Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tyrosine kinase | 0.0161 | 0.0946 | 0.0908 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.0622 | 0.0583 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0138 | 0.0622 | 0.5 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0138 | 0.0622 | 0.0583 |
Onchocerca volvulus | 0.0138 | 0.0622 | 0.5 | |
Echinococcus multilocularis | neuroligin | 0.0138 | 0.0622 | 0.0622 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0138 | 0.0622 | 0.0583 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0161 | 0.0946 | 0.0908 |
Brugia malayi | Carboxylesterase family protein | 0.0138 | 0.0622 | 0.0583 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0138 | 0.0622 | 0.0622 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.0622 | 0.0583 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0814 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.0622 | 0.0583 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0138 | 0.0622 | 0.0583 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.0622 | 0.0583 |
Schistosoma mansoni | acetylcholinesterase | 0.0138 | 0.0622 | 0.0583 |
Echinococcus multilocularis | insulin receptor | 0.0096 | 0.0042 | 0.0042 |
Echinococcus granulosus | acetylcholinesterase | 0.0814 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0814 | 1 | 1 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0138 | 0.0622 | 0.0583 |
Onchocerca volvulus | 0.0138 | 0.0622 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0138 | 0.0622 | 0.0583 |
Echinococcus multilocularis | acetylcholinesterase | 0.0814 | 1 | 1 |
Onchocerca volvulus | 0.0138 | 0.0622 | 0.5 | |
Echinococcus granulosus | neuroligin | 0.0138 | 0.0622 | 0.0583 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0138 | 0.0622 | 0.5 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0138 | 0.0622 | 0.0622 |
Schistosoma mansoni | tyrosine kinase | 0.0159 | 0.0922 | 0.0884 |
Schistosoma mansoni | tyrosine kinase | 0.0161 | 0.0946 | 0.0908 |
Echinococcus granulosus | carboxylesterase 5A | 0.0814 | 1 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0138 | 0.0622 | 0.5 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0138 | 0.0622 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0814 | 1 | 1 |
Onchocerca volvulus | 0.0138 | 0.0622 | 0.5 | |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0138 | 0.0622 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0138 | 0.0622 | 0.0583 |
Brugia malayi | Carboxylesterase family protein | 0.0138 | 0.0622 | 0.0583 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0138 | 0.0622 | 0.5 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0138 | 0.0622 | 0.0583 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.03 | 0.2866 | 0.2837 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.03 | 0.2866 | 0.2837 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0161 | 0.0946 | 0.0908 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.0622 | 0.0583 |
Loa Loa (eye worm) | hypothetical protein | 0.0814 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0814 | 1 | 1 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0138 | 0.0622 | 0.0622 |
Brugia malayi | Carboxylesterase family protein | 0.0138 | 0.0622 | 0.0583 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.0622 | 0.0583 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0161 | 0.0946 | 0.0946 |
Brugia malayi | Carboxylesterase family protein | 0.0814 | 1 | 1 |
Onchocerca volvulus | 0.0138 | 0.0622 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0814 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0159 | 0.0922 | 0.0884 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0138 | 0.0622 | 0.0583 |
Schistosoma mansoni | tyrosine kinase | 0.0159 | 0.0922 | 0.0884 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0138 | 0.0622 | 0.0583 |
Loa Loa (eye worm) | carboxylesterase | 0.0814 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0138 | 0.0622 | 0.0583 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0138 | 0.0622 | 0.0583 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.03 | 0.2866 | 0.2866 |
Loa Loa (eye worm) | carboxylesterase | 0.0138 | 0.0622 | 0.0583 |
Echinococcus multilocularis | acetylcholinesterase | 0.0814 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.03 | 0.2866 | 0.2837 |
Schistosoma mansoni | gliotactin | 0.0138 | 0.0622 | 0.0583 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0096 | 0.0042 | 0.0042 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.0622 | 0.0583 |
Echinococcus granulosus | epidermal growth factor receptor | 0.03 | 0.2866 | 0.2837 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI (functional) | = 6 % | Antibacterial activity against Mycobacterium tuberculosis H37Rv assessed as growth inhibition at 6.25 ug/mL by BACTEC 460 radiometric assay relative to control | ChEMBL. | 23850103 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.