Detailed information for compound 1769425

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 505.389 | Formula: C24H19Cl2FN2O3S
  • H donors: 1 H acceptors: 3 LogP: 4.21 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 2
  • SMILES: OCCn1c(C(=O)N(Cc2ccc(c(c2)Cl)Cl)C)c(c2ccc(cc2)F)c2c(c1=O)csc2
  • InChi: 1S/C24H19Cl2FN2O3S/c1-28(11-14-2-7-19(25)20(26)10-14)24(32)22-21(15-3-5-16(27)6-4-15)17-12-33-13-18(17)23(31)29(22)8-9-30/h2-7,10,12-13,30H,8-9,11H2,1H3
  • InChiKey: VTCORKXNZJLJSR-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens centromere protein E, 312kDa Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania infantum kinesin, putative Get druggable targets OG5_126585 All targets in OG5_126585
Trypanosoma brucei gambiense flagellar attachment zone protein, putative Get druggable targets OG5_126585 All targets in OG5_126585
Schistosoma mansoni hypothetical protein Get druggable targets OG5_126585 All targets in OG5_126585
Leishmania braziliensis kinesin, putative Get druggable targets OG5_126585 All targets in OG5_126585
Trypanosoma cruzi myosin heavy chain, putative Get druggable targets OG5_126585 All targets in OG5_126585
Leishmania infantum kinesin K39, putative Get druggable targets OG5_126585 All targets in OG5_126585
Leishmania mexicana Get druggable targets OG5_126585 All targets in OG5_126585
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126585 All targets in OG5_126585
Schistosoma japonicum IPR000237,GRIP,domain-containing Get druggable targets OG5_126585 All targets in OG5_126585
Trichomonas vaginalis trichohyalin, putative Get druggable targets OG5_126585 All targets in OG5_126585
Schistosoma japonicum IPR009053,Prefoldin;IPR010978,tRNA-binding arm,domain-containing Get druggable targets OG5_126585 All targets in OG5_126585
Trypanosoma brucei gambiense kinesin K39, putative Get druggable targets OG5_126585 All targets in OG5_126585
Candida albicans weak similarity to internal and C terminal regions of general vesicular transport factor/Vesicle docking protein Get druggable targets OG5_126585 All targets in OG5_126585
Trichomonas vaginalis trichohyalin, putative Get druggable targets OG5_126585 All targets in OG5_126585
Leishmania major kinesin, putative Get druggable targets OG5_126585 All targets in OG5_126585
Entamoeba histolytica Viral A-type inclusion protein repeat, putative Get druggable targets OG5_126585 All targets in OG5_126585
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_126585 All targets in OG5_126585
Cryptosporidium parvum large low complexity coiled coil protien with large repeat region Get druggable targets OG5_126585 All targets in OG5_126585
Trypanosoma cruzi Flagellar attachment zone protein 10 Get druggable targets OG5_126585 All targets in OG5_126585
Plasmodium falciparum gametocyte-specific protein Get druggable targets OG5_126585 All targets in OG5_126585
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_126585 All targets in OG5_126585
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126585 All targets in OG5_126585
Plasmodium vivax hypothetical protein, conserved Get druggable targets OG5_126585 All targets in OG5_126585
Trypanosoma cruzi R27-2 protein, putative Get druggable targets OG5_126585 All targets in OG5_126585
Leishmania mexicana Get druggable targets OG5_126585 All targets in OG5_126585
Leishmania mexicana kinesin K39, putative Get druggable targets OG5_126585 All targets in OG5_126585
Trypanosoma brucei gambiense Get druggable targets OG5_126585 All targets in OG5_126585
Plasmodium yoelii erythrocyte membrane-associated giant protein antigen 332 Get druggable targets OG5_126585 All targets in OG5_126585
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_126585 All targets in OG5_126585
Leishmania mexicana hypothetical protein, unknown function Get druggable targets OG5_126585 All targets in OG5_126585
Trypanosoma brucei kinesin K39, putative Get druggable targets OG5_126585 All targets in OG5_126585
Leishmania braziliensis hypothetical protein, unknown function Get druggable targets OG5_126585 All targets in OG5_126585
