TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 322.658 | Formula: C14H18Cl3NO
H donors: 1 H acceptors: 1 LogP: 3.95 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: CC(=O)C(c1ccc(c(c1)Cl)Cl)C1CCNCC1.Cl
InChi: 1S/C14H17Cl2NO.ClH/c1-9(18)14(10-4-6-17-7-5-10)11-2-3-12(15)13(16)8-11;/h2-3,8,10,14,17H,4-7H2,1H3;1H
InChiKey: YROYMUJBXFJCBF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	solute carrier family 6 (neurotransmitter transporter), member 2	Starlite/ChEMBL	References
Homo sapiens	solute carrier family 6 (neurotransmitter transporter), member 3	Starlite/ChEMBL	References
Homo sapiens	solute carrier family 6 (neurotransmitter transporter), member 4	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	ko:K05336 solute carrier family 6 (neurotransmitter transporter), invertebrate, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	norepinephrine transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma mansoni	norepinephrine/norepinephrine transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma mansoni	sodium/chloride dependent transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Echinococcus granulosus	serotonin transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent noradrenaline transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	serotonin transporter b	Get druggable targets OG5_128364	All targets in OG5_128364
Onchocerca volvulus		Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	solute carrier family 6 member 4	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128364	All targets in OG5_128364
Treponema pallidum	sodium- and chloride- dependent transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	IPR000175,Sodium:neurotransmitter symporter,domain-containing	Get druggable targets OG5_128364	All targets in OG5_128364
Brugia malayi	Sodium:neurotransmitter symporter family protein	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128364	All targets in OG5_128364
Echinococcus multilocularis	serotonin transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	Sodium:neurotransmitter symporter family protein	solute carrier family 6 (neurotransmitter transporter), member 4	630 aa	574 aa	31.5 %
Brugia malayi	Sodium:neurotransmitter symporter family protein	solute carrier family 6 (neurotransmitter transporter), member 3	620 aa	579 aa	33.2 %
Brugia malayi	Sodium:neurotransmitter symporter family protein	solute carrier family 6 (neurotransmitter transporter), member 2	617 aa	638 aa	32.5 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	conserved hypothetical protein	0.003	0.0075	0.0074
Echinococcus granulosus	neuropeptide receptor	0.0024	0.0052	0.0052
Echinococcus granulosus	3 ketodihydrosphingosine reductase	0.0086	0.0267	0.0267
Brugia malayi	Dopamine receptor protein 2	0.0024	0.0052	0.0313
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0024	0.0052	0.0052
Onchocerca volvulus		0.0024	0.0052	0.0001
Plasmodium falciparum	CDGSH iron-sulfur domain-containing protein, putative	0.003	0.0075	0.1872
Schistosoma mansoni	short chain dehydrogenase	0.0086	0.0267	0.0216
Leishmania major	quinonoid dihydropteridine reductase	0.0086	0.0267	0.0217
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0052	0.0052
Mycobacterium ulcerans	short chain dehydrogenase	0.0086	0.0267	0.0403
Mycobacterium ulcerans	hydrolase MutT1	0.0049	0.0139	0.0185
Schistosoma mansoni	hypothetical protein	0.0049	0.0139	0.0087
Mycobacterium leprae	conserved hypothetical protein	0.0049	0.0139	0.408
Mycobacterium tuberculosis	Probable shortchain dehydrogenase	0.0086	0.0267	1
Loa Loa (eye worm)	oxidoreductase	0.0086	0.0267	0.0267
Trypanosoma brucei	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.124	0.425	0.4169
Plasmodium vivax	phosphoglucomutase-2, putative	0.0049	0.0139	0.4594
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0086	0.0267	0.1601
Onchocerca volvulus		0.0049	0.0139	0.0088
Toxoplasma gondii	phosphoglycerate mutase family protein	0.0049	0.0139	0.3349
Echinococcus granulosus	geminin	0.0169	0.0552	0.0552
Onchocerca volvulus	Protein UBASH3A homolog	0.0049	0.0139	0.0088
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.005	0.0141	0.0845
Toxoplasma gondii	phosphoglycerate mutase family protein	0.0049	0.0139	0.3349
Echinococcus multilocularis	retinol dehydrogenase 13	0.0086	0.0267	0.0267
Echinococcus multilocularis	retinol dehydrogenase 11	0.0086	0.0267	0.0267
Mycobacterium ulcerans	bifunctional RNase H/acid phosphatase	0.0049	0.0139	0.0185
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0024	0.0052	0.0052
Echinococcus granulosus	g protein coupled receptor	0.0024	0.0052	0.0052
Leishmania major	short chain dehydrogenase, putative	0.0086	0.0267	0.0217
Onchocerca volvulus		0.0024	0.0052	0.0001
Trypanosoma cruzi	6-phosphofructo-2-kinase 1	0.2857	0.9831	0.9828
Loa Loa (eye worm)	hypothetical protein	0.0148	0.0482	0.0482
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0187	0.0135
Trypanosoma cruzi	hypothetical protein, conserved	0.0086	0.0267	0.013
Brugia malayi	Dehydrogenases, short chain protein 30	0.0086	0.0267	0.1601
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0024	0.0052	0.0052
Onchocerca volvulus	Protein UBASH3A homolog	0.0049	0.0139	0.0088
Echinococcus granulosus	phosphoglycerate mutase	0.0049	0.0139	0.0139
Echinococcus granulosus	carbonyl reductase 1	0.0086	0.0267	0.0267
Schistosoma mansoni	patched 1	0.0042	0.0115	0.0063
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0086	0.0267	0.1601
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0024	0.0052	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0215	0.071	0.071
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0052	0.0052
Mycobacterium leprae	Probable oxidoreductase	0.0086	0.0267	1
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.0093	0.0041
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0086	0.0267	1
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0052	0.0052
Onchocerca volvulus		0.0024	0.0052	0.0001
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.005	0.0141	0.0089
Treponema pallidum	sodium- and chloride- dependent transporter	0.0292	0.0978	1
Wolbachia endosymbiont of Brugia malayi	Short-chain alcohol dehydrogenase family enzyme	0.0086	0.0267	0.5
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0052	0.0052
Schistosoma mansoni	serine/threonine protein kinase	0.0492	0.1668	0.1624
Echinococcus granulosus	phosphoglycerate mutase	0.0049	0.0139	0.0139
Brugia malayi	hypothetical protein	0.0024	0.0052	0.0313
Echinococcus multilocularis	fmrfamide receptor	0.0024	0.0052	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0139	0.0139
Leishmania major	hypothetical protein, unknown function	0.003	0.0075	0.0024
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.2906	1	1
Mycobacterium leprae	conserved hypothetical protein	0.0049	0.0139	0.408
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0086	0.0267	0.1601
Plasmodium falciparum	CDGSH iron-sulfur domain-containing protein, putative	0.003	0.0075	0.1872
Brugia malayi	G protein-coupled receptor F59B2.13	0.0024	0.0052	0.0313
Echinococcus multilocularis	proto oncogene serine:threonine protein kinase	0.0492	0.1668	0.1667
Schistosoma mansoni	short chain dehydrogenase	0.0086	0.0267	0.0216
Loa Loa (eye worm)	norepinephrine transporter	0.0292	0.0978	0.0977
Leishmania major	quinonoid dihydropteridine reductase	0.0086	0.0267	0.0217
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0086	0.0267	0.0403
Chlamydia trachomatis	Ssodium-dependent amino acid transporter	0.005	0.0141	1
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0052	0.0052
