TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 568.706 | Formula: C34H40N4O4
H donors: 3 H acceptors: 3 LogP: 5.38 Rotable bonds: 9
Rule of 5 violations (Lipinski): 2
SMILES: CC(C[C@@H](C(=O)N[C@@H]1C(=O)N[C@@H](Cc2ccccc2)C(=O)N/C=C\c2ccc(O[C@H]1c1ccccc1)cc2)N(C)C)C
InChi: 1S/C34H40N4O4/c1-23(2)21-29(38(3)4)33(40)37-30-31(26-13-9-6-10-14-26)42-27-17-15-24(16-18-27)19-20-35-32(39)28(36-34(30)41)22-25-11-7-5-8-12-25/h5-20,23,28-31H,21-22H2,1-4H3,(H,35,39)(H,36,41)(H,37,40)/b20-19-/t28-,29-,30-,31-/m0/s1
InChiKey: NAMLDTWANUOXLT-WLDNGRNGSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	protein arginine N methyltransferase 5	0.1566	0.3354	0.3187
Echinococcus multilocularis	tensin	0.1125	0.2328	0.2135
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0762	0.1483	0.1268
Brugia malayi	SH2 domain containing protein	0.1125	0.2328	0.2135
Schistosoma mansoni	protein kinase	0.0762	0.1483	0.1483
Onchocerca volvulus		0.0762	0.1483	0.2898
Onchocerca volvulus		0.0762	0.1483	0.2898
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.1888	0.4102	0.3953
Schistosoma mansoni	tyrosine kinase	0.0762	0.1483	0.1483
Loa Loa (eye worm)	hypothetical protein	0.0762	0.1483	0.1268
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0762	0.1483	0.1268
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.1888	0.4102	0.3953
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0762	0.1483	0.1268
Loa Loa (eye worm)	TK protein kinase	0.0762	0.1483	0.1268
Loa Loa (eye worm)	hypothetical protein	0.0762	0.1483	0.1268
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.0762	0.1483	0.2898
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.1125	0.2328	0.2135
Giardia lamblia	Protein 21.1	0.0762	0.1483	0.5
Schistosoma mansoni	vav2	0.1125	0.2328	0.2328
Echinococcus multilocularis	protein kinase	0.0762	0.1483	0.1268
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.1125	0.2328	0.2135
Schistosoma mansoni	tensin	0.1125	0.2328	0.2328
Schistosoma mansoni	Protein orai-1	0.4422	1	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0762	0.1483	0.1268
Loa Loa (eye worm)	TK/ROR protein kinase	0.0762	0.1483	0.1268
Echinococcus granulosus	SH2 domain containing adapter protein F	0.1125	0.2328	0.2135
Loa Loa (eye worm)	TK/DDR protein kinase	0.0762	0.1483	0.1268
Giardia lamblia	Kinase, NEK	0.0762	0.1483	0.5
Echinococcus multilocularis	tyrosine protein kinase csk	0.0762	0.1483	0.1268
Brugia malayi	Protein kinase domain containing protein	0.0762	0.1483	0.1268
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0762	0.1483	0.1268
Echinococcus granulosus	tyrosine protein kinase	0.0762	0.1483	0.1268
Schistosoma mansoni	protein tyrosine kinase	0.0762	0.1483	0.1483
Brugia malayi	SH2 domain containing protein	0.1888	0.4102	0.3953
Echinococcus multilocularis	FL cytokine receptor	0.0762	0.1483	0.1268
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0762	0.1483	0.1268
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.1125	0.2328	0.2135
Schistosoma mansoni	tyrosine kinase	0.0762	0.1483	0.1483
Echinococcus multilocularis	tyrosine protein kinase csk	0.0762	0.1483	0.1268
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0762	0.1483	0.1268
Echinococcus granulosus	protein arginine N methyltransferase 5	0.1566	0.3354	0.3187
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0762	0.1483	0.1268
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.1125	0.2328	0.2135
Loa Loa (eye worm)	TK/FER protein kinase	0.0762	0.1483	0.1268
Schistosoma mansoni	hypothetical protein	0.1125	0.2328	0.2328
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0762	0.1483	0.1268
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0762	0.1483	0.1483
Onchocerca volvulus		0.1888	0.4102	1
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.1125	0.2328	0.2135
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0762	0.1483	0.1268
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0762	0.1483	0.1268
Schistosoma mansoni	hypothetical protein	0.1125	0.2328	0.2328
