TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 411.878 | Formula: C18H19ClFN3O3S
H donors: 1 H acceptors: 2 LogP: 5.21 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CC1CCCN(C1C)C(=O)c1nc(sc1Cl)Nc1cc2OCOc2cc1F
InChi: 1S/C18H19ClFN3O3S/c1-9-4-3-5-23(10(9)2)17(24)15-16(19)27-18(22-15)21-12-7-14-13(6-11(12)20)25-8-26-14/h6-7,9-10H,3-5,8H2,1-2H3,(H,21,22)
InChiKey: GGKQWFQQUMWVOB-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	transient receptor potential cation channel, subfamily C, member 3	Starlite/ChEMBL	References
Homo sapiens	transient receptor potential cation channel, subfamily C, member 6	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	expressed protein	Get druggable targets OG5_131097	All targets in OG5_131097
Echinococcus multilocularis	short transient receptor potential channel 6	Get druggable targets OG5_131097	All targets in OG5_131097
Echinococcus granulosus	short transient receptor potential channel 6	Get druggable targets OG5_131097	All targets in OG5_131097
Schistosoma japonicum	Short transient receptor potential channel 3, putative	Get druggable targets OG5_131097	All targets in OG5_131097
Schistosoma japonicum	Transient receptor potential-gamma protein, putative	Get druggable targets OG5_131097	All targets in OG5_131097
Schistosoma mansoni	transient receptor potential channel	Get druggable targets OG5_131097	All targets in OG5_131097
Schistosoma japonicum	Short transient receptor potential channel 7, putative	Get druggable targets OG5_131097	All targets in OG5_131097

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus granulosus	short transient receptor potential channel 6	transient receptor potential cation channel, subfamily C, member 6	931 aa	772 aa	32.5 %
Echinococcus granulosus	short transient receptor potential channel 6	transient receptor potential cation channel, subfamily C, member 3	921 aa	785 aa	31.9 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	activated cdc42 kinase 1	0.073	0.3618	0.3618
Loa Loa (eye worm)	TK protein kinase	0.073	0.3618	0.3618
Echinococcus granulosus	tyrosine protein kinase csk	0.073	0.3618	0.3618
Leishmania major	hypothetical protein, conserved	0.073	0.3618	0.5
Schistosoma mansoni	tensin	0.1084	0.5697	0.5697
Loa Loa (eye worm)	hypothetical protein	0.1084	0.5697	0.5697
Loa Loa (eye worm)	hypothetical protein	0.073	0.3618	0.3618
Loa Loa (eye worm)	TK/FAK protein kinase	0.073	0.3618	0.3618
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.073	0.3618	0.3618
Brugia malayi	STAT protein, DNA binding domain containing protein	0.1084	0.5697	0.3258
Echinococcus multilocularis	growth factor receptor bound protein 2	0.1084	0.5697	0.5697
Loa Loa (eye worm)	TK/FER protein kinase	0.1814	1	1
Loa Loa (eye worm)	TK/RYK protein kinase	0.073	0.3618	0.3618
Echinococcus granulosus	expressed conserved protein	0.1084	0.5697	0.5697
Brugia malayi	SH2 domain containing protein	0.1814	1	1
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.073	0.3618	0.5
Plasmodium vivax	tyrosine kinase-like protein, putative	0.073	0.3618	0.5
Schistosoma mansoni	tyrosine kinase	0.073	0.3618	0.3618
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.073	0.3618	0.3618
Loa Loa (eye worm)	SH2 domain-containing protein	0.1084	0.5697	0.5697
Giardia lamblia	Kinase, NEK	0.073	0.3618	1
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.073	0.3618	0.3618
Schistosoma mansoni	protein kinase	0.073	0.3618	0.3618
Echinococcus multilocularis	SH2 motif	0.1084	0.5697	0.5697
Echinococcus multilocularis	epidermal growth factor receptor	0.073	0.3618	0.3618
Loa Loa (eye worm)	TK/FER protein kinase	0.1814	1	1
Echinococcus granulosus	activated cdc42 kinase 1	0.073	0.3618	0.3618
