Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | tm gpcr rhodopsin | Get druggable targets OG5_145685 | All targets in OG5_145685 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | Get druggable targets OG5_145685 | All targets in OG5_145685 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0152 | 0 | 0.5 |
Echinococcus multilocularis | neuropeptide receptor | 0.3996 | 1 | 1 |
Brugia malayi | G protein-coupled receptor F59B2.13 | 0.0152 | 0 | 0.5 |
Brugia malayi | follicle stimulating hormone receptor | 0.0152 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0152 | 0 | 0.5 |
Brugia malayi | neuropeptide F receptor | 0.0152 | 0 | 0.5 |
Schistosoma mansoni | 6-phosphofructokinase | 0.3238 | 0.8029 | 0.8029 |
Brugia malayi | Serotonin/octopamine receptor family protein 7 | 0.0152 | 0 | 0.5 |
Brugia malayi | Dopamine receptor | 0.0152 | 0 | 0.5 |
Brugia malayi | Dopamine receptor protein 2 | 0.0152 | 0 | 0.5 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.1911 | 0.4577 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.1911 | 0.4577 | 0.5 |
Brugia malayi | G protein-coupled receptor | 0.0152 | 0 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.3184 | 0.7887 | 0.9706 |
Brugia malayi | putative neuropeptide receptor NPR1 | 0.0152 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.3238 | 0.8029 | 1 |
Brugia malayi | hypothetical protein | 0.0152 | 0 | 0.5 |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.1911 | 0.4577 | 0.5 |
Brugia malayi | G-protein coupled receptor | 0.0152 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0152 | 0 | 0.5 |
Brugia malayi | neuropeptide F receptor | 0.0152 | 0 | 0.5 |
Brugia malayi | AKH receptor | 0.0152 | 0 | 0.5 |
Brugia malayi | Tachykinin-like peptides receptor 99D | 0.0152 | 0 | 0.5 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.1152 | 0.2601 | 0.2601 |
Loa Loa (eye worm) | hypothetical protein | 0.3184 | 0.7887 | 0.9823 |
Brugia malayi | hypothetical protein | 0.0152 | 0 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.3238 | 0.8029 | 1 |
Brugia malayi | Melatonin receptor type 1A | 0.0152 | 0 | 0.5 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.1152 | 0.2601 | 0.2601 |
Brugia malayi | hypothetical protein | 0.0152 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0152 | 0 | 0.5 |
Brugia malayi | ORL1-like opioid receptor | 0.0152 | 0 | 0.5 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.3184 | 0.7887 | 0.9706 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.3238 | 0.8029 | 1 |
Brugia malayi | Dopamine receptor protein 1, putative (partial) | 0.0152 | 0 | 0.5 |
Brugia malayi | Dopamine receptor protein 1 | 0.0152 | 0 | 0.5 |
Brugia malayi | RE15519p | 0.0152 | 0 | 0.5 |
Brugia malayi | Serotonin receptor | 0.0152 | 0 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.3184 | 0.7887 | 0.9706 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.3238 | 0.8029 | 1 |
Brugia malayi | hypothetical protein | 0.0152 | 0 | 0.5 |
Brugia malayi | G-protein-linked acetylcholine receptor protein 2, putative | 0.0152 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0152 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0152 | 0 | 0.5 |
Brugia malayi | Unidentified vitellogenin-linked transcript protein 6, putative | 0.0152 | 0 | 0.5 |
Brugia malayi | putative neuropeptide receptor | 0.0152 | 0 | 0.5 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.3238 | 0.8029 | 1 |
Brugia malayi | gonadotropin-releasing hormone receptor 2 | 0.0152 | 0 | 0.5 |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.3184 | 0.7887 | 0.9706 |
Brugia malayi | G-protein coupled receptor | 0.0152 | 0 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.1911 | 0.4577 | 0.5 |
Echinococcus granulosus | 6 phosphofructo 2 kinase:fructose 2 | 0.3238 | 0.8029 | 0.8029 |
Mycobacterium ulcerans | hypothetical protein | 0.1911 | 0.4577 | 0.5 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.3238 | 0.8029 | 0.8029 |
Brugia malayi | sulfakinin receptor protein | 0.0152 | 0 | 0.5 |
Echinococcus multilocularis | G protein coupled receptor 139 | 0.3996 | 1 | 1 |
Onchocerca volvulus | 0.3238 | 0.8029 | 1 | |
Brugia malayi | GnHR receptor homolog | 0.0152 | 0 | 0.5 |
Brugia malayi | larval opioid receptor | 0.0152 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1857 | 0.4435 | 0.5523 |
Schistosoma mansoni | neuropeptide receptor | 0.3996 | 1 | 1 |
Brugia malayi | Serotonin receptor | 0.0152 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.16 nM | Antagonist activity at recombinant human 5-HT6 receptor expressed in HEK293 cells assessed as 5-HT-induced intracellular cAMP production after 30 mins | ChEMBL. | 23787290 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.