TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 377.824 | Formula: C21H16ClN3O2
H donors: 1 H acceptors: 2 LogP: 5.66 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: c1ccc(cc1)c1cccc(c1)Nc1ncnc2c1cc1OCOc1c2.Cl
InChi: 1S/C21H15N3O2.ClH/c1-2-5-14(6-3-1)15-7-4-8-16(9-15)24-21-17-10-19-20(26-13-25-19)11-18(17)22-12-23-21;/h1-12H,13H2,(H,22,23,24);1H
InChiKey: LHPLWSQPNALMBZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	epidermal growth factor receptor	Starlite/ChEMBL	References
Homo sapiens	ABL proto-oncogene 1, non-receptor tyrosine kinase	Starlite/ChEMBL	References
Homo sapiens	fibroblast growth factor receptor 1	Starlite/ChEMBL	References
Homo sapiens	kinase insert domain receptor	Starlite/ChEMBL	References
Homo sapiens	SRC proto-oncogene, non-receptor tyrosine kinase	Starlite/ChEMBL	References
Homo sapiens	platelet-derived growth factor receptor, beta polypeptide	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131234	All targets in OG5_131234
Brugia malayi	SRC-1	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_128597	All targets in OG5_128597
Brugia malayi	Furin-like cysteine rich region family protein	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus granulosus	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	IPR002048,Calcium-binding EF-hand;IPR001245,Tyrosine protein kinase;IPR000719,Protein kinase;IPR011009,Protein kinase-like,domai	Get druggable targets OG5_128769	All targets in OG5_128769
Echinococcus multilocularis	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FYN, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Blk	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	Get druggable targets OG5_128769	All targets in OG5_128769
Schistosoma japonicum	expressed protein	Get druggable targets OG5_131234	All targets in OG5_131234
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FYN, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Fibroblast growth factor receptor precursor, putative	Get druggable targets OG5_128769	All targets in OG5_128769
Echinococcus multilocularis	fibroblast growth factor receptor 4	Get druggable targets OG5_128769	All targets in OG5_128769
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase ABL1, putative	Get druggable targets OG5_131234	All targets in OG5_131234
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Onchocerca volvulus		Get druggable targets OG5_130320	All targets in OG5_130320
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128597	All targets in OG5_128597
Brugia malayi	Immunoglobulin I-set domain containing protein	Get druggable targets OG5_128769	All targets in OG5_128769
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FGR, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Onchocerca volvulus	Tyrosine kinase homolog	Get druggable targets OG5_130320	All targets in OG5_130320
Echinococcus multilocularis	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Receptor tyrosine-protein kinase erbB-4 precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus granulosus	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128769	All targets in OG5_128769
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus granulosus	tyrosine protein kinase Lyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase HCK	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Brugia malayi	Immunoglobulin I-set domain containing protein	Get druggable targets OG5_130320	All targets in OG5_130320
Loa Loa (eye worm)	TK/KIN16 protein kinase	Get druggable targets OG5_130320	All targets in OG5_130320
Brugia malayi	Tyrosine-protein kinase abl-1	Get druggable targets OG5_131234	All targets in OG5_131234
Echinococcus multilocularis	tyrosine protein kinase Abl	Get druggable targets OG5_131234	All targets in OG5_131234