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.1125	0.2328	0.2135
Schistosoma mansoni	tyrosine kinase	0.0762	0.1483	0.1483
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0762	0.1483	0.1268
Loa Loa (eye worm)	TK/FER protein kinase	0.1888	0.4102	0.3953
Brugia malayi	C-terminal src kinase protein 1	0.0762	0.1483	0.1268
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0762	0.1483	0.1268
Schistosoma mansoni	growth factor receptor-bound protein	0.1125	0.2328	0.2328
Plasmodium falciparum	tyrosine kinase-like protein	0.078	0.1525	0.0227
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.1888	0.4102	0.3953
Schistosoma mansoni	tyrosine kinase	0.0762	0.1483	0.1483
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0762	0.1483	0.1268
Echinococcus granulosus	epidermal growth factor receptor	0.0762	0.1483	0.1268
Brugia malayi	Protein kinase domain containing protein	0.0762	0.1483	0.1268
Loa Loa (eye worm)	TK/FER protein kinase	0.1888	0.4102	0.3953
Echinococcus granulosus	receptor type guanylyl cyclase	0.0762	0.1483	0.1268
Brugia malayi	Protein kinase domain containing protein	0.0762	0.1483	0.1268
Onchocerca volvulus		0.1125	0.2328	0.5191
Loa Loa (eye worm)	TK/CSK protein kinase	0.0762	0.1483	0.1268
Schistosoma mansoni	signal transduction protein lnk-related	0.1125	0.2328	0.2328
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.1125	0.2328	0.2328
Echinococcus multilocularis		0.1125	0.2328	0.2135
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.1888	0.4102	0.3953
Schistosoma mansoni	tyrosine kinase	0.0762	0.1483	0.1483
Echinococcus granulosus	tyrosine protein kinase Lyn	0.1888	0.4102	0.3953
Brugia malayi	Protein kinase domain containing protein	0.1888	0.4102	0.3953
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0762	0.1483	0.1268
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.1888	0.4102	0.3953
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.1888	0.4102	0.3953
Schistosoma mansoni	tyrosine kinase	0.0762	0.1483	0.1483
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.1125	0.2328	0.2135
Echinococcus multilocularis	tyrosine kinase	0.0762	0.1483	0.1268
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0762	0.1483	0.1268
Echinococcus multilocularis	tyrosine protein kinase	0.0762	0.1483	0.1268
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0762	0.1483	0.1268
Brugia malayi	Protein kinase domain containing protein	0.0762	0.1483	0.1268
Schistosoma mansoni	suppressor of cytokine signaling	0.1125	0.2328	0.2328
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.1888	0.4102	0.3953
Schistosoma mansoni	SH2A	0.1125	0.2328	0.2328
Onchocerca volvulus		0.1888	0.4102	1
Schistosoma mansoni	serine/threonine RGC	0.0762	0.1483	0.1483
Echinococcus multilocularis	SHC transforming protein 3	0.1125	0.2328	0.2135
Schistosoma mansoni	tyrosine kinase	0.0762	0.1483	0.1483
Schistosoma mansoni	tyrosine protein kinase	0.0762	0.1483	0.1483
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0762	0.1483	0.1268
Loa Loa (eye worm)	hypothetical protein	0.0762	0.1483	0.1268
Brugia malayi	protein-tyrosine kinase	0.1888	0.4102	0.3953
Echinococcus multilocularis	tyrosine protein kinase Blk	0.1888	0.4102	0.3953
Brugia malayi	Protein kinase domain containing protein	0.0762	0.1483	0.1268
Schistosoma mansoni	ephrin receptor	0.0762	0.1483	0.1483
Onchocerca volvulus		0.1888	0.4102	1
Brugia malayi	Protein kinase domain containing protein	0.0762	0.1483	0.1268
Echinococcus granulosus	tyrosine protein kinase Src42A	0.1888	0.4102	0.3953
Brugia malayi	Tyrosine-protein kinase abl-1	0.1888	0.4102	0.3953
Echinococcus multilocularis	SH2 motif	0.1125	0.2328	0.2135
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.1125	0.2328	0.2135
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0762	0.1483	0.1268
Echinococcus multilocularis	epidermal growth factor receptor	0.0762	0.1483	0.1268
Echinococcus multilocularis	epidermal growth factor receptor	0.0762	0.1483	0.1268
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0762	0.1483	0.1268
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0762	0.1483	0.1268
