Detailed information for compound 1769718

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 515.466 | Formula: C25H25NO11
  • H donors: 1 H acceptors: 5 LogP: 4.68 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(COc1cc(O)c2c(c1)oc(cc2=O)c1ccc2c(c1)OCCO2)OCCCCCCO[N+](=O)[O-]
  • InChi: 1S/C25H25NO11/c27-18-12-17(35-15-24(29)34-7-3-1-2-4-8-36-26(30)31)13-23-25(18)19(28)14-21(37-23)16-5-6-20-22(11-16)33-10-9-32-20/h5-6,11-14,27H,1-4,7-10,15H2
  • InChiKey: JOCZGATZURCUEP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Bos taurus Aldose reductase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis aldehyde reductase Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma mansoni aldo-keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania mexicana aldehyde reductase, putative,oxidoreductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis dihydrodiol dehydrogenase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania major prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania mexicana aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Entamoeba histolytica aldose reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania infantum prostaglandin f2-alpha synthase/D-arabinose dehydrogenase Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans see also nonallelic CaP19.2244 Get druggable targets OG5_126583 All targets in OG5_126583
Neospora caninum Oxidoreductase, aldo/keto reductase family, related Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma japonicum IPR001395,Aldo/keto reductase,domain-containing Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania donovani aldehyde reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans similar to mammalian aldo/keto reductases Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma brucei gambiense aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma mansoni pol-related Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania braziliensis aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo/keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Entamoeba histolytica aldose reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Brugia malayi oxidoreductase, aldo/keto reductase family protein Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus hypothetical protein Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis dihydrodiol dehydrogenase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania major aldehyde reductase, putative,oxidoreductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania mexicana prostaglandin f2-alpha synthase Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania braziliensis aldehyde reductase, putative,oxidoreductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans similar to mammalian aldo/keto reductases Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Toxoplasma gondii aldose reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma congolense prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania major aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma mansoni aldo-keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans similar to mammalian aldo/keto reductases Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma congolense aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldehyde reductase Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Giardia lamblia Aldose reductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo/keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo/keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma brucei prostaglandin f synthase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania mexicana prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma brucei aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma cruzi aldo-keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis dihydrodiol dehydrogenase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania infantum prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania donovani aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania infantum aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania donovani prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma cruzi aldo/keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania infantum aldehyde reductase, putative,oxidoreductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma japonicum ko:K00011 aldehyde reductase [EC1.1.1.21], putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Entamoeba histolytica aldose reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans Aldose reductase Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma brucei gambiense prostaglandin f synthase. putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Mycobacterium leprae Conserved hypothetical protein Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126583 All targets in OG5_126583