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_126585 All targets in OG5_126585
Leishmania mexicana hypothetical protein, unknown function Get druggable targets OG5_126585 All targets in OG5_126585
Trypanosoma congolense kinesin K39, putative Get druggable targets OG5_126585 All targets in OG5_126585
Leishmania donovani flagellar attachment zone protein, putative Get druggable targets OG5_126585 All targets in OG5_126585
Giardia lamblia Hypothetical protein Get druggable targets OG5_126585 All targets in OG5_126585
Leishmania mexicana hypothetical protein, conserved Get druggable targets OG5_126585 All targets in OG5_126585
Schistosoma japonicum IPR005479,Carbamoyl-phosphate synthase L chain, ATP-binding,domain-containing Get druggable targets OG5_126585 All targets in OG5_126585
Toxoplasma gondii hypothetical protein Get druggable targets OG5_126585 All targets in OG5_126585
Leishmania infantum kinesin, putative Get druggable targets OG5_126585 All targets in OG5_126585
Trichomonas vaginalis Intracellular protein transport protein USO1, putative Get druggable targets OG5_126585 All targets in OG5_126585
Theileria parva hypothetical protein Get druggable targets OG5_126585 All targets in OG5_126585
Trypanosoma brucei gambiense Get druggable targets OG5_126585 All targets in OG5_126585
Toxoplasma gondii surface antigen repeat-containing protein Get druggable targets OG5_126585 All targets in OG5_126585
Plasmodium berghei leucine-rich repeat protein Get druggable targets OG5_126585 All targets in OG5_126585
Leishmania braziliensis hypothetical protein, unknown function Get druggable targets OG5_126585 All targets in OG5_126585
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_126585 All targets in OG5_126585
Toxoplasma gondii hypothetical protein Get druggable targets OG5_126585 All targets in OG5_126585
Giardia lamblia Nucleotide-binding head-stalk protein, putative Get druggable targets OG5_126585 All targets in OG5_126585
Leishmania major kinesin, putative Get druggable targets OG5_126585 All targets in OG5_126585
Leishmania major kinesin K39, putative Get druggable targets OG5_126585 All targets in OG5_126585
Trichomonas vaginalis centromeric protein E, putative Get druggable targets OG5_126585 All targets in OG5_126585
Neospora caninum hypothetical protein Get druggable targets OG5_126585 All targets in OG5_126585
Leishmania infantum hypothetical protein, unknown function Get druggable targets OG5_126585 All targets in OG5_126585
Leishmania donovani flagellar attachment zone protein, putative Get druggable targets OG5_126585 All targets in OG5_126585
Giardia lamblia Axoneme-associated protein GASP-180 Get druggable targets OG5_126585 All targets in OG5_126585
Leishmania mexicana kinesin, putative Get druggable targets OG5_126585 All targets in OG5_126585
Plasmodium yoelii 250-270 copies of a 13 AA repeat, NSSTPITSSSIL Get druggable targets OG5_126585 All targets in OG5_126585
Plasmodium berghei autophagy-related protein 11, putative Get druggable targets OG5_126585 All targets in OG5_126585
Trypanosoma brucei gambiense Get druggable targets OG5_126585 All targets in OG5_126585
Giardia lamblia Coiled-coil protein Get druggable targets OG5_126585 All targets in OG5_126585
Leishmania braziliensis kinesin K39, putative Get druggable targets OG5_126585 All targets in OG5_126585
Plasmodium knowlesi conserved Plasmodium protein, unknown function Get druggable targets OG5_126585 All targets in OG5_126585
Trichomonas vaginalis centromeric protein E, putative Get druggable targets OG5_126585 All targets in OG5_126585
Schistosoma mansoni hypothetical protein Get druggable targets OG5_126585 All targets in OG5_126585
Plasmodium falciparum antigen 332, DBL-like protein Get druggable targets OG5_126585 All targets in OG5_126585
Leishmania braziliensis hypothetical protein, unknown function Get druggable targets OG5_126585 All targets in OG5_126585
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126585 All targets in OG5_126585
Plasmodium falciparum repetitive organellar protein, putative Get druggable targets OG5_126585 All targets in OG5_126585