Onchocerca volvulus	Dehydrogenase\/reductase SDR family member 13 homolog	0.0086	0.0267	0.0217
Echinococcus granulosus	neuropeptide receptor A26	0.0024	0.0052	0.0052
Leishmania major	phosphoglycerate mutase family member 5, putative	0.0049	0.0139	0.0088
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0187	0.0135
Echinococcus multilocularis	Dehydrogenase:reductase SDR family	0.0086	0.0267	0.0267
Echinococcus granulosus	hypothetical protein	0.0024	0.0052	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0139	0.0139
Mycobacterium ulcerans	dehydrogenase	0.0086	0.0267	0.0403
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0086	0.0267	0.0403
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0051	0.0307
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0139	0.0139
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0052	0.0052
Entamoeba histolytica	hypothetical protein, conserved	0.0086	0.0267	0.037
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0024	0.0052	0.0052
Plasmodium vivax	amine transporter, putative	0.005	0.0141	0.4668
Onchocerca volvulus		0.005	0.0141	0.009
Entamoeba histolytica	short chain dehydrogenase family protein	0.0086	0.0267	0.037
Echinococcus multilocularis	neuropeptide receptor A26	0.0024	0.0052	0.0052
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0086	0.0267	0.1601
Brugia malayi	hypothetical protein	0.0024	0.0052	0.0313
Echinococcus granulosus	epidermal retinal dehydrogenase 2	0.0086	0.0267	0.0267
Echinococcus granulosus	serine:threonine protein phosphatase PGAM5	0.0049	0.0139	0.0139
Echinococcus granulosus	sex peptide receptor	0.0024	0.0052	0.0052
Trypanosoma cruzi	short chain dehydrogenase, putative	0.0086	0.0267	0.013
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.005	0.0141	0.0141
Plasmodium falciparum	CDGSH iron-sulfur domain-containing protein, putative	0.003	0.0075	0.1872
Onchocerca volvulus		0.0086	0.0267	0.0217
Loa Loa (eye worm)	hypothetical protein	0.005	0.0141	0.0141
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0086	0.0267	0.0216
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0086	0.0267	0.0403
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0024	0.0052	0.0052
Mycobacterium tuberculosis	Possible iron-regulated short-chain dehydrogenase/reductase	0.0086	0.0267	1
Brugia malayi	Serotonin receptor	0.0024	0.0052	0.0313
Entamoeba histolytica	short chain dehydrogenase family protein	0.0086	0.0267	0.037
Trypanosoma cruzi	3-ketoacyl-CoA reductase, putative	0.0086	0.0267	0.013
Echinococcus granulosus	fmrfamide receptor	0.0024	0.0052	0.0052
Loa Loa (eye worm)	oxidoreductase	0.0086	0.0267	0.0267
Brugia malayi	Serine/threonine-protein kinase Pim-3	0.0492	0.1668	1
Entamoeba histolytica	hypothetical protein	0.0036	0.0093	0.0072
Schistosoma mansoni	cpg binding protein	0.0029	0.0069	0.0016
Schistosoma mansoni	short chain dehydrogenase	0.0086	0.0267	0.0216
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0052	0.0052
Schistosoma mansoni	sodium/chloride dependent transporter	0.0052	0.0151	0.0099
Trypanosoma cruzi	NAD(P)-dependent oxidoreductase, putative	0.0086	0.0267	0.013
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0052	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0052	0.0052
Schistosoma mansoni	short chain dehydrogenase	0.0086	0.0267	0.0216
Toxoplasma gondii	oxidoreductase, putative	0.0086	0.0267	1
Echinococcus granulosus	neuropeptide FF receptor 2	0.0024	0.0052	0.0052
Loa Loa (eye worm)	dehydrogenase	0.0086	0.0267	0.0267
Mycobacterium tuberculosis	Possible oxidoreductase	0.0086	0.0267	1
Entamoeba histolytica	hypothetical protein	0.0036	0.0093	0.0072
Mycobacterium tuberculosis	Probable oxidoreductase	0.0086	0.0267	1
Mycobacterium tuberculosis	Possible oxidoreductase	0.0086	0.0267	1
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0267	0.0267
Entamoeba histolytica	3-ketodihydrosphingosine reductase protein, putative	0.0086	0.0267	0.037
Loa Loa (eye worm)	oxidoreductase	0.0086	0.0267	0.0267
Echinococcus granulosus	tm gpcr rhodopsin	0.0024	0.0052	0.0052
Entamoeba histolytica	estradiol 17-beta-dehydrogenase, putative	0.0086	0.0267	0.037
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0307	0.0307
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0086	0.0267	0.0403
Mycobacterium ulcerans	short-chain dehydrogenase	0.0086	0.0267	0.0403
Onchocerca volvulus		0.0024	0.0052	0.0001
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.005	0.0141	0.0089
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.005	0.0141	0.0089
Schistosoma mansoni	serine/threonine protein kinase	0.0091	0.0284	0.0233
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0086	0.0267	0.1601
Trypanosoma cruzi	3-keto-dihydrosphingosine reductase	0.0086	0.0267	0.013
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0086	0.0267	0.1601
Echinococcus granulosus	dnaJ subfamily B	0.0407	0.1376	0.1376
Onchocerca volvulus	Serine\/threonine protein kinase homolog	0.0492	0.1668	0.1625
Mycobacterium ulcerans	carveol-like dehydrogenase	0.0086	0.0267	0.0403
Schistosoma mansoni	steroid dehydrogenase	0.0086	0.0267	0.0216
Leishmania major	quinonoid dihydropteridine reductase	0.0086	0.0267	0.0217
Brugia malayi	Retinol dehydrogenase 12	0.0086	0.0267	0.1601
Echinococcus granulosus	tm gpcr rhodopsin	0.0024	0.0052	0.0052
Mycobacterium tuberculosis	Probable oxidoreductase	0.0086	0.0267	1
Loa Loa (eye worm)	CAMK/PIM protein kinase	0.0492	0.1668	0.1667
Toxoplasma gondii	sterol carrier protein-2 HAD-2SCP-2	0.0086	0.0267	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0024	0.0052	0.0052
Toxoplasma gondii	oxidoreductase, putative	0.0086	0.0267	1
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0042	0.0115	0.0114
Onchocerca volvulus	Sepiapterin reductase homolog	0.0086	0.0267	0.0217
Toxoplasma gondii	hypothetical protein	0.005	0.0141	0.344
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0052	0.0052
Schistosoma mansoni	hypothetical protein	0.0049	0.0139	0.0087
Entamoeba histolytica	hypothetical protein, conserved	0.0086	0.0267	0.037
Trypanosoma brucei	beta-ketoacyl-ACP reductase 2	0.0086	0.0267	0.013
Echinococcus granulosus	rhodopsin orphan GPCR	0.0024	0.0052	0.0052
Echinococcus granulosus	g-protein coupled receptor	0.0024	0.0052	0.0052
Mycobacterium tuberculosis	Probable dehydrogenase	0.0086	0.0267	1
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.005	0.0141	0.344
Plasmodium falciparum	oxidoreductase, short-chain dehydrogenase family, putative	0.0086	0.0267	1
Loa Loa (eye worm)	hypothetical protein	0.0148	0.0482	0.0482
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0024	0.0052	0.0052
Echinococcus multilocularis	serotonin receptor	0.0024	0.0052	0.0052
Echinococcus granulosus	serine:threonine protein phosphatase PGAM5	0.0049	0.0139	0.0139
Onchocerca volvulus		0.0049	0.0139	0.0088
Echinococcus multilocularis	neuropeptide Y receptor	0.0024	0.0052	0.0052
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.005	0.0141	0.0089
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0086	0.0267	1
Brugia malayi	phosphoglycerate mutase family protein	0.0049	0.0139	0.0835
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0086	0.0267	0.013
Echinococcus granulosus	allatostatin A receptor	0.0024	0.0052	0.0052
Leishmania major	hypothetical protein, conserved	0.0049	0.0139	0.0088
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0052	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0052	0.0052
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.005	0.0141	0.0089
Schistosoma mansoni	steroid dehydrogenase	0.0086	0.0267	0.0216
Schistosoma mansoni	retinal dehydrogenase	0.0086	0.0267	0.0216
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.005	0.0141	0.0089