Echinococcus granulosus	natriuretic peptide receptor 1	0.0762	0.1483	0.1268
Schistosoma mansoni	tyrosine kinase	0.0762	0.1483	0.1483
Brugia malayi	Protein kinase domain containing protein	0.0762	0.1483	0.1268
Brugia malayi	SH2 domain containing protein	0.1125	0.2328	0.2135
Schistosoma mansoni	tyrosine kinase	0.0762	0.1483	0.1483
Loa Loa (eye worm)	TK protein kinase	0.0762	0.1483	0.1268
Echinococcus multilocularis	protein kinase	0.0762	0.1483	0.1268
Echinococcus granulosus	ephrin type A receptor 4 A	0.0762	0.1483	0.1268
Loa Loa (eye worm)	TK/FER protein kinase	0.0762	0.1483	0.1268
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0762	0.1483	0.1483
Schistosoma mansoni	protein kinase	0.0762	0.1483	0.1483
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0762	0.1483	0.1268
Echinococcus granulosus	signal transduction protein lnk realted	0.1125	0.2328	0.2135
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0762	0.1483	0.1268
Echinococcus multilocularis	heat shock protein 70	0.0762	0.1483	0.1268
Echinococcus granulosus	tensin	0.1125	0.2328	0.2135
Echinococcus granulosus	tyrosine kinase	0.0762	0.1483	0.1268
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0762	0.1483	0.1268
Echinococcus granulosus	tyrosine protein kinase Blk	0.1888	0.4102	0.3953
Loa Loa (eye worm)	TK protein kinase	0.1888	0.4102	0.3953
Loa Loa (eye worm)	hypothetical protein	0.1125	0.2328	0.2135
Echinococcus multilocularis	SH2 motif	0.1125	0.2328	0.2135
Brugia malayi	hypothetical protein	0.0762	0.1483	0.1268
Loa Loa (eye worm)	TK/FER protein kinase	0.0762	0.1483	0.1268
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.1888	0.4102	1
Schistosoma mansoni	adapter molecule crk	0.1125	0.2328	0.2328
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0762	0.1483	0.1268
Echinococcus granulosus	tyrosine protein kinase Srms	0.1888	0.4102	0.3953
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.1125	0.2328	0.2135
Brugia malayi	Protein kinase domain containing protein	0.0762	0.1483	0.1268
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0762	0.1483	0.1483
Brugia malayi	Protein kinase domain containing protein	0.0762	0.1483	0.1268
Trypanosoma brucei	arginine N-methyltransferase, type II	0.1003	0.2044	1
Loa Loa (eye worm)	hypothetical protein	0.1125	0.2328	0.2135
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.1888	0.4102	0.3953
Schistosoma mansoni	serine/threonine protein kinase	0.0762	0.1483	0.1483
Loa Loa (eye worm)	hypothetical protein	0.1125	0.2328	0.2135
Brugia malayi	Protein kinase domain containing protein	0.0762	0.1483	0.1268
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0762	0.1483	0.2898
Loa Loa (eye worm)	hypothetical protein	0.0762	0.1483	0.1268
Loa Loa (eye worm)	TK protein kinase	0.0762	0.1483	0.1268
Loa Loa (eye worm)	TK protein kinase	0.0762	0.1483	0.1268
Schistosoma mansoni	tyrosine kinase	0.1888	0.4102	0.4102
Brugia malayi	Skb1 methyltransferase family protein	0.1566	0.3354	0.3187
Loa Loa (eye worm)	TK protein kinase	0.0762	0.1483	0.1268
Brugia malayi	Furin-like cysteine rich region family protein	0.0762	0.1483	0.1268
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0762	0.1483	0.1268
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.1888	0.4102	0.3953
Schistosoma mansoni	protein kinase	0.0762	0.1483	0.1483
Trypanosoma cruzi	arginine N-methyltransferase, type II, putative	0.1003	0.2044	1
Echinococcus granulosus	SH2 motif	0.1125	0.2328	0.2135
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.1888	0.4102	0.3953
Loa Loa (eye worm)	hypothetical protein	0.0762	0.1483	0.1268
Brugia malayi	SH2 domain containing protein	0.1125	0.2328	0.2135
Echinococcus multilocularis	integrin linked protein kinase	0.0762	0.1483	0.1268
Loa Loa (eye worm)	Skb1 methyltransferase	0.1566	0.3354	0.3187
Schistosoma mansoni	ephrin receptor	0.0762	0.1483	0.1483
Onchocerca volvulus		0.0762	0.1483	0.2898
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0762	0.1483	0.1268
Loa Loa (eye worm)	serine/threonine protein kinase	0.0762	0.1483	0.1268
