 0.984 |
Loa Loa (eye worm) | TK/ABL protein kinase | 0.0134 | 0.9871 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0075 | 0.1926 | 0.1951 |
Trypanosoma brucei | aurora B kinase | 0.0118 | 0.7698 | 1 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0076 | 0.2055 | 0.0223 |
Onchocerca volvulus | 0.0134 | 0.9871 | 1 | |
Echinococcus granulosus | tyrosine protein kinase Srms | 0.0134 | 0.9871 | 0.984 |
Brugia malayi | protein-tyrosine kinase | 0.0134 | 0.9871 | 1 |
Echinococcus granulosus | aurora kinase A | 0.0118 | 0.7698 | 0.7149 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0134 | 0.9871 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Srms | 0.0134 | 0.9871 | 1 |
Brugia malayi | serine/threonine protein kinase 6 | 0.0118 | 0.7698 | 0.7265 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0134 | 0.9871 | 1 |
Entamoeba histolytica | tyrosin kinase, putative | 0.0075 | 0.1926 | 0.1951 |
Plasmodium vivax | serine/threonine protein kinase 6, putative | 0.0118 | 0.7698 | 1 |
Loa Loa (eye worm) | AUR protein kinase | 0.0118 | 0.7698 | 0.7265 |
Entamoeba histolytica | tyrosine kinase, putative | 0.0075 | 0.1926 | 0.1951 |
Entamoeba histolytica | protein kinase, putative | 0.0075 | 0.1926 | 0.1951 |
Brugia malayi | Protein kinase domain containing protein | 0.0134 | 0.9871 | 1 |
Entamoeba histolytica | protein tyrosine kinase domain-containing protein | 0.0075 | 0.1926 | 0.1951 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0134 | 0.9871 | 1 |
Entamoeba histolytica | receptor protein kinase, putative | 0.0075 | 0.1926 | 0.1951 |
Brugia malayi | serine/threonine kinase 12 | 0.0118 | 0.7698 | 0.7265 |
Trypanosoma cruzi | aurora B kinase, putative | 0.0118 | 0.7698 | 1 |
Entamoeba histolytica | protein tyrosine kinase domain-containing protein | 0.0075 | 0.1926 | 0.1951 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0134 | 0.9871 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0075 | 0.1926 | 0.1951 |
Entamoeba histolytica | tyrosine- protein kinase 2, putative | 0.0075 | 0.1926 | 0.1951 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0075 | 0.1926 | 0.1951 |
Entamoeba histolytica | tyrosin kinase, putative | 0.0075 | 0.1926 | 0.1951 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0107 | 0.6261 | 0.5457 |
Trichomonas vaginalis | AGC family protein kinase | 0.0118 | 0.7698 | 1 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.0134 | 0.9871 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0075 | 0.1926 | 0.1951 |
Entamoeba histolytica | protein tyrosine kinase domain-containing protein | 0.0075 | 0.1926 | 0.1951 |
Entamoeba histolytica | hypothetical protein | 0.0075 | 0.1926 | 0.1951 |
Echinococcus granulosus | activin receptor type | 0.0076 | 0.2055 | 0.016 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0075 | 0.1926 | 0.1951 |
Loa Loa (eye worm) | AUR protein kinase | 0.0118 | 0.7698 | 0.7265 |
Entamoeba histolytica | cysteine surface protein, putative | 0.0075 | 0.1926 | 0.1951 |
Entamoeba histolytica | serine/threonine kinase, putative | 0.0075 | 0.1926 | 0.1951 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0075 | 0.1926 | 0.1951 |
Entamoeba histolytica | hypothetical protein | 0.0075 | 0.1926 | 0.1951 |
Loa Loa (eye worm) | SRC-1 | 0.0134 | 0.9871 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0075 | 0.1926 | 0.1951 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0134 | 0.9871 | 1 |
Echinococcus granulosus | tyrosine kinase|tyrosine protein kinase Fyn | 0.0134 | 0.9871 | 0.984 |
Entamoeba histolytica | tyrosin kinase, putative | 0.0075 | 0.1926 | 0.1951 |
