Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Metabotropic glutamate receptor 5 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1235 | 1 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0041 | 0.0141 | 0.0141 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.006 | 0.03 | 0.0161 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.006 | 0.03 | 0.0161 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.1214 | 0.9828 | 0.9706 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0049 | 0.0207 | 1 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1214 | 0.9828 | 0.9706 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.0729 | 0.5821 | 0.5 |
Schistosoma mansoni | 6-phosphofructokinase | 0.1235 | 1 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0056 | 0.0262 | 0.0262 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0044 | 0.0169 | 0.8166 |
Onchocerca volvulus | 0.1235 | 1 | 0.5 | |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.1214 | 0.9828 | 0.9706 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1235 | 1 | 1 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.1235 | 1 | 1 |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.0729 | 0.5821 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0729 | 0.5821 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1214 | 0.9828 | 0.9824 |
Giardia lamblia | Hypothetical protein | 0.0729 | 0.5821 | 0.5 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1235 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.03 | 0.0095 |
Loa Loa (eye worm) | hypothetical protein | 0.0708 | 0.5649 | 0.5557 |
Loa Loa (eye worm) | hypothetical protein | 0.1235 | 1 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.1214 | 0.9828 | 0.9706 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1235 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.0729 | 0.5821 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 77 nM | Negative allosteric modulation of rat mGluR5 receptor expressed in HEK293 cells assessed as intracellular calcium flux after 170 seconds by FLIPR assay | ChEMBL. | 23850200 |
INH (binding) | = 401 nM | Displacement of [3H]MPEP from mGluR5 receptor in Sprague-Dawley rat cortical homogenate after 1 hr by liquid scintillation spectrometric analysis | ChEMBL. | 23850200 |
INH (ADMET) | < 0.75 uM | Inhibition of CYP1A2 (unknown origin) | ChEMBL. | 23850200 |
Inhibition (binding) | > 99 % | Inhibition of rat mGluR5 receptor expressed in HEK293 cells at 30 uM relative to control | ChEMBL. | 23850200 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.