Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | hypothetical protein | 0.0222 | 0.2852 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.037 | 0.9706 | 0.9604 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.037 | 0.9706 | 0.9706 |
Giardia lamblia | Hypothetical protein | 0.0222 | 0.2852 | 0.5 |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.037 | 0.9706 | 0.9706 |
Loa Loa (eye worm) | hypothetical protein | 0.0377 | 1 | 1 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.037 | 0.9706 | 0.9706 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0377 | 1 | 0.5 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.0222 | 0.2852 | 0.5 |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.0222 | 0.2852 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0377 | 1 | 1 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0377 | 1 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0377 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.0222 | 0.2852 | 0.5 |
Onchocerca volvulus | 0.0377 | 1 | 0.5 | |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.037 | 0.9706 | 0.9706 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0377 | 1 | 1 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.0377 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 0 % | Inhibition of C-terminal FLAG-tagged human recombinant autotaxin using synthetic substrate FS-3 at 10 uM measured every 2 mins by FRET assay relative to control | ChEMBL. | 23816044 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.