Schistosoma mansoni	tyrosine kinase	0.0762	0.1483	0.1483
Brugia malayi	Protein kinase domain containing protein	0.0762	0.1483	0.1268
Schistosoma mansoni	tensin-related	0.1125	0.2328	0.2328
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.1888	0.4102	0.3953
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0762	0.1483	0.1268
Loa Loa (eye worm)	SRC-1	0.1888	0.4102	0.3953
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.1888	0.4102	0.4102
Loa Loa (eye worm)	TK/FER protein kinase	0.0762	0.1483	0.1268
Echinococcus multilocularis	tyrosine kinase	0.1888	0.4102	0.3953
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0762	0.1483	0.1268
Schistosoma mansoni	tyrosine kinase	0.0762	0.1483	0.1483
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.1125	0.2328	0.2135
Loa Loa (eye worm)	TK/Met protein kinase	0.0762	0.1483	0.1268
Onchocerca volvulus		0.1125	0.2328	0.5191
Onchocerca volvulus		0.0762	0.1483	0.2898
Schistosoma mansoni	protein kinase	0.0762	0.1483	0.1483
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0762	0.1483	0.1268
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0762	0.1483	0.1268
Onchocerca volvulus		0.0762	0.1483	0.2898
Loa Loa (eye worm)	hypothetical protein	0.0762	0.1483	0.1268
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.1888	0.4102	0.3953
Schistosoma mansoni	tyrosine kinase	0.0762	0.1483	0.1483
Brugia malayi	Protein kinase domain containing protein	0.0762	0.1483	0.1268
Schistosoma mansoni	hypothetical protein	0.0762	0.1483	0.1483
Loa Loa (eye worm)	TK/FER protein kinase	0.1888	0.4102	0.3953
Brugia malayi	tRNA modification GTPase TrmE family protein	0.1125	0.2328	0.2135
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.1125	0.2328	0.3228
Giardia lamblia	Kinase, NEK	0.0762	0.1483	0.5
Echinococcus multilocularis	tyrosine protein kinase Abl	0.1888	0.4102	0.3953
Brugia malayi	RhoGAP domain containing protein	0.1125	0.2328	0.2135
Echinococcus granulosus	tyrosine protein kinase Src64B	0.1888	0.4102	0.3953
Brugia malayi	Protein kinase domain containing protein	0.1888	0.4102	0.3953
Loa Loa (eye worm)	TK/EPH protein kinase	0.0762	0.1483	0.1268
Loa Loa (eye worm)	TK/ABL protein kinase	0.1888	0.4102	0.3953
Schistosoma mansoni	serine/threonine protein kinase	0.0762	0.1483	0.1483
Loa Loa (eye worm)	TK protein kinase	0.0762	0.1483	0.1268
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0762	0.1483	0.1268
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.1125	0.2328	0.2328
Echinococcus multilocularis	tyrosine protein kinase shark	0.1888	0.4102	0.3953
Schistosoma mansoni	tyrosine kinase	0.0762	0.1483	0.1483
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0762	0.1483	0.1268
Echinococcus multilocularis	tyrosine protein kinase csk	0.0762	0.1483	0.1268
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0762	0.1483	0.1268
Echinococcus granulosus	tyrosine kinase	0.1888	0.4102	0.3953
Brugia malayi	Protein kinase domain containing protein	0.0762	0.1483	0.1268
Schistosoma mansoni	protein kinase	0.0762	0.1483	0.1483
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0762	0.1483	0.1483
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.1125	0.2328	0.2135
Loa Loa (eye worm)	hypothetical protein	0.1125	0.2328	0.2135
Loa Loa (eye worm)	TK/FER protein kinase	0.1888	0.4102	0.3953
Echinococcus granulosus	activated cdc42 kinase 1	0.0762	0.1483	0.1268
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0762	0.1483	0.1268
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0762	0.1483	0.1268
Plasmodium falciparum	protein arginine N-methyltransferase 5, putative	0.1566	0.3354	1
Onchocerca volvulus		0.0762	0.1483	0.2898
Brugia malayi	Protein kinase domain containing protein	0.1888	0.4102	0.3953
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.1888	0.4102	0.3953
Entamoeba histolytica	protein kinase, putative	0.1125	0.2328	0.3228
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0762	0.1483	0.1268
Loa Loa (eye worm)	TK/FER protein kinase	0.1888	0.4102	0.3953