Loa Loa (eye worm)	hypothetical protein	0.1084	0.5697	0.5697
Schistosoma mansoni	protein kinase	0.073	0.3618	0.3618
Schistosoma mansoni	tyrosine kinase	0.073	0.3618	0.3618
Schistosoma mansoni	tyrosine kinase	0.073	0.3618	0.3618
Loa Loa (eye worm)	hypothetical protein	0.1084	0.5697	0.5697
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.1814	1	1
Loa Loa (eye worm)	TK/ACK protein kinase	0.073	0.3618	0.3618
Echinococcus granulosus	tyrosine kinase	0.073	0.3618	0.3618
Loa Loa (eye worm)	TK/FER protein kinase	0.073	0.3618	0.3618
Loa Loa (eye worm)	TK/FER protein kinase	0.1814	1	1
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.1084	0.5697	0.5697
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.1084	0.5697	0.5697
Trypanosoma brucei	protein kinase, putative	0.073	0.3618	0.5
Echinococcus multilocularis	tyrosine protein kinase csk	0.073	0.3618	0.3618
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.073	0.3618	0.3618
Leishmania major	protein kinase, putative	0.073	0.3618	0.5
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.073	0.3618	0.5
Echinococcus multilocularis	insulin receptor	0.073	0.3618	0.3618
Loa Loa (eye worm)	TK/FER protein kinase	0.073	0.3618	0.3618
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.073	0.3618	0.3618
Echinococcus multilocularis	N chimaerin	0.1084	0.5697	0.5697
Brugia malayi	Variant SH3 domain containing protein	0.1084	0.5697	0.3258
Entamoeba histolytica	ankyrin repeat protein	0.073	0.3618	0.00000002787
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.1084	0.5697	0.5697
Echinococcus granulosus	tyrosine protein kinase Srms	0.1814	1	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.1814	1	1
Loa Loa (eye worm)	TK/EPH protein kinase	0.073	0.3618	0.3618
Entamoeba histolytica	protein kinase, putative	0.073	0.3618	0.00000002787
Plasmodium falciparum	protein kinase, putative	0.073	0.3618	0.5
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.1084	0.5697	0.5697
Echinococcus multilocularis	tyrosine protein kinase csk	0.073	0.3618	0.3618
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.073	0.3618	0.3618
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.073	0.3618	1
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.1084	0.5697	0.5697
Onchocerca volvulus		0.1814	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.073	0.3618	0.3618
Entamoeba histolytica	protein kinase, putative	0.073	0.3618	0.00000002787
Echinococcus multilocularis	FL cytokine receptor	0.073	0.3618	0.3618
Echinococcus granulosus	SH2 motif	0.1084	0.5697	0.5697
Echinococcus granulosus	retinal guanylyl cyclase 2	0.073	0.3618	0.3618
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.1814	1	1
Echinococcus granulosus	insulin receptor	0.073	0.3618	0.3618
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.1084	0.5697	0.5697
Schistosoma mansoni	tyrosine kinase	0.073	0.3618	0.3618
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.1814	1	1
Schistosoma mansoni	tyrosine kinase	0.073	0.3618	0.3618
Schistosoma mansoni	transient receptor potential channel	0.0383	0.1571	0.1571
Loa Loa (eye worm)	TK/FER protein kinase	0.1814	1	1
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.073	0.3618	0.5
Loa Loa (eye worm)	hypothetical protein	0.1084	0.5697	0.5697
Echinococcus multilocularis	tyrosine protein kinase Abl	0.1814	1	1
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.073	0.3618	0.3618
Schistosoma mansoni	tyrosine kinase	0.073	0.3618	0.3618
Brugia malayi	SH2 domain containing protein	0.1084	0.5697	0.3258
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.073	0.3618	0.3618
Echinococcus granulosus	c src tyrosine kinase	0.1814	1	1
Schistosoma mansoni	tyrosine kinase	0.1814	1	1
