TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 555.687 | Formula: C32H33N3O4S
H donors: 1 H acceptors: 2 LogP: 5.37 Rotable bonds: 9
Rule of 5 violations (Lipinski): 2
SMILES: CCN(CCC(=O)Nc1ccc(c2c1c1ccccc1s2)c1cccc2c1oc(cc2=O)N1CCOCC1)CC
InChi: 1S/C32H33N3O4S/c1-3-34(4-2)15-14-28(37)33-25-13-12-22(32-30(25)24-8-5-6-11-27(24)40-32)21-9-7-10-23-26(36)20-29(39-31(21)23)35-16-18-38-19-17-35/h5-13,20H,3-4,14-19H2,1-2H3,(H,33,37)
InChiKey: SLNKYLRBKDALBW-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	protein kinase, DNA-activated, catalytic polypeptide	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	Get druggable targets OG5_132688	All targets in OG5_132688
Echinococcus granulosus	DNA dependent protein kinase catalytic subunit	Get druggable targets OG5_132688	All targets in OG5_132688

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0303	0.9648	0.9648
Loa Loa (eye worm)	TK/FER protein kinase	0.0303	0.9648	1
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0182	0.5485	0.5485
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0121	0.3414	1
Echinococcus multilocularis	tensin	0.0182	0.5485	0.5485
Entamoeba histolytica	tyrosine kinase, putative	0.0121	0.3414	0.3538
Entamoeba histolytica	tyrosine kinase, putative	0.0121	0.3414	0.3538
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0303	0.9648	0.9648
Schistosoma mansoni	shc transforming protein	0.0182	0.5485	0.5686
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0121	0.3414	1
Echinococcus granulosus	hypothetical protein	0.0182	0.5485	0.5485
Echinococcus multilocularis	tyrosine kinase	0.0303	0.9648	0.9648
Toxoplasma gondii	protein kinase	0.0121	0.3414	1
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0182	0.5485	0.5485
Trichomonas vaginalis	TKL family protein kinase	0.0121	0.3414	1
Loa Loa (eye worm)	TK/RYK protein kinase	0.0121	0.3414	0.3538
Entamoeba histolytica	protein kinase domain containing protein	0.0121	0.3414	0.3538
Onchocerca volvulus		0.0182	0.5485	0.3323
Entamoeba histolytica	protein kinase domain containing protein	0.0121	0.3414	0.3538
Entamoeba histolytica	protein kinase domain containing protein	0.0121	0.3414	0.3538
Schistosoma mansoni	tyrosine kinase	0.0121	0.3414	0.3538
Loa Loa (eye worm)	TK/ROR protein kinase	0.0121	0.3414	0.3538
Echinococcus granulosus	N chimaerin	0.0182	0.5485	0.5485
Entamoeba histolytica	hypothetical protein	0.0121	0.3414	0.3538
Onchocerca volvulus		0.0182	0.5485	0.3323
Brugia malayi	Protein kinase domain containing protein	0.0121	0.3414	0.3538
Entamoeba histolytica	protein kinase, putative	0.0121	0.3414	0.3538
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0121	0.3414	0.3538
Trichomonas vaginalis	TKL family protein kinase	0.0121	0.3414	1
Loa Loa (eye worm)	SH2 domain-containing protein	0.0182	0.5485	0.5686
Trichomonas vaginalis	TKL family protein kinase	0.0121	0.3414	1
Echinococcus granulosus	tyrosine protein kinase Blk	0.0303	0.9648	0.9648
Entamoeba histolytica	protein kinase, putative	0.0121	0.3414	0.3538
Brugia malayi	Protein kinase domain containing protein	0.0121	0.3414	0.3538
Loa Loa (eye worm)	TK/EPH protein kinase	0.0121	0.3414	0.3538
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0182	0.5485	0.3323
Trichomonas vaginalis	TKL family protein kinase	0.0121	0.3414	1
Echinococcus granulosus	tyrosine protein kinase csk	0.0121	0.3414	0.3414
Plasmodium vivax	protein kinase, putative	0.0121	0.3414	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0121	0.3414	1
Schistosoma mansoni	serine/threonine RGC	0.0121	0.3414	0.3538
Schistosoma mansoni	serine/threonine protein kinase	0.0121	0.3414	0.3538
Loa Loa (eye worm)	hypothetical protein	0.0182	0.5485	0.5686
Schistosoma mansoni	signal transduction protein lnk-related	0.0182	0.5485	0.5686
Giardia lamblia	Kinase, NEK	0.0121	0.3414	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0303	0.9648	1
Echinococcus granulosus	SH2 domain containing protein 7	0.0182	0.5485	0.5485
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0303	0.9648	0.9648
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0121	0.3414	0.3414
Entamoeba histolytica	protein kinase domain containing protein	0.0121	0.3414	0.3538
Entamoeba histolytica	tyrosine kinase, putative	0.0121	0.3414	0.3538
Loa Loa (eye worm)	TK/Met protein kinase	0.0121	0.3414	0.3538
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0121	0.3414	0.3538
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0182	0.5485	0.5485
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0182	0.5485	0.5686
Loa Loa (eye worm)	TK/ABL protein kinase	0.0303	0.9648	1
Entamoeba histolytica	protein kinase, putative	0.0121	0.3414	0.3538
Trichomonas vaginalis	TKL family protein kinase	0.0121	0.3414	1
Trichomonas vaginalis	STE family protein kinase	0.0121	0.3414	1
Echinococcus multilocularis	signal transduction protein lnk realted	0.0182	0.5485	0.5485
Onchocerca volvulus		0.0303	0.9648	1
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0303	0.9648	0.9648
Trichomonas vaginalis	TKL family protein kinase	0.0121	0.3414	1
Schistosoma mansoni	growth factor receptor-bound protein	0.0182	0.5485	0.5686
Brugia malayi	Protein kinase domain containing protein	0.0303	0.9648	1
Schistosoma mansoni	tensin	0.0182	0.5485	0.5686
Schistosoma mansoni	tyrosine kinase	0.0303	0.9648	1
Echinococcus granulosus	tyrosine kinase	0.0121	0.3414	0.3414
Loa Loa (eye worm)	hypothetical protein	0.0121	0.3414	0.3538
Plasmodium falciparum	tyrosine kinase-like protein	0.0121	0.3414	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0121	0.3414	0.3538