Echinococcus granulosus	kinase suppressor of Ras 1	0.0762	0.1483	0.1268
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0762	0.1483	0.1268
Brugia malayi	hypothetical protein	0.0762	0.1483	0.1268
Loa Loa (eye worm)	hypothetical protein	0.1125	0.2328	0.2135
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.1125	0.2328	0.2135
Brugia malayi	SH2 domain containing protein	0.1125	0.2328	0.2135
Loa Loa (eye worm)	hypothetical protein	0.0762	0.1483	0.1268
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.1888	0.4102	0.3953
Loa Loa (eye worm)	TK/INSR protein kinase	0.0762	0.1483	0.1268
Echinococcus multilocularis	protein tyrosine kinase	0.0762	0.1483	0.1268
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.1125	0.2328	0.5191
Brugia malayi	Protein kinase domain containing protein	0.0762	0.1483	0.1268
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.1125	0.2328	0.2135
Onchocerca volvulus		0.1888	0.4102	1
Echinococcus granulosus	epidermal growth factor receptor	0.0762	0.1483	0.1268
Echinococcus multilocularis	NCK adaptor protein	0.1125	0.2328	0.2135
Loa Loa (eye worm)	hypothetical protein	0.0762	0.1483	0.1268
Echinococcus granulosus	integrin linked protein kinase	0.0762	0.1483	0.1268
Brugia malayi	Protein kinase domain containing protein	0.0762	0.1483	0.1268
Loa Loa (eye worm)	TK/FER protein kinase	0.1888	0.4102	0.3953
Loa Loa (eye worm)	TK/RYK protein kinase	0.0762	0.1483	0.1268
Loa Loa (eye worm)	TK/FER protein kinase	0.1888	0.4102	0.3953
Schistosoma mansoni	protein kinase	0.0762	0.1483	0.1483
Plasmodium vivax	protein arginine N-methyltransferase 5, putative	0.1566	0.3354	1
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0762	0.1483	0.1268
Schistosoma mansoni	shc transforming protein	0.1125	0.2328	0.2328
Brugia malayi	Tyrosine-protein kinase PR2	0.0762	0.1483	0.1268
Loa Loa (eye worm)	TK/ALK protein kinase	0.0762	0.1483	0.1268
Onchocerca volvulus		0.1888	0.4102	1
Brugia malayi	Tensin	0.1125	0.2328	0.2135
Schistosoma mansoni	tyrosine kinase	0.0762	0.1483	0.1483
Loa Loa (eye worm)	TK/FAK protein kinase	0.0762	0.1483	0.1268
Echinococcus granulosus	suppressor of cytokine signaling 6	0.1125	0.2328	0.2135
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.1125	0.2328	0.2328
Onchocerca volvulus		0.1125	0.2328	0.5191
Echinococcus granulosus	calcium release activated calcium channel	0.4422	1	1
Onchocerca volvulus		0.1125	0.2328	0.5191
Schistosoma mansoni	tyrosine kinase	0.0762	0.1483	0.1483
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.1125	0.2328	0.2135
Brugia malayi	Variant SH3 domain containing protein	0.1125	0.2328	0.2135
Brugia malayi	Protein kinase domain containing protein	0.0762	0.1483	0.1268
Brugia malayi	SRC-1	0.1888	0.4102	0.3953
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0762	0.1483	0.1268
Loa Loa (eye worm)	hypothetical protein	0.0762	0.1483	0.1268
Echinococcus granulosus	NCK adaptor protein	0.1125	0.2328	0.2135
Echinococcus granulosus	SHC transforming protein 3	0.1125	0.2328	0.2135
Loa Loa (eye worm)	hypothetical protein	0.4422	1	1
Schistosoma mansoni	serine/threonine protein kinase	0.0762	0.1483	0.1483
Onchocerca volvulus		0.1125	0.2328	0.5191
Leishmania major	arginine N-methyltransferase, type II, putative;with=GeneDB:Tb927.10.640	0.1003	0.2044	1
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.1125	0.2328	0.2135
Brugia malayi	Protein kinase domain containing protein	0.0762	0.1483	0.1268
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.1125	0.2328	0.2328
Echinococcus multilocularis	SH2 motif	0.1125	0.2328	0.2135
Brugia malayi	STAT protein, DNA binding domain containing protein	0.1125	0.2328	0.2135
Brugia malayi	cytokine inducible SH2-containing protein 5	0.1125	0.2328	0.2135
Trichomonas vaginalis	shk1 kinase-binding protein, putative	0.1003	0.2044	1
Echinococcus granulosus	activin receptor type	0.0762	0.1483	0.1268
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.1125	0.2328	0.2135
Brugia malayi	Protein kinase domain containing protein	0.1888	0.4102	0.3953
Brugia malayi	Variant SH3 domain containing protein	0.1125	0.2328	0.2135
