Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | acetylcholinesterase | 0.2038 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0344 | 0 | 0.5 |
Onchocerca volvulus | 0.0344 | 0 | 0.5 | |
Schistosoma mansoni | memapsin-2 (A01 family) | 0.1914 | 0.9269 | 0.9269 |
Onchocerca volvulus | 0.0344 | 0 | 0.5 | |
Brugia malayi | Carboxylesterase family protein | 0.2038 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.2038 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.2038 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2038 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.2038 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2038 | 1 | 1 |
Onchocerca volvulus | 0.0344 | 0 | 0.5 | |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0344 | 0 | 0.5 |
Onchocerca volvulus | 0.0344 | 0 | 0.5 | |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0344 | 0 | 0.5 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0344 | 0 | 0.5 |
Onchocerca volvulus | 0.0344 | 0 | 0.5 | |
Echinococcus granulosus | acetylcholinesterase | 0.2038 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.2038 | 1 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0344 | 0 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.2038 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.2038 | 1 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0344 | 0 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.2038 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | = -0.3 % | Induction of intracellular triglyceride accumulation in human HepG2 cells at 10 uM after 4 days relative to vehicle-treated control | ChEMBL. | 23844653 |
Activity (binding) | = 29 % | Agonist activity at LXRbeta in mouse BV2 cells assessed as degradation of intracellular soluble amyloid beta42 at 0.01 uM preincubated for 18 hrs followed by soluble amyloid beta42 addition measured after 24 hrs by ELISA relative to vehicle-treated control | ChEMBL. | 23844653 |
Activity (functional) | = 31 % | Antialzheimer activity in double transgenic B6C3 mouse overexpressing APP swedish mutant and PSEN1dE9 assessed as reduction of soluble amyloid beta42 level at 10 mg/kg, ip administered 3 times per week measured after 6 weeks by ELISA relative to vehicle-treated control | ChEMBL. | 23844653 |
Activity (binding) | = 52 % | Agonist activity at LXRbeta in mouse BV2 cells assessed as degradation of intracellular soluble amyloid beta42 at 0.1 uM preincubated for 18 hrs followed by soluble amyloid beta42 addition measured after 24 hrs by ELISA relative to vehicle-treated control | ChEMBL. | 23844653 |
Activity (binding) | = 59 % | Agonist activity at LXRbeta in mouse BV2 cells assessed as degradation of intracellular soluble amyloid beta42 at 1 uM preincubated for 18 hrs followed by soluble amyloid beta42 addition measured after 24 hrs by ELISA relative to vehicle-treated control | ChEMBL. | 23844653 |
FC (binding) | = 1.07 | Agonist activity at human LXRbeta transfected in HEK293 cells at 0.1 uM after 24 hrs by luciferase reporter gene assay relative to vehicle-treated control | ChEMBL. | 23844653 |
FC (binding) | = 1.79 | Agonist activity at human LXRbeta transfected in HEK293 cells at 1 uM after 24 hrs by luciferase reporter gene assay relative to vehicle-treated control | ChEMBL. | 23844653 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.