Echinococcus granulosus	tyrosine protein kinase pr2	0.0121	0.3414	0.3414
Schistosoma mansoni	tyrosine kinase	0.0121	0.3414	0.3538
Echinococcus multilocularis	heat shock protein 70	0.0121	0.3414	0.3414
Trichomonas vaginalis	TKL family protein kinase	0.0121	0.3414	1
Trichomonas vaginalis	TKL family protein kinase	0.0121	0.3414	1
Trypanosoma brucei	protein kinase, putative	0.0121	0.3414	1
Loa Loa (eye worm)	hypothetical protein	0.0182	0.5485	0.5686
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0182	0.5485	0.5686
Schistosoma mansoni	tyrosine kinase	0.0121	0.3414	0.3538
Loa Loa (eye worm)	SH2 domain-containing protein	0.0182	0.5485	0.5686
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0182	0.5485	0.5485
Echinococcus granulosus	tensin	0.0182	0.5485	0.5485
Trichomonas vaginalis	TKL family protein kinase	0.0121	0.3414	1
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0182	0.5485	0.5686
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0121	0.3414	0.3538
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0121	0.3414	0.3414
Echinococcus granulosus	epidermal growth factor receptor	0.0121	0.3414	0.3414
Entamoeba histolytica	tyrosin kinase, putative	0.0121	0.3414	0.3538
Echinococcus granulosus	protein kinase	0.0121	0.3414	0.3414
Loa Loa (eye worm)	SRC-1	0.0303	0.9648	1
Loa Loa (eye worm)	TK/ALK protein kinase	0.0121	0.3414	0.3538
Trichomonas vaginalis	TKL family protein kinase	0.0121	0.3414	1
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0182	0.5485	0.5686
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0303	0.9648	0.9648
Loa Loa (eye worm)	hypothetical protein	0.0121	0.3414	0.3538
Schistosoma mansoni	tyrosine kinase	0.0121	0.3414	0.3538
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0303	0.9648	0.9648
Schistosoma mansoni	tyrosine kinase	0.0303	0.9648	1
Loa Loa (eye worm)	hypothetical protein	0.0182	0.5485	0.5686
Loa Loa (eye worm)	TK/ACK protein kinase	0.0121	0.3414	0.3538
Onchocerca volvulus		0.0303	0.9648	1
Entamoeba histolytica	protein kinase, putative	0.0121	0.3414	0.3538
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0121	0.3414	1
Schistosoma mansoni	protein kinase	0.0121	0.3414	0.3538
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0121	0.3414	0.3538
Schistosoma mansoni	nck2/grb4	0.0182	0.5485	0.5686
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0121	0.3414	0.3414
Entamoeba histolytica	tyrosine kinase, putative	0.0121	0.3414	0.3538
Echinococcus multilocularis		0.0182	0.5485	0.5485
Entamoeba histolytica	protein kinase domain containing protein	0.0121	0.3414	0.3538
Entamoeba histolytica	hypothetical protein	0.0121	0.3414	0.3538
Loa Loa (eye worm)	hypothetical protein	0.0121	0.3414	0.3538
Trichomonas vaginalis	TK family protein kinase	0.0121	0.3414	1
Entamoeba histolytica	receptor protein kinase, putative	0.0121	0.3414	0.3538
Entamoeba histolytica	SH2 domain containing protein	0.0182	0.5485	0.5686
Schistosoma mansoni	protein kinase	0.0121	0.3414	0.3538
Entamoeba histolytica	hypothetical protein	0.0121	0.3414	0.3538
Trichomonas vaginalis	TKL family protein kinase	0.0121	0.3414	1
Echinococcus granulosus	tyrosine kinase	0.0303	0.9648	0.9648
Loa Loa (eye worm)	hypothetical protein	0.0182	0.5485	0.5686
Trichomonas vaginalis	protein kinase atn1, putative	0.0121	0.3414	1
Entamoeba histolytica	hypothetical protein	0.0121	0.3414	0.3538
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0182	0.5485	0.5686
Loa Loa (eye worm)	TK/FER protein kinase	0.0303	0.9648	1
Brugia malayi	Guanylyl cyclase protein 23	0.0121	0.3414	0.3538
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0182	0.5485	0.5686
Entamoeba histolytica	hypothetical protein, conserved	0.0121	0.3414	0.3538
Brugia malayi	Protein kinase domain containing protein	0.0121	0.3414	0.3538
Giardia lamblia	Kinase	0.0121	0.3414	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0303	0.9648	0.9648
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0121	0.3414	0.3538
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0182	0.5485	0.5485
Trichomonas vaginalis	TKL family protein kinase	0.0121	0.3414	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.0121	0.3414	0.3414
Onchocerca volvulus		0.0182	0.5485	0.3323
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0303	0.9648	0.9648
Schistosoma mansoni	protein kinase	0.0121	0.3414	0.3538
Trichomonas vaginalis	CAMK family protein kinase	0.0121	0.3414	1
Trichomonas vaginalis	TKL family protein kinase	0.0121	0.3414	1
Schistosoma mansoni	tyrosine kinase	0.0303	0.9648	1
Schistosoma mansoni	tyrosine kinase	0.0121	0.3414	0.3538
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0121	0.3414	0.3538
Schistosoma mansoni	protein kinase	0.0121	0.3414	0.3538
Loa Loa (eye worm)	hypothetical protein	0.0182	0.5485	0.5686
Brugia malayi	Protein kinase domain containing protein	0.0121	0.3414	0.3538
Entamoeba histolytica	tyrosine kinase, putative	0.0121	0.3414	0.3538
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0303	0.9648	0.9648
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0182	0.5485	0.5686
Trichomonas vaginalis	TKL family protein kinase	0.0121	0.3414	1
Schistosoma mansoni	tyrosine kinase	0.0121	0.3414	0.3538
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0121	0.3414	0.3538
Echinococcus multilocularis	transfer RNA-Thr	0.0121	0.3414	0.3414
Brugia malayi	Raf kinase	0.0121	0.3414	0.3538
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0303	0.9648	0.9648