Echinococcus multilocularis	tensin	0.1084	0.5697	0.5697
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.073	0.3618	0.3618
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.1814	1	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.1814	1	1
Echinococcus multilocularis	protein KINase family member (kin 25)	0.073	0.3618	0.3618
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.073	0.3618	0.3618
Schistosoma mansoni	hypothetical protein	0.073	0.3618	0.3618
Schistosoma mansoni	tyrosine kinase	0.073	0.3618	0.3618
Echinococcus multilocularis	integrin linked protein kinase	0.073	0.3618	0.3618
Brugia malayi	protein-tyrosine kinase	0.1814	1	1
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.1084	0.5697	0.5697
Echinococcus multilocularis	NCK adaptor protein	0.1084	0.5697	0.5697
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.073	0.3618	0.3618
Echinococcus granulosus	suppressor of cytokine signaling 6	0.1084	0.5697	0.5697
Brugia malayi	Variant SH3 domain containing protein	0.1084	0.5697	0.3258
Toxoplasma gondii	STE kinase	0.073	0.3618	0.5
Echinococcus granulosus	tyrosine protein kinase ABL1	0.1814	1	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.1084	0.5697	0.5697
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.073	0.3618	0.5
Loa Loa (eye worm)	TK/ALK protein kinase	0.073	0.3618	0.3618
Schistosoma mansoni	protein kinase	0.073	0.3618	0.3618
Echinococcus granulosus	tyrosine protein kinase csk	0.073	0.3618	0.3618
Schistosoma mansoni	signal transduction protein lnk-related	0.1084	0.5697	0.5697
Schistosoma mansoni	serine/threonine protein kinase	0.073	0.3618	0.3618
Schistosoma mansoni	tyrosine kinase	0.073	0.3618	0.3618
Schistosoma mansoni	tensin-related	0.1084	0.5697	0.5697
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.1084	0.5697	0.5697
Echinococcus granulosus	activated cdc42 kinase 1	0.073	0.3618	0.3618
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.073	0.3618	0.3618
Echinococcus multilocularis	tyrosine kinase	0.1814	1	1
Onchocerca volvulus		0.1814	1	1
Echinococcus multilocularis	raf serine:threonine protein kinase	0.073	0.3618	0.3618
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.1084	0.5697	0.5697
Echinococcus granulosus	N chimaerin	0.1084	0.5697	0.5697
Loa Loa (eye worm)	RGC/RGC protein kinase	0.073	0.3618	0.3618
Echinococcus multilocularis	tyrosine protein kinase pr2	0.073	0.3618	0.3618
Loa Loa (eye worm)	hypothetical protein	0.073	0.3618	0.3618
Schistosoma mansoni	ephrin receptor	0.073	0.3618	0.3618
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.073	0.3618	0.3618
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.073	0.3618	0.3618
Schistosoma mansoni	tyrosine kinase	0.1814	1	1
Echinococcus granulosus	tyrosine protein kinase Blk	0.1814	1	1
Loa Loa (eye worm)	hypothetical protein	0.1084	0.5697	0.5697
Schistosoma mansoni	serine/threonine protein kinase	0.073	0.3618	0.3618
Loa Loa (eye worm)	hypothetical protein	0.1084	0.5697	0.5697
Echinococcus multilocularis	short transient receptor potential channel 6	0.0383	0.1571	0.1571
Onchocerca volvulus		0.1084	0.5697	0.3258
Onchocerca volvulus		0.1814	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.1814	1	1
Loa Loa (eye worm)	TK protein kinase	0.073	0.3618	0.3618
Loa Loa (eye worm)	hypothetical protein	0.1084	0.5697	0.5697
Loa Loa (eye worm)	TK/FER protein kinase	0.073	0.3618	0.3618
Echinococcus granulosus	growth factor receptor bound protein 2	0.1084	0.5697	0.5697
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.073	0.3618	0.3618
Echinococcus granulosus	NCK adaptor protein	0.1084	0.5697	0.5697
Trypanosoma brucei	Flagellum attachment zone protein 20	0.073	0.3618	0.5