Brugia malayi oxidoreductase, aldo/keto reductase family protein Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Brugia malayi oxidoreductase, aldo/keto reductase family protein Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans see also nonallelic CaP19.2244 Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Giardia lamblia Aldose reductase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania braziliensis prostaglandin f2-alpha synthase/D-arabinose dehydrogenase Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans similar to mammalian aldo/keto reductases Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania donovani prostaglandin f2-alpha synthase Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans Aldose reductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Mycobacterium tuberculosis Probable oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Brugia malayi oxidoreductase, aldo/keto reductase family protein Get druggable targets OG5_126583 All targets in OG5_126583
Mycobacterium leprae PROBABLE OXIDOREDUCTASE Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania braziliensis prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Mycobacterium ulcerans oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Candida albicans see also nonallelic CaP19.6816 Aldose reductase   315 aa 279 aa 29.7 %
Onchocerca volvulus Aldose reductase   315 aa 324 aa 39.8 %
Neospora caninum aldo/keto reductase family oxidoreductase, putative Aldose reductase   315 aa 291 aa 21.3 %
Mycobacterium ulcerans hypothetical protein Aldose reductase   315 aa 322 aa 24.8 %
Candida albicans D-arabinose dehydrogenase, NADP-dependent Aldose reductase   315 aa 294 aa 35.4 %
Candida albicans D-arabinose dehydrogenase, NADP-dependent Aldose reductase   315 aa 294 aa 35.4 %
Candida albicans aryl alcohol dehydrogenase Aldose reductase   315 aa 319 aa 19.7 %
Onchocerca volvulus Multiple coagulation factor deficiency protein 2 homolog Aldose reductase   315 aa 323 aa 40.2 %
Candida albicans similar to putative aryl alcohol dehydrogenase family Aldose reductase   315 aa 314 aa 18.2 %
Leishmania mexicana aldo/keto reductase, putative,aldo/keto reductase family-like protein Aldose reductase   315 aa 349 aa 25.2 %
Candida albicans putative aryl alcohol dehydrogenase Aldose reductase   315 aa 310 aa 20.0 %
Toxoplasma gondii aldo/keto reductase family oxidoreductase Aldose reductase   315 aa 294 aa 24.8 %
Mycobacterium tuberculosis Conserved protein Aldose reductase   315 aa 323 aa 25.4 %
Candida albicans aryl alcohol dehydrogenase Aldose reductase   315 aa 319 aa 18.2 %
Candida albicans putative aryl alcohol dehydrogenase Aldose reductase   315 aa 326 aa 20.9 %
Candida albicans aryl alcohol dehydrogenase Aldose reductase   315 aa 319 aa 19.7 %
Candida albicans aryl alcohol dehydrogenase Aldose reductase   315 aa 319 aa 18.2 %
Onchocerca volvulus Aldose reductase   315 aa 316 aa 36.7 %
Trypanosoma cruzi aldo/keto reductase, putative Aldose reductase   315 aa 304 aa 29.3 %
Candida albicans see also nonallelic CaP19.6816 Aldose reductase   315 aa 279 aa 29.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni peroxidasin 0.0122 0.963 1
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0038 0.2664 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.2664 0.2766
Loa Loa (eye worm) hypothetical protein 0.0122 0.963 0.963
Brugia malayi latrophilin 2 splice variant baaae 0.0024 0.1468 0.1468
Loa Loa (eye worm) latrophilin receptor protein 2 0.0011 0.0401 0.0401
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.2664 1
Entamoeba histolytica aldose reductase, putative 0.0038 0.2664 1
Onchocerca volvulus 0.0011 0.0404 0.0404
Plasmodium falciparum aldehyde reductase, putative 0.0011 0.0404 0.5
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.2664 1
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0126 1 1
Schistosoma mansoni potassium channel beta 0.0011 0.0404 0.0419
Echinococcus granulosus aldehyde reductase 0.0027 0.1742 0.1809
Mycobacterium ulcerans oxidoreductase 0.0038 0.2664 1
Schistosoma mansoni hypothetical protein 0.0024 0.1468 0.1524
Echinococcus multilocularis aldehyde reductase 0.0027 0.1742 0.1809
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0038 0.2664 1
Loa Loa (eye worm) hypothetical protein 0.0122 0.963 0.963
Onchocerca volvulus 0.0038 0.2664 0.2664
Loa Loa (eye worm) hypothetical protein 0.0122 0.963 0.963