Echinococcus granulosus	tyrosine protein kinase pr2	0.0762	0.1483	0.1268
Loa Loa (eye worm)	TK/FER protein kinase	0.1888	0.4102	0.3953
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0762	0.1483	0.1483
Echinococcus multilocularis	N chimaerin	0.1125	0.2328	0.2135
Schistosoma mansoni	suppressor of cytokine signaling	0.1125	0.2328	0.2328
Loa Loa (eye worm)	hypothetical protein	0.1125	0.2328	0.2135
Onchocerca volvulus		0.1125	0.2328	0.5191
Echinococcus granulosus	tyrosine protein kinase csk	0.0762	0.1483	0.1268
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.1888	0.4102	0.3953
Schistosoma mansoni	tensin	0.1125	0.2328	0.2328
Brugia malayi	SH2 domain containing protein	0.1125	0.2328	0.2135
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.1888	0.4102	0.3953
Echinococcus granulosus	raf serine:threonine protein kinase	0.0762	0.1483	0.1268
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0762	0.1483	0.1268
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0762	0.1483	0.1268
Loa Loa (eye worm)	TK/FER protein kinase	0.1888	0.4102	0.3953
Brugia malayi	integrin-linked kinase	0.0762	0.1483	0.1268
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0762	0.1483	0.1268
Loa Loa (eye worm)	TK protein kinase	0.0762	0.1483	0.1268
Brugia malayi	Guanylyl cyclase protein 23	0.0762	0.1483	0.1268
Trichomonas vaginalis	shk1 kinase-binding protein, putative	0.1003	0.2044	1
Echinococcus granulosus	tyrosine protein kinase HCK	0.0762	0.1483	0.1268
Schistosoma mansoni	tyrosine kinase	0.0762	0.1483	0.1483
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0762	0.1483	0.1268
Loa Loa (eye worm)	TK protein kinase	0.0762	0.1483	0.1268
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0762	0.1483	0.1268
Loa Loa (eye worm)	SH2 domain-containing protein	0.1125	0.2328	0.2135
Schistosoma mansoni	tyrosine kinase	0.1888	0.4102	0.4102
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0762	0.1483	0.1268
Entamoeba histolytica	SH2 domain containing protein	0.1125	0.2328	0.3228
Onchocerca volvulus		0.0762	0.1483	0.2898
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0762	0.1483	0.1268
Schistosoma mansoni	tyrosine kinase	0.0762	0.1483	0.1483
Echinococcus granulosus	growth factor receptor bound protein 2	0.1125	0.2328	0.2135
Loa Loa (eye worm)	hypothetical protein	0.0762	0.1483	0.1268
Echinococcus granulosus	SH2 motif	0.1125	0.2328	0.2135
Loa Loa (eye worm)	hypothetical protein	0.0762	0.1483	0.1268
Echinococcus granulosus	tyrosine protein kinase csk	0.0762	0.1483	0.1268
Schistosoma mansoni	tyrosine kinase	0.0762	0.1483	0.1483
Brugia malayi	Receptor family ligand binding region containing protein	0.0762	0.1483	0.1268
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.1125	0.2328	0.2135
Onchocerca volvulus		0.0762	0.1483	0.2898
Loa Loa (eye worm)	TK protein kinase	0.0762	0.1483	0.1268
Schistosoma mansoni	growth factor receptor-bound protein	0.1125	0.2328	0.2328
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0762	0.1483	0.1483
Onchocerca volvulus		0.0762	0.1483	0.2898
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.1125	0.2328	0.2328
Brugia malayi	Protein kinase domain containing protein	0.0762	0.1483	0.1268
Schistosoma mansoni	tyrosine kinase	0.0762	0.1483	0.1483
Echinococcus granulosus	tyrosine kinase	0.1888	0.4102	0.3953
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.1125	0.2328	0.5191
Loa Loa (eye worm)	TK/FER protein kinase	0.0762	0.1483	0.1268
Loa Loa (eye worm)	STAT protein	0.1125	0.2328	0.2135
Brugia malayi	SH2 domain containing protein	0.1125	0.2328	0.2135
Echinococcus granulosus	hypothetical protein	0.1125	0.2328	0.2135
Schistosoma mansoni	tensin-related	0.1125	0.2328	0.2328
Brugia malayi	hypothetical protein	0.1125	0.2328	0.2135
Schistosoma mansoni	Protein orai-1	0.4422	1	1
Schistosoma mansoni	tyrosine kinase	0.1888	0.4102	0.4102
Giardia lamblia	Kinase	0.0762	0.1483	0.5
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0762	0.1483	0.1268
Schistosoma mansoni	protein kinase	0.0762	0.1483	0.1483
