TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 366.453 | Formula: C22H26N2O3
H donors: 1 H acceptors: 2 LogP: 4.65 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CCOc1ccccc1c1onc(c1)C(=O)NC12CC3CC(C2)CC(C1)C3
InChi: 1S/C22H26N2O3/c1-2-26-19-6-4-3-5-17(19)20-10-18(24-27-20)21(25)23-22-11-14-7-15(12-22)9-16(8-14)13-22/h3-6,10,14-16H,2,7-9,11-13H2,1H3,(H,23,25)
InChiKey: CEFOLKGBJRLMBK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cannabinoid receptor 2 (macrophage)	Starlite/ChEMBL	References
Homo sapiens	fatty acid amide hydrolase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	fatty acid amide hydrolase 1	Get druggable targets OG5_127783	All targets in OG5_127783
Candida albicans	one of two amidase genes similar to S. pombe SPCC550.07 and to S. cerevisiae AMD2 (YDR242W)	Get druggable targets OG5_127783	All targets in OG5_127783
Schistosoma japonicum	Fatty-acid amide hydrolase 1, putative	Get druggable targets OG5_127783	All targets in OG5_127783
Schistosoma japonicum	Fatty-acid amide hydrolase 1, putative	Get druggable targets OG5_127783	All targets in OG5_127783
Candida albicans	one of two amidase genes similar to S. pombe SPCC550.07 and to S. cerevisiae AMD2 (YDR242W)	Get druggable targets OG5_127783	All targets in OG5_127783
Brugia malayi	amidase	Get druggable targets OG5_127783	All targets in OG5_127783
Schistosoma mansoni	fatty-acid amide hydrolase	Get druggable targets OG5_127783	All targets in OG5_127783
Echinococcus granulosus	fatty acid amide hydrolase 1	Get druggable targets OG5_127783	All targets in OG5_127783
Echinococcus multilocularis	fatty acid amide hydrolase 1	Get druggable targets OG5_127783	All targets in OG5_127783
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127783	All targets in OG5_127783
Candida albicans	one of two amidase genes similar to S. pombe SPCC550.07 and to S. cerevisiae AMD2 (YDR242W)	Get druggable targets OG5_127783	All targets in OG5_127783
Candida albicans	one of two amidase genes similar to S. pombe SPCC550.07 and to S. cerevisiae AMD2 (YDR242W)	Get druggable targets OG5_127783	All targets in OG5_127783
Echinococcus multilocularis	fatty acid amide hydrolase 1	Get druggable targets OG5_127783	All targets in OG5_127783
Candida albicans	hypothetical protein	Get druggable targets OG5_127783	All targets in OG5_127783
Schistosoma japonicum	ko:K01175 fatty acid amide hydrolase [EC:3.1.-.-], putative	Get druggable targets OG5_127783	All targets in OG5_127783
Candida albicans	hypothetical protein	Get druggable targets OG5_127783	All targets in OG5_127783
Schistosoma mansoni	amidase	Get druggable targets OG5_127783	All targets in OG5_127783

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Leishmania major	hypothetical protein, conserved	fatty acid amide hydrolase	579 aa	471 aa	26.5 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0408	0.4956	0.2897
Schistosoma mansoni	tyrosine kinase	0.0408	0.4956	0.4956
Schistosoma mansoni	protein kinase	0.0408	0.4956	0.4956
Entamoeba histolytica	protein kinase domain containing protein	0.0408	0.4956	0.2897
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0408	0.4956	0.2897
Loa Loa (eye worm)	TK protein kinase	0.0408	0.4956	0.4956
Trichomonas vaginalis	TKL family protein kinase	0.0408	0.4956	0.5
Entamoeba histolytica	hypothetical protein	0.0408	0.4956	0.2897
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0408	0.4956	0.4956
Loa Loa (eye worm)	SRC-1	0.0697	1	1
Schistosoma mansoni	serine/threonine protein kinase	0.0408	0.4956	0.4956
Schistosoma mansoni	serine/threonine protein kinase	0.0408	0.4956	0.4956
Echinococcus granulosus	tyrosine protein kinase shark	0.0697	1	1
Trypanosoma cruzi	protein kinase, putative	0.0408	0.4956	0.5
Schistosoma mansoni	tensin-related	0.0289	0.2899	0.2899
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0408	0.4956	0.5
Entamoeba histolytica	protein kinase, putative	0.0408	0.4956	0.2897
Brugia malayi	Protein kinase domain containing protein	0.0697	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0408	0.4956	0.5
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0289	0.2899	0.2899
Loa Loa (eye worm)	TK protein kinase	0.0697	1	1
Loa Loa (eye worm)	hypothetical protein	0.0408	0.4956	0.4956
Brugia malayi	SH2 domain containing protein	0.0697	1	1
Onchocerca volvulus		0.0408	0.4956	0.2897
Loa Loa (eye worm)	TK/CSK protein kinase	0.0408	0.4956	0.4956
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0408	0.4956	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0697	1	1
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0697	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0408	0.4956	0.5
Schistosoma mansoni	tyrosine kinase	0.0408	0.4956	0.4956
Loa Loa (eye worm)	hypothetical protein	0.0289	0.2899	0.2899
Trichomonas vaginalis	TKL family protein kinase	0.0408	0.4956	0.5
Brugia malayi	Protein kinase domain containing protein	0.0408	0.4956	0.4956
Echinococcus multilocularis	insulin receptor	0.0408	0.4956	0.4956
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0408	0.4956	0.4956
Entamoeba histolytica	hypothetical protein	0.0408	0.4956	0.2897
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0408	0.4956	0.4956
Brugia malayi	SH2 domain containing protein	0.0289	0.2899	0.2899
Entamoeba histolytica	tyrosine kinase, putative	0.0408	0.4956	0.2897
Brugia malayi	SH2 domain containing protein	0.0289	0.2899	0.2899
Trichomonas vaginalis	conserved hypothetical protein	0.0408	0.4956	0.5
Echinococcus granulosus	tyrosine kinase	0.0408	0.4956	0.4956
Echinococcus multilocularis	SH2 motif	0.0289	0.2899	0.2899
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0408	0.4956	0.5
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0289	0.2899	0.2899
