Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | phosphodiesterase 10A | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | cAMP and cAMP inhibited cGMP 3'5' cyclic | Get druggable targets OG5_135363 | All targets in OG5_135363 |
Echinococcus multilocularis | cAMP and cAMP inhibited cGMP 3',5' cyclic | Get druggable targets OG5_135363 | All targets in OG5_135363 |
Brugia malayi | Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative | Get druggable targets OG5_135363 | All targets in OG5_135363 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_135363 | All targets in OG5_135363 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_135363 | All targets in OG5_135363 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | cAMP-specific phosphodiesterase | phosphodiesterase 10A | 789 aa | 666 aa | 30.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.1927 | 0.9806 | 0.9706 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.196 | 1 | 1 |
Onchocerca volvulus | 0.196 | 1 | 0.5 | |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.196 | 1 | 1 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.196 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.1157 | 0.5285 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.196 | 1 | 1 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.196 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.028 | 0.0138 | 0.0138 |
Loa Loa (eye worm) | hypothetical protein | 0.1124 | 0.5091 | 0.5091 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.1157 | 0.5285 | 0.5 |
Schistosoma mansoni | 6-phosphofructokinase | 0.196 | 1 | 0.5 |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.1157 | 0.5285 | 0.5 |
Brugia malayi | Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative | 0.0289 | 0.0191 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.196 | 1 | 1 |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.1927 | 0.9806 | 0.9706 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1927 | 0.9806 | 0.9706 |
Mycobacterium ulcerans | hypothetical protein | 0.1157 | 0.5285 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.1157 | 0.5285 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.1927 | 0.9806 | 0.9706 |
Loa Loa (eye worm) | hypothetical protein | 0.1927 | 0.9806 | 0.9806 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.