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0121	0.3414	0.3538
Trichomonas vaginalis	TKL family protein kinase	0.0121	0.3414	1
Schistosoma mansoni	SH2A	0.0182	0.5485	0.5686
Echinococcus granulosus	SHC transforming protein 3	0.0182	0.5485	0.5485
Brugia malayi	Protein kinase domain containing protein	0.0121	0.3414	0.3538
Echinococcus granulosus	integrin linked protein kinase	0.0121	0.3414	0.3414
Giardia lamblia	Kinase, NEK	0.0121	0.3414	1
Echinococcus multilocularis	epidermal growth factor receptor	0.0121	0.3414	0.3414
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.0121	0.3414	0.3538
Schistosoma mansoni	tensin-related	0.0182	0.5485	0.5686
Loa Loa (eye worm)	hypothetical protein	0.0182	0.5485	0.5686
Entamoeba histolytica	hypothetical protein	0.0121	0.3414	0.3538
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0121	0.3414	0.3414
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0303	0.9648	1
Trichomonas vaginalis	conserved hypothetical protein	0.0121	0.3414	1
Trichomonas vaginalis	TKL family protein kinase	0.0121	0.3414	1
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0121	0.3414	0.3414
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0121	0.3414	0.5
Loa Loa (eye worm)	hypothetical protein	0.0121	0.3414	0.3538
Trichomonas vaginalis	TKL family protein kinase	0.0121	0.3414	1
Entamoeba histolytica	hypothetical protein	0.0121	0.3414	0.3538
Trichomonas vaginalis	TKL family protein kinase	0.0121	0.3414	1
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0182	0.5485	0.3323
Trichomonas vaginalis	conserved hypothetical protein	0.0121	0.3414	1
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0121	0.3414	0.3538
Loa Loa (eye worm)	TK/FER protein kinase	0.0303	0.9648	1
Trichomonas vaginalis	TKL family protein kinase	0.0121	0.3414	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0182	0.5485	0.5485
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0303	0.9648	0.9648
Schistosoma mansoni	hypothetical protein	0.0182	0.5485	0.5686
Echinococcus multilocularis	integrin linked protein kinase	0.0121	0.3414	0.3414
Entamoeba histolytica	protein kinase domain containing protein	0.0121	0.3414	0.3538
Echinococcus multilocularis	activin receptor type	0.0121	0.3414	0.3414
Trichomonas vaginalis	conserved hypothetical protein	0.0121	0.3414	1
Loa Loa (eye worm)	hypothetical protein	0.0121	0.3414	0.3538
Schistosoma mansoni	serine/threonine protein kinase	0.0121	0.3414	0.3538
Echinococcus multilocularis	SH2 motif	0.0182	0.5485	0.5485
Brugia malayi	Tyrosine-protein kinase PR2	0.0121	0.3414	0.3538
Schistosoma mansoni	growth factor receptor-bound protein	0.0182	0.5485	0.5686
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0182	0.5485	0.5686
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0121	0.3414	1
Schistosoma mansoni	adapter molecule crk	0.0182	0.5485	0.5686
Schistosoma mansoni	protein kinase	0.0121	0.3414	0.3538
Brugia malayi	SH2 domain containing protein	0.0303	0.9648	1
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0121	0.3414	0.3414
Entamoeba histolytica	protein kinase, putative	0.0121	0.3414	0.3538
Loa Loa (eye worm)	TK/FER protein kinase	0.0121	0.3414	0.3538
Entamoeba histolytica	tyrosine kinase, putative	0.0121	0.3414	0.3538
Brugia malayi	SH2 domain containing protein	0.0182	0.5485	0.5686
Schistosoma mansoni	tyrosine kinase	0.0121	0.3414	0.3538
Trichomonas vaginalis	TKL family protein kinase	0.0121	0.3414	1
Echinococcus granulosus	epidermal growth factor receptor	0.0121	0.3414	0.3414
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0121	0.3414	0.3538
Entamoeba histolytica	tyrosine kinase, putative	0.0121	0.3414	0.3538
Brugia malayi	SH2 domain containing protein	0.0182	0.5485	0.5686
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0121	0.3414	0.3414
Entamoeba histolytica	protein kinase, putative	0.0121	0.3414	0.3538
Toxoplasma gondii	protein kinase domain-containing protein	0.0121	0.3414	1
Entamoeba histolytica	protein kinase domain containing protein	0.0121	0.3414	0.3538
Brugia malayi	Protein kinase domain containing protein	0.0121	0.3414	0.3538
Brugia malayi	Protein kinase domain containing protein	0.0303	0.9648	1
Brugia malayi	Protein kinase domain containing protein	0.0303	0.9648	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0303	0.9648	0.9648
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0303	0.9648	0.9648
Echinococcus multilocularis	tyrosine protein kinase csk	0.0121	0.3414	0.3414
Schistosoma mansoni	tyrosine kinase	0.0121	0.3414	0.3538
Brugia malayi	Protein kinase domain containing protein	0.0121	0.3414	0.3538
Onchocerca volvulus		0.0303	0.9648	1
Schistosoma mansoni	ephrin receptor	0.0121	0.3414	0.3538
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0121	0.3414	0.3414
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0121	0.3414	1
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0121	0.3414	1
Schistosoma mansoni	suppressor of cytokine signaling	0.0182	0.5485	0.5686
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0121	0.3414	0.3538
Entamoeba histolytica	protein kinase domain containing protein	0.0121	0.3414	0.3538
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0121	0.3414	1
Brugia malayi	Protein kinase domain containing protein	0.0121	0.3414	0.3538
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0121	0.3414	0.3414
Loa Loa (eye worm)	hypothetical protein	0.0182	0.5485	0.5686
Schistosoma mansoni	protein kinase	0.0121	0.3414	0.3538
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0121	0.3414	0.3414