Brugia malayi	SH2 domain containing protein	0.1084	0.5697	0.3258
Loa Loa (eye worm)	hypothetical protein	0.073	0.3618	0.3618
Entamoeba histolytica	SH2 domain containing protein	0.1084	0.5697	0.3258
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.073	0.3618	0.3618
Loa Loa (eye worm)	SH2 domain-containing protein	0.1084	0.5697	0.5697
Schistosoma mansoni	protein kinase	0.073	0.3618	0.3618
Loa Loa (eye worm)	TK protein kinase	0.073	0.3618	0.3618
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.1084	0.5697	0.5697
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.1084	0.5697	0.5697
Loa Loa (eye worm)	hypothetical protein	0.073	0.3618	0.3618
Brugia malayi	Tyrosine-protein kinase abl-1	0.1814	1	1
Echinococcus granulosus	integrin linked protein kinase	0.073	0.3618	0.3618
Brugia malayi	Protein kinase domain containing protein	0.1814	1	1
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.1814	1	1
Trichomonas vaginalis	TKL family protein kinase	0.073	0.3618	1
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.073	0.3618	0.3618
Echinococcus multilocularis	SHC transforming protein 3	0.1084	0.5697	0.5697
Trichomonas vaginalis	TKL family protein kinase	0.073	0.3618	1
Schistosoma mansoni	tyrosine kinase	0.073	0.3618	0.3618
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.073	0.3618	0.3618
Echinococcus granulosus	activin receptor type	0.073	0.3618	0.3618
Trichomonas vaginalis	TKL family protein kinase	0.073	0.3618	1
Schistosoma mansoni	transient receptor potential channel	0.0116	0.000000017787	0.000000017787
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.073	0.3618	0.3618
Loa Loa (eye worm)	TK protein kinase	0.1814	1	1
Loa Loa (eye worm)	SRC-1	0.1814	1	1
Loa Loa (eye worm)	TK protein kinase	0.073	0.3618	0.3618
Schistosoma mansoni	shc transforming protein	0.1084	0.5697	0.5697
Loa Loa (eye worm)	STAT protein	0.1084	0.5697	0.5697
Loa Loa (eye worm)	hypothetical protein	0.1084	0.5697	0.5697
Schistosoma mansoni	tyrosine kinase	0.073	0.3618	0.3618
Echinococcus granulosus	tyrosine protein kinase Lyn	0.1814	1	1
Echinococcus granulosus	tyrosine protein kinase pr2	0.073	0.3618	0.3618
Schistosoma mansoni	tensin	0.1084	0.5697	0.5697
Schistosoma mansoni	tyrosine kinase	0.1814	1	1
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.073	0.3618	0.3618
Plasmodium falciparum	tyrosine kinase-like protein	0.073	0.3618	0.5
Brugia malayi	SRC-1	0.1814	1	1
Schistosoma mansoni	tyrosine kinase	0.1814	1	1
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.073	0.3618	0.3618
Schistosoma mansoni	tyrosine kinase	0.073	0.3618	0.3618
Echinococcus granulosus	tyrosine protein kinase	0.073	0.3618	0.3618
Loa Loa (eye worm)	TK/DDR protein kinase	0.073	0.3618	0.3618
Plasmodium vivax	protein kinase, putative	0.073	0.3618	0.5
Echinococcus granulosus	tyrosine kinase	0.1814	1	1
Echinococcus granulosus	protein tyrosine kinase	0.073	0.3618	0.3618
Echinococcus multilocularis	protein tyrosine kinase	0.073	0.3618	0.3618
Trichomonas vaginalis	TKL family protein kinase	0.073	0.3618	1
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.073	0.3618	0.3618
Loa Loa (eye worm)	protein kinase domain-containing protein	0.073	0.3618	0.3618
Schistosoma mansoni	tyrosine kinase	0.073	0.3618	0.3618
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.073	0.3618	0.3618
Brugia malayi	cytokine inducible SH2-containing protein 5	0.1084	0.5697	0.3258
Loa Loa (eye worm)	TK/ROR protein kinase	0.073	0.3618	0.3618
Echinococcus granulosus	receptor type guanylyl cyclase	0.073	0.3618	0.3618
Schistosoma mansoni	serine/threonine protein kinase	0.073	0.3618	0.3618
Loa Loa (eye worm)	RGC/RGC protein kinase	0.073	0.3618	0.3618
Loa Loa (eye worm)	RGC/RGC protein kinase	0.073	0.3618	0.3618
