Detailed information for compound 1770252
Basic information
Technical information
- Name: Unnamed compound
- MW: 325.365 | Formula: C17H19N5O2
-
H donors: 3
H acceptors: 4
LogP: 1.96
Rotable bonds: 3
Rule of 5 violations (Lipinski): 1 - SMILES: O[C@@H]1CC[C@H](CC1)Nc1nc2ccc(cc2n2c1ncc2)C(=O)N
- InChi: 1S/C17H19N5O2/c18-15(24)10-1-6-13-14(9-10)22-8-7-19-17(22)16(21-13)20-11-2-4-12(23)5-3-11/h1,6-9,11-12,23H,2-5H2,(H2,18,24)(H,20,21)/t11-,12-
- InChiKey: FESDXUDFRLHTQL-HAQNSBGRSA-N
Network
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Synonyms
No synonyms found for this compound
Targets
Known targets for this compound
| Species | Target name | Source | Bibliographic reference |
|---|---|---|---|
| Homo sapiens | mitogen-activated protein kinase 8 | Starlite/ChEMBL | References |
Predicted pathogen targets for this compound
By orthology
| Species | Potential target | Known druggable target/s | Ortholog Group |
|---|---|---|---|
| Echinococcus multilocularis | c Jun NH2 terminal kinase | Get druggable targets OG5_129677 | All targets in OG5_129677 |
| Schistosoma japonicum | ko:K04440 c-Jun N-terminal kinase, putative | Get druggable targets OG5_129677 | All targets in OG5_129677 |
| Schistosoma mansoni | serine/threonine protein kinase | Get druggable targets OG5_129677 | All targets in OG5_129677 |
| Loa Loa (eye worm) | CMGC/MAPK/JNK protein kinase | Get druggable targets OG5_129677 | All targets in OG5_129677 |
| Schistosoma japonicum | IPR000164,Histone H3;IPR009072,Histone-fold,domain-containing | Get druggable targets OG5_129677 | All targets in OG5_129677 |
| Brugia malayi | Stress-activated protein kinase jnk-1 | Get druggable targets OG5_129677 | All targets in OG5_129677 |
| Echinococcus granulosus | c-Jun N-terminal kinases | Get druggable targets OG5_129677 | All targets in OG5_129677 |
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model
Ranking Plot
Putative Targets List
| Species | Potential target | Raw | Global | Species |
|---|---|---|---|---|
| Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0571 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0571 | 1 | 1 |
| Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0571 | 1 | 1 |
| Echinococcus multilocularis | acetylcholinesterase | 0.0571 | 1 | 1 |
| Echinococcus granulosus | acetylcholinesterase | 0.0571 | 1 | 1 |
| Echinococcus granulosus | carboxylesterase 5A | 0.0571 | 1 | 1 |
| Echinococcus multilocularis | acetylcholinesterase | 0.0571 | 1 | 1 |
| Echinococcus granulosus | acetylcholinesterase | 0.0571 | 1 | 1 |
| Loa Loa (eye worm) | carboxylesterase | 0.0571 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0571 | 1 | 1 |
| Echinococcus multilocularis | carboxylesterase 5A | 0.0571 | 1 | 1 |
| Brugia malayi | Carboxylesterase family protein | 0.0571 | 1 | 1 |
Activities
| Activity type | Activity value | Assay description | Source | Reference |
|---|---|---|---|---|
| IC50 (binding) | = 0.57 uM | Inhibition of human recombinant histidine-tagged full-length JNK1 expressed in insect cells using GST-tagged MAP2K7 as substrate after 1 hr by luminescence plate reader analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of PI4KA/PI4KAP2 in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of PEK in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of PCTAIRE1 in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of GCN2 in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of CDK2 in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of PRPK in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of PFTAIRE1 in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of MAST3 in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of ZAK in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of Wnk4 in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of Wnk2 in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of Wnk1 in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of TLK2 in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of TLK1 in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of TAO3 in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of TAO1 in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of SRPK2 in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of SRPK1 in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of SNRK in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of SLK in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of RSK2 domain2 in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of RON in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of ROCK2 in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of ROCK1 in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of PRP4 in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of PKR in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of PKCbeta in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of PKCalpha in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of PHKgamma2 in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of PDK1 in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of p70S6Kbeta in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of p70S6K in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of p38beta in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of p38alpha in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of NEK9 in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of NEK8 in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of NEK7 in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of NEK6 in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of NDR2 in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of YSK1 in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of MST4 in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of MST2 in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of MST1 in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of MRCKbeta in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of MLK3 in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of MET in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of MARK4 in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of MARK3 in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of MARK2 in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of MAP3K4 in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of MAP3K3 in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of MAP3K2 in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of MAP2K6 in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of MAP2K4 in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of MAP2K3 in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of MAP2K2 in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of MAP2K1 in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of LOK in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of IRAK4 in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of IRAK1 in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of ILK in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of YES in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of SRC in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of FYN in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of FER in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of FAK in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of Erk2 in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of Erk1 in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of EphB4 in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of EphB2 in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of EphA7 in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of EphA2 in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of EphA1 in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of EGFR in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of eEF2K in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of DNAPK in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of CSK in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of CLK2 in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of CDK5 in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of CDK8 in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of CDK11 in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of CASK in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of ATR in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of AGK in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of PIK3CB in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of IKKepsilon/TBK1 in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of LKB1 in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of CK2alpha2 in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of CHK2 in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of CaMK2gamma in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of CaMK2alpha/CaMK2beta/CaMK2delta/CaMK2gamma in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of AMPKalpha1/AMPKalpha2 in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | < 35 % | Inhibition of TAO2 in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | = 39.1 % | Inhibition of MPSK1 in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | = 44.4 % | Inhibition of p38delta/gamma in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | = 51.7 % | Inhibition of PKD2 in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | = 69 % | Inhibition of CK1alpha in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | = 78.1 % | Inhibition of PIP4K2C in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | = 90.4 % | Inhibition of CDK10 in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | = 91.3 % | Inhibition of CK1delta/CK1epsilon in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | = 94.2 % | Inhibition of PI4KB in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | = 96 % | Inhibition of GSK3beta in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | = 97.5 % | Inhibition of JNK1/JNK2/JNK3 in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
| Inhibition (binding) | = 98.6 % | Inhibition of CDK9 in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis | ChEMBL. | 23916259 |
Phenotypes
Whole-cell/tissue/organism interactions
We have no records of whole-cell/tissue assays done with this compound
What does this mean?
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
Annotated phenotypes:
We have no manually annotated phenotypes for this drug.
What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by
drugs, or by genetic manipulation of cells (e.g. gene knockouts or
knockdowns) is manually curated from the literature. These
descriptions help to describe the potential of the target for drug
development. If no information is available for this gene or if the
information is incomplete, this may mean that i) the papers
containing this information either appeared after the curation
effort for this organism was carried out or they were inadvertently
missed by curators; or that ii) the curation effort for this
organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.
External resources for this compound
- ChEMBL: CHEMBL2420587
Bibliographic References
1 literature reference was collected for this gene.
If you have references for this compound, please enter them in a user comment (below) or Contact us.