Trichomonas vaginalis	TKL family protein kinase	0.0408	0.4956	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0697	1	1
Entamoeba histolytica	protein kinase, putative	0.0408	0.4956	0.2897
Plasmodium falciparum	tyrosine kinase-like protein	0.0408	0.4956	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0408	0.4956	0.2897
Trichomonas vaginalis	TK family protein kinase	0.0408	0.4956	0.5
Echinococcus granulosus	tyrosine protein kinase HCK	0.0408	0.4956	0.4956
Loa Loa (eye worm)	TK/ACK protein kinase	0.0408	0.4956	0.4956
Entamoeba histolytica	protein kinase, putative	0.0408	0.4956	0.2897
Brugia malayi	SH2 domain containing protein	0.0289	0.2899	0.2899
Brugia malayi	Protein kinase domain containing protein	0.0408	0.4956	0.4956
Echinococcus multilocularis	heat shock protein 70	0.0408	0.4956	0.4956
Loa Loa (eye worm)	TK/FER protein kinase	0.0697	1	1
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0697	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0408	0.4956	0.5
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0289	0.2899	0.2899
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0408	0.4956	0.4956
Entamoeba histolytica	protein kinase domain containing protein	0.0408	0.4956	0.2897
Loa Loa (eye worm)	hypothetical protein	0.0289	0.2899	0.2899
Loa Loa (eye worm)	hypothetical protein	0.0289	0.2899	0.2899
Echinococcus granulosus	tyrosine protein kinase	0.0408	0.4956	0.4956
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0289	0.2899	0.2899
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0408	0.4956	0.5
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.0408	0.4956	0.2897
Echinococcus multilocularis		0.0289	0.2899	0.2899
Schistosoma mansoni	tyrosine kinase	0.0408	0.4956	0.4956
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0697	1	1
Schistosoma mansoni	protein kinase	0.0408	0.4956	0.4956
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0408	0.4956	0.4956
Brugia malayi	SH2 domain containing protein	0.0289	0.2899	0.2899
Brugia malayi	Variant SH3 domain containing protein	0.0289	0.2899	0.2899
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0408	0.4956	0.4956
Echinococcus multilocularis	tyrosine protein kinase csk	0.0408	0.4956	0.4956
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0697	1	1
Loa Loa (eye worm)	TK/ALK protein kinase	0.0408	0.4956	0.4956
Echinococcus granulosus	natriuretic peptide receptor 1	0.0408	0.4956	0.4956
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0408	0.4956	0.4956
Schistosoma mansoni	tyrosine kinase	0.0697	1	1
Entamoeba histolytica	ankyrin repeat protein	0.0408	0.4956	0.2897
Brugia malayi	integrin-linked kinase	0.0408	0.4956	0.4956
Echinococcus granulosus	ephrin type A receptor 4 A	0.0408	0.4956	0.4956
Schistosoma mansoni	serine/threonine RGC	0.0408	0.4956	0.4956
Giardia lamblia	Kinase, NEK	0.0408	0.4956	0.5
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0408	0.4956	0.4956
Echinococcus granulosus	tensin	0.0289	0.2899	0.2899
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0408	0.4956	0.4956
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0408	0.4956	0.4956
Brugia malayi	Protein kinase domain containing protein	0.0408	0.4956	0.4956
Echinococcus multilocularis	activated cdc42 kinase 1	0.0408	0.4956	0.4956
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0408	0.4956	0.4956
Plasmodium falciparum	protein kinase, putative	0.0408	0.4956	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0408	0.4956	0.2897
Trichomonas vaginalis	TKL family protein kinase	0.0408	0.4956	0.5
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0289	0.2899	0.2899
Loa Loa (eye worm)	SH2 domain-containing protein	0.0289	0.2899	0.2899
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0408	0.4956	0.4956
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0408	0.4956	0.4956
Loa Loa (eye worm)	hypothetical protein	0.0408	0.4956	0.4956
Schistosoma mansoni	tyrosine kinase	0.0408	0.4956	0.4956
Trichomonas vaginalis	TKL family protein kinase	0.0408	0.4956	0.5
Entamoeba histolytica	serine/threonine kinase, putative	0.0408	0.4956	0.2897
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0408	0.4956	0.2897
Brugia malayi	Protein kinase domain containing protein	0.0408	0.4956	0.4956
Schistosoma mansoni	tyrosine kinase	0.0697	1	1
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0408	0.4956	0.4956
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0408	0.4956	0.2897
Entamoeba histolytica	protein kinase domain containing protein	0.0408	0.4956	0.2897
Brugia malayi	hypothetical protein	0.0697	1	1
Entamoeba histolytica	protein kinase, putative	0.0408	0.4956	0.2897
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0408	0.4956	0.4956
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0408	0.4956	0.4956
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0289	0.2899	0.2899
Entamoeba histolytica	tyrosine kinase, putative	0.0408	0.4956	0.2897
Entamoeba histolytica	hypothetical protein	0.0408	0.4956	0.2897
Echinococcus multilocularis	tyrosine kinase	0.0408	0.4956	0.4956
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0408	0.4956	0.2897
Echinococcus granulosus	activated cdc42 kinase 1	0.0408	0.4956	0.4956
Echinococcus multilocularis	SH2 domain containing protein 7	0.0289	0.2899	0.2899
Entamoeba histolytica	serine/threonine kinase, putative	0.0408	0.4956	0.2897
Entamoeba histolytica	protein kinase, putative	0.0408	0.4956	0.2897
Loa Loa (eye worm)	TK protein kinase	0.0408	0.4956	0.4956
Trypanosoma brucei	protein kinase, putative	0.0408	0.4956	0.5
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0697	1	1
Schistosoma mansoni	tyrosine kinase	0.0408	0.4956	0.4956
Echinococcus multilocularis	SHC transforming protein 3	0.0289	0.2899	0.2899
