Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Peroxidasin homolog | 0.0062 | 0.5 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0062 | 0.5 | 0.5 |
Brugia malayi | Peroxidasin | 0.0062 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0062 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0062 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0062 | 0.5 | 0.5 | |
Brugia malayi | Animal haem peroxidase family protein | 0.0062 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0062 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0062 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.5 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.0062 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0062 | 0.5 | 0.5 |
Echinococcus granulosus | peroxidasin | 0.0062 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0062 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.5 | 0.5 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0062 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0062 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.5 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.0062 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0062 | 0.5 | 0.5 |
Echinococcus multilocularis | peroxidasin | 0.0062 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0062 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0062 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0062 | 0.5 | 0.5 | |
Onchocerca volvulus | Peroxidase homolog | 0.0062 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0062 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0062 | 0.5 | 0.5 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.0062 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 5 % | Inhibition of IL-6-stimulated STAT3 activation in human THP1 cells at 100 uM incubated for 30 mins prior to IL-6 stimulation measured after 15 mins by EMSA relative to control | ChEMBL. | 23287056 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.