Loa Loa (eye worm)	hypothetical protein	0.1666	0.572	0.572
Echinococcus multilocularis	g protein coupled receptor	0.0024	0.0052	0.0052
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0024	0.0052	0.0001
Leishmania major	short chain dehydrogenase/reductase, putative	0.0086	0.0267	0.0217
Onchocerca volvulus		0.0049	0.0139	0.0088
Echinococcus granulosus	biogenic amine 5HT receptor	0.0024	0.0052	0.0052
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0051	0.0035
Mycobacterium ulcerans	short chain dehydrogenase	0.0086	0.0267	0.0403
Echinococcus granulosus	sodium and chloride dependent glycine	0.005	0.0141	0.0141
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0187	0.0135
Brugia malayi	hypothetical protein	0.0036	0.0093	0.0559
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.005	0.0141	0.0845
Mycobacterium tuberculosis	Probable oxidoreductase	0.0086	0.0267	1
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0024	0.0052	0.0052
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0024	0.0052	0.0052
Leishmania major	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-1-like protein	0.124	0.425	0.422
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0267	0.0267
Echinococcus granulosus	phosphoglycerate mutase	0.0049	0.0139	0.0139
Echinococcus granulosus	7TM GPCR rhodopsin	0.0024	0.0052	0.0052
Schistosoma mansoni	phosphoglycerate mutase	0.0049	0.0139	0.0087
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0024	0.0052	0.0052
Schistosoma mansoni	steroid dehydrogenase	0.0086	0.0267	0.0216
Mycobacterium leprae	conserved hypothetical protein	0.0049	0.0139	0.408
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0086	0.0267	1
Brugia malayi	Serotonin receptor	0.0024	0.0052	0.0313
Loa Loa (eye worm)	G-protein coupled receptor	0.0024	0.0052	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0267	0.0267
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0052	0.0052
Brugia malayi	RNA binding protein	0.0063	0.0187	0.1122
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0086	0.0267	1
Leishmania major	glycerolphosphate mutase, putative	0.0049	0.0139	0.0088
Echinococcus multilocularis	G protein coupled receptor 139	0.0024	0.0052	0.0052
Mycobacterium ulcerans	short-chain dehydrogenase	0.0086	0.0267	0.0403
Mycobacterium ulcerans	3-alpha-hydroxysteroid dehydrogenase	0.0086	0.0267	0.0403
Leishmania major	hypothetical protein, conserved	0.0049	0.0139	0.0088
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0086	0.0267	0.013
Echinococcus granulosus	rhodopsin orphan GPCR	0.0024	0.0052	0.0052
Leishmania major	hypothetical protein, conserved	0.0086	0.0267	0.0217
Echinococcus granulosus	g protein coupled receptor	0.0024	0.0052	0.0052
Plasmodium falciparum	transporter, putative	0.005	0.0141	0.4668
Mycobacterium ulcerans	short chain dehydrogenase	0.0086	0.0267	0.0403
Brugia malayi	G protein-coupled receptor	0.0024	0.0052	0.0313
Echinococcus granulosus	Protein patched homolog 1	0.0042	0.0115	0.0114
Schistosoma mansoni	steroid dehydrogenase	0.0086	0.0267	0.0216
Schistosoma mansoni	hypothetical protein	0.0169	0.0552	0.0503
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0052	0.0052
Trypanosoma brucei	6-phosphofructo-2-kinase 2	0.2857	0.9831	0.9828
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0187	0.0135
Schistosoma mansoni	steroid dehydrogenase	0.0086	0.0267	0.0216
Brugia malayi	neuropeptide F receptor	0.0024	0.0052	0.0313
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.005	0.0141	0.344
Schistosoma mansoni	hypothetical protein	0.0049	0.0139	0.0087
Mycobacterium tuberculosis	Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase)	0.0049	0.0139	0.4669
Loa Loa (eye worm)	hypothetical protein	0.003	0.0075	0.0074
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0086	0.0267	1
Schistosoma mansoni	short chain dehydrogenase	0.0086	0.0267	0.0216
Schistosoma mansoni	hypothetical protein	0.0036	0.0093	0.0041
Echinococcus granulosus	neuropeptides capa receptor	0.0024	0.0052	0.0052
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0086	0.0267	1
Echinococcus multilocularis	g protein coupled receptor	0.0024	0.0052	0.0052
Echinococcus multilocularis	dnaJ subfamily B	0.0407	0.1376	0.1376
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.005	0.0141	0.0141
Echinococcus multilocularis	neuropeptide s receptor	0.0024	0.0052	0.0052
Trypanosoma cruzi	short chain dehydrogenase/reductase, putative	0.0086	0.0267	0.013
Leishmania major	quinonoid dihydropteridine reductase	0.0086	0.0267	0.0217
Schistosoma mansoni	hypothetical protein	0.0535	0.1816	0.1773
Echinococcus multilocularis	serine:threonine protein phosphatase PGAM5	0.0049	0.0139	0.0139
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0086	0.0267	0.1601
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0086	0.0267	0.1601
Echinococcus granulosus	retinol dehydrogenase 11	0.0086	0.0267	0.0267
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0024	0.0051	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0052	0.0052
Trypanosoma cruzi	hypothetical protein, conserved	0.0086	0.0267	0.013
Trypanosoma cruzi	beta-ketoacyl-ACP reductase 2, putative	0.0086	0.0267	0.013
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0086	0.0267	1
Brugia malayi	hypothetical protein	0.0086	0.0267	0.1601
Echinococcus multilocularis	phosphoglycerate mutase	0.0049	0.0139	0.0139
Echinococcus granulosus	neuropeptide Y receptor	0.0024	0.0052	0.0052
Onchocerca volvulus		0.0086	0.0267	0.0217
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.005	0.0141	0.0141
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0024	0.0052	0.0313
Schistosoma mansoni	steroid dehydrogenase	0.0086	0.0267	0.0216
Brugia malayi	hypothetical protein	0.0086	0.0267	0.1601
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.2906	1	1
Mycobacterium ulcerans	phosphoglycerate mutase	0.0049	0.0139	0.0185
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0086	0.0267	1
Trichomonas vaginalis	estradiol 17 beta-dehydrogenase, putative	0.0086	0.0267	1
Brugia malayi	Hypothetical oxidoreductase F56D1.5	0.0086	0.0267	0.1601
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0051	0.0035
Mycobacterium ulcerans	short chain dehydrogenase	0.0086	0.0267	0.0403
Trypanosoma brucei	oxidoreductase-like protein	0.0086	0.0267	0.013
Entamoeba histolytica	estradiol 17-beta-dehydrogenase, putative	0.0086	0.0267	0.037
Loa Loa (eye worm)	TAR-binding protein	0.0063	0.0187	0.0187
Echinococcus granulosus	rhodopsin orphan GPCR	0.0024	0.0052	0.0052
Leishmania major	pteridine reductase 1	0.0086	0.0267	0.0217
Leishmania major	quinonoid dihydropteridine reductase	0.0086	0.0267	0.0217
Mycobacterium ulcerans	short chain dehydrogenase	0.0086	0.0267	0.0403
Entamoeba histolytica	hypothetical protein	0.0091	0.0284	0.0399
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0024	0.0052	0.0052
Loa Loa (eye worm)	serotonin transporter b	0.0292	0.0978	0.0977
Schistosoma mansoni	short chain dehydrogenase	0.0086	0.0267	0.0216
Mycobacterium ulcerans	short-chain dehydrogenase	0.0086	0.0267	0.0403
Echinococcus multilocularis	g protein coupled receptor	0.0024	0.0052	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0292	0.0978	0.0977
Loa Loa (eye worm)	G-protein coupled receptor	0.0024	0.0052	0.0052
Mycobacterium tuberculosis	Probable oxidoreductase	0.0086	0.0267	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0031	0.003
Trypanosoma cruzi	short-chain dehydrogenase, putative	0.0086	0.0267	0.013
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0024	0.0052	0.0313
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0147	0.0147
Schistosoma mansoni	hypothetical protein	0.0169	0.0552	0.0503