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.1084	0.5697	0.5697
Schistosoma mansoni	tyrosine kinase	0.073	0.3618	0.3618
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.1084	0.5697	0.5697
Brugia malayi	tRNA modification GTPase TrmE family protein	0.1084	0.5697	0.3258
Brugia malayi	Protein kinase domain containing protein	0.1814	1	1
Echinococcus granulosus	epidermal growth factor receptor	0.073	0.3618	0.3618
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.073	0.3618	0.3618
Echinococcus multilocularis	tyrosine protein kinase shark	0.1814	1	1
Schistosoma mansoni	tyrosine protein kinase	0.073	0.3618	0.3618
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.073	0.3618	0.3618
Echinococcus multilocularis	receptor type guanylyl cyclase	0.073	0.3618	0.3618
Schistosoma mansoni	tyrosine kinase	0.073	0.3618	0.3618
Schistosoma mansoni	tyrosine kinase	0.1814	1	1
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.1084	0.5697	0.3258
Schistosoma mansoni	protein kinase	0.073	0.3618	0.3618
Loa Loa (eye worm)	TK protein kinase	0.073	0.3618	0.3618
Schistosoma mansoni	vav2	0.1084	0.5697	0.5697
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.1084	0.5697	0.3258
Onchocerca volvulus		0.1084	0.5697	0.3258
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.1814	1	1
Entamoeba histolytica	protein kinase, putative	0.1084	0.5697	0.3258
Schistosoma mansoni	tyrosine kinase	0.073	0.3618	0.3618
Schistosoma mansoni	tensin	0.1084	0.5697	0.5697
Trypanosoma cruzi	protein kinase, putative	0.073	0.3618	0.5
Loa Loa (eye worm)	hypothetical protein	0.1084	0.5697	0.5697
Echinococcus multilocularis	protein kinase	0.073	0.3618	0.3618
Schistosoma mansoni	tyrosine kinase	0.073	0.3618	0.3618
Brugia malayi	Sex muscle abnormal protein 5	0.1084	0.5697	0.3258
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.073	0.3618	0.3618
Loa Loa (eye worm)	TK protein kinase	0.073	0.3618	0.3618
Loa Loa (eye worm)	TK/FER protein kinase	0.1814	1	1
Loa Loa (eye worm)	hypothetical protein	0.073	0.3618	0.3618
Loa Loa (eye worm)	SH2 domain-containing protein	0.1084	0.5697	0.5697
Echinococcus multilocularis	tyrosine kinase	0.073	0.3618	0.3618
Brugia malayi	integrin-linked kinase	0.073	0.3618	0.00000002787
Echinococcus multilocularis	transfer RNA-Thr	0.073	0.3618	0.3618
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.073	0.3618	0.5
Echinococcus multilocularis	tyrosine protein kinase csk	0.073	0.3618	0.3618
Echinococcus multilocularis	tyrosine protein kinase Blk	0.1814	1	1
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.1814	1	1
Loa Loa (eye worm)	hypothetical protein	0.1084	0.5697	0.5697
Loa Loa (eye worm)	hypothetical protein	0.1084	0.5697	0.5697
Echinococcus granulosus	tyrosine protein kinase Src42A	0.1084	0.5697	0.5697
Echinococcus multilocularis	signal transduction protein lnk realted	0.1084	0.5697	0.5697
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.1814	1	1
Schistosoma mansoni	tyrosine kinase	0.073	0.3618	0.3618
Schistosoma mansoni	ephrin receptor	0.073	0.3618	0.3618
Echinococcus granulosus	protein kinase	0.073	0.3618	0.3618
Loa Loa (eye worm)	TK/Met protein kinase	0.073	0.3618	0.3618
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.073	0.3618	0.3618
Plasmodium vivax	tyrosine kinase-like protein, putative	0.073	0.3618	0.5
Schistosoma mansoni	protein kinase	0.073	0.3618	0.3618
Trypanosoma brucei	Pseudokinase, putative	0.073	0.3618	0.5
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.1084	0.5697	0.5697
Loa Loa (eye worm)	hypothetical protein	0.1084	0.5697	0.5697
Echinococcus granulosus	SH2 domain containing protein 7	0.1084	0.5697	0.5697
Schistosoma mansoni	tyrosine kinase	0.073	0.3618	0.3618
