Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glutaminyl-peptide cyclotransferase-like | No references | |
Homo sapiens | glutaminyl-peptide cyclotransferase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_129821 | All targets in OG5_129821 |
Schistosoma mansoni | glutaminyl cyclase (M28 family) | Get druggable targets OG5_129821 | All targets in OG5_129821 |
Schistosoma japonicum | ko:K00683 glutaminyl-peptide cyclotransferase [EC2.3.2.5], putative | Get druggable targets OG5_129821 | All targets in OG5_129821 |
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | Get druggable targets OG5_129821 | All targets in OG5_129821 |
Brugia malayi | Peptidase family M28 containing protein | Get druggable targets OG5_129821 | All targets in OG5_129821 |
Echinococcus granulosus | glutaminyl peptide cyclotransferase | Get druggable targets OG5_129821 | All targets in OG5_129821 |
Onchocerca volvulus | Glutaminyl cyclase homolog | Get druggable targets OG5_129821 | All targets in OG5_129821 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | glutaminyl-peptide cyclotransferase | 361 aa | 292 aa | 21.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.1083 | 1 | 1 |
Onchocerca volvulus | Glutaminyl cyclase homolog | 0.018 | 0.0508 | 0.5 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.1083 | 1 | 1 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.1083 | 1 | 1 |
Schistosoma mansoni | DNA topoisomerase type I | 0.0161 | 0.0308 | 0.0308 |
Echinococcus multilocularis | DNA topoisomerase 1 | 0.0215 | 0.0876 | 0.0876 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.0508 | 0.0508 |
Brugia malayi | DNA topoisomerase I | 0.0215 | 0.0876 | 0.0876 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.1083 | 1 | 1 |
Echinococcus granulosus | glutaminyl peptide cyclotransferase | 0.018 | 0.0508 | 0.0508 |
Schistosoma mansoni | glutaminyl cyclase (M28 family) | 0.018 | 0.0508 | 0.0508 |
Brugia malayi | Isocitrate dehydrogenase | 0.1083 | 1 | 1 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.1083 | 1 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.1083 | 1 | 1 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.1083 | 1 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.1083 | 1 | 1 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.1083 | 1 | 1 |
Mycobacterium leprae | PROBABLE 3-ISOPROPYLMALATE DEHYDROGENASE LEUB (BETA-IPM DEHYDROGENASE) (IMDH) (3-IPM-DH) | 0.0132 | 0 | 0.5 |
Loa Loa (eye worm) | DNA topoisomerase I | 0.0215 | 0.0876 | 0.0876 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.1083 | 1 | 1 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.1083 | 1 | 1 |
Mycobacterium ulcerans | 3-isopropylmalate dehydrogenase | 0.0132 | 0 | 0.5 |
Trichomonas vaginalis | isocitrate dehydrogenase, putative | 0.0132 | 0 | 0.5 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.1083 | 1 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.1083 | 1 | 1 |
Entamoeba histolytica | tartrate dehydrogenase, putative | 0.0132 | 0 | 0.5 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.1083 | 1 | 1 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.1083 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | isocitrate dehydrogenase | 0.0132 | 0 | 0.5 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.1083 | 1 | 1 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.1083 | 1 | 1 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.1083 | 1 | 1 |
Schistosoma mansoni | DNA topoisomerase type I | 0.0161 | 0.0308 | 0.0308 |
Leishmania major | DNA topoisomerase IB, large subunit | 0.0161 | 0.0308 | 0.0308 |
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | 0.018 | 0.0508 | 0.0508 |
Schistosoma mansoni | DNA topoisomerase type I | 0.0215 | 0.0876 | 0.0876 |
Echinococcus granulosus | DNA topoisomerase 1 | 0.0215 | 0.0876 | 0.0876 |
Brugia malayi | Peptidase family M28 containing protein | 0.018 | 0.0508 | 0.0508 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 640 nM | Spectrophotometric Assay | BINDINGDB. | No reference |
IC50 (binding) | = 2.38 uM | Inhibition of human glutaminyl cyclase expressed in Escherichia coli DH5alpha using H-Gln-AMC as substrate by fluorometric analysis in presence of pyroglutamyl aminopeptidase | ChEMBL. | 23886302 |
Ki (binding) | = 180 nM | Spectrophotometric Assay | BINDINGDB. | No reference |
Ki (binding) | = 0.333 uM | Inhibition of human glutaminyl cyclase expressed in Escherichia coli DH5alpha using H-Gln-AMC as substrate by fluorometric analysis in presence of pyroglutamyl aminopeptidase | ChEMBL. | 23886302 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.