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	ko:K05085 receptor tyrosine-protein kinase erbB-4, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus multilocularis		Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Tyrosine-protein kinase transforming protein Abl, putative	Get druggable targets OG5_131234	All targets in OG5_131234
Echinococcus granulosus	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus multilocularis	tyrosine protein kinase Blk	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_131234	All targets in OG5_131234
Echinococcus multilocularis	tyrosine protein kinase Src64B	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	TK protein kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	Get druggable targets OG5_128769	All targets in OG5_128769
Schistosoma japonicum	ko:K05703 proto-oncogene tyrosine-protein kinase Fyn, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase HCK	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase ABL1	Get druggable targets OG5_131234	All targets in OG5_131234
Loa Loa (eye worm)	SRC-1	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	IPR000494,EGF receptor, L domain,domain-containing	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus multilocularis	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Src64B	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Tyrosine-protein kinase transforming protein erbB, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase Yrk, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase ABL1	Get druggable targets OG5_131234	All targets in OG5_131234
Echinococcus multilocularis	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Receptor tyrosine-protein kinase erbB-2 precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	TK protein kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Tyrosine-protein kinase transforming protein Abl, putative	Get druggable targets OG5_131234	All targets in OG5_131234
Echinococcus multilocularis	tyrosine protein kinase Srms	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	TK/ABL protein kinase	Get druggable targets OG5_131234	All targets in OG5_131234
Schistosoma japonicum	ko:K08892 fyn-related kinase, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	TK protein kinase	Get druggable targets OG5_128769	All targets in OG5_128769
Echinococcus granulosus	fibroblast growth factor receptor 4	Get druggable targets OG5_128769	All targets in OG5_128769
Echinococcus multilocularis	tyrosine protein kinase Fgr	Get druggable targets OG5_127750	All targets in OG5_127750
Brugia malayi	protein-tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	IPR006212,Furin-like repeat;IPR009030,Growth factor, receptor,domain-containing	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Loa Loa (eye worm)	TK/EGFR protein kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	expressed protein	Get druggable targets OG5_131234	All targets in OG5_131234

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0043	0.0044	0.0028
Brugia malayi	Fibronectin type III domain containing protein	0.0037	0.0026	0.0215
Echinococcus multilocularis	snurportin 1	0.0348	0.0825	0.081
Giardia lamblia	Hypothetical protein	0.2314	0.5874	0.5
Trichomonas vaginalis	chromobox protein, putative	0.0047	0.0054	0.4027
Echinococcus multilocularis		0.0056	0.0075	0.006
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0217	0.049	1
Echinococcus granulosus	chromobox protein 1	0.0079	0.0134	0.0119
Onchocerca volvulus	Tyrosine kinase homolog	0.0183	0.0401	0.0381
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0126	0.0255	0.0239
Toxoplasma gondii	phosphoglycerate mutase	0.0066	0.0102	1
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.0037	0.0026	0.001
Echinococcus granulosus	phosphoglycerate mutase	0.0066	0.0102	0.0087
Trichomonas vaginalis	phosphoglycerate mutase, putative	0.0066	0.0102	0.7615
Leishmania major	phosphoglycerate mutase protein, putative	0.0066	0.0102	0.0102