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0121	0.3414	0.3414
Trichomonas vaginalis	TKL family protein kinase	0.0121	0.3414	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0121	0.3414	0.3538
Loa Loa (eye worm)	TK/FER protein kinase	0.0303	0.9648	1
Leishmania major	hypothetical protein, conserved	0.0114	0.3155	0.9241
Echinococcus granulosus	tyrosine protein kinase Srms	0.0303	0.9648	0.9648
Schistosoma mansoni	tyrosine kinase	0.0121	0.3414	0.3538
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0303	0.9648	0.9648
Entamoeba histolytica	protein kinase domain containing protein	0.0121	0.3414	0.3538
Brugia malayi	Protein kinase domain containing protein	0.0121	0.3414	0.3538
Trichomonas vaginalis	TKL family protein kinase	0.0121	0.3414	1
Loa Loa (eye worm)	TK protein kinase	0.0303	0.9648	1
Trichomonas vaginalis	TKL family protein kinase	0.0121	0.3414	1
Brugia malayi	hypothetical protein	0.0121	0.3414	0.3538
Entamoeba histolytica	cysteine surface protein, putative	0.0121	0.3414	0.3538
Plasmodium falciparum	protein kinase, putative	0.0121	0.3414	0.5
Schistosoma mansoni	tyrosine kinase	0.0121	0.3414	0.3538
Loa Loa (eye worm)	TK protein kinase	0.0121	0.3414	0.3538
Echinococcus granulosus	insulin receptor	0.0121	0.3414	0.3414
Trichomonas vaginalis	conserved hypothetical protein	0.0121	0.3414	1
Plasmodium falciparum	tyrosine kinase-like protein	0.0121	0.3414	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0121	0.3414	1
Entamoeba histolytica	serine/threonine kinase, putative	0.0121	0.3414	0.3538
Trichomonas vaginalis	TKL family protein kinase	0.0121	0.3414	1
Entamoeba histolytica	protein kinase, putative	0.0121	0.3414	0.3538
Brugia malayi	Protein kinase domain containing protein	0.0121	0.3414	0.3538
Brugia malayi	Protein kinase domain containing protein	0.0121	0.3414	0.3538
Trichomonas vaginalis	TKL family protein kinase	0.0121	0.3414	1
Echinococcus granulosus	activated cdc42 kinase 1	0.0121	0.3414	0.3414
Trichomonas vaginalis	TKL family protein kinase	0.0121	0.3414	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0303	0.9648	1
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0121	0.3414	0.3414
Echinococcus granulosus	growth factor receptor bound protein 2	0.0182	0.5485	0.5485
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0121	0.3414	0.3538
Echinococcus granulosus	signal transduction protein lnk realted	0.0182	0.5485	0.5485
Echinococcus multilocularis	activated cdc42 kinase 1	0.0121	0.3414	0.3414
Entamoeba histolytica	tyrosine kinase, putative	0.0121	0.3414	0.3538
Echinococcus granulosus	expressed conserved protein	0.0182	0.5485	0.5485
Brugia malayi	Sex muscle abnormal protein 5	0.0182	0.5485	0.5686
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0303	0.9648	0.9648
Onchocerca volvulus		0.0303	0.9648	1
Entamoeba histolytica	protein kinase, putative	0.0121	0.3414	0.3538
Schistosoma mansoni	tyrosine kinase	0.0121	0.3414	0.3538
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0121	0.3414	0.3414
Schistosoma mansoni	protein tyrosine kinase	0.0121	0.3414	0.3538
Loa Loa (eye worm)	hypothetical protein	0.0121	0.3414	0.3538
Entamoeba histolytica	hypothetical protein	0.0121	0.3414	0.3538
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0121	0.3414	0.3538
Loa Loa (eye worm)	TK protein kinase	0.0121	0.3414	0.3538
Entamoeba histolytica	hypothetical protein	0.0121	0.3414	0.3538
Trichomonas vaginalis	conserved hypothetical protein	0.0121	0.3414	1
Loa Loa (eye worm)	serine/threonine protein kinase	0.0121	0.3414	0.3538
Trichomonas vaginalis	TKL family protein kinase	0.0121	0.3414	1
Loa Loa (eye worm)	TK protein kinase	0.0121	0.3414	0.3538
Entamoeba histolytica	ankyrin repeat protein	0.0121	0.3414	0.3538
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0121	0.3414	0.3538
Loa Loa (eye worm)	hypothetical protein	0.0182	0.5485	0.5686
Brugia malayi	ephrin receptor 1 precursor	0.0121	0.3414	0.3538
Echinococcus granulosus	tyrosine kinase	0.0303	0.9648	0.9648
Loa Loa (eye worm)	TK protein kinase	0.0121	0.3414	0.3538
Entamoeba histolytica	protein kinase domain containing protein	0.0121	0.3414	0.3538
Schistosoma mansoni	tyrosine kinase	0.0121	0.3414	0.3538
Echinococcus multilocularis	insulin receptor	0.0121	0.3414	0.3414
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0303	0.9648	0.9648
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0121	0.3414	1
Entamoeba histolytica	protein kinase domain containing protein	0.0121	0.3414	0.3538
Echinococcus multilocularis	NCK adaptor protein	0.0182	0.5485	0.5485
Entamoeba histolytica	tyrosine kinase, putative	0.0121	0.3414	0.3538
Brugia malayi	hypothetical protein	0.0121	0.3414	0.3538
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0303	0.9648	0.9648
Brugia malayi	SRC-1	0.0303	0.9648	1
Schistosoma mansoni	tyrosine kinase	0.0121	0.3414	0.3538
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0121	0.3414	0.3414
Onchocerca volvulus		0.0303	0.9648	1
Brugia malayi	Protein kinase domain containing protein	0.0303	0.9648	1
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0182	0.5485	0.5686
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0303	0.9648	0.9648
Trichomonas vaginalis	TKL family protein kinase	0.0121	0.3414	1
Echinococcus granulosus	activated cdc42 kinase 1	0.0121	0.3414	0.3414
Brugia malayi	Protein kinase domain containing protein	0.0121	0.3414	0.3538
Trichomonas vaginalis	TKL family protein kinase	0.0121	0.3414	1
Toxoplasma gondii	STE kinase	0.0121	0.3414	1