Trichomonas vaginalis	TKL family protein kinase	0.0408	0.4956	0.5
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0408	0.4956	0.4956
Trichomonas vaginalis	TKL family protein kinase	0.0408	0.4956	0.5
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0289	0.2899	0.2899
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0408	0.4956	0.4956
Schistosoma mansoni	tensin	0.0289	0.2899	0.2899
Brugia malayi	Protein kinase domain containing protein	0.0408	0.4956	0.4956
Trichomonas vaginalis	TKL family protein kinase	0.0408	0.4956	0.5
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0408	0.4956	0.4956
Echinococcus granulosus	SH2 domain containing protein 7	0.0289	0.2899	0.2899
Trypanosoma cruzi	protein kinase, putative	0.0408	0.4956	0.5
Schistosoma mansoni	ephrin receptor	0.0408	0.4956	0.4956
Entamoeba histolytica	serine/threonine kinase, putative	0.0408	0.4956	0.2897
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0408	0.4956	0.4956
Echinococcus granulosus	epidermal growth factor receptor	0.0408	0.4956	0.4956
Entamoeba histolytica	protein kinase, putative	0.0408	0.4956	0.2897
Trichomonas vaginalis	TKL family protein kinase	0.0408	0.4956	0.5
Echinococcus granulosus	SH2 motif	0.0289	0.2899	0.2899
Echinococcus multilocularis	protein kinase	0.0408	0.4956	0.4956
Trichomonas vaginalis	TKL family protein kinase	0.0408	0.4956	0.5
Echinococcus granulosus	kinase suppressor of Ras 1	0.0408	0.4956	0.4956
Entamoeba histolytica	protein kinase, putative	0.0408	0.4956	0.2897
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0408	0.4956	0.4956
Loa Loa (eye worm)	hypothetical protein	0.0289	0.2899	0.2899
Brugia malayi	Tyrosine-protein kinase PR2	0.0408	0.4956	0.4956
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0408	0.4956	0.4956
Brugia malayi	RhoGAP domain containing protein	0.0289	0.2899	0.2899
Echinococcus granulosus	signal transduction protein lnk realted	0.0289	0.2899	0.2899
Echinococcus granulosus	tyrosine kinase	0.0697	1	1
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0408	0.4956	0.4956
Trichomonas vaginalis	TKL family protein kinase	0.0408	0.4956	0.5
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0289	0.2899	0.2899
Entamoeba histolytica	tyrosine kinase, putative	0.0408	0.4956	0.2897
Onchocerca volvulus		0.0408	0.4956	0.2897
Brugia malayi	Protein kinase domain containing protein	0.0408	0.4956	0.4956
Entamoeba histolytica	receptor protein kinase, putative	0.0408	0.4956	0.2897
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0289	0.2899	0.2899
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0289	0.2899	0.2899
Loa Loa (eye worm)	TK protein kinase	0.0408	0.4956	0.4956
Entamoeba histolytica	protein kinase, putative	0.0408	0.4956	0.2897
Trichomonas vaginalis	conserved hypothetical protein	0.0408	0.4956	0.5
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0289	0.2899	0.2899
Trichomonas vaginalis	conserved hypothetical protein	0.0408	0.4956	0.5
Echinococcus granulosus	growth factor receptor bound protein 2	0.0289	0.2899	0.2899
Brugia malayi	Protein kinase domain containing protein	0.0697	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0408	0.4956	0.5
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0408	0.4956	0.4956
Entamoeba histolytica	hypothetical protein, conserved	0.0408	0.4956	0.2897
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0408	0.4956	0.4956
Brugia malayi	Protein kinase domain containing protein	0.0408	0.4956	0.4956
Schistosoma mansoni	tyrosine kinase	0.0408	0.4956	0.4956
Schistosoma mansoni	protein kinase	0.0408	0.4956	0.4956
Schistosoma mansoni	suppressor of cytokine signaling	0.0289	0.2899	0.2899
Trichomonas vaginalis	TKL family protein kinase	0.0408	0.4956	0.5
Brugia malayi	ephrin receptor 1 precursor	0.0408	0.4956	0.4956
Schistosoma mansoni	tensin	0.0289	0.2899	0.2899
Brugia malayi	Protein kinase domain containing protein	0.0408	0.4956	0.4956
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0408	0.4956	0.4956
Entamoeba histolytica	protein kinase, putative	0.0408	0.4956	0.2897
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0289	0.2899	0.2899
Schistosoma mansoni	hypothetical protein	0.0408	0.4956	0.4956
Loa Loa (eye worm)	TK protein kinase	0.0408	0.4956	0.4956
Echinococcus granulosus	SH2 motif	0.0289	0.2899	0.2899
Brugia malayi	hypothetical protein	0.0289	0.2899	0.2899
Schistosoma mansoni	protein kinase	0.0408	0.4956	0.4956
Schistosoma mansoni	protein kinase	0.0408	0.4956	0.4956
Loa Loa (eye worm)	serine/threonine protein kinase	0.0408	0.4956	0.4956
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0408	0.4956	0.4956
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0408	0.4956	0.4956
Schistosoma mansoni	hypothetical protein	0.0289	0.2899	0.2899
Schistosoma mansoni	tyrosine kinase	0.0408	0.4956	0.4956
Schistosoma mansoni	vav2	0.0289	0.2899	0.2899
Schistosoma mansoni	protein kinase	0.0408	0.4956	0.4956
Entamoeba histolytica	protein kinase domain containing protein	0.0408	0.4956	0.2897
Loa Loa (eye worm)	TK protein kinase	0.0408	0.4956	0.4956
Brugia malayi	SH2 domain containing protein	0.0289	0.2899	0.2899
Schistosoma mansoni	protein kinase	0.0408	0.4956	0.4956
Entamoeba histolytica	tyrosine kinase, putative	0.0408	0.4956	0.2897
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0697	1	1
Schistosoma mansoni	tyrosine kinase	0.0408	0.4956	0.4956
Entamoeba histolytica	cysteine surface protein, putative	0.0408	0.4956	0.2897
Trichomonas vaginalis	TKL family protein kinase	0.0408	0.4956	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0408	0.4956	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0408	0.4956	0.2897
Brugia malayi	Protein kinase domain containing protein	0.0408	0.4956	0.4956
Trichomonas vaginalis	TKL family protein kinase	0.0408	0.4956	0.5