Plasmodium knowlesi leucine-rich repeat protein Get druggable targets OG5_126585 All targets in OG5_126585
Cryptosporidium parvum hypothetical protein Get druggable targets OG5_126585 All targets in OG5_126585
Plasmodium yoelii repeat organellar protein-related Get druggable targets OG5_126585 All targets in OG5_126585
Plasmodium knowlesi autophagy-related protein 11, putative Get druggable targets OG5_126585 All targets in OG5_126585
Trypanosoma cruzi myosin heavy chain, putative Get druggable targets OG5_126585 All targets in OG5_126585
Trichomonas vaginalis peptidoglycan DL-endopeptidase cwlO precursor, putative Get druggable targets OG5_126585 All targets in OG5_126585
Trypanosoma brucei flagellar attachment zone protein 1 Get druggable targets OG5_126585 All targets in OG5_126585
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_126585 All targets in OG5_126585
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_126585 All targets in OG5_126585
Plasmodium yoelii R27-2 protein Get druggable targets OG5_126585 All targets in OG5_126585
Plasmodium vivax repetitive organellar protein, putative Get druggable targets OG5_126585 All targets in OG5_126585
Plasmodium falciparum conserved Plasmodium protein, unknown function Get druggable targets OG5_126585 All targets in OG5_126585
Schistosoma japonicum expressed protein Get druggable targets OG5_126585 All targets in OG5_126585
Trypanosoma cruzi hypothetical protein, conserved Get druggable targets OG5_126585 All targets in OG5_126585
Plasmodium knowlesi conserved Plasmodium protein, unknown function Get druggable targets OG5_126585 All targets in OG5_126585
Trichomonas vaginalis nuclear anchorage protein, putative Get druggable targets OG5_126585 All targets in OG5_126585
Leishmania major kinesin K39, putative Get druggable targets OG5_126585 All targets in OG5_126585
Schistosoma japonicum expressed protein Get druggable targets OG5_126585 All targets in OG5_126585
Plasmodium yoelii hypothetical protein Get druggable targets OG5_126585 All targets in OG5_126585
Leishmania braziliensis kinesin, putative Get druggable targets OG5_126585 All targets in OG5_126585
Plasmodium berghei conserved Plasmodium protein, unknown function Get druggable targets OG5_126585 All targets in OG5_126585
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_126585 All targets in OG5_126585
Trypanosoma cruzi Flagellar attachment zone protein 1, putative Get druggable targets OG5_126585 All targets in OG5_126585
Leishmania mexicana kinesin, putative Get druggable targets OG5_126585 All targets in OG5_126585
Plasmodium falciparum conserved Plasmodium protein, unknown function Get druggable targets OG5_126585 All targets in OG5_126585
Trypanosoma brucei kinesin K39, putative Get druggable targets OG5_126585 All targets in OG5_126585
Leishmania infantum kinesin K39, putative Get druggable targets OG5_126585 All targets in OG5_126585
Plasmodium vivax hypothetical protein, conserved Get druggable targets OG5_126585 All targets in OG5_126585
Leishmania infantum hypothetical protein, conserved Get druggable targets OG5_126585 All targets in OG5_126585
Leishmania donovani flagellar attachment zone protein, putative Get druggable targets OG5_126585 All targets in OG5_126585
Trypanosoma brucei kinesin, putative Get druggable targets OG5_126585 All targets in OG5_126585
Candida albicans similar to S. cerevisiae USO1 (YDL058W) general vesicular transport factor/vesicle docking protein Get druggable targets OG5_126585 All targets in OG5_126585
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_126585 All targets in OG5_126585
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_126585 All targets in OG5_126585
Leishmania braziliensis hypothetical protein, conserved Get druggable targets OG5_126585 All targets in OG5_126585
Trichomonas vaginalis sporulation-specific protein, putative Get druggable targets OG5_126585 All targets in OG5_126585
Plasmodium berghei repetitive organellar protein, putative Get druggable targets OG5_126585 All targets in OG5_126585