Loa Loa (eye worm)	TK protein kinase	0.073	0.3618	0.3618
Echinococcus multilocularis	tensin	0.1084	0.5697	0.5697
Brugia malayi	SH2 domain containing protein	0.1084	0.5697	0.3258
Echinococcus granulosus	fibroblast growth factor receptor 4	0.073	0.3618	0.3618
Echinococcus granulosus	short transient receptor potential channel 6	0.0383	0.1571	0.1571
Echinococcus multilocularis		0.1084	0.5697	0.5697
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.1814	1	1
Echinococcus multilocularis	ephrin type A receptor 4 A	0.073	0.3618	0.3618
Echinococcus granulosus	tyrosine protein kinase Fyn	0.1814	1	1
Echinococcus multilocularis	c src tyrosine kinase	0.1814	1	1
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.1084	0.5697	0.3258
Loa Loa (eye worm)	TK/FER protein kinase	0.1814	1	1
Brugia malayi	hypothetical protein	0.1084	0.5697	0.3258
Trypanosoma cruzi	protein kinase, putative	0.073	0.3618	0.5
Echinococcus granulosus	kinase suppressor of Ras 1	0.073	0.3618	0.3618
Schistosoma mansoni	adapter molecule crk	0.1084	0.5697	0.5697
Leishmania major	protein kinase, putative	0.073	0.3618	0.5
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.1814	1	1
Loa Loa (eye worm)	TK protein kinase	0.073	0.3618	0.3618
Onchocerca volvulus		0.1814	1	1
Schistosoma mansoni	nck2/grb4	0.1084	0.5697	0.5697
Brugia malayi	SH2 domain containing protein	0.1084	0.5697	0.3258
Loa Loa (eye worm)	TK/FER protein kinase	0.1814	1	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.1814	1	1
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.073	0.3618	0.3618
Schistosoma mansoni	hypothetical protein	0.1084	0.5697	0.5697
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.073	0.3618	0.3618
Onchocerca volvulus		0.1084	0.5697	0.3258
Onchocerca volvulus		0.1084	0.5697	0.3258
Schistosoma mansoni	suppressor of cytokine signaling	0.1084	0.5697	0.5697
Schistosoma mansoni	serine/threonine RGC	0.073	0.3618	0.3618
Schistosoma mansoni	GTPase activating protein	0.1084	0.5697	0.5697
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.073	0.3618	0.3618
Onchocerca volvulus		0.1084	0.5697	0.3258
Echinococcus granulosus	tyrosine kinase	0.1814	1	1
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.1084	0.5697	0.5697
Brugia malayi	Protein kinase domain containing protein	0.073	0.3618	0.00000002787
Loa Loa (eye worm)	TK/INSR protein kinase	0.073	0.3618	0.3618
Schistosoma mansoni	suppressor of cytokine signaling	0.1084	0.5697	0.5697
Schistosoma mansoni	growth factor receptor-bound protein	0.1084	0.5697	0.5697
Loa Loa (eye worm)	TK/FER protein kinase	0.1814	1	1
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.073	0.3618	0.3618
Echinococcus granulosus	retinal guanylyl cyclase 2	0.073	0.3618	0.3618
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.1084	0.5697	0.5697
Echinococcus multilocularis	tyrosine protein kinase HCK	0.073	0.3618	0.3618
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.1814	1	1
Echinococcus granulosus	hypothetical protein	0.1084	0.5697	0.5697
Echinococcus granulosus	tyrosine protein kinase Src42A	0.1814	1	1
Plasmodium falciparum	protein kinase, putative	0.073	0.3618	0.5
Schistosoma mansoni	tyrosine kinase	0.073	0.3618	0.3618
Echinococcus multilocularis	SH2 motif	0.1084	0.5697	0.5697
Schistosoma mansoni	tyrosine kinase	0.073	0.3618	0.3618
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.1084	0.5697	0.5697
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.1084	0.5697	0.5697
Brugia malayi	Protein kinase domain containing protein	0.1814	1	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.073	0.3618	0.3618
Echinococcus multilocularis	SH2 motif	0.1084	0.5697	0.5697