Entamoeba histolytica | hypothetical protein | 0.0075 | 0.1926 | 0.1951 |
Entamoeba histolytica | tyrosine kinase, putative | 0.0075 | 0.1926 | 0.1951 |
Echinococcus multilocularis | dual specificity testis specific protein kinase | 0.0076 | 0.2055 | 0.0162 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0076 | 0.2055 | 0.0223 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0134 | 0.9871 | 1 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0134 | 0.9871 | 0.984 |
Schistosoma mansoni | tyrosine kinase | 0.0134 | 0.9871 | 1 |
Trypanosoma brucei | protein kinase, putative | 0.0076 | 0.2055 | 0.0223 |
Entamoeba histolytica | tyrosine kinase, putative | 0.0075 | 0.1926 | 0.1951 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0075 | 0.1926 | 0.1951 |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.0134 | 0.9871 | 1 |
Entamoeba histolytica | protein tyrosine kinase domain-containing protein | 0.0075 | 0.1926 | 0.1951 |
Brugia malayi | SH2 domain containing protein | 0.0134 | 0.9871 | 1 |
Entamoeba histolytica | tyrosine kinase, putative | 0.0075 | 0.1926 | 0.1951 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0134 | 0.9871 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0075 | 0.1926 | 0.1951 |
Echinococcus granulosus | tyrosine kinase | 0.0134 | 0.9871 | 0.984 |
Toxoplasma gondii | aurora kinase | 0.0118 | 0.7698 | 1 |
Entamoeba histolytica | protein kinase , putative | 0.0118 | 0.7698 | 0.7799 |
Entamoeba histolytica | protein kinase, putative | 0.0075 | 0.1926 | 0.1951 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0118 | 0.7698 | 0.7265 |
Entamoeba histolytica | protein tyrosine kinase domain-containing protein | 0.0075 | 0.1926 | 0.1951 |
Entamoeba histolytica | serine/threonine- protein kinase 6, putative | 0.0118 | 0.7698 | 0.7799 |
Entamoeba histolytica | protein kinase, putative | 0.0075 | 0.1926 | 0.1951 |
Entamoeba histolytica | receptor protein kinase, putative | 0.0075 | 0.1926 | 0.1951 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0134 | 0.9871 | 1 |
Loa Loa (eye worm) | TK protein kinase | 0.0134 | 0.9871 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.9871 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0134 | 0.9871 | 1 |
Entamoeba histolytica | protein kinase with ankyrin repeats, putative | 0.0075 | 0.1926 | 0.1951 |
Entamoeba histolytica | hypothetical protein | 0.0075 | 0.1926 | 0.1951 |
Entamoeba histolytica | protein kinase, putative | 0.0075 | 0.1926 | 0.1951 |
Entamoeba histolytica | protein tyrosine kinase domain-containing protein | 0.0075 | 0.1926 | 0.1951 |
Echinococcus granulosus | tyrosine protein kinase Fps85D | 0.0134 | 0.9871 | 0.984 |
Schistosoma mansoni | protein kinase | 0.0076 | 0.2055 | 0.0162 |
Echinococcus granulosus | dual specificity testis-specific protein kinase | 0.0076 | 0.2055 | 0.016 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0134 | 0.9871 | 0.984 |
Brugia malayi | serine/threonine-protein kinase 6 | 0.0118 | 0.7698 | 0.7265 |
Onchocerca volvulus | 0.0134 | 0.9871 | 1 | |
Entamoeba histolytica | tyrosine kinase, putative | 0.0075 | 0.1926 | 0.1951 |
Entamoeba histolytica | tyrosine kinase, putative | 0.0075 | 0.1926 | 0.1951 |
Entamoeba histolytica | protein kinase, putative | 0.0075 | 0.1926 | 0.1951 |
Onchocerca volvulus | 0.0134 | 0.9871 | 1 | |
Entamoeba histolytica | hypothetical protein | 0.0075 | 0.1926 | 0.1951 |
Entamoeba histolytica | tyrosine kinase, putative | 0.0075 | 0.1926 | 0.1951 |
Entamoeba histolytica | protein kinase, putative | 0.0075 | 0.1926 | 0.1951 |
