Detailed information for compound 1769845

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 335.396 | Formula: C21H21NO3
  • H donors: 1 H acceptors: 2 LogP: 4.91 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCOc1ccc(cc1)/N=C/1\C=C(O)C(=O)c2c1cccc2
  • InChi: 1S/C21H21NO3/c1-2-3-6-13-25-16-11-9-15(10-12-16)22-19-14-20(23)21(24)18-8-5-4-7-17(18)19/h4-5,7-12,14,23H,2-3,6,13H2,1H3/b22-19+
  • InChiKey: HOIVKNBPVWBRNZ-ZBJSNUHESA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0054 0.0165
Brugia malayi phosphoglycerate mutase family protein 0.003 0.0005 0.0022
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0054 0.0258
Echinococcus multilocularis musashi 0.0053 0.0072 0.0068
Trichomonas vaginalis esterase, putative 0.004 0.0033 1
Onchocerca volvulus 0.004 0.0033 0.0056
Loa Loa (eye worm) hypothetical protein 0.0035 0.0019 0.0038
Brugia malayi TAR-binding protein 0.0063 0.0101 0.0486
Brugia malayi hypothetical protein 0.017 0.0412 0.1973
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0033 1
Echinococcus granulosus Smad4 0.0033 0.0014 0.0009
Echinococcus multilocularis GPCR, family 2 0.0046 0.0052 0.0048
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0033 0.0029
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0054 0.0165
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0046 0.0052 0.0048
Schistosoma mansoni hypothetical protein 0.0169 0.0411 0.0406
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0047 0.0054 0.0165
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.0033 0.0436
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0033 0.016
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0014 0.0136
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0046 0.0052 0.0048
Loa Loa (eye worm) hypothetical protein 0.01 0.021 0.0409
Loa Loa (eye worm) hypothetical protein 0.0035 0.0019 0.0038
Onchocerca volvulus Huntingtin homolog 0.0125 0.0283 0.0543
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0056 0.0051
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0033 0.0029
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0056 0.0051
Giardia lamblia Hypothetical protein 0.1053 0.2992 0.5
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0047 0.0054 0.075
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.0129 0.0124
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.0762 0.214 0.4169
Mycobacterium ulcerans hypothetical protein 0.004 0.0033 0.0096
Loa Loa (eye worm) hypothetical protein 0.004 0.0033 0.0065
Brugia malayi RNA binding protein 0.0063 0.0101 0.0486
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.0075 0.007
Brugia malayi intermediate filament protein 0.0053 0.0072 0.0346
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0054 1
Brugia malayi mbt repeat family protein 0.0048 0.0056 0.0267
Loa Loa (eye worm) MBCTL1 0.0054 0.0075 0.0146
Onchocerca volvulus 0.0152 0.0359 0.0692
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0147 0.0346 0.1656
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0054 1
Brugia malayi MH2 domain containing protein 0.049 0.1347 0.6455
Loa Loa (eye worm) MH1 domain-containing protein 0.0033 0.0014 0.0028
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.1755 0.5039 0.9828
Brugia malayi MH2 domain containing protein 0.0033 0.0014 0.0068
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0035 0.0019 1
Onchocerca volvulus 0.017 0.0412 0.0795
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0101 0.0097
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0056 0.0051
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0054 0.0258
Echinococcus multilocularis lamin 0.0053 0.0072 0.0068
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0033 1
Toxoplasma gondii ABC1 family protein 0.004 0.0033 1
Schistosoma mansoni hypothetical protein 0.0152 0.0359 0.0355
Onchocerca volvulus Huntingtin homolog 0.0125 0.0283 0.0543
Brugia malayi Smad1 0.0033 0.0014 0.0068
Loa Loa (eye worm) transcription factor SMAD2 0.049 0.1347 0.2627
Loa Loa (eye worm) latrophilin receptor protein 2 0.0046 0.0052 0.0102
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0101 0.0486
Loa Loa (eye worm) hypothetical protein 0.0047 0.0054 0.0105
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0047 0.0054 0.0165
Loa Loa (eye worm) MH2 domain-containing protein 0.0033 0.0014 0.0028
Schistosoma mansoni smad1 5 8 and 0.0033 0.0014 0.0009