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0408	0.4956	0.4956
Echinococcus multilocularis	integrin linked protein kinase	0.0408	0.4956	0.4956
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0408	0.4956	0.4956
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0408	0.4956	0.2897
Echinococcus multilocularis	tyrosine protein kinase csk	0.0408	0.4956	0.4956
Entamoeba histolytica	tyrosine kinase, putative	0.0408	0.4956	0.2897
Schistosoma mansoni	tyrosine kinase	0.0408	0.4956	0.4956
Echinococcus granulosus	NCK adaptor protein	0.0289	0.2899	0.2899
Entamoeba histolytica	hypothetical protein	0.0408	0.4956	0.2897
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0408	0.4956	0.4956
Entamoeba histolytica	serine/threonine kinase, putative	0.0408	0.4956	0.2897
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0408	0.4956	0.4956
Schistosoma mansoni	tyrosine kinase	0.0408	0.4956	0.4956
Schistosoma mansoni	tyrosine kinase	0.0408	0.4956	0.4956
Schistosoma mansoni	growth factor receptor-bound protein	0.0289	0.2899	0.2899
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0408	0.4956	0.4956
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0408	0.4956	0.5
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0408	0.4956	0.4956
Echinococcus multilocularis	tensin	0.0289	0.2899	0.2899
Entamoeba histolytica	protein kinase domain containing protein	0.0408	0.4956	0.2897
Schistosoma mansoni	tyrosine kinase	0.0408	0.4956	0.4956
Onchocerca volvulus		0.0697	1	1
Brugia malayi	Protein kinase domain containing protein	0.0408	0.4956	0.4956
Brugia malayi	Protein kinase domain containing protein	0.0408	0.4956	0.4956
Loa Loa (eye worm)	hypothetical protein	0.0408	0.4956	0.4956
Trichomonas vaginalis	TKL family protein kinase	0.0408	0.4956	0.5
Entamoeba histolytica	protein kinase, putative	0.0408	0.4956	0.2897
Loa Loa (eye worm)	hypothetical protein	0.0408	0.4956	0.4956
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0408	0.4956	0.4956
Echinococcus multilocularis	FL cytokine receptor	0.0408	0.4956	0.4956
Entamoeba histolytica	protein kinase domain containing protein	0.0408	0.4956	0.2897
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0289	0.2899	0.2899
Loa Loa (eye worm)	TK/FER protein kinase	0.0697	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0408	0.4956	0.5
Onchocerca volvulus		0.0408	0.4956	0.2897
Trichomonas vaginalis	STE family protein kinase	0.0408	0.4956	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0408	0.4956	0.5
Loa Loa (eye worm)	hypothetical protein	0.0289	0.2899	0.2899
Entamoeba histolytica	tyrosine kinase, putative	0.0408	0.4956	0.2897
Trichomonas vaginalis	TKL family protein kinase	0.0408	0.4956	0.5
Onchocerca volvulus		0.0697	1	1
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0697	1	1
Brugia malayi	hypothetical protein	0.0408	0.4956	0.4956
Entamoeba histolytica	protein kinase domain containing protein	0.0408	0.4956	0.2897
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0289	0.2899	0.2899
Entamoeba histolytica	receptor protein kinase, putative	0.0408	0.4956	0.2897
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0408	0.4956	0.2897
Echinococcus multilocularis	tyrosine protein kinase csk	0.0408	0.4956	0.4956
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0697	1	1
Schistosoma mansoni	protein kinase	0.0408	0.4956	0.4956
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0289	0.2899	0.2899
Trichomonas vaginalis	TKL family protein kinase	0.0408	0.4956	0.5
Loa Loa (eye worm)	hypothetical protein	0.0408	0.4956	0.4956
Entamoeba histolytica	protein kinase domain containing protein	0.0408	0.4956	0.2897
Plasmodium vivax	protein kinase, putative	0.0408	0.4956	0.5
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0697	1	1
Loa Loa (eye worm)	TK/Met protein kinase	0.0408	0.4956	0.4956
Entamoeba histolytica	protein kinase domain containing protein	0.0408	0.4956	0.2897
Plasmodium falciparum	protein kinase, putative	0.0408	0.4956	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0408	0.4956	0.2897
Entamoeba histolytica	tyrosine kinase, putative	0.0408	0.4956	0.2897
Trichomonas vaginalis	TKL family protein kinase	0.0408	0.4956	0.5
Echinococcus granulosus	tyrosine protein kinase Srms	0.0697	1	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0408	0.4956	0.2897
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0697	1	1
Entamoeba histolytica	serine/threonine kinase, putative	0.0408	0.4956	0.2897
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0408	0.4956	0.4956
Schistosoma mansoni	GTPase activating protein	0.0289	0.2899	0.2899
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0408	0.4956	0.4956
Trichomonas vaginalis	TKL family protein kinase	0.0408	0.4956	0.5
Loa Loa (eye worm)	hypothetical protein	0.0697	1	1
Onchocerca volvulus		0.0408	0.4956	0.2897
Trichomonas vaginalis	TKL family protein kinase	0.0408	0.4956	0.5
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0408	0.4956	0.5
Loa Loa (eye worm)	hypothetical protein	0.0289	0.2899	0.2899
Trichomonas vaginalis	conserved hypothetical protein	0.0408	0.4956	0.5
Schistosoma mansoni	protein kinase	0.0408	0.4956	0.4956
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0697	1	1
Loa Loa (eye worm)	hypothetical protein	0.0289	0.2899	0.2899
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0408	0.4956	0.4956
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0289	0.2899	0.2899
Trichomonas vaginalis	TKL family protein kinase	0.0408	0.4956	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0408	0.4956	0.2897
Trichomonas vaginalis	TKL family protein kinase	0.0408	0.4956	0.5
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0408	0.4956	0.4956
