Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | N-acylethanolamine acid amidase | Starlite/ChEMBL | References |
Rattus norvegicus | N-acylethanolamine-hydrolyzing acid amidase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_131053 | All targets in OG5_131053 |
Brugia malayi | hypothetical protein | Get druggable targets OG5_131053 | All targets in OG5_131053 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.2435 | 0.3957 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.2435 | 0.3957 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.2435 | 0.3957 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.2435 | 0.3957 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.2435 | 0.3957 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.2435 | 0.3957 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.2435 | 0.3957 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2435 | 0.3957 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.2435 | 0.3957 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.2435 | 0.3957 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.2435 | 0.3957 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.2435 | 0.3957 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 8.14 | Inhibition of NAAA in Sprague-Dawley rat lung assessed as inhibition of hydrolysis of 10-cis-heptadecenoylethanolamide by UPLC/MS method | ChEMBL. | 25380517 |
IC50 (binding) | = 7 nM | Enzymatic Assay | BINDINGDB. | No reference |
IC50 (binding) | = 7 nM | UPLC/MS Assay | BINDINGDB. | No reference |
IC50 (binding) | = 0.007 uM | Inhibition of C-terminal His-6-tagged recombinant human spleen NAAA enzyme expressed in HEK293 cells | ChEMBL. | 23991897 |
IC50 (binding) | = 0.007 uM | Inhibition of Sprague Dawley rat lung native NAAA enzyme using heptadecenoylethanolamide as substrate preincubated for 30 mins followed by substrate addition measured after 30 mins by UPLC-MS analysis | ChEMBL. | 23991897 |
IC50 (binding) | = 0.007 uM | Inhibition of NAAA in Sprague-Dawley rat lung assessed as inhibition of hydrolysis of 10-cis-heptadecenoylethanolamide by UPLC/MS method | ChEMBL. | 25380517 |
Inhibition (binding) | < 10 % | Inhibition of rat brain FAAH using [3H]anandamide as substrate preincubated at 10 uM for 10 mins followed by substrate addition by liquid scintillation counting | ChEMBL. | 23991897 |
Inhibition (binding) | = 30 % | Inhibition of rat lung acid ceramidase overexpressed in HEK293 cells using N-Lauroyl ceramide as substrate preincubated at 10 uM for 30 mins followed by substrate addition by LC-MS analysis | ChEMBL. | 23991897 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.