Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adenosine A1 receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | hypothetical protein | adenosine A1 receptor | 326 aa | 305 aa | 21.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0038 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0226 | 0.2557 | 0.2557 |
Onchocerca volvulus | 0.0038 | 0 | 0.5 | |
Echinococcus granulosus | sodium channel protein | 0.0086 | 0.0652 | 0.0652 |
Echinococcus granulosus | voltage gated sodium channel Nav1 alpha subunit | 0.0086 | 0.0652 | 0.0652 |
Echinococcus multilocularis | acetylcholinesterase | 0.0226 | 0.2557 | 0.2557 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0038 | 0 | 0.5 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0771 | 1 | 1 |
Onchocerca volvulus | 0.0038 | 0 | 0.5 | |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0133 | 0.13 | 0.5083 |
Onchocerca volvulus | 0.0038 | 0 | 0.5 | |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0038 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0226 | 0.2557 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0226 | 0.2557 | 0.2557 |
Onchocerca volvulus | 0.0038 | 0 | 0.5 | |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0038 | 0 | 0.5 |
Echinococcus multilocularis | sodium channel protein | 0.0086 | 0.0652 | 0.0652 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0226 | 0.2557 | 1 |
Leishmania major | calcium channel protein, putative,ion transporter, putative | 0.0086 | 0.0652 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0133 | 0.13 | 0.5083 |
Echinococcus granulosus | acetylcholinesterase | 0.0226 | 0.2557 | 0.2557 |
Echinococcus multilocularis | acetylcholinesterase | 0.0226 | 0.2557 | 0.2557 |
Onchocerca volvulus | 0.0038 | 0 | 0.5 | |
Brugia malayi | Carboxylesterase family protein | 0.0226 | 0.2557 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0226 | 0.2557 | 0.2557 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0038 | 0 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0226 | 0.2557 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0038 | 0 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0226 | 0.2557 | 0.2557 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0771 | 1 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0133 | 0.13 | 0.5083 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 0.2557 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 0.2557 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Agonist activity at human adenosine A1 receptor expressed in CHO cells assessed as Gi-mediated inhibition of forskolin-stimulated SPAP secretion incubated for 10 mins prior to forskolin challenge measured after 5 hrs in presence of 1 uM adenosine A1 receptor antagonist XAC by spectrophotometry | ChEMBL. | No reference | |
Activity (binding) | Binding affinity to human adenosine A1 receptor expressed in CHO cells at 100 nM after 30 mins by confocal microscopy | ChEMBL. | No reference | |
Activity (functional) | Agonist activity at human adenosine A1 receptor expressed in CHO cells assessed as Gs-mediated activation of forskolin-stimulated SPAP secretion incubated for 10 mins prior to forskolin challenge measured after 5 hrs by spectrophotometry | ChEMBL. | No reference | |
Activity (binding) | Binding affinity to human adenosine A1 receptor expressed in CHO cells at 100 nM after 30 mins by confocal microscopy in presence of DPCPX | ChEMBL. | No reference | |
IC50 (functional) | = 7.13 | Agonist activity at human adenosine A1 receptor expressed in CHO cells assessed as Gi-mediated inhibition of forskolin-stimulated SPAP secretion incubated for 10 mins prior to forskolin challenge measured after 5 hrs by spectrophotometry | ChEMBL. | No reference |
Inhibition (functional) | = 102 % | Agonist activity at human adenosine A1 receptor expressed in CHO cells assessed as Gi-mediated inhibition of forskolin-stimulated SPAP secretion incubated for 10 mins prior to forskolin challenge measured after 5 hrs by spectrophotometry | ChEMBL. | No reference |
Kd (functional) | = 7.75 | Antagonist activity at human adenosine A1 receptor expressed in CHO cells coexpressing cAMP response element assessed as inhibition of agonist-induced response by SPAP reporter gene assay in presence of forskolin | ChEMBL. | 23200243 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.