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0289	0.2899	0.2899
Brugia malayi	Protein kinase domain containing protein	0.0408	0.4956	0.4956
Loa Loa (eye worm)	TK/FER protein kinase	0.0408	0.4956	0.4956
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0408	0.4956	0.4956
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0289	0.2899	0.2899
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0408	0.4956	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0408	0.4956	0.4956
Loa Loa (eye worm)	SH2 domain-containing protein	0.0289	0.2899	0.2899
Entamoeba histolytica	hypothetical protein	0.0408	0.4956	0.2897
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0408	0.4956	0.4956
Entamoeba histolytica	protein kinase domain containing protein	0.0408	0.4956	0.2897
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0289	0.2899	0.2899
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0408	0.4956	0.4956
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0697	1	1
Echinococcus granulosus	hypothetical protein	0.0289	0.2899	0.2899
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0408	0.4956	0.2897
Schistosoma mansoni	growth factor receptor-bound protein	0.0289	0.2899	0.2899
Trichomonas vaginalis	TKL family protein kinase	0.0408	0.4956	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0408	0.4956	0.5
Brugia malayi	Variant SH3 domain containing protein	0.0289	0.2899	0.2899
Loa Loa (eye worm)	hypothetical protein	0.0289	0.2899	0.2899
Toxoplasma gondii	protein kinase	0.0408	0.4956	0.5
Echinococcus multilocularis	tyrosine protein kinase	0.0408	0.4956	0.4956
Loa Loa (eye worm)	hypothetical protein	0.0408	0.4956	0.4956
Brugia malayi	Protein kinase domain containing protein	0.0408	0.4956	0.4956
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0408	0.4956	0.5
Entamoeba histolytica	protein kinase, putative	0.0408	0.4956	0.2897
Schistosoma mansoni	tyrosine kinase	0.0408	0.4956	0.4956
Brugia malayi	SH2 domain containing protein	0.0289	0.2899	0.2899
Entamoeba histolytica	tyrosine kinase, putative	0.0408	0.4956	0.2897
Echinococcus granulosus	N chimaerin	0.0289	0.2899	0.2899
Loa Loa (eye worm)	TK/FER protein kinase	0.0697	1	1
Entamoeba histolytica	protein kinase, putative	0.0408	0.4956	0.2897
Schistosoma mansoni	ephrin receptor	0.0408	0.4956	0.4956
Schistosoma mansoni	tyrosine kinase	0.0408	0.4956	0.4956
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0697	1	1
Brugia malayi	Protein kinase domain containing protein	0.0408	0.4956	0.4956
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0289	0.2899	0.2899
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0289	0.2899	0.2899
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0408	0.4956	0.4956
Schistosoma mansoni	protein kinase	0.0408	0.4956	0.4956
Toxoplasma gondii	STE kinase	0.0408	0.4956	0.5
Schistosoma mansoni	nck2/grb4	0.0289	0.2899	0.2899
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0697	1	1
Schistosoma mansoni	tyrosine kinase	0.0408	0.4956	0.4956
Brugia malayi	Raf kinase	0.0408	0.4956	0.4956
Loa Loa (eye worm)	TK/FER protein kinase	0.0697	1	1
Echinococcus multilocularis	signal transduction protein lnk realted	0.0289	0.2899	0.2899
Onchocerca volvulus		0.0408	0.4956	0.2897
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0289	0.2899	0.2899
Echinococcus granulosus	tyrosine protein kinase csk	0.0408	0.4956	0.4956
Echinococcus granulosus	activin receptor type	0.0408	0.4956	0.4956
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0408	0.4956	0.2897
Trichomonas vaginalis	TKL family protein kinase	0.0408	0.4956	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0408	0.4956	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0408	0.4956	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0408	0.4956	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0408	0.4956	0.5
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0408	0.4956	0.5
Brugia malayi	Protein kinase domain containing protein	0.0408	0.4956	0.4956
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0408	0.4956	0.4956
Loa Loa (eye worm)	hypothetical protein	0.0289	0.2899	0.2899
Brugia malayi	Furin-like cysteine rich region family protein	0.0408	0.4956	0.4956
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0408	0.4956	0.5
Echinococcus granulosus	raf serine:threonine protein kinase	0.0408	0.4956	0.4956
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0408	0.4956	0.4956
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0408	0.4956	0.4956
Loa Loa (eye worm)	TK protein kinase	0.0408	0.4956	0.4956
Echinococcus multilocularis	tyrosine protein kinase csk	0.0408	0.4956	0.4956
Echinococcus granulosus	SHC transforming protein 3	0.0289	0.2899	0.2899
Echinococcus granulosus	epidermal growth factor receptor	0.0408	0.4956	0.4956
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0289	0.2899	0.2899
Brugia malayi	Variant SH3 domain containing protein	0.0289	0.2899	0.2899
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0408	0.4956	0.4956
Echinococcus multilocularis	tensin	0.0289	0.2899	0.2899
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0408	0.4956	0.4956
Schistosoma mansoni	tyrosine protein kinase	0.0408	0.4956	0.4956
Schistosoma mansoni	tyrosine kinase	0.0408	0.4956	0.4956
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0408	0.4956	0.4956
Loa Loa (eye worm)	hypothetical protein	0.0289	0.2899	0.2899
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0289	0.2899	0.2899
Trichomonas vaginalis	TKL family protein kinase	0.0408	0.4956	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0408	0.4956	0.2897
Onchocerca volvulus		0.0697	1	1
Trichomonas vaginalis	CAMK family protein kinase	0.0408	0.4956	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0408	0.4956	0.2897