Schistosoma mansoni	serine/threonine protein kinase	0.073	0.3618	0.3618
Loa Loa (eye worm)	hypothetical protein	0.1084	0.5697	0.5697
Echinococcus granulosus	tensin	0.1084	0.5697	0.5697
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.073	0.3618	0.3618
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.1814	1	1
Toxoplasma gondii	protein kinase	0.073	0.3618	0.5
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.1814	1	1
Echinococcus granulosus	tyrosine protein kinase csk	0.073	0.3618	0.3618
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.1084	0.5697	0.5697
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.073	0.3618	0.3618
Plasmodium falciparum	tyrosine kinase-like protein	0.073	0.3618	0.5
Brugia malayi	Protein kinase domain containing protein	0.1814	1	1
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.073	0.3618	0.5
Schistosoma mansoni	tyrosine kinase	0.073	0.3618	0.3618
Echinococcus granulosus	retinal guanylyl cyclase 2	0.073	0.3618	0.3618
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.073	0.3618	0.3618
Echinococcus granulosus	SH2 motif	0.1084	0.5697	0.5697
Echinococcus multilocularis	protein kinase	0.073	0.3618	0.3618
Brugia malayi	SH2 domain containing protein	0.1814	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.073	0.3618	0.3618
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.1814	1	1
Echinococcus multilocularis	kinase suppressor of Ras 1	0.073	0.3618	0.3618
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.1084	0.5697	0.5697
Echinococcus granulosus	raf serine:threonine protein kinase	0.073	0.3618	0.3618
Schistosoma mansoni	tyrosine kinase	0.073	0.3618	0.3618
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.1084	0.5697	0.5697
Schistosoma mansoni	protein kinase	0.073	0.3618	0.3618
Loa Loa (eye worm)	TK/EGFR protein kinase	0.073	0.3618	0.3618
Echinococcus multilocularis	heat shock protein 70	0.073	0.3618	0.3618
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.1814	1	1
Loa Loa (eye worm)	serine/threonine protein kinase	0.073	0.3618	0.3618
Loa Loa (eye worm)	hypothetical protein	0.073	0.3618	0.3618
Echinococcus granulosus	tyrosine protein kinase Src64B	0.1814	1	1
Brugia malayi	RhoGAP domain containing protein	0.1084	0.5697	0.3258
Loa Loa (eye worm)	TK/FER protein kinase	0.073	0.3618	0.3618
Echinococcus granulosus	epidermal growth factor receptor	0.073	0.3618	0.3618
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.073	0.3618	0.3618
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.1814	1	1
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.1084	0.5697	0.5697
Schistosoma mansoni	protein kinase	0.073	0.3618	0.3618
Loa Loa (eye worm)	hypothetical protein	0.1084	0.5697	0.5697
Loa Loa (eye worm)	hypothetical protein	0.1084	0.5697	0.5697
Schistosoma mansoni	protein kinase	0.073	0.3618	0.3618
Echinococcus granulosus	natriuretic peptide receptor 1	0.073	0.3618	0.3618
Echinococcus multilocularis	SH2 domain containing protein 7	0.1084	0.5697	0.5697
Loa Loa (eye worm)	TK protein kinase	0.073	0.3618	0.3618
Loa Loa (eye worm)	hypothetical protein	0.073	0.3618	0.3618
Schistosoma mansoni	SH2A	0.1084	0.5697	0.5697
Echinococcus granulosus	SHC transforming protein 3	0.1084	0.5697	0.5697
Loa Loa (eye worm)	hypothetical protein	0.073	0.3618	0.3618
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.1084	0.5697	0.5697
Echinococcus multilocularis	activin receptor type	0.073	0.3618	0.3618
Brugia malayi	SH2 domain containing protein	0.1084	0.5697	0.3258
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.073	0.3618	0.3618
Loa Loa (eye worm)	hypothetical protein	0.073	0.3618	0.3618
Schistosoma mansoni	hypothetical protein	0.1084	0.5697	0.5697
Brugia malayi	Protein kinase domain containing protein	0.1814	1	1
