Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Kinase, CMGC MAPK | 0.0049 | 0.32 | 1 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0059 | 0.468 | 1 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0049 | 0.32 | 0.32 |
Brugia malayi | MAP kinase sur-1 | 0.0049 | 0.32 | 0.32 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0049 | 0.32 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.314 | 0.6709 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0059 | 0.4656 | 0.4656 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0049 | 0.32 | 0.32 |
Plasmodium vivax | hypothetical protein, conserved | 0.0028 | 0 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 0.4656 | 0.6612 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0049 | 0.32 | 0.5 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0049 | 0.32 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0049 | 0.32 | 0.5 |
Plasmodium falciparum | phd finger protein, putative | 0.0028 | 0 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.4656 | 0.5 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0059 | 0.4656 | 0.4656 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 0.4656 | 0.6612 |
Onchocerca volvulus | Alhambra homolog | 0.0028 | 0 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0049 | 0.32 | 0.4545 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0059 | 0.4656 | 0.5 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0093 | 1 | 1 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0059 | 0.4656 | 1 |
Echinococcus multilocularis | jumonji domain containing protein | 0.004 | 0.1721 | 0.1721 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0049 | 0.32 | 0.5 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0034 | 0.0925 | 0.1313 |
Trypanosoma brucei | protein kinase, putative | 0.0049 | 0.32 | 0.5 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0034 | 0.0925 | 0.0925 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0049 | 0.32 | 0.6874 |
Brugia malayi | jmjC domain containing protein | 0.0034 | 0.0925 | 0.0925 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.4656 | 0.5 |
Schistosoma mansoni | jumonji domain containing protein | 0.0074 | 0.7041 | 1 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0034 | 0.0925 | 0.0925 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0093 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0049 | 0.32 | 0.32 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0049 | 0.32 | 0.5 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0049 | 0.32 | 0.6838 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.4656 | 0.5 |
Echinococcus granulosus | jumonji domain containing protein | 0.004 | 0.1721 | 0.1721 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0049 | 0.32 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0049 | 0.32 | 0.5 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0059 | 0.4656 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0034 | 0.0925 | 0.1313 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0049 | 0.32 | 0.5 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0034 | 0.0925 | 0.1976 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0049 | 0.32 | 0.32 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.31 uM | Antitrypanosomal activity against Trypanosoma brucei brucei 427 bloodstream form after 48 hrs by Alamar blue assay | ChEMBL. | 23831695 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Trypanosoma brucei gambiense | 23831695 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.