Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Metabotropic glutamate receptor 5 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Blistered cuticle protein 3 | 0.0078 | 1 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0041 | 0.3158 | 0.3158 |
Brugia malayi | Animal haem peroxidase family protein | 0.0078 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0078 | 1 | 1 |
Onchocerca volvulus | 0.0078 | 1 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.6704 | 0.3872 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 1 | 1 |
Echinococcus multilocularis | peroxidasin | 0.0078 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0078 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0078 | 1 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0078 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 1 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.0078 | 1 | 0.5 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.006 | 0.6704 | 0.5183 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.006 | 0.6704 | 0.5183 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0078 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0078 | 1 | 0.5 |
Onchocerca volvulus | 0.0078 | 1 | 0.5 | |
Onchocerca volvulus | 0.0078 | 1 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0078 | 1 | 1 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0078 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0078 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 1 | 1 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0044 | 0.3773 | 0.3773 |
Brugia malayi | Peroxidasin | 0.0078 | 1 | 1 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0049 | 0.4621 | 0.4621 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 1 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0056 | 0.5856 | 0.5856 |
Brugia malayi | Animal haem peroxidase family protein | 0.0078 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0078 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0078 | 1 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0078 | 1 | 1 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0078 | 1 | 0.5 |
Echinococcus granulosus | peroxidasin | 0.0078 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.0078 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0078 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 3994 nM | Negative allosteric modulation of rat mGluR5 receptor expressed in HEK293 cells assessed as intracellular calcium flux after 170 seconds by FLIPR assay | ChEMBL. | 23850200 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.