Trypanosoma cruzi	phosphoglycerate mutase, putative	0.0066	0.0102	0.0102
Onchocerca volvulus		0.0066	0.0102	0.0081
Plasmodium falciparum	phosphoglucomutase-2	0.0066	0.0102	1
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0058	0.0081	0.0065
Onchocerca volvulus		0.0066	0.0102	0.0081
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0043	0.0044	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0021	0.0005
Trypanosoma cruzi	phosphoglycerate mutase family member 5, putative	0.0066	0.0102	0.0102
Brugia malayi	phosphoglycerate mutase family protein	0.0066	0.0102	0.1823
Schistosoma mansoni	cell adhesion molecule	0.0044	0.0045	0.0029
Trichomonas vaginalis	conserved hypothetical protein	0.0044	0.0045	0.3386
Echinococcus multilocularis	serine:threonine protein phosphatase PGAM5	0.0066	0.0102	0.0087
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0126	0.0255	0.0239
Echinococcus multilocularis	tyrosine protein kinase Blk	0.005	0.0061	0.0045
Echinococcus granulosus	p2X purinoceptor 4	0.0968	0.2418	0.2406
Mycobacterium leprae	probable isochorismate synthase EntC	0.0066	0.0102	0.5
Onchocerca volvulus		0.0066	0.0102	0.0081
Brugia malayi	phosphoglycerate mutase family protein	0.0066	0.0102	0.1823
Mycobacterium leprae	Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase)	0.0066	0.0102	0.5
Schistosoma mansoni	hypothetical protein	0.0066	0.0102	0.0087
Trichomonas vaginalis	phosphoglycerate mutase, putative	0.0066	0.0102	0.7615
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0063	0.0094	0.0079
Onchocerca volvulus		0.0167	0.036	0.034
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0012	0.0922
Leishmania major	hypothetical protein, conserved	0.0066	0.0102	0.0102
Schistosoma mansoni	hypothetical protein	0.0066	0.0102	0.0087
Schistosoma mansoni	chromobox protein	0.0079	0.0134	0.0119
Schistosoma mansoni	tyrosine kinase	0.0256	0.0589	0.0574
Mycobacterium tuberculosis	Glucosyl-3-phosphoglycerate phosphatase GpgP	0.0066	0.0102	0.5
Schistosoma mansoni	nephrin	0.0046	0.005	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0026	0.001
Echinococcus multilocularis	phosphoglycerate mutase	0.0066	0.0102	0.0087
Mycobacterium tuberculosis	Conserved protein	0.0066	0.0102	0.5
Mycobacterium tuberculosis	Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase)	0.0066	0.0102	0.5
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0058	0.0081	0.0065
Leishmania major	hypothetical protein, unknown function	0.0066	0.0102	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0026	0.001
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0012	0.0922
Trypanosoma cruzi	Histidine phosphatase superfamily (branch 1), putative	0.0066	0.0102	0.0102
Loa Loa (eye worm)	TK/INSR protein kinase	0.0063	0.0094	0.0079
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0102	0.0087
Mycobacterium ulcerans	hypothetical protein	0.2314	0.5874	1
Schistosoma mansoni	tyrosine kinase	0.0102	0.0195	0.018
Toxoplasma gondii	phosphoglycerate mutase family protein	0.0066	0.0102	1
Echinococcus multilocularis	p2X purinoceptor 4	0.0968	0.2418	0.2406
Mycobacterium leprae	PROBABLE PHOSPHOGLYCERATE MUTASE 1 GPM1 (PHOSPHOGLYCEROMUTASE) (PGAM) (BPG-DEPENDENT PGAM)	0.0066	0.0102	0.5
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0045	0.003
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0058	0.0081	0.0065
Echinococcus granulosus	epidermal growth factor receptor	0.0102	0.0195	0.018
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0126	0.0255	0.0239
Entamoeba histolytica	phosphoglycerate mutase family protein, putative	0.0066	0.0102	0.0174
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0058	0.0081	0.0065
Toxoplasma gondii	phosphoglycerate mutase family protein	0.0066	0.0102	1
Schistosoma mansoni	hypothetical protein	0.0066	0.0102	0.0087
Echinococcus granulosus	epidermal growth factor receptor	0.0186	0.0409	0.0394
