Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0733 | 0.3744 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0046 | 0.0116 | 0.0116 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.0093 | 0.5 |
Echinococcus multilocularis | tumor protein p63 | 0.0329 | 0.1611 | 0.1611 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0125 | 0.0125 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0046 | 0.0116 | 0.0116 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0046 | 0.0116 | 0.0116 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0064 | 0.0207 | 0.0207 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.1917 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0146 | 0.064 | 0.064 |
Schistosoma mansoni | hypothetical protein | 0.0073 | 0.0258 | 0.0258 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0066 | 0.022 | 0.0139 |
Brugia malayi | glutaminase DH11.1 | 0.032 | 0.1559 | 0.1559 |
Loa Loa (eye worm) | glutaminase 2 | 0.032 | 0.1559 | 0.1559 |
Echinococcus multilocularis | GPCR, family 2 | 0.0034 | 0.005 | 0.005 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0144 | 0.0629 | 0.0468 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0046 | 0.0116 | 0.0116 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0042 | 0.0093 | 0.0093 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0129 | 0.0553 | 0.039 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0046 | 0.0116 | 0.0116 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0733 | 0.3744 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0046 | 0.0116 | 0.0116 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0129 | 0.0553 | 0.039 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0066 | 0.022 | 0.022 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0046 | 0.0116 | 0.0116 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0046 | 0.0116 | 0.0116 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0046 | 0.0116 | 0.0116 |
Loa Loa (eye worm) | glutathione reductase | 0.0057 | 0.017 | 0.017 |
Trichomonas vaginalis | set domain proteins, putative | 0.0524 | 0.264 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.005 | 0.005 |
Echinococcus granulosus | tumor protein p63 | 0.0329 | 0.1611 | 0.1611 |
Schistosoma mansoni | dihydrofolate reductase | 0.1917 | 1 | 1 |
Schistosoma mansoni | neuropeptide receptor | 0.0128 | 0.0548 | 0.0548 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0046 | 0.0116 | 0.0116 |
Mycobacterium tuberculosis | Probable reductase | 0.0129 | 0.0553 | 0.039 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0046 | 0.0116 | 0.0116 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0034 | 0.005 | 0.005 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.1917 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0107 | 0.0438 | 0.0438 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0046 | 0.0116 | 0.0116 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0146 | 0.064 | 0.064 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0046 | 0.0116 | 0.0116 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0046 | 0.0116 | 0.0116 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0146 | 0.064 | 0.064 |
Brugia malayi | glutathione reductase | 0.0057 | 0.017 | 0.017 |
Echinococcus granulosus | neuropeptide receptor | 0.0128 | 0.0548 | 0.0548 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0107 | 0.0438 | 0.0438 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.0093 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0046 | 0.0116 | 0.0116 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0046 | 0.0116 | 0.0116 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0046 | 0.0116 | 0.0116 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0046 | 0.0116 | 0.0116 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0057 | 0.017 | 0.017 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0046 | 0.0116 | 0.0116 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0046 | 0.0116 | 0.0116 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0046 | 0.0116 | 0.0116 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.022 | 0.022 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0116 | 0.0116 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.005 | 0.005 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.005 | 0.005 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0046 | 0.0116 | 0.0116 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0129 | 0.0553 | 0.039 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0116 | 0.0116 |
Echinococcus multilocularis | dihydrofolate reductase | 0.1917 | 1 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0042 | 0.0093 | 0.0093 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.0093 | 0.0093 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0046 | 0.0116 | 0.0116 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0232 | 0.1095 | 0.1095 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0116 | 0.0116 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0046 | 0.0116 | 0.0116 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0144 | 0.0629 | 0.0081 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0066 | 0.022 | 0.022 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0046 | 0.0116 | 0.0116 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0057 | 0.017 | 0.017 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0116 | 0.0116 |
Onchocerca volvulus | 0.0066 | 0.022 | 0.0412 | |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0144 | 0.0629 | 0.0468 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0846 | 0.4342 | 0.4342 |
Chlamydia trachomatis | dihydrofolate reductase | 0.1917 | 1 | 0.5 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0144 | 0.0629 | 0.0468 |
Brugia malayi | steroid hormone receptor | 0.0046 | 0.0116 | 0.0116 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0034 | 0.005 | 0.005 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0733 | 0.3744 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0034 | 0.005 | 0.005 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0146 | 0.064 | 0.064 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0066 | 0.022 | 0.022 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0042 | 0.0093 | 0.0093 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0034 | 0.005 | 0.005 |
