Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Hypothetical protein | 0.352 | 0.2852 | 0.5 |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.5864 | 0.9706 | 0.9706 |
Loa Loa (eye worm) | hypothetical protein | 0.5864 | 0.9706 | 0.9606 |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.352 | 0.2852 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.5864 | 0.9706 | 0.9706 |
Loa Loa (eye worm) | hypothetical protein | 0.5965 | 1 | 1 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.5864 | 0.9706 | 0.9706 |
Mycobacterium tuberculosis | Probable C4-dicarboxylate-transport transmembrane protein DctA | 0.3409 | 0.2525 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.5965 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.342 | 0.2557 | 0.0043 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.352 | 0.2852 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | Na+/H+-dicarboxylate symporter | 0.3409 | 0.2525 | 0.5 |
Chlamydia trachomatis | glutamate symporter | 0.3409 | 0.2525 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.352 | 0.2852 | 0.5 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.5965 | 1 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.5965 | 1 | 1 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.5965 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.352 | 0.2852 | 0.5 |
Schistosoma mansoni | 6-phosphofructokinase | 0.5965 | 1 | 1 |
Onchocerca volvulus | 0.5965 | 1 | 1 | |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.5864 | 0.9706 | 0.9706 |
Brugia malayi | Excitatory amino acid transporter | 0.3409 | 0.2525 | 0.5 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.5965 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (ADMET) | > 250 uM | Cytotoxicity against human MT4 cells by MTT assay | ChEMBL. | 24900718 |
IC50 (binding) | = 79 uM | Inhibition of strand transfer activity of HIV1 integrase using pre-cleaved oligonucleotide as substrate after 1 hr by ELISA | ChEMBL. | 24900718 |
IC50 (binding) | = 199 uM | Inhibition of HIV1 integrase overall inhibition using 5'-digoxigenin-labeled 5'-GACCCTTTTAGTCAGTGTGGAAAATCTCTAGCAGT-3' as substrate after 1 hr by ELISA | ChEMBL. | 24900718 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.