Loa Loa (eye worm) hypothetical protein 0.0122 0.963 0.963
Schistosoma mansoni peroxidasin 0.0122 0.963 1
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.0011 0.0404 0.5
Brugia malayi Animal haem peroxidase family protein 0.0122 0.963 0.963
Leishmania major prostaglandin f synthase, putative 0.0038 0.2664 1
Brugia malayi Latrophilin receptor protein 2 0.0011 0.0401 0.0401
Onchocerca volvulus Peroxidasin homolog 0.0122 0.963 0.963
Brugia malayi Peroxidasin 0.0122 0.963 0.963
Mycobacterium leprae Conserved hypothetical protein 0.0027 0.1742 0.5922
Loa Loa (eye worm) oxidoreductase 0.0038 0.2664 0.2664
Loa Loa (eye worm) hypothetical protein 0.0122 0.963 0.963
Schistosoma mansoni pol-related 0.0038 0.2664 0.2766
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.2664 0.2766
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.2664 1
Trichomonas vaginalis aldo/keto reductase, putative 0.0038 0.2664 1
Loa Loa (eye worm) hypothetical protein 0.0122 0.963 0.963
Onchocerca volvulus Peroxidase homolog 0.0122 0.963 0.963
Giardia lamblia Aldose reductase 0.0038 0.2664 0.5
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0011 0.0404 0.0404
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.2664 0.2766
Onchocerca volvulus Dual oxidase homolog 0.0122 0.963 0.963
Brugia malayi hypothetical protein 0.0122 0.963 0.963
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.2664 0.2766
Schistosoma mansoni hypothetical protein 0.0011 0.0401 0.0417
Onchocerca volvulus 0.0122 0.963 0.963
Loa Loa (eye worm) hypothetical protein 0.0038 0.2664 0.2664
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.2664 0.2766
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0011 0.0401 0.0417
Schistosoma mansoni aldo-keto reductase 0.0038 0.2664 0.2766
Plasmodium falciparum aldo-keto reductase, putative 0.0011 0.0404 0.5
Loa Loa (eye worm) blistered cuticle protein 3 0.0122 0.963 0.963
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.2664 0.2766
Echinococcus granulosus GPCR family 2 0.0011 0.0401 0.0417
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.2664 0.2766
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0038 0.2664 1
Plasmodium vivax aldehyde reductase, putative 0.0011 0.0404 0.5
Echinococcus granulosus peroxidasin 0.0122 0.963 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0038 0.2664 1
Echinococcus granulosus aldo keto reductase 0.0038 0.2664 0.2766
Onchocerca volvulus Peroxidasin homolog 0.0122 0.963 0.963
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0011 0.0404 0.0419
Brugia malayi Blistered cuticle protein 3 0.0122 0.963 0.963
Echinococcus granulosus voltage gated potassium channel subunit 0.0011 0.0404 0.0419
Giardia lamblia Aldose reductase 0.0038 0.2664 0.5
Loa Loa (eye worm) hypothetical protein 0.0122 0.963 0.963
Leishmania major aldo-keto reductase-like protein 0.0038 0.2664 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0011 0.0401 0.0401
Schistosoma mansoni hypothetical protein 0.0011 0.0401 0.0417
Schistosoma mansoni aldo-keto reductase 0.0038 0.2664 0.2766
Onchocerca volvulus 0.0038 0.2664 0.2664
Loa Loa (eye worm) hypothetical protein 0.0011 0.0401 0.0401
Brugia malayi Animal haem peroxidase family protein 0.0122 0.963 0.963
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.2664 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0011 0.0401 0.0417
Trypanosoma cruzi aldo-keto reductase 0.0038 0.2664 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.2664 0.2766
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.2664 1
Loa Loa (eye worm) hypothetical protein 0.0122 0.963 0.963
Loa Loa (eye worm) hypothetical protein 0.0122 0.963 0.963
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.2664 0.2766
Echinococcus granulosus aldo keto reductase 0.0038 0.2664 0.2766
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0038 0.2664 1
Onchocerca volvulus 0.0038 0.2664 0.2664
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.2664 0.2766
Loa Loa (eye worm) hypothetical protein 0.0122 0.963 0.963
Echinococcus granulosus hypothetical protein 0.0038 0.2664 0.2766
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0011 0.0401 0.0417
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.2664 0.2766
Loa Loa (eye worm) animal heme peroxidase 0.0122 0.963 0.963
Trypanosoma brucei prostaglandin f synthase 0.0038 0.2664 1
Trichomonas vaginalis aldo/keto reductase, putative 0.0038 0.2664 1
Echinococcus multilocularis aldo keto reductase 0.0038 0.2664 0.2766
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.2664 0.2766
Loa Loa (eye worm) oxidoreductase 0.0038 0.2664 0.2664