Echinococcus granulosus	protein kinase	0.0408	0.4956	0.4956
Loa Loa (eye worm)	TK/FER protein kinase	0.0697	1	1
Loa Loa (eye worm)	hypothetical protein	0.0408	0.4956	0.4956
Entamoeba histolytica	hypothetical protein	0.0408	0.4956	0.2897
Trichomonas vaginalis	TKL family protein kinase	0.0408	0.4956	0.5
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0697	1	1
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0408	0.4956	0.4956
Echinococcus multilocularis	activin receptor type	0.0408	0.4956	0.4956
Entamoeba histolytica	hypothetical protein	0.0408	0.4956	0.2897
Schistosoma mansoni	tyrosine kinase	0.0697	1	1
Onchocerca volvulus	Tyrosine kinase homolog	0.0408	0.4956	0.2897
Brugia malayi	Protein kinase domain containing protein	0.0408	0.4956	0.4956
Loa Loa (eye worm)	hypothetical protein	0.0408	0.4956	0.4956
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0408	0.4956	0.4956
Brugia malayi	Protein kinase domain containing protein	0.0408	0.4956	0.4956
Schistosoma mansoni	tyrosine kinase	0.0408	0.4956	0.4956
Onchocerca volvulus		0.0697	1	1
Echinococcus multilocularis	tyrosine kinase	0.0697	1	1
Brugia malayi	Variant SH3 domain containing protein	0.0289	0.2899	0.2899
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0697	1	1
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0408	0.4956	0.4956
Entamoeba histolytica	protein kinase domain containing protein	0.0408	0.4956	0.2897
Trichomonas vaginalis	TKL family protein kinase	0.0408	0.4956	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0408	0.4956	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0408	0.4956	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0697	1	1
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.0408	0.4956	0.2897
Toxoplasma gondii	protein kinase domain-containing protein	0.0408	0.4956	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0408	0.4956	0.4956
Entamoeba histolytica	tyrosin kinase, putative	0.0408	0.4956	0.2897
Schistosoma mansoni	shc transforming protein	0.0289	0.2899	0.2899
Loa Loa (eye worm)	TK protein kinase	0.0408	0.4956	0.4956
Loa Loa (eye worm)	TK/FER protein kinase	0.0408	0.4956	0.4956
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0697	1	1
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0408	0.4956	0.4956
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0408	0.4956	0.4956
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0408	0.4956	0.4956
Giardia lamblia	Protein 21.1	0.0408	0.4956	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0408	0.4956	0.5
Loa Loa (eye worm)	hypothetical protein	0.0289	0.2899	0.2899
Trichomonas vaginalis	TKL family protein kinase	0.0408	0.4956	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0408	0.4956	0.2897
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0408	0.4956	0.5
Loa Loa (eye worm)	TK/ABL protein kinase	0.0697	1	1
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0697	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0408	0.4956	0.5
Loa Loa (eye worm)	hypothetical protein	0.0408	0.4956	0.4956
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0408	0.4956	0.2897
Loa Loa (eye worm)	TK/FER protein kinase	0.0697	1	1
Echinococcus multilocularis	epidermal growth factor receptor	0.0408	0.4956	0.4956
Loa Loa (eye worm)	hypothetical protein	0.0408	0.4956	0.4956
Brugia malayi	SRC-1	0.0697	1	1
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0697	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0408	0.4956	0.5
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0408	0.4956	0.4956
Entamoeba histolytica	hypothetical protein	0.0408	0.4956	0.2897
Trichomonas vaginalis	TKL family protein kinase	0.0408	0.4956	0.5
Echinococcus multilocularis	protein kinase	0.0408	0.4956	0.4956
Schistosoma mansoni	tyrosine kinase	0.0408	0.4956	0.4956
Entamoeba histolytica	protein kinase, putative	0.0408	0.4956	0.2897
Loa Loa (eye worm)	SH2 domain-containing protein	0.0289	0.2899	0.2899
Brugia malayi	SH2 domain containing protein	0.0697	1	1
Schistosoma mansoni	tensin	0.0289	0.2899	0.2899
Loa Loa (eye worm)	TK/FER protein kinase	0.0408	0.4956	0.4956
Echinococcus granulosus	protein tyrosine kinase	0.0408	0.4956	0.4956
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0697	1	1
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0408	0.4956	0.4956
Loa Loa (eye worm)	TK protein kinase	0.0408	0.4956	0.4956
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0289	0.2899	0.2899
Trichomonas vaginalis	TKL family protein kinase	0.0408	0.4956	0.5
Echinococcus multilocularis	epidermal growth factor receptor	0.0408	0.4956	0.4956
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0408	0.4956	0.4956
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0408	0.4956	0.4956
Entamoeba histolytica	protein kinase domain containing protein	0.0408	0.4956	0.2897
Entamoeba histolytica	protein kinase, putative	0.0408	0.4956	0.2897
Echinococcus multilocularis	SH2 motif	0.0289	0.2899	0.2899
Echinococcus multilocularis	protein tyrosine kinase	0.0408	0.4956	0.4956
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0408	0.4956	0.5
Entamoeba histolytica	protein kinase, putative	0.0408	0.4956	0.2897
Brugia malayi	Protein kinase domain containing protein	0.0408	0.4956	0.4956
Onchocerca volvulus		0.0408	0.4956	0.2897
Loa Loa (eye worm)	TK/FER protein kinase	0.0408	0.4956	0.4956
Trichomonas vaginalis	TKL family protein kinase	0.0408	0.4956	0.5
Trichomonas vaginalis	protein kinase atn1, putative	0.0408	0.4956	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0408	0.4956	0.5
Echinococcus granulosus	expressed conserved protein	0.0289	0.2899	0.2899
Entamoeba histolytica	tyrosine kinase, putative	0.0408	0.4956	0.2897
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0697	1	1