Mycobacterium leprae	conserved hypothetical protein	0.0066	0.0102	0.5
Mycobacterium tuberculosis	Conserved protein	0.0066	0.0102	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0044	0.0045	0.3386
Loa Loa (eye worm)	phosphoglycerate mutase	0.0066	0.0102	0.0087
Mycobacterium leprae	PROBABLE PHOSPHOGLYCERATE MUTASE (PHOSPHOGLYCEROMUTASE)	0.0066	0.0102	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0058	0.0081	0.0065
Brugia malayi	Furin-like cysteine rich region family protein	0.0186	0.0409	0.8297
Echinococcus granulosus	snurportin 1	0.0348	0.0825	0.081
Entamoeba histolytica	protein kinase, putative	0.0042	0.004	0.0068
Trypanosoma cruzi	Histidine phosphatase superfamily (branch 1), putative	0.0066	0.0102	0.0102
Echinococcus granulosus	phosphoglycerate mutase	0.0066	0.0102	0.0087
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0037	0.0026	0.001
Brugia malayi	RNA, U transporter 1	0.0093	0.017	0.3252
Schistosoma mansoni	6-phosphofructokinase	0.3921	1	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0026	0.001
Trichomonas vaginalis	chromobox protein, putative	0.0079	0.0134	1
Trypanosoma brucei	phosphoglycerate mutase, putative	0.0066	0.0102	0.0087
Trypanosoma brucei	Serine/threonine-protein phosphatase PGAM5, mitochondrial, putative	0.0066	0.0102	0.0087
Toxoplasma gondii	phosphoglycerate mutase family protein	0.0066	0.0102	1
Trichomonas vaginalis	phosphoglycerate mutase, putative	0.0066	0.0102	0.7615
Trypanosoma cruzi	phosphoglycerate mutase family member 5, putative	0.0066	0.0102	0.0102
Loa Loa (eye worm)	hypothetical protein	0.3855	0.983	0.983
Echinococcus granulosus	phosphoglycerate mutase	0.0066	0.0102	0.0087
Schistosoma mansoni	hypothetical protein	0.0066	0.0102	0.0087
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0044	0.0045	0.0025
Brugia malayi	chromobox protein homolog 3	0.0044	0.0045	0.0625
Schistosoma mansoni	tyrosine kinase	0.0058	0.0081	0.0065
Trypanosoma cruzi	phosphoglycerate mutase protein, putative	0.0066	0.0102	0.0102
Echinococcus multilocularis	Immunoglobulin	0.0037	0.0026	0.001
Schistosoma mansoni	vesicular amine transporter	0.0037	0.0026	0.001
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0348	0.0825	0.081
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0026	0.001
Echinococcus multilocularis	epidermal growth factor receptor	0.0186	0.0409	0.0394
Trichomonas vaginalis	phosphoglycerate mutase, putative	0.0066	0.0102	0.7615
Mycobacterium tuberculosis	PE-PGRS family protein PE_PGRS11	0.0066	0.0102	0.5
Schistosoma mansoni	tyrosine kinase	0.0063	0.0094	0.0079
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0058	0.0081	0.0065
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0066	0.0102	0.5
Mycobacterium tuberculosis	Possible phosphoglycerate mutase Gpm2 (phosphoglyceromutase) (PGAM) (BPG-dependent PGAM)	0.0066	0.0102	0.5
Brugia malayi	UBASH3A protein homolog	0.0066	0.0102	0.1823
Trypanosoma brucei	Histidine phosphatase superfamily (branch 1), putative	0.0066	0.0102	0.0087
Chlamydia trachomatis	2,3-bisphosphoglycerate-dependent phosphoglycerate mutase	0.0066	0.0102	0.5
Mycobacterium tuberculosis	Probable conserved lipoprotein LpqD	0.0066	0.0102	0.5
Mycobacterium leprae	conserved hypothetical protein	0.0066	0.0102	0.5
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0063	0.0094	0.0079
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0264	0.061	0.0595
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0217	0.049	0.0475
Trypanosoma brucei	Histidine phosphatase superfamily (branch 1), putative	0.0066	0.0102	0.0087
Trypanosoma brucei	glycerolphosphate mutase, putative	0.0066	0.0102	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0069	0.0053
Schistosoma mansoni	tyrosine kinase	0.0096	0.0178	0.0162
Trypanosoma cruzi	glycerolphosphate mutase, putative	0.0066	0.0102	0.0102
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.3921	1	1