Entamoeba histolytica	protein kinase domain containing protein	0.0121	0.3414	0.3538
Schistosoma mansoni	tensin-related	0.0182	0.5485	0.5686
Echinococcus granulosus	NCK adaptor protein	0.0182	0.5485	0.5485
Entamoeba histolytica	protein kinase, putative	0.0121	0.3414	0.3538
Schistosoma mansoni	tensin	0.0182	0.5485	0.5686
Entamoeba histolytica	hypothetical protein	0.0121	0.3414	0.3538
Schistosoma mansoni	tyrosine kinase	0.0121	0.3414	0.3538
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0182	0.5485	0.5686
Entamoeba histolytica	protein kinase domain containing protein	0.0121	0.3414	0.3538
Trypanosoma brucei	Pseudokinase, putative	0.0121	0.3414	1
Brugia malayi	Protein kinase domain containing protein	0.0121	0.3414	0.3538
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0182	0.5485	0.5485
Entamoeba histolytica	serine/threonine kinase, putative	0.0121	0.3414	0.3538
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0121	0.3414	0.3414
Brugia malayi	SH2 domain containing protein	0.0182	0.5485	0.5686
Brugia malayi	Protein kinase domain containing protein	0.0121	0.3414	0.3538
Trichomonas vaginalis	TKL family protein kinase	0.0121	0.3414	1
Schistosoma mansoni	serine/threonine protein kinase	0.0121	0.3414	0.3538
Loa Loa (eye worm)	TK/FER protein kinase	0.0121	0.3414	0.3538
Trichomonas vaginalis	TKL family protein kinase	0.0121	0.3414	1
Loa Loa (eye worm)	hypothetical protein	0.0182	0.5485	0.5686
Brugia malayi	Furin-like cysteine rich region family protein	0.0121	0.3414	0.3538
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0121	0.3414	0.3414
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0121	0.3414	0.3538
Schistosoma mansoni	tyrosine kinase	0.0121	0.3414	0.3538
Brugia malayi	Protein kinase domain containing protein	0.0121	0.3414	0.3538
Trichomonas vaginalis	TKL family protein kinase	0.0121	0.3414	1
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0121	0.3414	0.3414
Brugia malayi	Protein kinase domain containing protein	0.0121	0.3414	0.3538
Trichomonas vaginalis	TKL family protein kinase	0.0121	0.3414	1
Loa Loa (eye worm)	TK/CSK protein kinase	0.0121	0.3414	0.3538
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0121	0.3414	0.3538
Entamoeba histolytica	tyrosine kinase, putative	0.0121	0.3414	0.3538
Trichomonas vaginalis	TKL family protein kinase	0.0121	0.3414	1
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0121	0.3414	0.3414
Entamoeba histolytica	tyrosine kinase, putative	0.0121	0.3414	0.3538
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0121	0.3414	0.3414
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0182	0.5485	0.5686
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0121	0.3414	0.3538
Trypanosoma cruzi	protein kinase, putative	0.0121	0.3414	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0303	0.9648	1
Brugia malayi	Protein kinase domain containing protein	0.0303	0.9648	1
Brugia malayi	Protein kinase domain containing protein	0.0121	0.3414	0.3538
Echinococcus granulosus	tyrosine protein kinase HCK	0.0121	0.3414	0.3414
Echinococcus granulosus	tyrosine protein kinase csk	0.0121	0.3414	0.3414
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0121	0.3414	0.3414
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0303	0.9648	0.9648
Loa Loa (eye worm)	hypothetical protein	0.0121	0.3414	0.3538
Loa Loa (eye worm)	STAT protein	0.0182	0.5485	0.5686
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0121	0.3414	0.3538
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0303	0.9648	0.9648
Entamoeba histolytica	serine/threonine kinase, putative	0.0121	0.3414	0.3538
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0182	0.5485	0.5485
Schistosoma mansoni	tyrosine kinase	0.0121	0.3414	0.3538
Entamoeba histolytica	ankyrin repeat protein	0.0121	0.3414	0.3538
Brugia malayi	Protein kinase domain containing protein	0.0121	0.3414	0.3538
Schistosoma mansoni	vav2	0.0182	0.5485	0.5686
Brugia malayi	Variant SH3 domain containing protein	0.0182	0.5485	0.5686
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.0121	0.3414	0.3538
Schistosoma mansoni	tyrosine kinase	0.0121	0.3414	0.3538
Onchocerca volvulus		0.0182	0.5485	0.3323
Schistosoma mansoni	hypothetical protein	0.0121	0.3414	0.3538
Brugia malayi	Protein kinase domain containing protein	0.0121	0.3414	0.3538
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0121	0.3414	0.3538
Loa Loa (eye worm)	TK/FER protein kinase	0.0303	0.9648	1
Leishmania major	protein kinase, putative	0.0121	0.3414	1
Brugia malayi	SH2 domain containing protein	0.0303	0.9648	1
Echinococcus granulosus	receptor type guanylyl cyclase	0.0121	0.3414	0.3414
Brugia malayi	Variant SH3 domain containing protein	0.0182	0.5485	0.5686
Entamoeba histolytica	protein kinase domain containing protein	0.0121	0.3414	0.3538
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0121	0.3414	0.3538
Echinococcus multilocularis	c src tyrosine kinase	0.0303	0.9648	0.9648
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0121	0.3414	1
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0121	0.3414	1
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0121	0.3414	0.3538
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0121	0.3414	0.3414
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0121	0.3414	0.3538
Trichomonas vaginalis	conserved hypothetical protein	0.0121	0.3414	1
Trichomonas vaginalis	TKL family protein kinase	0.0121	0.3414	1
Trichomonas vaginalis	TKL family protein kinase	0.0121	0.3414	1
Trichomonas vaginalis	TKL family protein kinase	0.0121	0.3414	1