Echinococcus granulosus	tyrosine protein kinase Blk	0.0697	1	1
Schistosoma mansoni	tyrosine kinase	0.0408	0.4956	0.4956
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0289	0.2899	0.2899
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0289	0.2899	0.2899
Brugia malayi	Guanylyl cyclase protein 23	0.0408	0.4956	0.4956
Echinococcus multilocularis	NCK adaptor protein	0.0289	0.2899	0.2899
Brugia malayi	Protein kinase domain containing protein	0.0697	1	1
Entamoeba histolytica	protein kinase, putative	0.0408	0.4956	0.2897
Trichomonas vaginalis	TKL family protein kinase	0.0408	0.4956	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0408	0.4956	0.5
Brugia malayi	Receptor family ligand binding region containing protein	0.0408	0.4956	0.4956
Echinococcus granulosus	activated cdc42 kinase 1	0.0408	0.4956	0.4956
Leishmania major	hypothetical protein, conserved	0.0408	0.4956	0.5
Brugia malayi	Protein kinase domain containing protein	0.0408	0.4956	0.4956
Trichomonas vaginalis	TKL family protein kinase	0.0408	0.4956	0.5
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0408	0.4956	0.4956
Schistosoma mansoni	tyrosine kinase	0.0408	0.4956	0.4956
Loa Loa (eye worm)	TK/ROR protein kinase	0.0408	0.4956	0.4956
Leishmania major	protein kinase, putative	0.0408	0.4956	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0408	0.4956	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0408	0.4956	0.2897
Onchocerca volvulus		0.0697	1	1
Echinococcus granulosus	c src tyrosine kinase	0.0697	1	1
Entamoeba histolytica	serine/threonine kinase, putative	0.0408	0.4956	0.2897
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0408	0.4956	0.4956
Trichomonas vaginalis	TKL family protein kinase	0.0408	0.4956	0.5
Schistosoma mansoni	tensin-related	0.0289	0.2899	0.2899
Entamoeba histolytica	tyrosine kinase, putative	0.0408	0.4956	0.2897
Brugia malayi	Protein kinase domain containing protein	0.0697	1	1
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0408	0.4956	0.4956
Brugia malayi	Sex muscle abnormal protein 5	0.0289	0.2899	0.2899
Echinococcus granulosus	integrin linked protein kinase	0.0408	0.4956	0.4956
Entamoeba histolytica	protein kinase domain containing protein	0.0408	0.4956	0.2897
Plasmodium falciparum	protein kinase, putative	0.0408	0.4956	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0408	0.4956	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0408	0.4956	0.2897
Brugia malayi	Tyrosine-protein kinase abl-1	0.0697	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0408	0.4956	0.5
Brugia malayi	Protein kinase domain containing protein	0.0408	0.4956	0.4956
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0289	0.2899	0.2899
Entamoeba histolytica	protein kinase, putative	0.0408	0.4956	0.2897
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0408	0.4956	0.5
Onchocerca volvulus		0.0408	0.4956	0.2897
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0289	0.2899	0.2899
Trichomonas vaginalis	conserved hypothetical protein	0.0408	0.4956	0.5
Loa Loa (eye worm)	TK/DDR protein kinase	0.0408	0.4956	0.4956
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0289	0.2899	0.2899
Entamoeba histolytica	tyrosin kinase, putative	0.0408	0.4956	0.2897
Trichomonas vaginalis	TKL family protein kinase	0.0408	0.4956	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0408	0.4956	0.5
Schistosoma mansoni	tyrosine kinase	0.0408	0.4956	0.4956
Entamoeba histolytica	protein kinase domain containing protein	0.0408	0.4956	0.2897
Schistosoma mansoni	hypothetical protein	0.0289	0.2899	0.2899
Loa Loa (eye worm)	hypothetical protein	0.0408	0.4956	0.4956
Echinococcus multilocularis	N chimaerin	0.0289	0.2899	0.2899
Onchocerca volvulus		0.0408	0.4956	0.2897
Schistosoma mansoni	suppressor of cytokine signaling	0.0289	0.2899	0.2899
Onchocerca volvulus		0.0408	0.4956	0.2897
Brugia malayi	Tensin	0.0289	0.2899	0.2899
Giardia lamblia	Kinase	0.0408	0.4956	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0408	0.4956	0.5
Loa Loa (eye worm)	TK/RYK protein kinase	0.0408	0.4956	0.4956
Giardia lamblia	Kinase, NEK	0.0408	0.4956	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0408	0.4956	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0408	0.4956	0.2897
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0408	0.4956	0.2897
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0408	0.4956	0.2897
Entamoeba histolytica	protein kinase, putative	0.0408	0.4956	0.2897
Trichomonas vaginalis	TKL family protein kinase	0.0408	0.4956	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0408	0.4956	0.4956
Entamoeba histolytica	protein kinase domain containing protein	0.0408	0.4956	0.2897
Brugia malayi	Protein kinase domain containing protein	0.0408	0.4956	0.4956
Echinococcus multilocularis	transfer RNA-Thr	0.0408	0.4956	0.4956
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0408	0.4956	0.4956
Echinococcus multilocularis	tyrosine protein kinase shark	0.0697	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0408	0.4956	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0408	0.4956	0.5
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0697	1	1
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0697	1	1
Loa Loa (eye worm)	hypothetical protein	0.0408	0.4956	0.4956
Schistosoma mansoni	tyrosine kinase	0.0408	0.4956	0.4956
Loa Loa (eye worm)	TK/FER protein kinase	0.0697	1	1
Schistosoma mansoni	tyrosine kinase	0.0697	1	1
Brugia malayi	C-terminal src kinase protein 1	0.0408	0.4956	0.4956
Trichomonas vaginalis	TKL family protein kinase	0.0408	0.4956	0.5
Entamoeba histolytica	hypothetical protein	0.0408	0.4956	0.2897
Schistosoma mansoni	tyrosine kinase	0.0408	0.4956	0.4956
Trichomonas vaginalis	TKL family protein kinase	0.0408	0.4956	0.5