Echinococcus multilocularis	phosphoglycerate mutase	0.0066	0.0102	0.0087
Brugia malayi	protein-tyrosine kinase	0.005	0.0061	0.0947
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0135	0.0279	0.555
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.0037	0.0026	0.001
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.3921	1	1
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0069	0.0053
Schistosoma mansoni	tyrosine kinase	0.0096	0.0178	0.0162
Leishmania major	fructose-6-phosphate2-kinase/fructose-2,6-bisph os phatase-likeprotein	0.0066	0.0102	0.0102
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0102	0.0195	0.018
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0058	0.0081	0.0065
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0037	0.0026	0.0215
Loa Loa (eye worm)	hypothetical protein	0.2248	0.5704	0.5697
Toxoplasma gondii	phosphoglycerate mutase PGMII	0.0066	0.0102	1
Mycobacterium leprae	Possible phosphoglycerate mutase	0.0066	0.0102	0.5
Echinococcus granulosus	twitchin	0.0046	0.005	0.0034
Brugia malayi	SRC-1	0.0058	0.0081	0.1379
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.1673	0.4228	0.4228
Echinococcus multilocularis	chromobox protein 1	0.0079	0.0134	0.0119
Mycobacterium tuberculosis	Possible hydrolase MutT1	0.0066	0.0102	0.5
Schistosoma mansoni	P2X receptor subunit	0.0968	0.2418	0.2406
Echinococcus granulosus	Immunoglobulin	0.0037	0.0026	0.001
Schistosoma mansoni	tyrosine kinase	0.0058	0.0081	0.0065
Mycobacterium ulcerans	fructose-2,6-bisphosphatase GpmB	0.2314	0.5874	1
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0058	0.0081	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0102	0.0087
Onchocerca volvulus	Protein UBASH3A homolog	0.0066	0.0102	0.0081
Echinococcus multilocularis	phosphoglycerate mutase	0.0066	0.0102	0.0087
Leishmania major	glycerolphosphate mutase, putative	0.0066	0.0102	0.0102
Mycobacterium leprae	POSSIBLE HYDROLASE MUTT1	0.0066	0.0102	0.5
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0102	0.0087
Plasmodium vivax	phosphoglycerate mutase, putative	0.0066	0.0102	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0058	0.0081	0.0065
Schistosoma mansoni	phosphoglycerate mutase	0.0066	0.0102	0.0087
Loa Loa (eye worm)	SRC-1	0.0058	0.0081	0.0065
Leishmania major	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.3855	0.983	0.983
Treponema pallidum	phosphoglyceromutase	0.0066	0.0102	0.5
Trypanosoma cruzi	Histidine phosphatase superfamily (branch 1), putative	0.0066	0.0102	0.0102
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0058	0.0081	0.0065
Onchocerca volvulus	Protein UBASH3A homolog	0.0066	0.0102	0.0081
Echinococcus multilocularis	roundabout 2	0.0053	0.0069	0.0053
Echinococcus multilocularis	serine:threonine protein phosphatase PGAM5	0.0066	0.0102	0.0087
Leishmania major	hypothetical protein, conserved	0.0066	0.0102	0.0102
Echinococcus multilocularis	phosphoglycerate mutase	0.0066	0.0102	0.0087
Loa Loa (eye worm)	TK/ABL protein kinase	0.0264	0.061	0.0595
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0194	0.0178
Leishmania major	phosphoglycerate mutase, putative	0.0066	0.0102	0.0102
Trypanosoma brucei	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative	0.0066	0.0102	0.0087
Trypanosoma brucei	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.1673	0.4228	0.4219
Echinococcus granulosus	neuroglian	0.0046	0.005	0.0034
Trypanosoma brucei	6-phosphofructo-2-kinase 2	0.3855	0.983	0.983
Mycobacterium leprae	conserved hypothetical protein	0.0066	0.0102	0.5
Onchocerca volvulus	Protein UBASH3A homolog	0.0066	0.0102	0.0081
Echinococcus granulosus	chromobox protein 1	0.0079	0.0134	0.0119
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0126	0.0255	0.0239
Giardia lamblia	Hypothetical protein	0.2314	0.5874	0.5
Echinococcus multilocularis	6 phosphofructo 2 kinase:fructose 2	0.3921	1	1