Trichomonas vaginalis	TKL family protein kinase	0.0121	0.3414	1
Entamoeba histolytica	serine/threonine kinase, putative	0.0121	0.3414	0.3538
Brugia malayi	Protein kinase domain containing protein	0.0121	0.3414	0.3538
Schistosoma mansoni	tyrosine kinase	0.0303	0.9648	1
Entamoeba histolytica	tyrosine kinase, putative	0.0121	0.3414	0.3538
Entamoeba histolytica	protein kinase domain containing protein	0.0121	0.3414	0.3538
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0121	0.3414	0.3538
Schistosoma mansoni	GTPase activating protein	0.0182	0.5485	0.5686
Entamoeba histolytica	protein kinase domain containing protein	0.0121	0.3414	0.3538
Schistosoma mansoni	tyrosine kinase	0.0121	0.3414	0.3538
Echinococcus multilocularis	tyrosine protein kinase	0.0121	0.3414	0.3414
Trichomonas vaginalis	TKL family protein kinase	0.0121	0.3414	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0121	0.3414	0.3538
Echinococcus granulosus	protein tyrosine kinase	0.0121	0.3414	0.3414
Echinococcus multilocularis	SHC transforming protein 3	0.0182	0.5485	0.5485
Entamoeba histolytica	protein kinase, putative	0.0182	0.5485	0.5686
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0303	0.9648	0.9648
Trichomonas vaginalis	TKL family protein kinase	0.0121	0.3414	1
Loa Loa (eye worm)	hypothetical protein	0.0182	0.5485	0.5686
Schistosoma mansoni	tyrosine kinase	0.0121	0.3414	0.3538
Schistosoma mansoni	ephrin receptor	0.0121	0.3414	0.3538
Trypanosoma cruzi	hypothetical protein, conserved	0.011	0.3011	0.8819
Trichomonas vaginalis	TKL family protein kinase	0.0121	0.3414	1
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0182	0.5485	0.5485
Schistosoma mansoni	tyrosine kinase	0.0121	0.3414	0.3538
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0121	0.3414	0.3414
Trichomonas vaginalis	TKL family protein kinase	0.0121	0.3414	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.0121	0.3414	0.3414
Schistosoma mansoni	protein kinase	0.0121	0.3414	0.3538
Brugia malayi	Receptor family ligand binding region containing protein	0.0121	0.3414	0.3538
Brugia malayi	hypothetical protein	0.0182	0.5485	0.5686
Schistosoma mansoni	tyrosine kinase	0.0121	0.3414	0.3538
Brugia malayi	Protein kinase domain containing protein	0.0121	0.3414	0.3538
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0182	0.5485	0.5485
Trypanosoma cruzi	protein kinase, putative	0.0121	0.3414	1
Trichomonas vaginalis	TKL family protein kinase	0.0121	0.3414	1
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0121	0.3414	0.3414
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0121	0.3414	0.3414
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0121	0.3414	0.3414
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0121	0.3414	0.3414
Trichomonas vaginalis	TKL family protein kinase	0.0121	0.3414	1
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0121	0.3414	0.3414
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0182	0.5485	0.5485
Loa Loa (eye worm)	hypothetical protein	0.0182	0.5485	0.5686
Brugia malayi	SH2 domain containing protein	0.0182	0.5485	0.5686
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0121	0.3414	0.3538
Leishmania major	hypothetical protein, conserved	0.0121	0.3414	1
Loa Loa (eye worm)	hypothetical protein	0.0121	0.3414	0.3538
Schistosoma mansoni	hypothetical protein	0.0182	0.5485	0.5686
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0303	0.9648	0.9648
Trichomonas vaginalis	TKL family protein kinase	0.0121	0.3414	1
Echinococcus granulosus	natriuretic peptide receptor 1	0.0121	0.3414	0.3414
Trichomonas vaginalis	TKL family protein kinase	0.0121	0.3414	1
Echinococcus granulosus	kinase suppressor of Ras 1	0.0121	0.3414	0.3414
Schistosoma mansoni	protein kinase	0.0121	0.3414	0.3538
Echinococcus multilocularis	protein kinase	0.0121	0.3414	0.3414
Loa Loa (eye worm)	TK protein kinase	0.0121	0.3414	0.3538
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0121	0.3414	0.3538
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0121	0.3414	0.5
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0121	0.3414	1
Entamoeba histolytica	protein kinase, putative	0.0121	0.3414	0.3538
Loa Loa (eye worm)	hypothetical protein	0.0121	0.3414	0.3538
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0121	0.3414	0.3538
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0121	0.3414	0.3414
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0182	0.5485	0.5485
Onchocerca volvulus		0.0303	0.9648	1
Brugia malayi	SH2 domain containing protein	0.0182	0.5485	0.5686
Loa Loa (eye worm)	hypothetical protein	0.0121	0.3414	0.3538
Schistosoma mansoni	protein kinase	0.0121	0.3414	0.3538
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0182	0.5485	0.5686
Entamoeba histolytica	protein kinase, putative	0.0121	0.3414	0.3538
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0121	0.3414	0.3538
Trichomonas vaginalis	TKL family protein kinase	0.0121	0.3414	1
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0121	0.3414	0.3538
Entamoeba histolytica	protein kinase, putative	0.0121	0.3414	0.3538
Entamoeba histolytica	protein kinase domain containing protein	0.0121	0.3414	0.3538
Loa Loa (eye worm)	TK/FER protein kinase	0.0303	0.9648	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0303	0.9648	0.9648
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0182	0.5485	0.5686
Echinococcus granulosus	tyrosine protein kinase	0.0121	0.3414	0.3414
Entamoeba histolytica	hypothetical protein	0.0121	0.3414	0.3538