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0762	0.1483	0.1268
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0762	0.1483	0.1268
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0762	0.1483	0.1268
Brugia malayi	Protein kinase domain containing protein	0.0762	0.1483	0.1268
Brugia malayi	Protein kinase domain containing protein	0.0762	0.1483	0.1268
Entamoeba histolytica	Skb1 methyltransferase, putative	0.1566	0.3354	0.7144
Loa Loa (eye worm)	SH2 domain-containing protein	0.1125	0.2328	0.2135
Schistosoma mansoni	protein kinase	0.0762	0.1483	0.1483
Echinococcus granulosus	N chimaerin	0.1125	0.2328	0.2135
Echinococcus multilocularis	activated cdc42 kinase 1	0.0762	0.1483	0.1268
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.1125	0.2328	0.2135
Echinococcus granulosus	expressed conserved protein	0.1125	0.2328	0.2135
Plasmodium vivax	tyrosine kinase-like protein, putative	0.078	0.1525	0.0227
Plasmodium falciparum	protein kinase, putative	0.078	0.1525	0.0227
Loa Loa (eye worm)	hypothetical protein	0.0762	0.1483	0.1268
Echinococcus multilocularis	growth factor receptor bound protein 2	0.1125	0.2328	0.2135
Echinococcus granulosus	tyrosine protein kinase Fyn	0.1888	0.4102	0.3953
Brugia malayi	ephrin receptor 1 precursor	0.0762	0.1483	0.1268
Loa Loa (eye worm)	hypothetical protein	0.1125	0.2328	0.2135
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0762	0.1483	0.1268
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0762	0.1483	0.1268
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0762	0.1483	0.1268
Schistosoma mansoni	tyrosine kinase	0.0762	0.1483	0.1483
Schistosoma mansoni	shk1 kinase-binding protein	0.1566	0.3354	0.3354
Schistosoma mansoni	tyrosine kinase	0.1888	0.4102	0.4102
Loa Loa (eye worm)	hypothetical protein	0.1125	0.2328	0.2135
Echinococcus granulosus	tyrosine protein kinase ABL1	0.1888	0.4102	0.3953
Loa Loa (eye worm)	TK/FER protein kinase	0.1888	0.4102	0.3953
Schistosoma mansoni	GTPase activating protein	0.1125	0.2328	0.2328
Echinococcus multilocularis	tyrosine protein kinase Srms	0.1888	0.4102	0.3953
Loa Loa (eye worm)	SH2 domain-containing protein	0.1125	0.2328	0.2135
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0762	0.1483	0.1268
Brugia malayi	Protein kinase domain containing protein	0.1888	0.4102	0.3953
Echinococcus multilocularis	tyrosine protein kinase csk	0.0762	0.1483	0.1268
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.1125	0.2328	0.2135
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.1888	0.4102	0.3953
Echinococcus multilocularis	c src tyrosine kinase	0.1888	0.4102	0.3953
Echinococcus granulosus	SH2 domain containing protein 7	0.1125	0.2328	0.2135
Echinococcus granulosus	tyrosine protein kinase Src42A	0.1125	0.2328	0.2135
Echinococcus multilocularis	SH2 domain containing protein 7	0.1125	0.2328	0.2135
Loa Loa (eye worm)	TK/FER protein kinase	0.0762	0.1483	0.1268
Echinococcus granulosus	protein tyrosine kinase	0.0762	0.1483	0.1268
Loa Loa (eye worm)	hypothetical protein	0.1125	0.2328	0.2135
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0762	0.1483	0.1268
Brugia malayi	Sex muscle abnormal protein 5	0.1125	0.2328	0.2135
Loa Loa (eye worm)	TK/FER protein kinase	0.0762	0.1483	0.1268
Loa Loa (eye worm)	hypothetical protein	0.1125	0.2328	0.2135
Schistosoma mansoni	tyrosine kinase	0.0762	0.1483	0.1483
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0762	0.1483	0.1268
Onchocerca volvulus		0.1888	0.4102	1
Brugia malayi	Protein kinase domain containing protein	0.0762	0.1483	0.1268
Loa Loa (eye worm)	hypothetical protein	0.1125	0.2328	0.2135
Brugia malayi	SH2 domain containing protein	0.1125	0.2328	0.2135
Loa Loa (eye worm)	hypothetical protein	0.1888	0.4102	0.3953
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.1125	0.2328	0.2135
Echinococcus granulosus	tyrosine protein kinase shark	0.1888	0.4102	0.3953
Brugia malayi	hypothetical protein	0.1888	0.4102	0.3953
Loa Loa (eye worm)	hypothetical protein	0.1125	0.2328	0.2135
Brugia malayi	Raf kinase	0.0762	0.1483	0.1268