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0058	0.0081	0.0065
Schistosoma mansoni	hypothetical protein	0.0348	0.0825	0.081
Echinococcus granulosus	tyrosine kinase	0.005	0.0061	0.0045
Trypanosoma cruzi	glycerolphosphate mutase, putative	0.0066	0.0102	0.0102
Brugia malayi	Protein kinase domain containing protein	0.0063	0.0094	0.1658
Trypanosoma brucei	Histidine phosphatase superfamily (branch 1), putative	0.0066	0.0102	0.0087
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0118	0.0235	0.022
Trypanosoma cruzi	phosphoglycerate mutase protein, putative	0.0066	0.0102	0.0102
Schistosoma mansoni	tyrosine kinase	0.0096	0.0178	0.0162
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.005	0.0061	0.0045
Schistosoma mansoni	hypothetical protein	0.0066	0.0102	0.0087
Echinococcus granulosus	tyrosine protein kinase Blk	0.005	0.0061	0.0045
Onchocerca volvulus	Protein UBASH3A homolog	0.0066	0.0102	0.0081
Schistosoma mansoni	P2X receptor subunit	0.0968	0.2418	0.2406
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0058	0.0081	0.0065
Echinococcus multilocularis	neuroglian	0.0046	0.005	0.0034
Echinococcus granulosus	roundabout 2	0.0053	0.0069	0.0053
Loa Loa (eye worm)	TK protein kinase	0.005	0.0061	0.0045
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0058	0.0081	0.0065
Echinococcus multilocularis	Immunoglobulin	0.0037	0.0026	0.001
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.005	0.0061	0.0045
Schistosoma mansoni	tyrosine kinase	0.0063	0.0094	0.0079
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative	0.0066	0.0102	0.0102
Onchocerca volvulus		0.3921	1	1
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0186	0.0409	0.0394
Plasmodium vivax	phosphoglucomutase-2, putative	0.0066	0.0102	1
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0058	0.0081	0.0065
Schistosoma mansoni	tyrosine kinase	0.0102	0.0195	0.018
Echinococcus multilocularis	insulin receptor	0.0063	0.0094	0.0079
Brugia malayi	Tyrosine-protein kinase abl-1	0.0154	0.0327	0.6571
Entamoeba histolytica	phosphoglycerate mutase family protein. putative	0.0066	0.0102	0.0174
Echinococcus multilocularis	chromobox protein 1	0.0079	0.0134	0.0119
Entamoeba histolytica	phosphoglycerate mutase family protein, putative	0.0066	0.0102	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0026	0.001
Echinococcus granulosus	defective proboscis extension response	0.0037	0.0026	0.001
Schistosoma mansoni	P2X receptor subunit	0.0968	0.2418	0.2406
Echinococcus multilocularis	phosphoglycerate mutase	0.0066	0.0102	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0045	0.0029
Schistosoma mansoni	tyrosine kinase	0.0186	0.0409	0.0394
Echinococcus granulosus	p2X purinoceptor 4	0.0968	0.2418	0.2406
Echinococcus granulosus	insulin receptor	0.0063	0.0094	0.0079
Echinococcus multilocularis	p2X purinoceptor 4	0.0968	0.2418	0.2406
Trichomonas vaginalis	phosphoglycerate mutase, putative	0.0066	0.0102	0.7615
Brugia malayi	hypothetical protein	0.0037	0.0026	0.0215
Plasmodium falciparum	phosphoglycerate mutase, putative	0.0066	0.0102	1
Brugia malayi	Heterochromatin protein 1	0.0079	0.0134	0.2498
Trypanosoma brucei	phosphoglycerate mutase protein, putative	0.0066	0.0102	0.0087
Echinococcus multilocularis	tyrosine protein kinase Srms	0.005	0.0061	0.0045
Brugia malayi	Tyrosine-protein kinase abl-1	0.0118	0.0235	0.4631
Loa Loa (eye worm)	TK protein kinase	0.0135	0.0279	0.0263
Echinococcus multilocularis	phosphoglycerate mutase	0.0066	0.0102	0.0087
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0058	0.0081	0.0065
Schistosoma mansoni	phosphoglycerate mutase	0.0066	0.0102	0.0087
Leishmania major	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-1-like protein	0.1673	0.4228	0.4228
Trichomonas vaginalis	chromobox protein, putative	0.0047	0.0054	0.4027
Trypanosoma cruzi	6-phosphofructo-2-kinase 1	0.3855	0.983	0.983
Echinococcus granulosus	p2X purinoceptor 4	0.0968	0.2418	0.2406
