Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Ovis aries | Cyclooxygenase-1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | peroxidasin | 0.0048 | 0.406 | 1 |
Leishmania major | NAD synthase, putative | 0.0093 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0048 | 0.406 | 1 |
Echinococcus granulosus | peroxidasin | 0.0048 | 0.406 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0048 | 0.406 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.406 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.406 | 1 |
Schistosoma mansoni | peroxidasin | 0.0048 | 0.406 | 0.2712 |
Onchocerca volvulus | 0.0048 | 0.406 | 1 | |
Onchocerca volvulus | 0.0048 | 0.406 | 1 | |
Echinococcus multilocularis | GMP synthase (glutamine hydrolyzing) | 0.0037 | 0.2717 | 0.3925 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0048 | 0.406 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.406 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.406 | 1 |
Brugia malayi | GMP synthase | 0.0037 | 0.2717 | 0.6693 |
Schistosoma mansoni | GMP synthetase | 0.0037 | 0.2717 | 0.1064 |
Schistosoma mansoni | peroxidasin | 0.0048 | 0.406 | 0.2712 |
Onchocerca volvulus | Peroxidase homolog | 0.0048 | 0.406 | 1 |
Schistosoma mansoni | glutamine-dependent NAD(+) synthetase | 0.0056 | 0.5148 | 0.4047 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.185 | 0.4556 |
Trypanosoma cruzi | NAD+ synthase, putative | 0.0093 | 1 | 0.5 |
Trypanosoma brucei | NAD+ synthase, putative | 0.0093 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0048 | 0.406 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.406 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0048 | 0.406 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0048 | 0.406 | 1 |
Echinococcus granulosus | GMP synthase glutamine hydrolyzing | 0.0037 | 0.2717 | 0.3925 |
Onchocerca volvulus | Peroxidase homolog | 0.0048 | 0.406 | 1 |
Mycobacterium tuberculosis | Glutamine-dependent NAD(+) synthetase NadE (NAD(+) synthase [glutamine-hydrolysing]) | 0.0093 | 1 | 0.5 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0048 | 0.406 | 1 |
Giardia lamblia | NH3-dependent NAD+ synthetase | 0.0093 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.406 | 1 |
Brugia malayi | Peroxidasin | 0.0048 | 0.406 | 1 |
Schistosoma mansoni | glutamine-dependent NAD(+) synthetase | 0.0093 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.1777 | 0.4377 |
Trichomonas vaginalis | nh(3)-dependent NAD(+) synthetase, putative | 0.0093 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.406 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0048 | 0.406 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0031 | 0.185 | 0.4556 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.406 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0048 | 0.406 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.0048 | 0.406 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.406 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0048 | 0.406 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0031 | 0.185 | 0.4556 |
Loa Loa (eye worm) | intermediate filament protein | 0.0031 | 0.185 | 0.4556 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.406 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0048 | 0.406 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.406 | 1 |
Brugia malayi | hypothetical protein | 0.0048 | 0.406 | 1 |
Brugia malayi | Blistered cuticle protein 3 | 0.0048 | 0.406 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.406 | 1 |
Plasmodium falciparum | glutamine-dependent NAD(+) synthetase, putative | 0.0093 | 1 | 1 |
Onchocerca volvulus | 0.0048 | 0.406 | 1 | |
Brugia malayi | Animal haem peroxidase family protein | 0.0048 | 0.406 | 1 |
Trypanosoma cruzi | NAD+ synthase, putative | 0.0093 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.406 | 1 |
Brugia malayi | intermediate filament protein | 0.0031 | 0.185 | 0.4556 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0048 | 0.406 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.406 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.2717 | 0.6693 |
Plasmodium vivax | glutamine-dependent NAD(+) synthetase, putative | 0.0093 | 1 | 1 |
Mycobacterium leprae | PROBABLE GLUTAMINE-DEPENDENT NAD(+) SYNTHETASE NADE (NAD(+) SYNTHASE [GLUTAMINE-HYDROLYSING]) | 0.0093 | 1 | 0.5 |
Toxoplasma gondii | glutamine-dependent NAD(+) synthetase protein, putative | 0.0093 | 1 | 1 |
Treponema pallidum | NAD synthetase | 0.0093 | 1 | 0.5 |
Mycobacterium ulcerans | NAD synthetase | 0.0093 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.28 uM | Inhibition of ovine COX1 using arachidonic acid as substrate assessed as production of PGF2alpha preincubated for 10 mins followed by substrate addition measured after 2 mins by EIA in presence of stannous chloride | ChEMBL. | 23769654 |
IC50 (binding) | > 30 uM | Inhibition of ovine COX2 using arachidonic acid as substrate assessed as production of PGF2alpha preincubated for 10 mins followed by substrate addition measured after 2 mins by EIA in presence of stannous chloride | ChEMBL. | 23769654 |
Inhibition (binding) | = 60.7 % | Inhibition of ovine COX2 using arachidonic acid as substrate assessed as production of PGF2alpha at 30 uM preincubated for 10 mins followed by substrate addition measured after 2 mins by EIA in presence of stannous chloride relative to control | ChEMBL. | 23769654 |
Inhibition (binding) | = 99.9 % | Inhibition of ovine COX1 using arachidonic acid as substrate assessed as production of PGF2alpha at 30 uM preincubated for 10 mins followed by substrate addition measured after 2 mins by EIA in presence of stannous chloride relative to control | ChEMBL. | 23769654 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.