Onchocerca volvulus		0.005	0.0141	0.009
Echinococcus granulosus	phosphoglycerate mutase	0.0049	0.0139	0.0139
Brugia malayi	GnHR receptor homolog	0.0024	0.0052	0.0313
Mycobacterium leprae	POSSIBLE HYDROLASE MUTT1	0.0049	0.0139	0.408
Echinococcus multilocularis	phosphoglycerate mutase	0.0049	0.0139	0.0139
Brugia malayi	neuropeptide F receptor	0.0024	0.0052	0.0313
Schistosoma mansoni	short chain dehydrogenase	0.0086	0.0267	0.0216
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0024	0.0052	0.0052
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0086	0.0267	1
Schistosoma mansoni	steroid dehydrogenase	0.0086	0.0267	0.0216
Mycobacterium ulcerans	phosphoglycerate mutase	0.0049	0.0139	0.0185
Brugia malayi	oxidoreductase	0.0086	0.0267	0.1601
Echinococcus granulosus	G protein coupled receptor 139	0.0024	0.0052	0.0052
Mycobacterium ulcerans	ketoacyl reductase	0.0086	0.0267	0.0403
Schistosoma mansoni	cpg binding protein	0.003	0.0074	0.0022
Leishmania major	hypothetical protein, conserved	0.0086	0.0267	0.0217
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.005	0.0141	0.0141
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.005	0.0141	0.0845
Trichomonas vaginalis	steroid dehydrogenase, putative	0.0086	0.0267	1
Mycobacterium tuberculosis	Probable oxidoreductase	0.0086	0.0267	1
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0086	0.0267	0.1601
Onchocerca volvulus		0.003	0.0075	0.0024
Echinococcus granulosus	7tm_1 domain containing protein	0.0024	0.0052	0.0052
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0051	0.0307
Echinococcus granulosus	proto oncogene serine:threonine protein kinase	0.0492	0.1668	0.1667
Schistosoma mansoni	oxidoreductase short chain dehydrogenase/reductase family	0.0086	0.0267	0.0216
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0024	0.0052	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0051	0.0051
Brugia malayi	putative neuropeptide receptor NPR1	0.0024	0.0052	0.0313
Schistosoma mansoni	3-keto-dihydrosphingosine reductase	0.0086	0.0267	0.0216
Mycobacterium leprae	Possible short-chain dehydrogenase EphD	0.0086	0.0267	1
Mycobacterium ulcerans	oxidoreductase	0.0086	0.0267	0.0403
Mycobacterium ulcerans	hypothetical protein	0.0049	0.0139	0.0185
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0267	0.0267
Schistosoma mansoni	CDGSH-type Zn finger-containing protein-like protein	0.0535	0.1816	0.1773
Loa Loa (eye worm)	hypothetical protein	0.005	0.0141	0.0141
Mycobacterium leprae	ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE	0.0086	0.0267	1
Trichomonas vaginalis	phosphoglycerate mutase, putative	0.0049	0.0139	0.1608
Echinococcus granulosus	Dehydrogenase:reductase SDR family	0.0086	0.0267	0.0267
Toxoplasma gondii	phosphoglycerate mutase	0.0049	0.0139	0.3349
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0024	0.0052	0.0052
Onchocerca volvulus		0.0215	0.071	0.0663
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0086	0.0267	1
Brugia malayi	hypothetical protein	0.0024	0.0052	0.0313
Echinococcus granulosus	sterol regulatory element binding protein	0.0042	0.0115	0.0114
Mycobacterium ulcerans	hypothetical protein	0.0049	0.0139	0.0185
Mycobacterium tuberculosis	Probable dehydrogenase/reductase	0.0086	0.0267	1
Leishmania major	hypothetical protein, unknown function	0.0049	0.0139	0.0088
Plasmodium vivax	hypothetical protein, conserved	0.003	0.0075	0.1872
Mycobacterium tuberculosis	Probable oxidoreductase	0.0086	0.0267	1
Mycobacterium leprae	Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase)	0.0049	0.0139	0.408
Brugia malayi	follicle stimulating hormone receptor	0.0024	0.0052	0.0313
Onchocerca volvulus		0.0086	0.0267	0.0217
Brugia malayi	hypothetical protein	0.0024	0.0052	0.0313
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0052	0.0052
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0024	0.0052	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0052	0.0052
Echinococcus multilocularis	geminin	0.0169	0.0552	0.0552
Mycobacterium leprae	Probable short-chain type dehydrogenase/reductase	0.0086	0.0267	1
Trypanosoma brucei	beta-D-hydroxybutyrate dehydrogenase	0.0086	0.0267	0.013
Toxoplasma gondii	phosphoglycerate mutase family protein	0.0049	0.0139	0.3349
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0024	0.0052	0.0052
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0086	0.0267	0.0267
Loa Loa (eye worm)	oxidoreductase	0.0086	0.0267	0.0267
Schistosoma mansoni	6-phosphofructokinase	0.2906	1	1
Loa Loa (eye worm)	short chain dehydrogenase/reductase family oxidoreductase	0.0086	0.0267	0.0267
Schistosoma mansoni	sodium/chloride dependent transporter	0.0292	0.0978	0.093
Schistosoma mansoni	short chain dehydrogenase	0.0086	0.0267	0.0216
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0024	0.0052	0.0052
Onchocerca volvulus	Protein UBASH3A homolog	0.0049	0.0139	0.0088
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.0093	0.0093
Leishmania major	hypothetical protein, conserved	0.0049	0.0139	0.0088
Mycobacterium ulcerans	short chain dehydrogenase	0.0086	0.0267	0.0403
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0024	0.0051	0.0035
Trypanosoma cruzi	quinonoid dihydropteridine reductase, putative	0.0086	0.0267	0.013
Echinococcus granulosus	muscleblind protein	0.0148	0.0482	0.0482
Echinococcus granulosus	neuropeptide s receptor	0.0024	0.0052	0.0052
Brugia malayi	sulfakinin receptor protein	0.0024	0.0052	0.0313
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0052	0.0052
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0086	0.0267	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0024	0.0052	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0115	0.0114
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0086	0.0267	0.0403
Leishmania major	hypothetical protein, conserved	0.0086	0.0267	0.0217
Echinococcus multilocularis	transient receptor potential cation channel	0.0086	0.0267	0.0267
Mycobacterium ulcerans	short-chain type oxidoreductase	0.0086	0.0267	0.0403
Schistosoma mansoni	short chain dehydrogenase	0.0086	0.0267	0.0216
Loa Loa (eye worm)	hypothetical protein	0.005	0.0141	0.0141
Schistosoma mansoni	cpg binding protein	0.003	0.0074	0.0022
Mycobacterium ulcerans	ketoacyl reductase	0.0086	0.0267	0.0403
Onchocerca volvulus		0.0086	0.0267	0.0217
Onchocerca volvulus		0.0086	0.0267	0.0217
Onchocerca volvulus		0.0024	0.0052	0.0001
Onchocerca volvulus		0.0024	0.0052	0.0001
Trypanosoma brucei	3-ketoacyl-CoA reductase, putative	0.0086	0.0267	0.013
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0018	0.0031	0.0138
Echinococcus multilocularis	steroid dehydrogenase	0.0086	0.0267	0.0267
Brugia malayi	TAR-binding protein	0.0063	0.0187	0.1122
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0086	0.0267	1
Loa Loa (eye worm)	hypothetical protein	0.0292	0.0978	0.0977
Leishmania major	hypothetical protein, conserved	0.0086	0.0267	0.0217
Schistosoma mansoni	hypothetical protein	0.003	0.0075	0.0023
Leishmania major	quinonoid dihydropteridine reductase	0.0086	0.0267	0.0217
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0051	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0052	0.0052
Echinococcus granulosus	orexin receptor type 2	0.0024	0.0052	0.0052
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0086	0.0267	1
Brugia malayi	Dopamine receptor	0.0024	0.0052	0.0313
Echinococcus granulosus	neuropeptide receptor	0.0024	0.0052	0.0052
Schistosoma mansoni	hypothetical protein	0.004	0.0109	0.0058
Schistosoma mansoni	hypothetical protein	0.004	0.0109	0.0058
Mycobacterium tuberculosis	Probable short chain alcohol dehydrogenase/reductase	0.0086	0.0267	1
Loa Loa (eye worm)	oxidoreductase	0.0086	0.0267	0.0267