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0264	0.061	0.0595
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0044	0.0045	0.0029
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.1673	0.4228	0.4228
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0047	0.0054	0.0033
Echinococcus multilocularis	p2X purinoceptor 4	0.0968	0.2418	0.2406
Schistosoma mansoni	chromobox protein	0.0079	0.0134	0.0119
Trypanosoma cruzi	6-phosphofructo-2-kinase 1	0.3855	0.983	0.983
Schistosoma mansoni	tyrosine kinase	0.0126	0.0255	0.0239
Trypanosoma cruzi	phosphoglycerate mutase, putative	0.0066	0.0102	0.0102
Trichomonas vaginalis	conserved hypothetical protein	0.0066	0.0102	0.7615
Leishmania major	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.3921	1	1
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0058	0.0081	0.0065
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative	0.0066	0.0102	0.0102
Schistosoma mansoni	P2X receptor subunit	0.0968	0.2418	0.2406
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0058	0.0081	0.0065
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0042	0.004	0.0024
Trichomonas vaginalis	conserved hypothetical protein	0.0066	0.0102	0.7615
Schistosoma mansoni	hypothetical protein	0.0066	0.0102	0.0087
Leishmania major	phosphoglycerate mutase family member 5, putative	0.0066	0.0102	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0026	0.001
Trichomonas vaginalis	chromobox protein, putative	0.0079	0.0134	1
Loa Loa (eye worm)	heterochromatin protein 1	0.0079	0.0134	0.0119
Loa Loa (eye worm)	hypothetical protein	0.3921	1	1
Echinococcus granulosus	phosphoglycerate mutase	0.0066	0.0102	0.0087
Echinococcus granulosus	phosphoglycerate mutase	0.0066	0.0102	0.0087
Leishmania major	hypothetical protein, conserved	0.0066	0.0102	0.0102
Trypanosoma brucei	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.3921	1	1
Echinococcus granulosus	tyrosine protein kinase HCK	0.0042	0.004	0.0024
Echinococcus multilocularis	epidermal growth factor receptor	0.0102	0.0195	0.018
Trypanosoma cruzi	Histidine phosphatase superfamily (branch 1), putative	0.0066	0.0102	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0102	0.0087
Loa Loa (eye worm)	TK protein kinase	0.0042	0.004	0.0024
Echinococcus granulosus	serine:threonine protein phosphatase PGAM5	0.0066	0.0102	0.0087
Entamoeba histolytica	phosphoglycerate mutase family protein, putative	0.2314	0.5874	1
Toxoplasma gondii	phosphoglycerate mutase family protein	0.0066	0.0102	1
Trypanosoma cruzi	Histidine phosphatase superfamily (branch 1), putative	0.0066	0.0102	0.0102
Echinococcus granulosus	serine:threonine protein phosphatase PGAM5	0.0066	0.0102	0.0087

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.002 uM	Inhibition of EGFR (unknown origin)	ChEMBL.	23900004
IC50 (binding)	= 0.032 uM	Inhibition of Src (unknown origin)	ChEMBL.	23900004
IC50 (binding)	= 0.051 uM	Inhibition of Abl (unknown origin)	ChEMBL.	23900004
IC50 (binding)	= 0.063 uM	Inhibition of FGFR1 (unknown origin)	ChEMBL.	23900004
IC50 (binding)	= 0.243 uM	Inhibition of PDGFRbeta (unknown origin)	ChEMBL.	23900004
IC50 (ADMET)	= 0.6 uM	Antiproliferative activity against mouse NIH/3T3 cells after 72 hrs by MTT assay	ChEMBL.	23900004
IC50 (ADMET)	= 0.75 uM	Antiproliferative activity against HUVEC after 72 hrs by MTT assay	ChEMBL.	23900004
IC50 (binding)	= 0.848 uM	Inhibition of VEGFR2 (unknown origin)	ChEMBL.	23900004
Inhibition (functional)		Inhibition of FGF2-induced neovascularization in C57/BL6 mouse assessed as reduction in hemoglobin concentration in matrigel plug at 1 uM, sc measured after 7 days	ChEMBL.	23900004

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	23900004
Mus musculus	ChEMBL23	23900004

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2419760

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1770075