Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | potassium inwardly-rectifying channel, subfamily J, member 6 | Starlite/ChEMBL | References |
Homo sapiens | potassium inwardly-rectifying channel, subfamily J, member 5 | Starlite/ChEMBL | References |
Homo sapiens | potassium inwardly-rectifying channel, subfamily J, member 3 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | tyrosine protein kinase Blk | 0.0568 | 1 | 1 |
Onchocerca volvulus | 0.0568 | 1 | 1 | |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.0568 | 1 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0568 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0568 | 1 | 1 |
Onchocerca volvulus | 0.0568 | 1 | 1 | |
Echinococcus multilocularis | tyrosine kinase | 0.0568 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase shark | 0.0568 | 1 | 1 |
Onchocerca volvulus | 0.0568 | 1 | 1 | |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0568 | 1 | 1 |
Echinococcus granulosus | c src tyrosine kinase | 0.0568 | 1 | 1 |
Loa Loa (eye worm) | TK protein kinase | 0.0568 | 1 | 1 |
Echinococcus granulosus | tyrosine kinase | 0.0568 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Srms | 0.0568 | 1 | 1 |
Onchocerca volvulus | 0.0568 | 1 | 1 | |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0568 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0568 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0568 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0568 | 1 | 1 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0568 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.0568 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Srms | 0.0568 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0568 | 1 | 1 |
Loa Loa (eye worm) | TK/ABL protein kinase | 0.0568 | 1 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0568 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0568 | 1 | 1 |
Loa Loa (eye worm) | SRC-1 | 0.0568 | 1 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0568 | 1 | 1 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0568 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0568 | 1 | 1 |
Onchocerca volvulus | 0.0568 | 1 | 1 | |
Brugia malayi | SH2 domain containing protein | 0.0568 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0568 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0568 | 1 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0568 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0568 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0568 | 1 | 1 |
Brugia malayi | SRC-1 | 0.0568 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0568 | 1 | 1 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.0568 | 1 | 1 |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.0568 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0568 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0568 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0568 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0568 | 1 | 1 |
Onchocerca volvulus | 0.0568 | 1 | 1 | |
Echinococcus granulosus | tyrosine kinase | 0.0568 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0568 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0568 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0568 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fps85D | 0.0568 | 1 | 1 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0568 | 1 | 1 |
Echinococcus granulosus | tyrosine kinase|tyrosine protein kinase Fyn | 0.0568 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0568 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0568 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0568 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0568 | 1 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0568 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase ABL1 | 0.0568 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0568 | 1 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0568 | 1 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0568 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase shark | 0.0568 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Blk | 0.0568 | 1 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0568 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0568 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Fps85D | 0.0568 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0568 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0568 | 1 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0568 | 1 | 1 |
Brugia malayi | protein-tyrosine kinase | 0.0568 | 1 | 1 |
Brugia malayi | SH2 domain containing protein | 0.0568 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0568 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase ABL1 | 0.0568 | 1 | 1 |
Echinococcus multilocularis | c src tyrosine kinase | 0.0568 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 7.8 uM | Activation of GIRK1/4 (unknown origin) transfected in HEK293 cells after 4 mins by thallium flux-based fluorescence assay | ChEMBL. | 23916258 |
EC50 (binding) | > 10 uM | Activation of GIRK1/2 (unknown origin) transfected in HEK293 cells after 4 mins by thallium flux-based fluorescence assay | ChEMBL. | 23916258 |
Efficacy (binding) | = 119 % | Activation of GIRK1/4 (unknown origin) transfected in HEK293 cells at 20 uM after 4 mins by thallium flux-based fluorescence assay relative to ML297 | ChEMBL. | 23916258 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.