Plasmodium falciparum	protein kinase, putative	0.073	0.3618	0.5
Echinococcus multilocularis	natriuretic peptide receptor 1	0.073	0.3618	0.3618
Loa Loa (eye worm)	hypothetical protein	0.073	0.3618	0.3618
Brugia malayi	Tensin	0.1084	0.5697	0.3258
Loa Loa (eye worm)	TK/CSK protein kinase	0.073	0.3618	0.3618
Schistosoma mansoni	growth factor receptor-bound protein	0.1084	0.5697	0.5697
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.1084	0.5697	0.5697
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.1814	1	1
Onchocerca volvulus		0.1084	0.5697	0.3258
Brugia malayi	SH2 domain containing protein	0.1084	0.5697	0.3258
Loa Loa (eye worm)	hypothetical protein	0.073	0.3618	0.3618
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.073	0.3618	0.3618
Schistosoma mansoni	tyrosine kinase	0.073	0.3618	0.3618
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.073	0.3618	0.3618
Echinococcus granulosus	suppressor of cytokine signaling 7	0.1084	0.5697	0.5697
Onchocerca volvulus		0.1814	1	1
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.073	0.3618	0.3618
Echinococcus granulosus	tyrosine protein kinase HCK	0.073	0.3618	0.3618
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.1814	1	1
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.1814	1	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.073	0.3618	0.3618
Schistosoma mansoni	protein tyrosine kinase	0.073	0.3618	0.3618
Schistosoma mansoni	protein kinase	0.073	0.3618	0.3618
Brugia malayi	SH2 domain containing protein	0.1084	0.5697	0.3258
Brugia malayi	Variant SH3 domain containing protein	0.1084	0.5697	0.3258
Onchocerca volvulus		0.1814	1	1
Loa Loa (eye worm)	hypothetical protein	0.073	0.3618	0.3618
Schistosoma mansoni	tyrosine kinase	0.073	0.3618	0.3618
Echinococcus granulosus	signal transduction protein lnk realted	0.1084	0.5697	0.5697
Brugia malayi	Variant SH3 domain containing protein	0.1084	0.5697	0.3258
Echinococcus granulosus	ephrin type A receptor 4 A	0.073	0.3618	0.3618
Onchocerca volvulus		0.073	0.3618	0.00000002787
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.073	0.3618	0.3618
Schistosoma mansoni	tyrosine kinase	0.073	0.3618	0.3618
Loa Loa (eye worm)	TK/FER protein kinase	0.1814	1	1
Loa Loa (eye worm)	TK/ABL protein kinase	0.1814	1	1
Loa Loa (eye worm)	hypothetical protein	0.1814	1	1
Schistosoma mansoni	tensin-related	0.1084	0.5697	0.5697
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.1084	0.5697	0.3258
Toxoplasma gondii	protein kinase domain-containing protein	0.073	0.3618	0.5
Giardia lamblia	Protein 21.1	0.073	0.3618	1
Schistosoma mansoni	tyrosine kinase	0.1814	1	1
Schistosoma mansoni	protein kinase	0.073	0.3618	0.3618
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.073	0.3618	0.3618
Loa Loa (eye worm)	TK/FER protein kinase	0.073	0.3618	0.3618
Brugia malayi	hypothetical protein	0.1814	1	1
Echinococcus multilocularis	tyrosine protein kinase	0.073	0.3618	0.3618
Echinococcus granulosus	SH2 domain containing adapter protein F	0.1084	0.5697	0.5697
Echinococcus multilocularis	tyrosine protein kinase Srms	0.1814	1	1
Echinococcus multilocularis	epidermal growth factor receptor	0.073	0.3618	0.3618
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.073	0.3618	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 4 nM	Inhibition of human recombinant TRPC6 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay	ChEMBL.	23886683
IC50 (binding)	= 32 nM	Inhibition of human recombinant TRPC3 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay	ChEMBL.	23886683

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2418809

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1768946