Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glutamate receptor, metabotropic 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0274 | 1 | 0.5 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0274 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0274 | 1 | 1 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0044 | 0.0984 | 0.0818 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0274 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0274 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.1608 | 0.1608 |
Loa Loa (eye worm) | glutamate receptor | 0.0049 | 0.1164 | 0.1164 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0274 | 1 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0274 | 1 | 1 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.006 | 0.1608 | 0.0825 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0274 | 1 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0274 | 1 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0274 | 1 | 0.5 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0274 | 1 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0274 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0274 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0274 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0274 | 1 | 0.5 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0274 | 1 | 0.5 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0041 | 0.0853 | 0.0685 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0274 | 1 | 0.5 |
Trypanosoma brucei | protein kinase, putative | 0.0274 | 1 | 0.5 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0056 | 0.1427 | 0.127 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0274 | 1 | 0.5 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0049 | 0.1164 | 0.1002 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0274 | 1 | 1 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.006 | 0.1608 | 0.0825 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
%max (binding) | = 56.6 % | Negative allosteric modulation of human mGlu1 receptor expressed in HEK293A TREx cells assessed as calcium flux at 30 uM after 45 mins relative to glutamate | ChEMBL. | 23932792 |
IC50 (binding) | > 5 | Negative allosteric modulation of human mGlu1 receptor expressed in HEK293A TREx cells assessed as calcium flux after 45 mins | ChEMBL. | 23932792 |
IC50 (binding) | > 10000 nM | Negative allosteric modulation of human mGlu1 receptor expressed in HEK293A TREx cells assessed as calcium flux after 45 mins | ChEMBL. | 23932792 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.