Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | acetylcholinesterase | 0.0333 | 0.5 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0333 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0333 | 0.5 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0333 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0333 | 0.5 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0333 | 0.5 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0333 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0333 | 0.5 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0333 | 0.5 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0333 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0333 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0333 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 20 % | Inhibition of IL-6-stimulated STAT3 activation in human THP1 cells at 100 uM incubated for 30 mins prior to IL-6 stimulation measured after 15 mins by EMSA relative to control | ChEMBL. | 23287056 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.