Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | carbonic anhydrase I | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase IX | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase II | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase XII | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | carbonic anhydrase XII | 354 aa | 295 aa | 23.1 % |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | carbonic anhydrase II | 260 aa | 259 aa | 32.0 % |
Trypanosoma brucei | carbonic anhydrase-like protein | carbonic anhydrase I | 261 aa | 281 aa | 25.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.4403 | 0.9706 | 0.9706 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.4479 | 1 | 1 |
Onchocerca volvulus | 0.4479 | 1 | 0.5 | |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.4479 | 1 | 1 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.4479 | 1 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.4479 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.2643 | 0.2852 | 0.5 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.4479 | 1 | 0.5 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.2643 | 0.2852 | 0.5 |
Schistosoma mansoni | 6-phosphofructokinase | 0.4479 | 1 | 0.5 |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.2643 | 0.2852 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.4479 | 1 | 1 |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.4403 | 0.9706 | 0.9706 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.4403 | 0.9706 | 0.9706 |
Mycobacterium ulcerans | hypothetical protein | 0.2643 | 0.2852 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.2643 | 0.2852 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.4403 | 0.9706 | 0.9706 |
Loa Loa (eye worm) | hypothetical protein | 0.4403 | 0.9706 | 0.9604 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 7.7 nM | Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay | ChEMBL. | 23859774 |
Ki (binding) | = 10.9 nM | Inhibition of human carbonic anhydrase 9 preincubated for 15 mins by stopped flow CO2 hydration assay | ChEMBL. | 23859774 |
Ki (binding) | = 30.3 nM | Inhibition of human carbonic anhydrase 12 preincubated for 15 mins by stopped flow CO2 hydration assay | ChEMBL. | 23859774 |
Ki (binding) | = 2420 nM | Inhibition of human carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay | ChEMBL. | 23859774 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.