Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | solute carrier family 6 (neurotransmitter transporter), member 4 | Starlite/ChEMBL | References |
Homo sapiens | solute carrier family 6 (neurotransmitter transporter), member 3 | Starlite/ChEMBL | References |
Homo sapiens | solute carrier family 6 (neurotransmitter transporter), member 2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Sodium:neurotransmitter symporter family protein | solute carrier family 6 (neurotransmitter transporter), member 4 | 630 aa | 574 aa | 31.5 % |
Brugia malayi | Sodium:neurotransmitter symporter family protein | solute carrier family 6 (neurotransmitter transporter), member 2 | 617 aa | 638 aa | 32.5 % |
Brugia malayi | Sodium:neurotransmitter symporter family protein | solute carrier family 6 (neurotransmitter transporter), member 3 | 620 aa | 579 aa | 33.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | steroid hormone receptor | 0.0173 | 0.0355 | 0.0355 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0173 | 0.0355 | 0.0626 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0173 | 0.0355 | 0.0181 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0292 | 0.0927 | 0.0927 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.0355 | 0.0355 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0173 | 0.0355 | 0.0181 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0173 | 0.0355 | 0.0181 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0173 | 0.0355 | 0.0626 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0173 | 0.0355 | 0.0747 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0292 | 0.0927 | 0.2259 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.07 | 0.289 | 1 |
Loa Loa (eye worm) | integrin beta-2 | 0.0368 | 0.1291 | 0.1291 |
Brugia malayi | Integrin beta pat-3 precursor | 0.0368 | 0.1291 | 0.1134 |
Loa Loa (eye worm) | serotonin transporter b | 0.0292 | 0.0927 | 0.0927 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0292 | 0.0927 | 0.0764 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0173 | 0.0355 | 0.0181 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0173 | 0.0355 | 0.0181 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0173 | 0.0355 | 0.0747 |
Schistosoma mansoni | integrin beta subunit | 0.0216 | 0.0565 | 0.0828 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0173 | 0.0355 | 0.0355 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0292 | 0.0927 | 0.5 |
Echinococcus multilocularis | integrin beta 2 | 0.0272 | 0.0833 | 0.2858 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0173 | 0.0355 | 0.0626 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0173 | 0.0355 | 0.0181 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 0.0927 | 0.0927 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0173 | 0.0355 | 0.0626 |
Loa Loa (eye worm) | hypothetical protein | 0.218 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.0355 | 0.0355 |
Loa Loa (eye worm) | integrin alpha pat-2 | 0.0277 | 0.0854 | 0.0854 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0173 | 0.0355 | 0.0747 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0173 | 0.0355 | 0.0747 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.0177 | 0.0177 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0173 | 0.0355 | 0.0355 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 0.0927 | 0.0927 |
Echinococcus multilocularis | serotonin transporter | 0.0292 | 0.0927 | 0.3275 |
Brugia malayi | Integrin alpha pat-2 precursor | 0.0179 | 0.0387 | 0.0214 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 0.0927 | 0.0927 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0173 | 0.0355 | 0.0181 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0292 | 0.0927 | 0.2259 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.07 | 0.289 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0173 | 0.0355 | 0.0747 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0173 | 0.0355 | 0.0747 |
Echinococcus granulosus | FTZ F1 alpha | 0.0173 | 0.0355 | 0.0626 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0173 | 0.0355 | 0.0355 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0173 | 0.0355 | 0.0181 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.0355 | 0.0355 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0609 | 0.2451 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0173 | 0.0355 | 0.0181 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0173 | 0.0355 | 0.0355 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.0355 | 0.0355 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0173 | 0.0355 | 0.0181 |
Onchocerca volvulus | Bile acid receptor homolog | 0.218 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0173 | 0.0355 | 0.0181 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0173 | 0.0355 | 0.0355 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0173 | 0.0355 | 0.0181 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0173 | 0.0355 | 0.0626 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.0355 | 0.0355 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0173 | 0.0355 | 0.0181 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0173 | 0.0355 | 0.0747 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0173 | 0.0355 | 0.0747 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0292 | 0.0927 | 0.0927 |
Echinococcus granulosus | integrin beta 2 | 0.0272 | 0.0833 | 0.2394 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0173 | 0.0355 | 0.0181 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0173 | 0.0355 | 0.0355 |
Brugia malayi | nuclear hormone receptor | 0.0173 | 0.0355 | 0.0181 |
Echinococcus granulosus | serotonin transporter | 0.0292 | 0.0927 | 0.2744 |
Brugia malayi | steroid hormone receptor | 0.0173 | 0.0355 | 0.0181 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.0201 | 0.0201 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.0355 | 0.0355 |
Brugia malayi | nuclear receptor NHR-88 | 0.0173 | 0.0355 | 0.0181 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0173 | 0.0355 | 0.0626 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.0355 | 0.0355 |
Schistosoma mansoni | integrin alpha | 0.0179 | 0.0387 | 0.0126 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0173 | 0.0355 | 0.0626 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0173 | 0.0355 | 0.0181 |
Onchocerca volvulus | 0.0292 | 0.0927 | 0.0594 | |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0173 | 0.0355 | 0.0355 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0173 | 0.0355 | 0.0747 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0173 | 0.0355 | 0.0181 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 8.7 nM | Displacement of [3H]-norepinephrine from human NET expressed in CHO cells by TopCounting analysis | ChEMBL. | 23769168 |
IC50 (binding) | = 9.2 nM | Displacement of [3H]-hydroxytryptamine from human SERT expressed in CHO cells by TopCounting analysis | ChEMBL. | 23769168 |
IC50 (binding) | = 72 nM | Displacement of [3H]-dopamine from human DAT expressed in CHO cells by TopCounting analysis | ChEMBL. | 23769168 |
Inhibition (ADMET) | = 55 % | Inhibition of CYP2D6 (unknown origin) assessed as 1'-hydroxybufuralol production at 10 uM after 20 mins by LC/MS/MS analysis relative to control | ChEMBL. | 23769168 |
Inhibition (binding) | = 94 % | Inhibition of human ERG channel at 10 uM by ionworks assay relative to control | ChEMBL. | 23769168 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.