Trypanosoma brucei gambiense T. brucei spp.-specific protein,hypothetical protein Get druggable targets OG5_126585 All targets in OG5_126585
Leishmania braziliensis hypothetical protein, unknown function Get druggable targets OG5_126585 All targets in OG5_126585
Leishmania braziliensis kinesin, putative Get druggable targets OG5_126585 All targets in OG5_126585
Neospora caninum viral A-type inclusion protein repeat family, putative Get druggable targets OG5_126585 All targets in OG5_126585
Echinococcus granulosus sporulation specific protein 15 Get druggable targets OG5_126585 All targets in OG5_126585
Leishmania mexicana Get druggable targets OG5_126585 All targets in OG5_126585
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126585 All targets in OG5_126585
Brugia malayi hypothetical protein Get druggable targets OG5_126585 All targets in OG5_126585
Plasmodium falciparum leucine-rich repeat protein Get druggable targets OG5_126585 All targets in OG5_126585
Plasmodium falciparum autophagy-related protein 11, putative Get druggable targets OG5_126585 All targets in OG5_126585
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126585 All targets in OG5_126585
Leishmania infantum hypothetical protein, unknown function Get druggable targets OG5_126585 All targets in OG5_126585
Leishmania infantum hypothetical protein, unknown function Get druggable targets OG5_126585 All targets in OG5_126585
Trypanosoma congolense kinesin, putative Get druggable targets OG5_126585 All targets in OG5_126585
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126585 All targets in OG5_126585
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_126585 All targets in OG5_126585
Trypanosoma brucei Flagellar attachment zone protein 10 Get druggable targets OG5_126585 All targets in OG5_126585
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_126585 All targets in OG5_126585
Plasmodium yoelii repeat organellar protein-related Get druggable targets OG5_126585 All targets in OG5_126585
Trypanosoma congolense Flagellar attachment zone protein 1, putative Get druggable targets OG5_126585 All targets in OG5_126585
Trypanosoma brucei antigenic protein, conserved Get druggable targets OG5_126585 All targets in OG5_126585
Plasmodium vivax autophagy-related protein 11, putative Get druggable targets OG5_126585 All targets in OG5_126585
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_126585 All targets in OG5_126585
Plasmodium falciparum mature parasite-infected erythrocyte surface antigen Get druggable targets OG5_126585 All targets in OG5_126585
Trichomonas vaginalis centromeric protein E, putative Get druggable targets OG5_126585 All targets in OG5_126585
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126585 All targets in OG5_126585
Echinococcus multilocularis conserved hypothetical protein Get druggable targets OG5_126585 All targets in OG5_126585
Wolbachia endosymbiont of Brugia malayi hypothetical protein Get druggable targets OG5_126585 All targets in OG5_126585
Theileria parva hypothetical protein, conserved Get druggable targets OG5_126585 All targets in OG5_126585
Plasmodium yoelii hypothetical protein Get druggable targets OG5_126585 All targets in OG5_126585
Trypanosoma brucei Microtubule-associated protein futsch, putative Get druggable targets OG5_126585 All targets in OG5_126585
Plasmodium vivax Plasmodium exported protein, unknown function Get druggable targets OG5_126585 All targets in OG5_126585
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126585 All targets in OG5_126585
Candida albicans large glutamic acid-rich orf Get druggable targets OG5_126585 All targets in OG5_126585
Leishmania mexicana Get druggable targets OG5_126585 All targets in OG5_126585
Trichomonas vaginalis Microtubule-associated protein futsch, putative Get druggable targets OG5_126585 All targets in OG5_126585
Candida albicans large glutamic acid-rich orf Get druggable targets OG5_126585 All targets in OG5_126585
Plasmodium vivax hypothetical protein, conserved Get druggable targets OG5_126585 All targets in OG5_126585
Leishmania major hypothetical protein, conserved Get druggable targets OG5_126585 All targets in OG5_126585