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.2664 0.2766
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.2664 1
Loa Loa (eye worm) animal heme peroxidase 0.0122 0.963 0.963
Brugia malayi Animal haem peroxidase family protein 0.0122 0.963 0.963
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.2664 1
Loa Loa (eye worm) animal heme peroxidase 0.0122 0.963 0.963
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0035 0.2387 0.2387
Loa Loa (eye worm) hypothetical protein 0.0126 1 1
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0038 0.2664 0.2664
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0038 0.2664 1
Loa Loa (eye worm) oxidoreductase 0.0038 0.2664 0.2664
Onchocerca volvulus Chorion peroxidase homolog 0.0122 0.963 0.963
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.2664 0.2766
Entamoeba histolytica aldose reductase, putative 0.0038 0.2664 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.2664 1
Trypanosoma cruzi aldo/keto reductase, putative 0.0038 0.2664 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.2387 0.2387
Loa Loa (eye worm) hypothetical protein 0.0024 0.1468 0.1468
Echinococcus granulosus aldo keto reductase 0.0038 0.2664 0.2766
Echinococcus multilocularis voltage gated potassium channel subunit 0.0011 0.0404 0.0419
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.2664 0.2766
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.2664 1
Echinococcus multilocularis aldo keto reductase 0.0038 0.2664 0.2766
Onchocerca volvulus 0.0038 0.2664 0.2664
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0038 0.2664 1
Schistosoma mansoni hypothetical protein 0.0011 0.0401 0.0417
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.2664 1
Loa Loa (eye worm) hypothetical protein 0.0122 0.963 0.963
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.2664 1
Onchocerca volvulus 0.0038 0.2664 0.2664
Trypanosoma brucei aldo-keto reductase, putative 0.0038 0.2664 1
Loa Loa (eye worm) hypothetical protein 0.0122 0.963 0.963
Brugia malayi NADH-dependent xylose reductase 0.0011 0.0404 0.0404
Brugia malayi Animal haem peroxidase family protein 0.0122 0.963 0.963
Trichomonas vaginalis aldo/keto reductase, putative 0.0038 0.2664 1
Echinococcus multilocularis aldo keto reductase 0.0038 0.2664 0.2766
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.0011 0.0404 0.1516
Loa Loa (eye worm) hypothetical protein 0.0122 0.963 0.963
Loa Loa (eye worm) animal heme peroxidase 0.0122 0.963 0.963
Onchocerca volvulus 0.0122 0.963 0.963
Onchocerca volvulus 0.0122 0.963 0.963
Toxoplasma gondii aldose reductase, putative 0.0038 0.2664 1
Schistosoma mansoni hypothetical protein 0.0011 0.0401 0.0417
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0011 0.0404 0.0404
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.2664 0.2766
Loa Loa (eye worm) hypothetical protein 0.0122 0.963 0.963
Onchocerca volvulus 0.0038 0.2664 0.2664
Entamoeba histolytica aldose reductase, putative 0.0038 0.2664 1
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0038 0.2664 0.2664
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0038 0.2664 0.2664
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0035 0.2387 0.2387
Echinococcus multilocularis GPCR, family 2 0.0011 0.0401 0.0417
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.2664 0.2766
Toxoplasma gondii aldo-keto reductase 0.0011 0.0404 0.1516
Onchocerca volvulus Peroxidase homolog 0.0122 0.963 0.963
Brugia malayi Calcitonin receptor-like protein seb-1 0.0035 0.2387 0.2387
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0011 0.0401 0.0417
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.2664 0.2766
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.2664 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.2664 0.2766
Echinococcus multilocularis peroxidasin 0.0122 0.963 1
Brugia malayi Animal haem peroxidase family protein 0.0122 0.963 0.963
Loa Loa (eye worm) oxidoreductase 0.0038 0.2664 0.2664
Loa Loa (eye worm) oxidoreductase 0.0038 0.2664 0.2664
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.0011 0.0404 0.1516
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.2664 0.2766
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0038 0.2664 0.2664
Echinococcus multilocularis aldo keto reductase 0.0038 0.2664 0.2766

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1.302 uM Inhibition of bovine lens aldose reductase using DL-glyceraldehyde as substrate assessed as NADPH oxidation measured for 10 mins by spectrophotometric analysis ChEMBL. 23683835

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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