Echinococcus granulosus	cpg binding protein	0.003	0.0074	0.0074
Echinococcus multilocularis	orexin receptor type 2	0.0024	0.0052	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0052	0.0052
Leishmania major	oxidoreductase-like protein	0.0086	0.0267	0.0217
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0052	0.0052
Mycobacterium ulcerans	lipoprotein LpqD	0.0049	0.0139	0.0185
Schistosoma mansoni	sodium/chloride dependent transporter	0.005	0.0141	0.0089
Mycobacterium leprae	PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE	0.0086	0.0267	1
Giardia lamblia	Hypothetical protein	0.1715	0.5889	1
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0024	0.0052	0.0001
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0024	0.0052	0.0052
Mycobacterium ulcerans	short chain dehydrogenase	0.0086	0.0267	0.0403
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0086	0.0267	0.0403
Echinococcus multilocularis	serine:threonine protein phosphatase PGAM5	0.0049	0.0139	0.0139
Brugia malayi	RNA recognition motif domain containing protein	0.0063	0.0187	0.1122
Mycobacterium ulcerans	short chain dehydrogenase	0.0086	0.0267	0.0403
Echinococcus multilocularis	sodium and chloride dependent glycine	0.005	0.0141	0.0141
Trypanosoma cruzi	oxidoreductase-like protein, putative	0.0086	0.0267	0.013
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0052	0.0052
Echinococcus granulosus	carbonyl reductase 1	0.0086	0.0267	0.0267
Trypanosoma brucei	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.2906	1	1
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.005	0.0141	0.0141
Leishmania major	quinonoid dihydropteridine reductase	0.0086	0.0267	0.0217
Onchocerca volvulus		0.0024	0.0052	0.0001
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0051	0.0307
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0024	0.0052	0.0052
Echinococcus granulosus	serotonin transporter	0.0292	0.0978	0.0977
Mycobacterium ulcerans	short chain dehydrogenase	0.0086	0.0267	0.0403
Echinococcus granulosus	steroid dehydrogenase	0.0086	0.0267	0.0267
Mycobacterium tuberculosis	Possible fatty acyl-CoA reductase	0.0086	0.0267	1
Loa Loa (eye worm)	oxidoreductase	0.0086	0.0267	0.0267
Echinococcus multilocularis	neuropeptide receptor	0.0024	0.0052	0.0052
Onchocerca volvulus	Protein UBASH3A homolog	0.0049	0.0139	0.0088
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0086	0.0267	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0031	0.003
Onchocerca volvulus		0.0024	0.0052	0.0001
Echinococcus multilocularis	dual specificity	0.0091	0.0284	0.0284
Mycobacterium ulcerans	short chain dehydrogenase	0.0086	0.0267	0.0403
Echinococcus granulosus	oxidoreductase	0.0086	0.0267	0.0267
Plasmodium falciparum	phosphoglucomutase-2	0.0049	0.0139	0.4594
Mycobacterium tuberculosis	Probable conserved lipoprotein LpqD	0.0049	0.0139	0.4669
Echinococcus granulosus	expressed conserved protein	0.0092	0.0287	0.0287
Entamoeba histolytica	hypothetical protein	0.0036	0.0093	0.0072
Trypanosoma cruzi	oxidoreductase-like protein, putative	0.0086	0.0267	0.013
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0024	0.0052	0.0313
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0267	0.0267
Echinococcus multilocularis	cdgsh iron sulfur domain containing protein	0.0505	0.1711	0.1711
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0024	0.0052	0.0052
Onchocerca volvulus		0.0024	0.0052	0.0001
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0024	0.0052	0.0052
Echinococcus multilocularis	oxidoreductase	0.0086	0.0267	0.0267
Onchocerca volvulus		0.0024	0.0052	0.0001
Trypanosoma cruzi	short chain dehydrogenase, putative	0.0086	0.0267	0.013
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0024	0.0051	0.0035
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0292	0.0978	0.5863
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0086	0.0267	0.0403
Schistosoma mansoni	carbonyl reductase	0.0086	0.0267	0.0216
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.005	0.0141	0.0089
Echinococcus multilocularis	protein patched	0.0042	0.0115	0.0114
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0267	0.0267
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0086	0.0267	0.1601
Mycobacterium tuberculosis	Probable short-chain dehydrogenase/reductase	0.0086	0.0267	1
Brugia malayi	dehydrogenases, short chain protein 9	0.0086	0.0267	0.1601
Mycobacterium ulcerans	short-chain dehydrogenase	0.0086	0.0267	0.0403
Toxoplasma gondii	2,4-dienoyl CoA reductase 2, peroxisomal family protein	0.0086	0.0267	1
Plasmodium vivax	hypothetical protein, conserved	0.003	0.0075	0.1872
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.0069	0.0068
Brugia malayi	AKH receptor	0.0024	0.0052	0.0313
Schistosoma mansoni	hypothetical protein	0.0049	0.0139	0.0087
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.005	0.0141	0.0141
Echinococcus multilocularis	sterol regulatory element binding protein	0.0042	0.0115	0.0114
Trypanosoma brucei	beta-ketoacyl-ACP reductase 3, putative	0.0086	0.0267	0.013
Schistosoma mansoni	short chain dehydrogenase	0.0086	0.0267	0.0216
Trypanosoma cruzi	NAD(P)-dependent oxidoreductase, putative	0.0086	0.0267	0.013
Loa Loa (eye worm)	hypothetical protein	0.0292	0.0978	0.0977
Mycobacterium leprae	Probable short-chain type dehydrogenase/reductase	0.0086	0.0267	1
Brugia malayi	Melatonin receptor type 1A	0.0024	0.0052	0.0313
Echinococcus multilocularis	Niemann Pick C1 protein	0.014	0.0452	0.0452
Loa Loa (eye worm)	TYRA-2 protein	0.0024	0.0052	0.0052
Trypanosoma cruzi	short chain dehydrogenase/reductase, putative	0.0086	0.0267	0.013
Echinococcus granulosus	somatostatin receptor	0.0024	0.0052	0.0052
Loa Loa (eye worm)	CMGC/DYRK/DYRK1 protein kinase	0.0091	0.0284	0.0284
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0024	0.0052	0.0052
Echinococcus granulosus	dro:myosuppressin receptor	0.0024	0.0052	0.0052
Echinococcus granulosus	WW domain containing oxidoreductase	0.0086	0.0267	0.0267
Onchocerca volvulus		0.0086	0.0267	0.0217
Onchocerca volvulus		0.0029	0.0069	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0274	0.0274
Trypanosoma brucei	3-keto-dihydrosphingosine reductase	0.0086	0.0267	0.013
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0061	0.0179	0.0128
Echinococcus granulosus	tar DNA binding protein	0.0063	0.0187	0.0187
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0086	0.0267	0.0403
Schistosoma mansoni	hypothetical protein	0.0049	0.0139	0.0087
Mycobacterium tuberculosis	Possible short-chain dehydrogenase EphD	0.0086	0.0267	1
Schistosoma mansoni	hypothetical protein	0.0049	0.0139	0.0087
Echinococcus granulosus	rhodopsin orphan GPCR	0.0024	0.0052	0.0052
Loa Loa (eye worm)	RNA binding protein	0.0063	0.0187	0.0187
Schistosoma mansoni	short chain dehydrogenase	0.0086	0.0267	0.0216
Brugia malayi	CXXC zinc finger family protein	0.0029	0.0069	0.0411
Loa Loa (eye worm)	oxidoreductase	0.0086	0.0267	0.0267
Trichomonas vaginalis	hydroxyacyl dehydrogenase, putative	0.0086	0.0267	1
Echinococcus granulosus	dual specificity	0.0091	0.0284	0.0284
Echinococcus multilocularis	epidermal retinal dehydrogenase 2	0.0086	0.0267	0.0267
Mycobacterium leprae	PROBABLE PHOSPHOGLYCERATE MUTASE (PHOSPHOGLYCEROMUTASE)	0.0049	0.0139	0.408
Echinococcus multilocularis	sex peptide receptor	0.0024	0.0052	0.0052
Leishmania major	serine/threonine-protein kinase, putative,protein kinase, putative	0.0091	0.0284	0.0234
Onchocerca volvulus	Dehydrogenase\/reductase SDR family member 13 homolog	0.0086	0.0267	0.0217
Echinococcus multilocularis	muscleblind protein 1	0.0148	0.0482	0.0482
Echinococcus granulosus	phosphoglycerate mutase	0.0049	0.0139	0.0139