Brugia malayi	Variant SH3 domain containing protein	0.1125	0.2328	0.2135
Echinococcus granulosus	tyrosine protein kinase Fyn	0.1888	0.4102	0.3953
Echinococcus granulosus	tyrosine protein kinase csk	0.0762	0.1483	0.1268
Schistosoma mansoni	nck2/grb4	0.1125	0.2328	0.2328
Schistosoma mansoni	tensin	0.1125	0.2328	0.2328
Echinococcus multilocularis	transfer RNA-Thr	0.0762	0.1483	0.1268
Echinococcus multilocularis	tensin	0.1125	0.2328	0.2135
Schistosoma mansoni	protein kinase	0.0762	0.1483	0.1483
Schistosoma mansoni	tyrosine kinase	0.0762	0.1483	0.1483
Echinococcus multilocularis	calcium release activated calcium channel	0.4422	1	1
Loa Loa (eye worm)	hypothetical protein	0.1125	0.2328	0.2135
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.1888	0.4102	0.3953
Schistosoma mansoni	tyrosine kinase	0.0762	0.1483	0.1483
Schistosoma mansoni	serine/threonine protein kinase	0.0762	0.1483	0.1483
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.1125	0.2328	0.2135
Echinococcus multilocularis	insulin receptor	0.0762	0.1483	0.1268
Echinococcus granulosus	tyrosine protein kinase Fyn	0.1888	0.4102	0.3953
Brugia malayi	Protein kinase domain containing protein	0.0762	0.1483	0.1268
Echinococcus granulosus	protein kinase	0.0762	0.1483	0.1268
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0762	0.1483	0.1268
Echinococcus granulosus	activated cdc42 kinase 1	0.0762	0.1483	0.1268
Echinococcus multilocularis	activin receptor type	0.0762	0.1483	0.1268
Echinococcus multilocularis	signal transduction protein lnk realted	0.1125	0.2328	0.2135
Brugia malayi	Variant SH3 domain containing protein	0.1125	0.2328	0.2135
Brugia malayi	Protein kinase domain containing protein	0.0762	0.1483	0.1268
Schistosoma mansoni	protein kinase	0.0762	0.1483	0.1483
Echinococcus granulosus	insulin receptor	0.0762	0.1483	0.1268
Onchocerca volvulus	Tyrosine kinase homolog	0.0762	0.1483	0.2898
Schistosoma mansoni	tyrosine kinase	0.0762	0.1483	0.1483
Brugia malayi	Protein kinase domain containing protein	0.0762	0.1483	0.1268
Brugia malayi	Protein kinase domain containing protein	0.0762	0.1483	0.1268
Schistosoma mansoni	protein kinase	0.0762	0.1483	0.1483
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0762	0.1483	0.1268
Schistosoma mansoni	tyrosine kinase	0.0762	0.1483	0.1483
Loa Loa (eye worm)	TK/ACK protein kinase	0.0762	0.1483	0.1268
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0762	0.1483	0.1268
Echinococcus granulosus	suppressor of cytokine signaling 7	0.1125	0.2328	0.2135
Loa Loa (eye worm)	hypothetical protein	0.1125	0.2328	0.2135
Schistosoma mansoni	tyrosine kinase	0.1888	0.4102	0.4102
Toxoplasma gondii	histone arginine methyltransferase PRMT5	0.1566	0.3354	1
Loa Loa (eye worm)	hypothetical protein	0.1125	0.2328	0.2135
Echinococcus granulosus	c src tyrosine kinase	0.1888	0.4102	0.3953
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0762	0.1483	0.1268
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0762	0.1483	0.1268
Schistosoma mansoni	tyrosine kinase	0.1888	0.4102	0.4102
Brugia malayi	SH2 domain containing protein	0.1888	0.4102	0.3953

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	> 50 ug	Antifungal activity against Cryptococcus neoformans ATCC 28952 assessed as concentration required to inhibit fungal growth after 24 hrs by TLC assay	ChEMBL.	23819826
Activity (functional)	> 50 ug	Antifungal activity against Candida albicans ATCC 10231 assessed as concentration required to inhibit fungal growth after 24 hrs by TLC assay	ChEMBL.	23819826
Activity (functional)	> 50 ug	Antifungal activity against Saccharomyces cerevisiae ATCC 2601 assessed as concentration required to inhibit fungal growth after 24 hrs by TLC assay	ChEMBL.	23819826
Activity (functional)	> 50 ug	Antibacterial activity against Escherichia coli ATCC 11103 assessed as concentration required to inhibit bacterial growth after 24 hrs by TLC assay	ChEMBL.	23819826

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2407351

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1771167