Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | carbonic anhydrase II | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase XII | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase VA, mitochondrial | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase I | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase IX | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | carbonic anhydrase XII | 354 aa | 295 aa | 23.1 % |
Leishmania major | carbonic anhydrase-like protein | carbonic anhydrase VA, mitochondrial | 305 aa | 255 aa | 25.9 % |
Trypanosoma brucei | carbonic anhydrase-like protein | carbonic anhydrase I | 261 aa | 281 aa | 25.3 % |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | carbonic anhydrase II | 260 aa | 259 aa | 32.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.0407 | 0.9706 | 0.9706 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0281 | 0.4406 | 0.2484 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0281 | 0.4406 | 0.4406 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0281 | 0.4406 | 0.5 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0414 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0281 | 0.4406 | 0.2708 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.0407 | 0.9706 | 0.9706 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 1 | 1 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0414 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0281 | 0.4406 | 0.2708 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.0245 | 0.2852 | 0.5 |
Leishmania major | carbonic anhydrase-like protein | 0.0281 | 0.4406 | 0.4406 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0414 | 1 | 1 |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.0245 | 0.2852 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0245 | 0.2852 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0407 | 0.9706 | 0.9604 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0281 | 0.4406 | 0.4406 |
Giardia lamblia | Hypothetical protein | 0.0245 | 0.2852 | 0.5 |
Onchocerca volvulus | 0.0414 | 1 | 0.5 | |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0281 | 0.4406 | 0.4406 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0281 | 0.4406 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.0407 | 0.9706 | 0.9706 |
Mycobacterium ulcerans | hypothetical protein | 0.0245 | 0.2852 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0414 | 1 | 1 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0407 | 0.9706 | 0.9706 |
Trypanosoma brucei | RNA helicase, putative | 0.0232 | 0.2329 | 0.2329 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0414 | 1 | 1 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0281 | 0.4406 | 0.2484 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.0414 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | Inhibition of human cytosolic carbonic anhydrase 1 up to 50 uM after 6 hrs by stopped flow CO2 hydrase assay | ChEMBL. | 23769167 | |
Inhibition (binding) | Inhibition of human transmembrane carbonic anhydrase 12 up to 50 uM after 6 hrs by stopped flow CO2 hydrase assay | ChEMBL. | 23769167 | |
Inhibition (binding) | Inhibition of human transmembrane carbonic anhydrase 9 up to 50 uM after 6 hrs by stopped flow CO2 hydrase assay | ChEMBL. | 23769167 | |
Ki (binding) | = 1.9 nM | Inhibition of human cytosolic carbonic anhydrase 2 after 6 hrs by stopped flow CO2 hydrase assay | ChEMBL. | 23769167 |
Ki (binding) | = 7060 nM | Inhibition of human mitochondrial carbonic anhydrase 5a after 6 hrs by stopped flow CO2 hydrase assay | ChEMBL. | 23769167 |
Ki (binding) | > 10000 nM | Inhibition of human transmembrane carbonic anhydrase 12 after 6 hrs by stopped flow CO2 hydrase assay | ChEMBL. | 23769167 |
Ki (binding) | > 10000 nM | Inhibition of human transmembrane carbonic anhydrase 9 after 6 hrs by stopped flow CO2 hydrase assay | ChEMBL. | 23769167 |
Ki (binding) | > 10000 nM | Inhibition of human cytosolic carbonic anhydrase 1 after 6 hrs by stopped flow CO2 hydrase assay | ChEMBL. | 23769167 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.