Mycobacterium tuberculosis	Probable dehydrogenase/reductase	0.0086	0.0267	1
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.005	0.0141	0.0141
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0024	0.0052	0.0313
Schistosoma mansoni	short chain dehydrogenase	0.0086	0.0267	0.0216
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0052	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0052	0.0052
Onchocerca volvulus		0.0024	0.0052	0.0001
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0024	0.0052	0.0052
Toxoplasma gondii	hypothetical protein	0.005	0.0141	0.344
Schistosoma mansoni	short chain dehydrogenase	0.0086	0.0267	0.0216
Onchocerca volvulus		0.0024	0.0052	0.0001
Echinococcus granulosus	hypothetical protein	0.0086	0.0267	0.0267
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0052	0.0052
Echinococcus multilocularis	expressed conserved protein	0.0092	0.0287	0.0287
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0052	0.0052
Brugia malayi	hypothetical protein	0.0024	0.0052	0.0313
Brugia malayi	hypothetical protein	0.0024	0.0052	0.0313
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.005	0.0141	0.344
Leishmania major	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.2857	0.9831	0.983
Echinococcus multilocularis	phosphoglycerate mutase	0.0049	0.0139	0.0139
Loa Loa (eye worm)	dehydrogenase	0.0086	0.0267	0.0267
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.124	0.425	0.4169
Echinococcus multilocularis	phosphoglycerate mutase	0.0049	0.0139	0.0139
Onchocerca volvulus		0.0093	0.0291	0.0241
Loa Loa (eye worm)	hypothetical protein	0.2906	1	1
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0052	0.0052
Echinococcus granulosus	g protein coupled receptor	0.0024	0.0052	0.0052
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0024	0.0052	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0267	0.0267
Onchocerca volvulus		0.0292	0.0978	0.0931
Loa Loa (eye worm)	melatonin receptor type 1A	0.0024	0.0052	0.0052
Entamoeba histolytica	phosphoglycerate mutase family protein, putative	0.1715	0.5889	1
Echinococcus granulosus	carbonyl reductase 1	0.0086	0.0267	0.0267
Entamoeba histolytica	hypothetical protein	0.0086	0.0267	0.037
Onchocerca volvulus		0.0086	0.0267	0.0217
Mycobacterium leprae	PROBABLE PHOSPHOGLYCERATE MUTASE 1 GPM1 (PHOSPHOGLYCEROMUTASE) (PGAM) (BPG-DEPENDENT PGAM)	0.0049	0.0139	0.408
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0086	0.0267	0.1601
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0024	0.0052	0.0052
Mycobacterium tuberculosis	PE-PGRS family protein PE_PGRS11	0.0049	0.0139	0.4669
Brugia malayi	phosphoglycerate mutase family protein	0.0049	0.0139	0.0835
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0086	0.0267	1
Leishmania major	phosphoglycerate mutase, putative	0.0049	0.0139	0.0088
Echinococcus multilocularis	retinol dehydrogenase 11	0.0086	0.0267	0.0267
Echinococcus multilocularis	6 phosphofructo 2 kinase:fructose 2	0.2906	1	1
Echinococcus granulosus	retinol dehydrogenase 11	0.0086	0.0267	0.0267
Plasmodium vivax	hypothetical protein, conserved	0.003	0.0075	0.1872
Echinococcus multilocularis	carbonyl reductase 1	0.0086	0.0267	0.0267
Schistosoma mansoni	steroid dehydrogenase	0.0086	0.0267	0.0216
Onchocerca volvulus		0.003	0.0075	0.0024
Toxoplasma gondii	phosphoglycerate mutase family protein	0.0049	0.0139	0.3349
Schistosoma mansoni	short chain dehydrogenase	0.0086	0.0267	0.0216
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0187	0.0135
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0052	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0031	0.003
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0031	0.003
Onchocerca volvulus		0.0024	0.0052	0.0001
Plasmodium vivax	hypothetical protein, conserved	0.0086	0.0267	1
Trypanosoma cruzi	3-ketoacyl-CoA reductase, putative	0.0086	0.0267	0.013
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.0091	0.0284	0.0147
Echinococcus multilocularis	muscleblind protein	0.0148	0.0482	0.0482
Entamoeba histolytica	protein kinase, putative	0.0091	0.0284	0.0399
Plasmodium vivax	hypothetical protein, conserved	0.005	0.0141	0.4668
Mycobacterium ulcerans	dehydrogenase/decarboxylase protein	0.0086	0.0267	0.0403
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.0093	0.0093
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0086	0.0267	0.1601
Trypanosoma cruzi	hypothetical protein, conserved	0.0086	0.0267	0.013
Echinococcus granulosus	Niemann Pick C1 protein	0.0098	0.0307	0.0307
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0024	0.0052	0.0052
Schistosoma mansoni	carbonyl reductase	0.0086	0.0267	0.0216
Echinococcus granulosus	carbonyl reductase 1	0.0086	0.0267	0.0267
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0139	0.0139
Mycobacterium tuberculosis	Possible hydrolase MutT1	0.0049	0.0139	0.4669
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0086	0.0267	0.1601
Echinococcus granulosus	cdgsh iron sulfur domain containing protein	0.0505	0.1711	0.1711
Trypanosoma cruzi	hypothetical protein, conserved	0.0086	0.0267	0.013
Schistosoma mansoni	short chain dehydrogenase	0.0086	0.0267	0.0216
Trypanosoma cruzi	short-chain dehydrogenase, putative	0.0086	0.0267	0.013
Loa Loa (eye worm)	CAMK/PIM protein kinase	0.0492	0.1668	0.1667
Plasmodium falciparum	amino acid transporter, putative	0.005	0.0141	0.4668
Echinococcus granulosus	hypothetical protein	0.0086	0.0267	0.0267
Echinococcus multilocularis	phosphoglycerate mutase	0.0049	0.0139	0.0139
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0024	0.0052	0.0052
Mycobacterium ulcerans	short chain dehydrogenase	0.0086	0.0267	0.0403
Echinococcus granulosus	rhodopsin orphan GPCR	0.0024	0.0052	0.0052
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0086	0.0267	1
Plasmodium falciparum	steroid dehydrogenase, putative	0.0086	0.0267	1
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0024	0.0052	0.0052
Leishmania major	3-keto-dihydrosphingosine reductase	0.0086	0.0267	0.0217
Mycobacterium tuberculosis	Decaprenylphosphoryl-D-2-keto erythro pentose reductase	0.0086	0.0267	1
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0024	0.0052	0.0052
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0086	0.0267	1
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0052	0.0052
Onchocerca volvulus		0.0086	0.0267	0.0217
Brugia malayi	CHE-14 protein	0.0042	0.0115	0.0688
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0086	0.0267	1
Echinococcus granulosus	neuropeptide Y receptor	0.0024	0.0052	0.0052
Leishmania major	short chain dehydrogenase/reductase, putative	0.0086	0.0267	0.0217
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0086	0.0267	0.0217
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0086	0.0267	0.1601
Leishmania major	fructose-6-phosphate2-kinase/fructose-2,6-bisph os phatase-likeprotein	0.0049	0.0139	0.0088
Onchocerca volvulus		0.2906	1	1
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0267	0.0267
Mycobacterium ulcerans	short chain dehydrogenase	0.0086	0.0267	0.0403
Echinococcus multilocularis	estradiol 17 beta dehydrogenase 12	0.0086	0.0267	0.0267
Mycobacterium tuberculosis	Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1	0.0086	0.0267	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0024	0.0052	0.0052
Mycobacterium ulcerans	short chain dehydrogenase	0.0086	0.0267	0.0403
Schistosoma mansoni	short-chain dehydrogenase/reductase	0.0086	0.0267	0.0216
Echinococcus granulosus	biogenic amine 5HT receptor	0.0024	0.0052	0.0052
Onchocerca volvulus		0.0024	0.0052	0.0001
Brugia malayi	Protein kinase domain containing protein	0.0492	0.1668	1
