Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0142 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0142 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.4395 | 0.4395 |
Echinococcus granulosus | voltage gated potassium channel | 0.0012 | 0.0283 | 0.0283 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0142 | 1 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0142 | 1 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0142 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.4395 | 0.4395 |
Brugia malayi | nuclear receptor RXR | 0.0075 | 0.4995 | 0.4995 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0142 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.2067 | 0.2067 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0142 | 1 | 1 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0041 | 0.2474 | 0.2474 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0142 | 1 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0067 | 0.4395 | 0.4395 |
Brugia malayi | hypothetical protein | 0.0067 | 0.4395 | 0.4395 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0012 | 0.0283 | 0.0283 |
Onchocerca volvulus | 0.0142 | 1 | 1 | |
Brugia malayi | nuclear hormone receptor | 0.0142 | 1 | 1 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0067 | 0.4395 | 0.4395 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0142 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0142 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0142 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0142 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.4995 | 0.4995 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0142 | 1 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0142 | 1 | 1 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0075 | 0.4995 | 0.4995 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0067 | 0.4395 | 0.4395 |
Brugia malayi | conserved hypotetical protein | 0.0067 | 0.4395 | 0.4395 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0142 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.4395 | 0.4395 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0142 | 1 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0142 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0142 | 1 | 1 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0067 | 0.4395 | 0.4395 |
Loa Loa (eye worm) | DR-78 | 0.0067 | 0.4395 | 0.4395 |
Brugia malayi | hypothetical protein | 0.0075 | 0.4995 | 0.4995 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.4995 | 0.4995 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0142 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0142 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0067 | 0.4395 | 0.4395 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0142 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 1 | 1 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0041 | 0.2474 | 0.2474 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0067 | 0.4395 | 0.4395 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0142 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0012 | 0.0283 | 0.0283 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0012 | 0.0283 | 0.0283 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0067 | 0.4395 | 0.4395 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0142 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0142 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0067 | 0.4395 | 0.4395 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0142 | 1 | 1 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0067 | 0.4395 | 0.4395 |
Schistosoma mansoni | zinc finger protein | 0.0067 | 0.4395 | 0.4395 |
Brugia malayi | nuclear receptor NHR-67 | 0.0067 | 0.4395 | 0.4395 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0045 | 0.2758 | 0.2758 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0039 | 0.2272 | 1 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0075 | 0.4995 | 0.4995 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0067 | 0.4395 | 0.4395 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0012 | 0.0283 | 0.0283 |
Brugia malayi | nuclear receptor NHR-88 | 0.0067 | 0.4395 | 0.4395 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0075 | 0.4995 | 0.4995 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0142 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0142 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0067 | 0.4395 | 0.4395 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0041 | 0.2474 | 0.2474 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0142 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0075 | 0.4995 | 0.4995 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.4395 | 0.4395 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0142 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0142 | 1 | 1 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0012 | 0.0283 | 0.0283 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0067 | 0.4395 | 0.4395 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0142 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.4995 | 0.4995 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0041 | 0.2474 | 0.2474 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0142 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0142 | 1 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0142 | 1 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0142 | 1 | 1 |
Brugia malayi | ecdysone receptor | 0.0067 | 0.4395 | 0.4395 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0075 | 0.4995 | 0.4995 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0142 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0142 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0283 | 0.0283 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0142 | 1 | 1 |
Brugia malayi | tailless protein | 0.0067 | 0.4395 | 0.4395 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.4395 | 0.4395 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0067 | 0.4395 | 0.4395 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0142 | 1 | 1 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0067 | 0.4395 | 0.4395 |
Brugia malayi | steroid hormone receptor | 0.0142 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0075 | 0.4995 | 0.4995 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0075 | 0.4995 | 0.4995 |
Schistosoma mansoni | thyroid hormone receptor | 0.0142 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.4395 | 0.4395 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.4395 | 0.4395 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0039 | 0.2272 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.4395 | 0.4395 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0142 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 1 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0142 | 1 | 1 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0067 | 0.4395 | 0.4395 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0142 | 1 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0142 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0067 | 0.4395 | 0.4395 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0075 | 0.4995 | 0.4995 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0067 | 0.4395 | 0.4395 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0067 | 0.4395 | 0.4395 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0142 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0142 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0142 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.4395 | 0.4395 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0142 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0142 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.4395 | 0.4395 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0142 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.4995 | 0.4995 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.4395 | 0.4395 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0067 | 0.4395 | 0.4395 |
Schistosoma mansoni | coup transcription factor | 0.0142 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0067 | 0.4395 | 0.4395 |
Schistosoma mansoni | nuclear receptor | 0.0067 | 0.4395 | 0.4395 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0067 | 0.4395 | 0.4395 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0142 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.4995 | 0.4995 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0067 | 0.4395 | 0.4395 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.4395 | 0.4395 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0012 | 0.0283 | 0.0283 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.4395 | 0.4395 |
Brugia malayi | nuclear receptor RXR | 0.0067 | 0.4395 | 0.4395 |
Schistosoma mansoni | nuclear receptor | 0.0067 | 0.4395 | 0.4395 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0142 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0142 | 1 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0142 | 1 | 1 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0067 | 0.4395 | 0.4395 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0067 | 0.4395 | 0.4395 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0142 | 1 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0142 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0142 | 1 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0067 | 0.4395 | 0.4395 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0142 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0067 | 0.4395 | 0.4395 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0067 | 0.4395 | 0.4395 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0045 | 0.2758 | 0.2758 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0067 | 0.4395 | 0.4395 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 23831694 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.