Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable C4-dicarboxylate-transport transmembrane protein DctA | 0.3409 | 0.2525 | 0.5 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.5864 | 0.9706 | 0.9706 |
Loa Loa (eye worm) | hypothetical protein | 0.5965 | 1 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.5864 | 0.9706 | 0.9706 |
Loa Loa (eye worm) | hypothetical protein | 0.5864 | 0.9706 | 0.9606 |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.352 | 0.2852 | 0.5 |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.5864 | 0.9706 | 0.9706 |
Giardia lamblia | Hypothetical protein | 0.352 | 0.2852 | 0.5 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.5965 | 1 | 1 |
Brugia malayi | Excitatory amino acid transporter | 0.3409 | 0.2525 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.5864 | 0.9706 | 0.9706 |
Onchocerca volvulus | 0.5965 | 1 | 1 | |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.5965 | 1 | 1 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.5965 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.352 | 0.2852 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.5965 | 1 | 1 |
Schistosoma mansoni | 6-phosphofructokinase | 0.5965 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.352 | 0.2852 | 0.5 |
Chlamydia trachomatis | glutamate symporter | 0.3409 | 0.2525 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | Na+/H+-dicarboxylate symporter | 0.3409 | 0.2525 | 0.5 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.352 | 0.2852 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.342 | 0.2557 | 0.0043 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.5965 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (ADMET) | > 250 uM | Cytotoxicity against human MT4 cells by MTT assay | ChEMBL. | 24900718 |
IC50 (binding) | > 250 uM | Inhibition of strand transfer activity of HIV1 integrase using pre-cleaved oligonucleotide as substrate after 1 hr by ELISA | ChEMBL. | 24900718 |
IC50 (binding) | > 250 uM | Inhibition of HIV1 integrase overall inhibition using 5'-digoxigenin-labeled 5'-GACCCTTTTAGTCAGTGTGGAAAATCTCTAGCAGT-3' as substrate after 1 hr by ELISA | ChEMBL. | 24900718 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.