Loa Loa (eye worm)	hypothetical protein	0.005	0.0141	0.0141
Schistosoma mansoni	sodium-dependent amino acid transporter	0.005	0.0141	0.0089
Echinococcus multilocularis	allatostatin A receptor	0.0024	0.0052	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0052	0.0052
Echinococcus multilocularis	3 ketodihydrosphingosine reductase	0.0086	0.0267	0.0267
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0024	0.0052	0.0052
Echinococcus multilocularis	neuropeptide Y receptor	0.0024	0.0052	0.0052
Leishmania major	short chain dehydrogenase, putative	0.0086	0.0267	0.0217
Echinococcus multilocularis	protein dispatched 1	0.0048	0.0135	0.0135
Onchocerca volvulus		0.0024	0.0052	0.0001
Echinococcus multilocularis	serotonin transporter	0.0292	0.0978	0.0977
Trypanosoma cruzi	3-keto-dihydrosphingosine reductase	0.0086	0.0267	0.013
Echinococcus granulosus	Niemann Pick C1 protein	0.014	0.0452	0.0452
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0052	0.0052
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0024	0.0052	0.0052
Echinococcus multilocularis	somatostatin receptor	0.0024	0.0052	0.0052
Mycobacterium ulcerans	short chain dehydrogenase	0.0086	0.0267	0.0403
Entamoeba histolytica	protein kinase, putative	0.0091	0.0284	0.0399
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0052	0.0052
Mycobacterium ulcerans	dehydrogenase/reductase	0.0086	0.0267	0.0403
Mycobacterium ulcerans	fructose-2,6-bisphosphatase GpmB	0.1715	0.5889	1
Onchocerca volvulus		0.005	0.0141	0.009
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0052	0.0052
Echinococcus multilocularis	sodium and chloride dependent glycine	0.005	0.0141	0.0141
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0086	0.0267	0.0403
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.005	0.0141	0.0089
Chlamydia trachomatis	2,3-bisphosphoglycerate-dependent phosphoglycerate mutase	0.0049	0.0139	0.9842
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0086	0.0267	0.1601
Loa Loa (eye worm)	hypothetical protein	0.003	0.0075	0.0074
Trichomonas vaginalis	phosphoglycerate mutase, putative	0.0049	0.0139	0.1608
Mycobacterium ulcerans	short chain dehydrogenase	0.0086	0.0267	0.0403
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0274	0.0274
Mycobacterium ulcerans	phosphohistidine phosphatase SixA	0.0049	0.0139	0.0185
Leishmania major	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.2906	1	1
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0267	0.0267
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0024	0.0051	0.0035
Echinococcus multilocularis	serotonin receptor	0.0024	0.0052	0.0052
Echinococcus multilocularis	g-protein coupled receptor	0.0024	0.0052	0.0052
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.124	0.425	0.4169
Brugia malayi	hypothetical protein	0.0024	0.0052	0.0313
Toxoplasma gondii	3-ketoacyl-CoA reductase, putative	0.0086	0.0267	1
Trichomonas vaginalis	phosphoglycerate mutase, putative	0.0049	0.0139	0.1608
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0063	0.0187	0.0187
Onchocerca volvulus		0.0086	0.0267	0.0217
Brugia malayi	Niemann-Pick C1 protein precursor	0.0098	0.0307	0.1843
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0052	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0051	0.0051
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0086	0.0267	0.0403
Mycobacterium leprae	probable isochorismate synthase EntC	0.0049	0.0139	0.408
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0052	0.0052
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0086	0.0267	0.1601
Trichomonas vaginalis	conserved hypothetical protein	0.0049	0.0139	0.1608
Mycobacterium ulcerans	phosphoglyceromutase	0.0049	0.0139	0.0185
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0024	0.0052	0.0052
Entamoeba histolytica	hypothetical protein	0.0036	0.0093	0.0072
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0086	0.0267	0.013
Loa Loa (eye worm)	neuropeptide F receptor	0.0024	0.0052	0.0052
Echinococcus multilocularis	fmrfamide receptor	0.0024	0.0052	0.0052
Loa Loa (eye worm)	neuropeptide F receptor	0.0024	0.0052	0.0052
Trypanosoma cruzi	beta-ketoacyl-ACP reductase 2, putative	0.0086	0.0267	0.013
Mycobacterium ulcerans	short chain dehydrogenase	0.0086	0.0267	0.0403
Brugia malayi	Dopamine receptor protein 1	0.0024	0.0052	0.0313
Brugia malayi	ORL1-like opioid receptor	0.0024	0.0052	0.0313
Mycobacterium tuberculosis	Possible phosphoglycerate mutase Gpm2 (phosphoglyceromutase) (PGAM) (BPG-dependent PGAM)	0.0049	0.0139	0.4669
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0086	0.0267	0.1601
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0024	0.0052	0.0313
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0267	0.0267
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.005	0.0141	0.0845
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0024	0.0051	0.0996
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0031	0.003
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0052	0.0052
Loa Loa (eye worm)	oxidoreductase	0.0086	0.0267	0.0267
Mycobacterium tuberculosis	Probable short-chain type oxidoreductase	0.0086	0.0267	1
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0052	0.0052
Brugia malayi	RE15519p	0.0024	0.0052	0.0313
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.005	0.0141	0.0141
Onchocerca volvulus		0.0086	0.0267	0.0217
Echinococcus granulosus	rhodopsin orphan GPCR	0.0024	0.0052	0.0052
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0086	0.0267	0.1601
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0051	0.0035
Mycobacterium tuberculosis	Conserved protein	0.0049	0.0139	0.4669
Echinococcus granulosus	neuropeptides capa receptor	0.0024	0.0052	0.0052
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0099	0.0313	0.0262
Mycobacterium ulcerans	short chain dehydrogenase	0.0086	0.0267	0.0403
Trypanosoma cruzi	6-phosphofructo-2-kinase 1	0.2857	0.9831	0.9828
Mycobacterium tuberculosis	Conserved protein	0.0049	0.0139	0.4669
Echinococcus multilocularis	tar DNA binding protein	0.0063	0.0187	0.0187
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0052	0.0052
Brugia malayi	hypothetical protein	0.0024	0.0052	0.0313
Schistosoma mansoni	phosphoglycerate mutase	0.0049	0.0139	0.0087
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0086	0.0267	1
Onchocerca volvulus	Dehydrogenase\/reductase SDR family member 1 homolog	0.0086	0.0267	0.0217
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.0091	0.0284	0.0147
Entamoeba histolytica	phosphoglycerate mutase family protein, putative	0.0049	0.0139	0.0151
Loa Loa (eye worm)	hypothetical protein	0.005	0.0141	0.0141
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0024	0.0052	0.0052
Brugia malayi	Uncharacterized hematopoietic stem/progenitor cells protein MDS029	0.0215	0.071	0.426
Entamoeba histolytica	estradiol 17-beta-dehydrogenase, putative	0.0086	0.0267	0.037
Schistosoma mansoni	hypothetical protein	0.004	0.0109	0.0058
Schistosoma mansoni	steroid dehydrogenase	0.0086	0.0267	0.0216
Plasmodium vivax	steroid dehydrogenase, putative	0.0086	0.0267	1
Brugia malayi	RE40412p	0.003	0.0075	0.0449
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0086	0.0267	0.0267
Mycobacterium ulcerans	short chain dehydrogenase	0.0086	0.0267	0.0403
Mycobacterium tuberculosis	Glucosyl-3-phosphoglycerate phosphatase GpgP	0.0049	0.0139	0.4669
Brugia malayi	hypothetical protein	0.0024	0.0052	0.0313
Loa Loa (eye worm)	hypothetical protein	0.005	0.0141	0.0141
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0086	0.0267	1
Trypanosoma brucei	CMGC/DYRK protein kinase, putative	0.0091	0.0284	0.0147
Echinococcus granulosus	rhodopsin orphan GPCR	0.0024	0.0052	0.0052
