Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ABL proto-oncogene 2, non-receptor tyrosine kinase | Starlite/ChEMBL | References |
Homo sapiens | ABL proto-oncogene 1, non-receptor tyrosine kinase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Hypothetical protein | 0.0257 | 0.4962 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.0016 | 0.0142 | 0.0142 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0016 | 0.0142 | 0.0142 |
Schistosoma mansoni | tyrosine kinase | 0.0016 | 0.0142 | 0.0144 |
Brugia malayi | Sex muscle abnormal protein 5 | 0.0014 | 0.0101 | 0.0137 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0185 | 0.3536 | 0.1841 |
Loa Loa (eye worm) | hypothetical protein | 0.0427 | 0.839 | 0.839 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0185 | 0.3536 | 0.1841 |
Schistosoma mansoni | growth factor receptor-bound protein | 0.0014 | 0.0101 | 0.0103 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.0427 | 0.839 | 0.976 |
Loa Loa (eye worm) | hypothetical protein | 0.0249 | 0.4815 | 0.4815 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0016 | 0.0142 | 0.0142 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0016 | 0.0142 | 0.0142 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0378 | 0.7394 | 0.7504 |
Entamoeba histolytica | protein kinase, putative | 0.0009 | 0.0001 | 0.0001 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.0016 | 0.0142 | 0.0144 |
Schistosoma mansoni | tyrosine kinase | 0.0016 | 0.0142 | 0.0144 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0018 | 0.0184 | 0.0184 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0207 | 0.3966 | 0.3966 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0016 | 0.0142 | 0.0142 |
Loa Loa (eye worm) | variant SH3 domain-containing protein | 0.0014 | 0.0101 | 0.0101 |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.0257 | 0.4962 | 0.5 |
Schistosoma mansoni | growth factor receptor-bound protein | 0.0014 | 0.0101 | 0.0103 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0016 | 0.0142 | 0.0142 |
Schistosoma mansoni | tyrosine kinase | 0.05 | 0.9854 | 1 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0207 | 0.3966 | 0.5364 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0435 | 0.8537 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0185 | 0.3536 | 0.1841 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0016 | 0.0142 | 0.0142 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0016 | 0.0142 | 0.0142 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0016 | 0.0142 | 0.0142 |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.0427 | 0.839 | 0.976 |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.0009 | 0.0001 | 0.0001 |
Echinococcus granulosus | growth factor receptor bound protein 2 | 0.0014 | 0.0101 | 0.0101 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.0427 | 0.839 | 0.976 |
Mycobacterium ulcerans | hypothetical protein | 0.0257 | 0.4962 | 0.5 |
Brugia malayi | Variant SH3 domain containing protein | 0.0014 | 0.0101 | 0.0137 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.0435 | 0.8537 | 0.8537 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0016 | 0.0142 | 0.0142 |
Brugia malayi | SRC-1 | 0.0016 | 0.0142 | 0.0193 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0016 | 0.0142 | 0.0142 |
Schistosoma mansoni | tyrosine kinase | 0.0016 | 0.0142 | 0.0144 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0016 | 0.0142 | 0.0142 |
Echinococcus multilocularis | tyrosine protein kinase ABL1 | 0.0507 | 1 | 1 |
Onchocerca volvulus | 0.0435 | 0.8537 | 1 | |
Echinococcus multilocularis | growth factor receptor bound protein 2 | 0.0014 | 0.0101 | 0.0101 |
Echinococcus multilocularis | c src tyrosine kinase | 0.0016 | 0.0142 | 0.0142 |
Echinococcus granulosus | c src tyrosine kinase | 0.0016 | 0.0142 | 0.0142 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase abl1 | 0.0014 | 0.0101 | 0.0103 |
Giardia lamblia | Hypothetical protein | 0.0257 | 0.4962 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.3678 | 0.3678 |
Loa Loa (eye worm) | TK/ABL protein kinase | 0.0507 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0101 | 0.0101 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0016 | 0.0142 | 0.0142 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0016 | 0.0142 | 0.0142 |
Loa Loa (eye worm) | SRC-1 | 0.0016 | 0.0142 | 0.0142 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0308 | 0.5989 | 0.81 |
Brugia malayi | Protein kinase domain containing protein | 0.0378 | 0.7394 | 1 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.0257 | 0.4962 | 1 |
Echinococcus multilocularis | NCK adaptor protein | 0.0014 | 0.0101 | 0.0101 |
Echinococcus granulosus | NCK adaptor protein | 0.0014 | 0.0101 | 0.0101 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0427 | 0.839 | 0.976 |
Schistosoma mansoni | nck2/grb4 | 0.0014 | 0.0101 | 0.0103 |
Brugia malayi | Variant SH3 domain containing protein | 0.0014 | 0.0101 | 0.0137 |
Schistosoma mansoni | adapter molecule crk | 0.0014 | 0.0101 | 0.0103 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0016 | 0.0142 | 0.0142 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0016 | 0.0142 | 0.0142 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.0016 | 0.0142 | 0.0142 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0435 | 0.8537 | 1 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-1-like protein | 0.0185 | 0.3536 | 0.1841 |
Loa Loa (eye worm) | hypothetical protein | 0.0435 | 0.8537 | 0.8537 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0435 | 0.8537 | 0.8664 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0435 | 0.8537 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0435 | 0.8537 | 1 |
Echinococcus granulosus | 6 phosphofructo 2 kinase:fructose 2 | 0.0435 | 0.8537 | 0.8537 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0016 | 0.0142 | 0.0142 |
Loa Loa (eye worm) | sex muscle abnormal protein 5 | 0.0014 | 0.0101 | 0.0101 |
Schistosoma mansoni | tyrosine kinase | 0.0016 | 0.0142 | 0.0144 |
Loa Loa (eye worm) | CAMK/CAMKL/CHK1 protein kinase | 0.0378 | 0.7394 | 0.7394 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.