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_126585 All targets in OG5_126585
Plasmodium berghei TRAP-like protein Get druggable targets OG5_126585 All targets in OG5_126585
Plasmodium yoelii hypothetical protein Get druggable targets OG5_126585 All targets in OG5_126585
Leishmania major hypothetical protein, unknown function Get druggable targets OG5_126585 All targets in OG5_126585
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126585 All targets in OG5_126585
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126585 All targets in OG5_126585
Brugia malayi GRIP domain containing protein Get druggable targets OG5_126585 All targets in OG5_126585
Leishmania donovani hypothetical protein, unknown function Get druggable targets OG5_126585 All targets in OG5_126585
Leishmania infantum kinesin K39, putative Get druggable targets OG5_126585 All targets in OG5_126585
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_126585 All targets in OG5_126585
Leishmania mexicana kinesin K39, putative Get druggable targets OG5_126585 All targets in OG5_126585
Trypanosoma cruzi Flagellar attachment zone protein 1, putative Get druggable targets OG5_126585 All targets in OG5_126585
Leishmania infantum hypothetical protein, conserved Get druggable targets OG5_126585 All targets in OG5_126585
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126585 All targets in OG5_126585
Trichomonas vaginalis centromeric protein E, putative Get druggable targets OG5_126585 All targets in OG5_126585
Plasmodium knowlesi repetitive organellar protein, putative Get druggable targets OG5_126585 All targets in OG5_126585
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_126585 All targets in OG5_126585
Leishmania braziliensis hypothetical protein, unknown function Get druggable targets OG5_126585 All targets in OG5_126585
Leishmania infantum hypothetical protein, unknown function Get druggable targets OG5_126585 All targets in OG5_126585
Onchocerca volvulus Get druggable targets OG5_126585 All targets in OG5_126585
Plasmodium berghei conserved Plasmodium protein, unknown function Get druggable targets OG5_126585 All targets in OG5_126585
Leishmania braziliensis kinesin K39, putative Get druggable targets OG5_126585 All targets in OG5_126585
Plasmodium yoelii hypothetical protein Get druggable targets OG5_126585 All targets in OG5_126585
Leishmania mexicana kinesin K39, putative Get druggable targets OG5_126585 All targets in OG5_126585
Trypanosoma cruzi Flagellar attachment zone protein 10 Get druggable targets OG5_126585 All targets in OG5_126585
Leishmania major kinesin K39, putative Get druggable targets OG5_126585 All targets in OG5_126585
Cryptosporidium parvum hypothetical protein Get druggable targets OG5_126585 All targets in OG5_126585
Plasmodium yoelii hypothetical protein Get druggable targets OG5_126585 All targets in OG5_126585
Trichomonas vaginalis centromeric protein E, putative Get druggable targets OG5_126585 All targets in OG5_126585
Schistosoma japonicum IPR009053,Prefoldin,domain-containing Get druggable targets OG5_126585 All targets in OG5_126585
Trypanosoma cruzi kinesin, putative Get druggable targets OG5_126585 All targets in OG5_126585
Trichomonas vaginalis centromeric protein E, putative Get druggable targets OG5_126585 All targets in OG5_126585
Onchocerca volvulus Get druggable targets OG5_126585 All targets in OG5_126585
Leishmania braziliensis kinesin K39, putative Get druggable targets OG5_126585 All targets in OG5_126585
Plasmodium knowlesi conserved Plasmodium protein, unknown function Get druggable targets OG5_126585 All targets in OG5_126585
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_126585 All targets in OG5_126585
Schistosoma japonicum expressed protein Get druggable targets OG5_126585 All targets in OG5_126585
Treponema pallidum exonuclease (sbcC) Get druggable targets OG5_126585 All targets in OG5_126585
Trichomonas vaginalis trichohyalin, putative Get druggable targets OG5_126585 All targets in OG5_126585
Cryptosporidium hominis myosin heavy chain Get druggable targets OG5_126585 All targets in OG5_126585