Trichomonas vaginalis	TKL family protein kinase	0.0121	0.3414	1
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0182	0.5485	0.5485
Loa Loa (eye worm)	TK protein kinase	0.0121	0.3414	0.3538
Trichomonas vaginalis	TKL family protein kinase	0.0121	0.3414	1
Entamoeba histolytica	protein kinase domain containing protein	0.0121	0.3414	0.3538
Trichomonas vaginalis	TKL family protein kinase	0.0121	0.3414	1
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0121	0.3414	0.3414
Entamoeba histolytica	protein kinase, putative	0.0121	0.3414	0.3538
Trichomonas vaginalis	TKL family protein kinase	0.0121	0.3414	1
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0303	0.9648	0.9648
Brugia malayi	Tyrosine-protein kinase abl-1	0.0303	0.9648	1
Schistosoma mansoni	protein kinase	0.0121	0.3414	0.3538
Loa Loa (eye worm)	hypothetical protein	0.0303	0.9648	1
Entamoeba histolytica	tyrosin kinase, putative	0.0121	0.3414	0.3538
Trichomonas vaginalis	TKL family protein kinase	0.0121	0.3414	1
Loa Loa (eye worm)	hypothetical protein	0.0182	0.5485	0.5686
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0121	0.3414	0.3414
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0121	0.3414	0.3414
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0121	0.3414	1
Trichomonas vaginalis	TKL family protein kinase	0.0121	0.3414	1
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0182	0.5485	0.5686
Loa Loa (eye worm)	TK protein kinase	0.0121	0.3414	0.3538
Schistosoma mansoni	tyrosine kinase	0.0303	0.9648	1
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0182	0.5485	0.5485
Trichomonas vaginalis	TKL family protein kinase	0.0121	0.3414	1
Trichomonas vaginalis	conserved hypothetical protein	0.0121	0.3414	1
Echinococcus granulosus	activin receptor type	0.0121	0.3414	0.3414
Echinococcus multilocularis	protein tyrosine kinase	0.0121	0.3414	0.3414
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0121	0.3414	0.3538
Trichomonas vaginalis	TKL family protein kinase	0.0121	0.3414	1
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0121	0.3414	0.3414
Entamoeba histolytica	receptor protein kinase, putative	0.0121	0.3414	0.3538
Schistosoma mansoni	tyrosine protein kinase	0.0121	0.3414	0.3538
Onchocerca volvulus		0.0182	0.5485	0.3323
Schistosoma mansoni	serine/threonine protein kinase	0.0121	0.3414	0.3538
Loa Loa (eye worm)	TK/FER protein kinase	0.0303	0.9648	1
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0121	0.3414	0.3538
Giardia lamblia	Protein 21.1	0.0121	0.3414	1
Schistosoma mansoni	tyrosine kinase	0.0121	0.3414	0.3538
Entamoeba histolytica	protein kinase, putative	0.0121	0.3414	0.3538
Echinococcus multilocularis	tyrosine kinase	0.0121	0.3414	0.3414
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0303	0.9648	0.9648
Schistosoma mansoni	suppressor of cytokine signaling	0.0182	0.5485	0.5686
Entamoeba histolytica	protein kinase domain containing protein	0.0121	0.3414	0.3538
Echinococcus granulosus	raf serine:threonine protein kinase	0.0121	0.3414	0.3414
Brugia malayi	Protein kinase domain containing protein	0.0121	0.3414	0.3538
Loa Loa (eye worm)	hypothetical protein	0.0182	0.5485	0.5686
Brugia malayi	protein-tyrosine kinase	0.0303	0.9648	1
Entamoeba histolytica	tyrosine kinase, putative	0.0121	0.3414	0.3538
Trichomonas vaginalis	TKL family protein kinase	0.0121	0.3414	1
Entamoeba histolytica	tyrosin kinase, putative	0.0121	0.3414	0.3538
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0121	0.3414	0.3538
Entamoeba histolytica	protein kinase, putative	0.0121	0.3414	0.3538
Loa Loa (eye worm)	hypothetical protein	0.0182	0.5485	0.5686
Schistosoma mansoni	tyrosine kinase	0.0121	0.3414	0.3538
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0303	0.9648	0.9648
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0121	0.3414	0.3414
Trichomonas vaginalis	TKL family protein kinase	0.0121	0.3414	1
Entamoeba histolytica	protein kinase domain containing protein	0.0121	0.3414	0.3538
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0121	0.3414	0.3414
Loa Loa (eye worm)	hypothetical protein	0.0121	0.3414	0.3538
Entamoeba histolytica	hypothetical protein	0.0121	0.3414	0.3538
Brugia malayi	C-terminal src kinase protein 1	0.0121	0.3414	0.3538
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0121	0.3414	1
Brugia malayi	Tensin	0.0182	0.5485	0.5686
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0121	0.3414	0.3414
Schistosoma mansoni	tyrosine kinase	0.0303	0.9648	1
Brugia malayi	hypothetical protein	0.0303	0.9648	1
Loa Loa (eye worm)	TK/FAK protein kinase	0.0121	0.3414	0.3538
Echinococcus granulosus	ephrin type A receptor 4 A	0.0121	0.3414	0.3414
Echinococcus multilocularis	SH2 motif	0.0182	0.5485	0.5485
Loa Loa (eye worm)	TK/FER protein kinase	0.0121	0.3414	0.3538
Brugia malayi	SH2 domain containing protein	0.0182	0.5485	0.5686
Plasmodium falciparum	protein kinase, putative	0.0121	0.3414	0.5
Loa Loa (eye worm)	SH2 domain-containing protein	0.0182	0.5485	0.5686
Brugia malayi	Variant SH3 domain containing protein	0.0182	0.5485	0.5686
Trichomonas vaginalis	TKL family protein kinase	0.0121	0.3414	1
Entamoeba histolytica	protein kinase domain containing protein	0.0121	0.3414	0.3538
Echinococcus multilocularis	SH2 domain containing protein 7	0.0182	0.5485	0.5485
Brugia malayi	Variant SH3 domain containing protein	0.0182	0.5485	0.5686
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0303	0.9648	0.9648
Entamoeba histolytica	serine/threonine kinase, putative	0.0121	0.3414	0.3538