Entamoeba histolytica | serine/threonine kinase, putative | 0.0075 | 0.1926 | 0.1951 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0134 | 0.9871 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0075 | 0.1926 | 0.1951 |
Entamoeba histolytica | tyrosine kinase, putative | 0.0075 | 0.1926 | 0.1951 |
Schistosoma mansoni | protein kinase | 0.0118 | 0.7698 | 0.7265 |
Echinococcus granulosus | tyrosine protein kinase shark | 0.0134 | 0.9871 | 0.984 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0075 | 0.1926 | 0.1951 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0134 | 0.9871 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0134 | 0.9871 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0075 | 0.1926 | 0.1951 |
Entamoeba histolytica | protein kinase, putative | 0.0075 | 0.1926 | 0.1951 |
Brugia malayi | SH2 domain containing protein | 0.0134 | 0.9871 | 1 |
Entamoeba histolytica | tyrosine kinase, putative | 0.0075 | 0.1926 | 0.1951 |
Entamoeba histolytica | ankyrin repeat protein | 0.0075 | 0.1926 | 0.1951 |
Trichomonas vaginalis | AGC family protein kinase | 0.0118 | 0.7698 | 1 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0134 | 0.9871 | 0.984 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0134 | 0.9871 | 0.984 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0134 | 0.9871 | 1 |
Echinococcus granulosus | c src tyrosine kinase | 0.0134 | 0.9871 | 0.984 |
Entamoeba histolytica | protein kinase, putative | 0.0075 | 0.1926 | 0.1951 |
Schistosoma mansoni | tyrosine kinase | 0.0134 | 0.9871 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0118 | 0.7698 | 0.7799 |
Leishmania major | protein kinase, putative | 0.0076 | 0.2055 | 0.0223 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0134 | 0.9871 | 1 |
Onchocerca volvulus | 0.0134 | 0.9871 | 1 | |
Brugia malayi | hypothetical protein | 0.0134 | 0.9871 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0118 | 0.7698 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0134 | 0.9871 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0075 | 0.1926 | 0.1951 |
Echinococcus multilocularis | tyrosine protein kinase Blk | 0.0134 | 0.9871 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0118 | 0.7698 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0134 | 0.9871 | 1 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0134 | 0.9871 | 0.984 |
Entamoeba histolytica | tyrosine kinase, putative | 0.0075 | 0.1926 | 0.1951 |
Schistosoma mansoni | protein kinase | 0.0076 | 0.2055 | 0.0162 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0134 | 0.9871 | 1 |
Echinococcus granulosus | tyrosine protein kinase Blk | 0.0134 | 0.9871 | 0.984 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0075 | 0.1926 | 0.1951 |
Schistosoma mansoni | tyrosine kinase | 0.0134 | 0.9871 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0075 | 0.1926 | 0.1951 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0134 | 0.9871 | 1 |
Entamoeba histolytica | tyrosin kinase, putative | 0.0075 | 0.1926 | 0.1951 |
Brugia malayi | Protein kinase domain containing protein | 0.0134 | 0.9871 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0134 | 0.9871 | 1 |
Echinococcus multilocularis | tyrosine protein kinase ABL1 | 0.0134 | 0.9871 | 1 |
Schistosoma mansoni | protein kinase | 0.0076 | 0.2055 | 0.0162 |
Schistosoma mansoni | tyrosine kinase | 0.0134 | 0.9871 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0134 | 0.9871 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | = 1.68 uM | Cytotoxicity against human DU145 cells by SRB method | ChEMBL. | 23867604 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.