Loa Loa (eye worm)	TK protein kinase	0.0408	0.4956	0.4956
Trichomonas vaginalis	TKL family protein kinase	0.0408	0.4956	0.5
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0408	0.4956	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0408	0.4956	0.2897
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0408	0.4956	0.4956
Schistosoma mansoni	tyrosine kinase	0.0408	0.4956	0.4956
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0289	0.2899	0.2899
Entamoeba histolytica	tyrosine kinase, putative	0.0408	0.4956	0.2897
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0408	0.4956	0.2897
Loa Loa (eye worm)	hypothetical protein	0.0289	0.2899	0.2899
Entamoeba histolytica	tyrosin kinase, putative	0.0408	0.4956	0.2897
Schistosoma mansoni	adapter molecule crk	0.0289	0.2899	0.2899
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.0408	0.4956	0.2897
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0408	0.4956	0.4956
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0289	0.2899	0.2899
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0697	1	1
Onchocerca volvulus		0.0697	1	1
Schistosoma mansoni	protein kinase	0.0408	0.4956	0.4956
Echinococcus multilocularis	SH2 motif	0.0289	0.2899	0.2899
Entamoeba histolytica	protein kinase, putative	0.0408	0.4956	0.2897
Loa Loa (eye worm)	hypothetical protein	0.0289	0.2899	0.2899
Plasmodium falciparum	tyrosine kinase-like protein	0.0408	0.4956	0.5
Brugia malayi	Protein kinase domain containing protein	0.0408	0.4956	0.4956
Schistosoma mansoni	serine/threonine protein kinase	0.0408	0.4956	0.4956
Brugia malayi	protein-tyrosine kinase	0.0697	1	1
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0697	1	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0289	0.2899	0.2899
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0408	0.4956	0.4956
Trichomonas vaginalis	TKL family protein kinase	0.0408	0.4956	0.5
Echinococcus granulosus	tyrosine protein kinase pr2	0.0408	0.4956	0.4956
Loa Loa (eye worm)	TK/FER protein kinase	0.0408	0.4956	0.4956
Leishmania major	protein kinase, putative	0.0408	0.4956	0.5
Brugia malayi	SH2 domain containing protein	0.0289	0.2899	0.2899
Schistosoma mansoni	tyrosine kinase	0.0697	1	1
Echinococcus granulosus	receptor type guanylyl cyclase	0.0408	0.4956	0.4956
Entamoeba histolytica	hypothetical protein	0.0408	0.4956	0.2897
Loa Loa (eye worm)	TK/INSR protein kinase	0.0408	0.4956	0.4956
Loa Loa (eye worm)	STAT protein	0.0289	0.2899	0.2899
Echinococcus granulosus	insulin receptor	0.0408	0.4956	0.4956
Loa Loa (eye worm)	hypothetical protein	0.0289	0.2899	0.2899
Brugia malayi	Protein kinase domain containing protein	0.0408	0.4956	0.4956
Entamoeba histolytica	hypothetical protein	0.0408	0.4956	0.2897
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0697	1	1
Loa Loa (eye worm)	TK/FAK protein kinase	0.0408	0.4956	0.4956
Schistosoma mansoni	tyrosine kinase	0.0697	1	1
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0408	0.4956	0.5
Loa Loa (eye worm)	hypothetical protein	0.0289	0.2899	0.2899
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0408	0.4956	0.2897
Echinococcus multilocularis	c src tyrosine kinase	0.0697	1	1
Brugia malayi	Protein kinase domain containing protein	0.0408	0.4956	0.4956
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0697	1	1
Echinococcus granulosus	tyrosine protein kinase csk	0.0408	0.4956	0.4956
Brugia malayi	hypothetical protein	0.0408	0.4956	0.4956
Trichomonas vaginalis	TKL family protein kinase	0.0408	0.4956	0.5
Loa Loa (eye worm)	TK/EPH protein kinase	0.0408	0.4956	0.4956
Loa Loa (eye worm)	TK/FER protein kinase	0.0697	1	1
Brugia malayi	Protein kinase domain containing protein	0.0408	0.4956	0.4956
Trichomonas vaginalis	TKL family protein kinase	0.0408	0.4956	0.5
Schistosoma mansoni	tyrosine kinase	0.0408	0.4956	0.4956
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0408	0.4956	0.4956
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0289	0.2899	0.2899
Schistosoma mansoni	SH2A	0.0289	0.2899	0.2899
Entamoeba histolytica	ankyrin repeat protein	0.0408	0.4956	0.2897
Echinococcus granulosus	tyrosine kinase	0.0697	1	1
Trypanosoma brucei	Pseudokinase, putative	0.0408	0.4956	0.5
Schistosoma mansoni	protein tyrosine kinase	0.0408	0.4956	0.4956
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0697	1	1
Schistosoma mansoni	signal transduction protein lnk-related	0.0289	0.2899	0.2899
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0408	0.4956	0.4956
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0697	1	1
Echinococcus granulosus	tyrosine protein kinase csk	0.0408	0.4956	0.4956
Entamoeba histolytica	tyrosin kinase, putative	0.0408	0.4956	0.2897
Entamoeba histolytica	protein kinase domain containing protein	0.0408	0.4956	0.2897

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)		Agonist activity at human CB2 receptor by [35S]-GTPgammaS binding assay	ChEMBL.	24508127
Emax (functional)		Agonist activity at human CB2 receptor by [35S]-GTPgammaS binding assay relative to control	ChEMBL.	24508127
IC50 (binding)	> 10 uM	Inhibition of human recombinant FAAH expressed in Escherichia coli assessed as hydrolysis of [3H]-AEA	ChEMBL.	24508127
Ki (binding)		Binding affinity to human CB1 receptor	ChEMBL.	24508127
Ki (binding)	> 1000 nM	Displacement of [3H]-CP55,940 from human CB2 receptor expressed in CHO membranes after 1 hr by liquid scintillation counting	ChEMBL.	23849204
Ki (binding)	> 1000 nM	Binding affinity to human CB2 receptor	ChEMBL.	24508127

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2414019

Bibliographic References

2 literature references were collected for this gene.

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Detailed information for compound 1768391