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0182	0.5485	0.5485
Trichomonas vaginalis	TKL family protein kinase	0.0121	0.3414	1
Echinococcus granulosus	tyrosine protein kinase csk	0.0121	0.3414	0.3414
Loa Loa (eye worm)	TK/INSR protein kinase	0.0121	0.3414	0.3538
Echinococcus multilocularis	protein kinase	0.0121	0.3414	0.3414
Onchocerca volvulus		0.0182	0.5485	0.3323
Loa Loa (eye worm)	hypothetical protein	0.0182	0.5485	0.5686
Trichomonas vaginalis	TKL family protein kinase	0.0121	0.3414	1
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0182	0.5485	0.5485
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0121	0.3414	0.3414
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0121	0.3414	0.3538
Entamoeba histolytica	protein kinase, putative	0.0121	0.3414	0.3538
Brugia malayi	RhoGAP domain containing protein	0.0182	0.5485	0.5686
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0182	0.5485	0.5485
Echinococcus granulosus	SH2 motif	0.0182	0.5485	0.5485
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0121	0.3414	0.3538
Brugia malayi	Protein kinase domain containing protein	0.0121	0.3414	0.3538
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0121	0.3414	0.3538
Entamoeba histolytica	serine/threonine kinase, putative	0.0121	0.3414	0.3538
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0303	0.9648	0.9648
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0121	0.3414	0.3538
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0182	0.5485	0.5485
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0182	0.5485	0.5686
Echinococcus multilocularis	epidermal growth factor receptor	0.0121	0.3414	0.3414
Loa Loa (eye worm)	TK protein kinase	0.0121	0.3414	0.3538
Schistosoma mansoni	tensin	0.0182	0.5485	0.5686
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.0313	1	1
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0121	0.3414	0.3414
Echinococcus multilocularis	SH2 motif	0.0182	0.5485	0.5485
Brugia malayi	Protein kinase domain containing protein	0.0121	0.3414	0.3538
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0121	0.3414	0.3538
Schistosoma mansoni	tyrosine kinase	0.0121	0.3414	0.3538
Leishmania major	protein kinase, putative	0.0121	0.3414	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0121	0.3414	0.3538
Schistosoma mansoni	protein kinase	0.0121	0.3414	0.3538
Trichomonas vaginalis	TKL family protein kinase	0.0121	0.3414	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0121	0.3414	0.3538
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0121	0.3414	0.3538
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0121	0.3414	0.3414
Echinococcus multilocularis	FL cytokine receptor	0.0121	0.3414	0.3414
Trichomonas vaginalis	TKL family protein kinase	0.0121	0.3414	1
Entamoeba histolytica	protein kinase, putative	0.0121	0.3414	0.3538
Entamoeba histolytica	protein kinase, putative	0.0121	0.3414	0.3538
Brugia malayi	SH2 domain containing protein	0.0182	0.5485	0.5686
Plasmodium falciparum	protein kinase, putative	0.0121	0.3414	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0121	0.3414	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0121	0.3414	0.3538
Brugia malayi	Protein kinase domain containing protein	0.0121	0.3414	0.3538
Loa Loa (eye worm)	TK/DDR protein kinase	0.0121	0.3414	0.3538
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0182	0.5485	0.5686
Loa Loa (eye worm)	TK protein kinase	0.0121	0.3414	0.3538
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0303	0.9648	1
Brugia malayi	integrin-linked kinase	0.0121	0.3414	0.3538
Echinococcus multilocularis	tyrosine protein kinase shark	0.0303	0.9648	0.9648
Echinococcus granulosus	tyrosine protein kinase shark	0.0303	0.9648	0.9648
Entamoeba histolytica	protein kinase, putative	0.0121	0.3414	0.3538
Echinococcus multilocularis	tensin	0.0182	0.5485	0.5485
Echinococcus granulosus	c src tyrosine kinase	0.0303	0.9648	0.9648
Loa Loa (eye worm)	hypothetical protein	0.0121	0.3414	0.3538
Loa Loa (eye worm)	TK/FER protein kinase	0.0121	0.3414	0.3538
Trichomonas vaginalis	AGC family protein kinase	0.0121	0.3414	1
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0121	0.3414	0.3414
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0121	0.3414	0.3538
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0121	0.3414	0.3538
Echinococcus multilocularis	tyrosine protein kinase csk	0.0121	0.3414	0.3414
Entamoeba histolytica	tyrosin kinase, putative	0.0121	0.3414	0.3538
Loa Loa (eye worm)	TK/FER protein kinase	0.0121	0.3414	0.3538
Schistosoma mansoni	tyrosine kinase	0.0121	0.3414	0.3538
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0182	0.5485	0.5485
Echinococcus multilocularis	N chimaerin	0.0182	0.5485	0.5485
Entamoeba histolytica	tyrosine kinase, putative	0.0121	0.3414	0.3538
Echinococcus granulosus	SH2 motif	0.0182	0.5485	0.5485
Entamoeba histolytica	tyrosine kinase, putative	0.0121	0.3414	0.3538
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0121	0.3414	0.3538
Entamoeba histolytica	tyrosine kinase, putative	0.0121	0.3414	0.3538
Trichomonas vaginalis	TKL family protein kinase	0.0121	0.3414	1
Entamoeba histolytica	protein kinase domain containing protein	0.0121	0.3414	0.3538

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 12 nM	Inhibition of human DNA-PK using GST-tagged p53N66 as substrate after 1 hr by ELISA-based chemiluminiscence assay	ChEMBL.	23855836

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2420293

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1771534