Brugia malayi	G-protein coupled receptor	0.0024	0.0052	0.0313
Mycobacterium ulcerans	short chain dehydrogenase	0.0086	0.0267	0.0403
Trypanosoma cruzi	hypothetical protein, conserved	0.0086	0.0267	0.013
Leishmania major	phosphoglycerate mutase protein, putative	0.0049	0.0139	0.0088
Trypanosoma cruzi	hypothetical protein, conserved	0.0086	0.0267	0.013
Brugia malayi	G-protein coupled receptor	0.0024	0.0052	0.0313
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0049	0.0139	0.4669
Mycobacterium ulcerans	oxidoreductase	0.0086	0.0267	0.0403
Trichomonas vaginalis	phosphoglycerate mutase, putative	0.0049	0.0139	0.1608
Leishmania major	dehydrogenase-like protein	0.0086	0.0267	0.0217
Brugia malayi	D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor	0.0086	0.0267	0.1601
Brugia malayi	hypothetical protein	0.0024	0.0052	0.0313
Echinococcus multilocularis	neuropeptides capa receptor	0.0024	0.0052	0.0052
Brugia malayi	Protein kinase domain containing protein	0.0091	0.0284	0.1703
Echinococcus multilocularis	dro:myosuppressin receptor	0.0024	0.0052	0.0052
Leishmania major	short chain dehydrogenase-like protein	0.0086	0.0267	0.0217
Echinococcus multilocularis	steroid dehydrogenase	0.0086	0.0267	0.0267
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0052	0.0052
Onchocerca volvulus		0.0024	0.0052	0.0001
Mycobacterium ulcerans	short-chain membrane-associated dehydrogenase	0.0086	0.0267	0.0403
Onchocerca volvulus		0.0024	0.0052	0.0001
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0024	0.0052	0.0052
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0086	0.0267	0.013
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0052	0.0052
Brugia malayi	larval opioid receptor	0.0024	0.0052	0.0313
Mycobacterium ulcerans	hypothetical protein	0.1715	0.5889	1
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0052	0.0052
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0086	0.0267	1
Mycobacterium leprae	Possible phosphoglycerate mutase	0.0049	0.0139	0.408
Brugia malayi	dehydrogenases, short chain protein 2	0.0086	0.0267	0.1601
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0292	0.0978	0.093
Trichomonas vaginalis	short-chain dehydrogenases/reductase, putative	0.0086	0.0267	1
Echinococcus multilocularis	conserved hypothetical protein	0.003	0.0075	0.0074
Leishmania major	hypothetical protein, conserved	0.0086	0.0267	0.0217
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0098	0.0307	0.0439
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0052	0.0052
Entamoeba histolytica	phosphoglycerate mutase family protein, putative	0.0049	0.0139	0.0151
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0024	0.0052	0.0052
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0086	0.0267	0.0403
Brugia malayi	RE40412p	0.003	0.0075	0.0449
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0054	0.0157	0.4272
Brugia malayi	Dehydrogenases, short chain protein 2	0.0086	0.0267	0.1601
Loa Loa (eye worm)	hypothetical protein	0.005	0.0141	0.0141
Giardia lamblia	Hypothetical protein	0.1715	0.5889	1
Trichomonas vaginalis	conserved hypothetical protein	0.0049	0.0139	0.1608
Loa Loa (eye worm)	hypothetical protein	0.2857	0.9831	0.9831
Schistosoma mansoni	carbonyl reductase	0.0086	0.0267	0.0216
Echinococcus granulosus	sodium and chloride dependent glycine	0.005	0.0141	0.0141
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0024	0.0051	0.0996
Mycobacterium ulcerans	short chain dehydrogenase	0.0086	0.0267	0.0403
Echinococcus granulosus	serotonin receptor	0.0024	0.0052	0.0052
Loa Loa (eye worm)	oxidoreductase	0.0086	0.0267	0.0267
Mycobacterium ulcerans	short chain dehydrogenase	0.0086	0.0267	0.0403
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0086	0.0267	0.0403
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0052	0.0052
Plasmodium falciparum	phosphoglycerate mutase, putative	0.0049	0.0139	0.4594
Mycobacterium ulcerans	acid phosphatase	0.0049	0.0139	0.0185
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0267	0.0267
Brugia malayi	putative neuropeptide receptor	0.0024	0.0052	0.0313
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0052	0.0052
Brugia malayi	Muscleblind-like protein	0.0148	0.0482	0.289
Trichomonas vaginalis	phosphoglycerate mutase, putative	0.0049	0.0139	0.1608
Echinococcus multilocularis	carbonyl reductase 1	0.0086	0.0267	0.0267
Onchocerca volvulus		0.0086	0.0267	0.0217
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.005	0.0141	0.0141
Echinococcus granulosus	tm gpcr rhodopsin	0.0024	0.0052	0.0052
Plasmodium vivax	phosphoglycerate mutase, putative	0.0049	0.0139	0.4594
Echinococcus multilocularis	conserved hypothetical protein	0.0086	0.0267	0.0267
Entamoeba histolytica	phosphoglycerate mutase family protein. putative	0.0049	0.0139	0.0151
Echinococcus multilocularis	Niemann Pick C1 protein	0.0098	0.0307	0.0307
Entamoeba histolytica	protein kinase domain containing protein	0.0091	0.0284	0.0399
Mycobacterium tuberculosis	Possible ketoacyl reductase	0.0086	0.0267	1
Mycobacterium ulcerans	ketoacyl reductase	0.0086	0.0267	0.0403
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0024	0.0052	0.0313
Brugia malayi	hypothetical protein	0.005	0.0141	0.0845
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0086	0.0267	0.1601
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0024	0.0052	0.0052
Echinococcus multilocularis	carbonyl reductase 1	0.0086	0.0267	0.0267
Echinococcus multilocularis	neuropeptide receptor	0.0024	0.0052	0.0052
Loa Loa (eye worm)	phosphoglycerate mutase	0.0049	0.0139	0.0139
Toxoplasma gondii	carbonyl reductase 1, putative	0.0086	0.0267	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0086	0.0267	0.0403
Echinococcus multilocularis	carbonyl reductase 1	0.0086	0.0267	0.0267
Echinococcus multilocularis	phosphoglycerate mutase	0.0049	0.0139	0.0139
Schistosoma mansoni	hypothetical protein	0.0407	0.1376	0.1331
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0086	0.0267	0.013
Schistosoma mansoni	steroid dehydrogenase	0.0086	0.0267	0.0216
Schistosoma mansoni	hypothetical protein	0.004	0.0109	0.0058
Entamoeba histolytica	oxidoreductase, short chain dehydrogenase/reductase family	0.0086	0.0267	0.037
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0292	0.0978	0.0977
Toxoplasma gondii	phosphoglycerate mutase PGMII	0.0049	0.0139	0.3349
Brugia malayi	UBASH3A protein homolog	0.0049	0.0139	0.0835
Echinococcus multilocularis	cpg binding protein	0.003	0.0074	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0052	0.0052
Mycobacterium ulcerans	hypothetical protein	0.0024	0.0051	0.0035
Onchocerca volvulus		0.0086	0.0267	0.0217

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 21 nM	Displacement of [3H]-hydroxytryptamine from human SERT expressed in CHO cells by TopCounting analysis	ChEMBL.	23769168
IC50 (binding)	= 44 nM	Displacement of [3H]-norepinephrine from human NET expressed in CHO cells by TopCounting analysis	ChEMBL.	23769168
IC50 (binding)	= 180 nM	Displacement of [3H]-dopamine from human DAT expressed in CHO cells by TopCounting analysis	ChEMBL.	23769168
Inhibition (ADMET)	= 11 %	Inhibition of CYP2D6 (unknown origin) assessed as 1'-hydroxybufuralol production at 10 uM after 20 mins by LC/MS/MS analysis relative to control	ChEMBL.	23769168
Inhibition (binding)	= 40 %	Inhibition of human ERG channel at 10 uM by ionworks assay relative to control	ChEMBL.	23769168
MED (functional)	= 30 mg kg-1	Antidepressant activity in orally dosed ICR mouse after 60 mins by tail suspension test	ChEMBL.	23769168

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2407325

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1771141