Plasmodium vivax | SET domain protein, putative | 0.0066 | 0.022 | 0.0139 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.1917 | 1 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0046 | 0.0116 | 0.0116 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0046 | 0.0116 | 0.0116 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0046 | 0.0116 | 0.0116 |
Echinococcus multilocularis | neuropeptide receptor | 0.0128 | 0.0548 | 0.0548 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0057 | 0.017 | 0.017 |
Echinococcus granulosus | dihydrofolate reductase | 0.1917 | 1 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0146 | 0.064 | 0.064 |
Onchocerca volvulus | 0.0524 | 0.264 | 1 | |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0215 | 0.1005 | 0.1005 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0046 | 0.0116 | 0.0116 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0733 | 0.3744 | 1 |
Brugia malayi | hypothetical protein | 0.0042 | 0.0093 | 0.0093 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0146 | 0.064 | 0.064 |
Brugia malayi | nuclear hormone receptor | 0.0046 | 0.0116 | 0.0116 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0232 | 0.1095 | 0.1095 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0046 | 0.0116 | 0.0116 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0046 | 0.0116 | 0.0116 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0046 | 0.0116 | 0.0116 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0116 | 0.0116 |
Echinococcus granulosus | FTZ F1 alpha | 0.0046 | 0.0116 | 0.0116 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0073 | 0.0258 | 0.0258 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0066 | 0.022 | 0.022 |
Onchocerca volvulus | 0.0048 | 0.0125 | 0.0038 | |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0048 | 0.0125 | 0.0125 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.005 | 0.005 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0116 | 0.0116 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0046 | 0.0116 | 0.0116 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0046 | 0.0116 | 0.0116 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0215 | 0.1005 | 0.1005 |
Schistosoma mansoni | nuclear hormone receptor | 0.0046 | 0.0116 | 0.0116 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0034 | 0.005 | 0.005 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.005 | 0.005 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0046 | 0.0116 | 0.0116 |
Brugia malayi | Thioredoxin reductase | 0.0057 | 0.017 | 0.017 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0288 | 0.1393 | 0.1393 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0733 | 0.3744 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.0093 | 0.5 |
Loa Loa (eye worm) | glutaminase | 0.032 | 0.1559 | 0.1559 |
Schistosoma mansoni | glutaminase | 0.032 | 0.1559 | 0.1559 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0046 | 0.0116 | 0.0116 |
Brugia malayi | Pre-SET motif family protein | 0.0066 | 0.022 | 0.022 |
Brugia malayi | Dihydrofolate reductase | 0.1917 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0116 | 0.0116 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0129 | 0.0553 | 0.039 |
Echinococcus multilocularis | G protein coupled receptor 139 | 0.0128 | 0.0548 | 0.0548 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0116 | 0.0116 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0733 | 0.3744 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0046 | 0.0116 | 0.0116 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0046 | 0.0116 | 0.0116 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0129 | 0.0553 | 0.039 |
Brugia malayi | ecdysteroid receptor | 0.0046 | 0.0116 | 0.0116 |
Brugia malayi | nuclear receptor NHR-88 | 0.0046 | 0.0116 | 0.0116 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0046 | 0.0116 | 0.0116 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0461 | 0.2304 | 0.2304 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0146 | 0.064 | 0.064 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0046 | 0.0116 | 0.0116 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0046 | 0.0116 | 0.0116 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.1917 | 1 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0461 | 0.2304 | 0.2304 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0046 | 0.0116 | 0.0116 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0046 | 0.0116 | 0.0116 |
Schistosoma mansoni | coup transcription factor | 0.0046 | 0.0116 | 0.0116 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.0093 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0232 | 0.1095 | 0.1095 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0146 | 0.064 | 0.064 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0034 | 0.005 | 0.005 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0046 | 0.0116 | 0.0116 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0046 | 0.0116 | 0.0116 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0046 | 0.0116 | 0.0116 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0066 | 0.022 | 0.022 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.0258 | 0.0258 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0066 | 0.022 | 0.022 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0046 | 0.0116 | 0.0116 |
Schistosoma mansoni | thyroid hormone receptor | 0.0046 | 0.0116 | 0.0116 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0046 | 0.0116 | 0.0116 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0046 | 0.0116 | 0.0116 |
Loa Loa (eye worm) | hypothetical protein | 0.0288 | 0.1393 | 0.1393 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0066 | 0.022 | 0.022 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0046 | 0.0116 | 0.0116 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0146 | 0.064 | 0.064 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0046 | 0.0116 | 0.0116 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | < 30 % | Antagonist activity at OX2 receptor (unknown origin) expressed in RD-HGA16 cells assessed as inhibition orexin A-induced calcium mobilization at 10 uM by fluorescence assay | ChEMBL. | 23941044 |
Ke(app) (functional) | = 3250 nM | Antagonist activity at OX1 receptor (unknown origin) expressed in RD-HGA16 cells assessed as inhibition orexin A-induced calcium mobilization by fluorescence assay | ChEMBL. | 23941044 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.