Leishmania braziliensis hypothetical protein, conserved Get druggable targets OG5_126585 All targets in OG5_126585
Giardia lamblia Hypothetical protein Get druggable targets OG5_126585 All targets in OG5_126585
Plasmodium vivax hypothetical protein, conserved Get druggable targets OG5_126585 All targets in OG5_126585
Trypanosoma brucei gambiense hypothetical protein, conserved Get druggable targets OG5_126585 All targets in OG5_126585
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0363 0.4729 1
Loa Loa (eye worm) hypothetical protein 0.0208 0.2619 0.5539
Brugia malayi G-protein coupled receptor 0.0016 0 0.5
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.0363 0.4729 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0016 0 0.5
Schistosoma mansoni 6-phosphofructokinase 0.0363 0.4729 0.4729
Brugia malayi Serotonin receptor 0.0016 0 0.5
Brugia malayi AKH receptor 0.0016 0 0.5
Echinococcus granulosus 6 phosphofructo 2 kinase:fructose 2 0.0363 0.4729 1
Loa Loa (eye worm) hypothetical protein 0.0357 0.4646 0.9823
Brugia malayi neuropeptide F receptor 0.0016 0 0.5
Brugia malayi sulfakinin receptor protein 0.0016 0 0.5
Brugia malayi hypothetical protein 0.0016 0 0.5
Mycobacterium ulcerans fructose-2,6-bisphosphatase GpmB 0.0214 0.2703 0.5
Brugia malayi hypothetical protein 0.0016 0 0.5
Brugia malayi hypothetical protein 0.0016 0 0.5
Brugia malayi putative neuropeptide receptor NPR1 0.0016 0 0.5
Brugia malayi hypothetical protein 0.0016 0 0.5
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.0357 0.4646 0.9706
Loa Loa (eye worm) hypothetical protein 0.0363 0.4729 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0016 0 0.5
Brugia malayi hypothetical protein 0.0016 0 0.5
Trypanosoma cruzi 6-phosphofructo-2-kinase 1 0.0357 0.4646 0.9706
Brugia malayi Melatonin receptor type 1A 0.0016 0 0.5
Trypanosoma cruzi 6-phosphofructo-2-kinase 1 0.0357 0.4646 0.9706
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0016 0 0.5
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0016 0 0.5
Brugia malayi Dopamine receptor protein 1 0.0016 0 0.5
Brugia malayi Serotonin receptor 0.0016 0 0.5
Trypanosoma brucei 6-phosphofructo-2-kinase 2 0.0357 0.4646 0.9706
Brugia malayi hypothetical protein 0.0016 0 0.5
Brugia malayi hypothetical protein 0.0016 0 0.5
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.0363 0.4729 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0016 0 0.5
Brugia malayi hypothetical protein 0.0016 0 0.5
Mycobacterium ulcerans hypothetical protein 0.0214 0.2703 0.5
Echinococcus multilocularis 6 phosphofructo 2 kinase:fructose 2 0.0363 0.4729 1
Entamoeba histolytica phosphoglycerate mutase family protein, putative 0.0214 0.2703 0.5
Brugia malayi GnHR receptor homolog 0.0016 0 0.5
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.0363 0.4729 1
Brugia malayi neuropeptide F receptor 0.0016 0 0.5
Brugia malayi follicle stimulating hormone receptor 0.0016 0 0.5
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0016 0 0.5
Brugia malayi G-protein coupled receptor 0.0016 0 0.5
Brugia malayi G protein-coupled receptor 0.0016 0 0.5
Giardia lamblia Hypothetical protein 0.0214 0.2703 0.5
Brugia malayi ORL1-like opioid receptor 0.0016 0 0.5
Trypanosoma brucei 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.0363 0.4729 1
Brugia malayi putative neuropeptide receptor 0.0016 0 0.5
Brugia malayi Dopamine receptor protein 2 0.0016 0 0.5
Brugia malayi hypothetical protein 0.0016 0 0.5
Brugia malayi Dopamine receptor 0.0016 0 0.5
Brugia malayi hypothetical protein 0.0016 0 0.5
Brugia malayi larval opioid receptor 0.0016 0 0.5
Giardia lamblia Hypothetical protein 0.0214 0.2703 0.5
Brugia malayi RE15519p 0.0016 0 0.5
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0016 0 0.5

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1800 nM Inhibition of human ATPase activity of CENP-E motor domain assessed as ADP production after 60 mins by ADP-Glo luminescence assay ChEMBL. 23816042

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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