Loa Loa (eye worm) hypothetical protein 0.0053 0.0072 0.0141
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0033 0.0014 0.0009
Mycobacterium ulcerans lipase LipD 0.004 0.0033 0.0096
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0054 0.0096
Loa Loa (eye worm) hypothetical protein 0.004 0.0033 0.0065
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.0033 0.0436
Mycobacterium tuberculosis Probable hydrolase 0.004 0.0033 0.0436
Schistosoma mansoni hypothetical protein 0.0046 0.0052 0.0048
Echinococcus granulosus tumor protein p63 0.0332 0.0887 0.0883
Echinococcus multilocularis geminin 0.0169 0.0411 0.0406
Treponema pallidum phosphoglyceromutase 0.003 0.0005 0.5
Echinococcus multilocularis lamin dm0 0.0053 0.0072 0.0068
Loa Loa (eye worm) hypothetical protein 0.0035 0.0019 0.0038
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.0129 0.0124
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0054 0.0165
Schistosoma mansoni hypothetical protein 0.0046 0.0052 0.0048
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.1785 0.5127 1
Schistosoma mansoni lamin 0.0053 0.0072 0.0068
Brugia malayi Calcitonin receptor-like protein seb-1 0.0147 0.0346 0.1656
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0014 0.0136
Loa Loa (eye worm) phosphoglycerate mutase 0.003 0.0005 0.0009
Loa Loa (eye worm) hypothetical protein 0.1785 0.5127 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0255 0.0662 1
Loa Loa (eye worm) hypothetical protein 0.017 0.0412 0.0803
Loa Loa (eye worm) hypothetical protein 0.0047 0.0054 0.0105
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.0033 0.0096
Schistosoma mansoni hypothetical protein 0.0073 0.0129 0.0124
Loa Loa (eye worm) hypothetical protein 0.0035 0.0019 0.0038
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.0033 0.0436
Schistosoma mansoni lamin 0.0053 0.0072 0.0068
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0033 0.0056
Entamoeba histolytica acyl-coA synthetase, putative 0.0047 0.0054 0.0165
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.0033 0.0436
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0101 0.0097
Echinococcus multilocularis tumor protein p63 0.0332 0.0887 0.0883
Brugia malayi phosphoglycerate mutase family protein 0.003 0.0005 0.0022
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0033 0.0056
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0101 0.0097
Entamoeba histolytica hypothetical protein 0.0073 0.0129 0.0416
Echinococcus multilocularis microtubule associated protein 2 0.3454 1 1
Loa Loa (eye worm) Smad1 0.0033 0.0014 0.0028
Schistosoma mansoni hypothetical protein 0.0046 0.0052 0.0048
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0053 0.0072 0.0141
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0035 0.0019 0.0049
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0152 0.0359 0.1722
Echinococcus multilocularis Smad4 0.0033 0.0014 0.0009
Plasmodium vivax acyl-CoA synthetase, putative 0.0035 0.0019 0.5085
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0046 0.0052 0.0251
Echinococcus multilocularis smad 0.0033 0.0014 0.0009
Echinococcus multilocularis 6 phosphofructo 2 kinase:fructose 2 0.1785 0.5127 0.5125
Onchocerca volvulus 0.0049 0.0059 0.0106
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0033 1
Brugia malayi mbt repeat family protein 0.0048 0.0056 0.0267
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0054 0.0165
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0054 0.0258
Onchocerca volvulus 0.0048 0.0056 0.01
Echinococcus granulosus GPCR family 2 0.0046 0.0052 0.0048
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0147 0.0346 0.0674
Trypanosoma brucei 6-phosphofructo-2-kinase 2 0.1755 0.5039 0.9828
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0035 0.0019 0.0222
Echinococcus granulosus 6 phosphofructo 2 kinase:fructose 2 0.1785 0.5127 0.5125
Schistosoma mansoni Smad4 0.0033 0.0014 0.0009
Schistosoma mansoni 6-phosphofructokinase 0.1785 0.5127 0.5125
Loa Loa (eye worm) hypothetical protein 0.0047 0.0054 0.0105
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.0075 0.007
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0101 0.0198
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0188 0.0465 0.046
Entamoeba histolytica hypothetical protein 0.0073 0.0129 0.0416
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0056 0.0051
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0033 0.0065
Entamoeba histolytica phosphoglycerate mutase family protein, putative 0.1053 0.2992 1
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0056 0.0109
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0056 0.01
Brugia malayi MH1 domain containing protein 0.0033 0.0014 0.0068
Schistosoma mansoni smad1 5 8 and 0.0033 0.0014 0.0009
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0014 0.0136
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0101 0.0097
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-1-like protein 0.0762 0.214 0.4169
Onchocerca volvulus 0.004 0.0033 0.0056
Mycobacterium tuberculosis Conserved protein 0.004 0.0033 0.0436
Entamoeba histolytica hypothetical protein 0.0073 0.0129 0.0416
Schistosoma mansoni smad 0.0033 0.0014 0.0009
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.0033 0.0436
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0033 0.0014 0.0009
Schistosoma mansoni hypothetical protein 0.029 0.0762 0.0758
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0014 0.0136
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0046 0.0052 0.0048
Brugia malayi hypothetical protein 0.0125 0.0283 0.1355
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0033 0.0029
Mycobacterium tuberculosis Conserved protein 0.004 0.0033 0.0436
Loa Loa (eye worm) hypothetical protein 0.004 0.0033 0.0065
Mycobacterium ulcerans hypothetical protein 0.1053 0.2992 1
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0033 0.0056
Loa Loa (eye worm) intermediate filament protein 0.0053 0.0072 0.0141
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.083 0.2339 0.2336
Entamoeba histolytica hypothetical protein 0.0073 0.0129 0.0416
Echinococcus granulosus lamin dm0 0.0053 0.0072 0.0068
Echinococcus multilocularis survival motor neuron protein 1 0.0743 0.2087 0.2083
Loa Loa (eye worm) hypothetical protein 0.003 0.0005 0.0009
Mycobacterium ulcerans fructose-2,6-bisphosphatase GpmB 0.1053 0.2992 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0054 0.0096
Echinococcus granulosus mothers against decapentaplegic 5 0.0033 0.0014 0.0009
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0047 0.0054 0.0165
Loa Loa (eye worm) hypothetical protein 0.004 0.0033 0.0065
Brugia malayi latrophilin 2 splice variant baaae 0.01 0.021 0.1006
Brugia malayi beta-lactamase family protein 0.004 0.0033 0.016
Plasmodium falciparum acyl-CoA synthetase 0.0035 0.0019 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0059 0.0115
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0033 0.0029
Loa Loa (eye worm) hypothetical protein 0.004 0.0033 0.0065
Echinococcus granulosus intermediate filament protein 0.0053 0.0072 0.0068
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0033 1
Mycobacterium leprae conserved hypothetical protein 0.004 0.0033 0.5811
Leishmania major hypothetical protein, conserved 0.004 0.0033 0.0056
Brugia malayi beta-lactamase family protein 0.004 0.0033 0.016
Loa Loa (eye worm) hypothetical protein 0.1755 0.5039 0.9828
Loa Loa (eye worm) hypothetical protein 0.0048 0.0056 0.0109
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.0075 0.007
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0056 0.0051
Onchocerca volvulus 0.0047 0.0054 0.0096
Loa Loa (eye worm) hypothetical protein 0.0052 0.0069 0.0135
Schistosoma mansoni intermediate filament proteins 0.0053 0.0072 0.0068
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.1785 0.5127 1
Mycobacterium ulcerans hypothetical protein 0.0047 0.0054 0.0165
Mycobacterium leprae Probable lipase LipE 0.004 0.0033 0.5811
Loa Loa (eye worm) MH2 domain-containing protein 0.049 0.1347 0.2627
Loa Loa (eye worm) hypothetical protein 0.0035 0.0019 0.0038
Loa Loa (eye worm) hypothetical protein 0.003 0.0005 0.0009
Loa Loa (eye worm) hypothetical protein 0.1023 0.2904 0.5664
Brugia malayi MH1 domain containing protein 0.0033 0.0014 0.0068
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0101 0.0097
Loa Loa (eye worm) hypothetical protein 0.0125 0.0283 0.0551
Loa Loa (eye worm) hypothetical protein 0.0743 0.2087 0.407
Trypanosoma cruzi 6-phosphofructo-2-kinase 1 0.1755 0.5039 0.9828
Loa Loa (eye worm) hypothetical protein 0.0046 0.0052 0.0102
Echinococcus granulosus tar DNA binding protein 0.0063 0.0101 0.0097
Echinococcus multilocularis mothers against decapentaplegic 5 0.0033 0.0014 0.0009
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0188 0.0465 0.046
Schistosoma mansoni hypothetical protein 0.0046 0.0052 0.0048
Onchocerca volvulus 0.0053 0.0072 0.0132
Brugia malayi UBASH3A protein homolog 0.003 0.0005 0.0022
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.0075 0.0359
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0033 1
Trypanosoma cruzi 6-phosphofructo-2-kinase 1 0.1755 0.5039 0.9828
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0047 0.0054 0.0165
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0059 0.0054
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0047 0.0054 0.075
Loa Loa (eye worm) hypothetical protein 0.003 0.0005 0.0009
Onchocerca volvulus 0.1785 0.5127 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.0129 0.0124
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0101 0.0198
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0101 0.0097
Schistosoma mansoni microtubule-associated protein tau 0.3454 1 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0075 0.0146
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.0075 0.007
Brugia malayi Intermediate filament tail domain containing protein 0.0053 0.0072 0.0346
Mycobacterium ulcerans beta-lactamase 0.004 0.0033 0.0096
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0054 0.0165
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.0075 0.007
Echinococcus granulosus smad 0.0033 0.0014 0.0009
Schistosoma mansoni hypothetical protein 0.0169 0.0411 0.0406
Brugia malayi hypothetical protein 0.0743 0.2087 1
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.0033 0.0436
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0056 0.0051
Loa Loa (eye worm) hypothetical protein 0.003 0.0005 0.0009
Trypanosoma brucei 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.0762 0.214 0.4169
Onchocerca volvulus 0.004 0.0033 0.0056
Echinococcus granulosus geminin 0.0169 0.0411 0.0406
Brugia malayi Latrophilin receptor protein 2 0.0046 0.0052 0.0251
Schistosoma mansoni hypothetical protein 0.01 0.021 0.0205
Loa Loa (eye worm) beta-lactamase 0.004 0.0033 0.0065
Schistosoma mansoni survival motor neuron protein 0.0152 0.0359 0.0355
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0056 0.0051
Brugia malayi hypothetical protein 0.0073 0.0129 0.0618
Brugia malayi beta-lactamase 0.004 0.0033 0.016
Schistosoma mansoni smad1 5 8 and 0.0033 0.0014 0.0009
Mycobacterium tuberculosis Conserved protein 0.004 0.0033 0.0436
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0054 0.0096
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.1785 0.5127 1
Brugia malayi MH2 domain containing protein 0.0033 0.0014 0.0068
Echinococcus granulosus survival motor neuron protein 1 0.0743 0.2087 0.2083
Trypanosoma brucei 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.1785 0.5127 1
Onchocerca volvulus 0.0053 0.0072 0.0132
Loa Loa (eye worm) hypothetical protein 0.004 0.0033 0.0065
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.0033 0.0096
Giardia lamblia Hypothetical protein 0.1053 0.2992 0.5
Loa Loa (eye worm) hypothetical protein 0.0125 0.0283 0.0551
Loa Loa (eye worm) hypothetical protein 0.0147 0.0346 0.0674
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.0762 0.214 0.4169
Echinococcus granulosus lamin 0.0053 0.0072 0.0068
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0046 0.0052 0.0048
Plasmodium vivax hypothetical protein, conserved 0.004 0.0033 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.0033 0.0014 0.0009
Loa Loa (eye worm) RNA binding protein 0.0063 0.0101 0.0198

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 0 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 1.82 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 2.17 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 2.9 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 10 % GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. ChEMBL. 20485427
Inhibition (binding) = 20 % Inhibition of C-terminal FLAG-tagged human recombinant autotaxin using synthetic substrate FS-3 at 10 uM measured every 2 mins by FRET assay relative to control ChEMBL. 23816044
Inhibition (functional) = 96 % GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 99 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
XC50 (functional) = 0.24305 uM GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. ChEMBL. 20485427

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.