Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Metabotropic glutamate receptor 5 | Starlite/ChEMBL | References |
Homo sapiens | monoamine oxidase B | Starlite/ChEMBL | References |
Homo sapiens | glutamate receptor, metabotropic 5 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | amine oxidase, flavin-containing family protein | monoamine oxidase B | 520 aa | 462 aa | 19.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0048 | 0.0427 | 0.2169 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-1-like protein | 0.0075 | 0.1263 | 0.2898 |
Onchocerca volvulus | 0.0175 | 0.4357 | 1 | |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.0172 | 0.4266 | 0.9791 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0075 | 0.1263 | 0.2898 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0175 | 0.4357 | 1 |
Loa Loa (eye worm) | glutamate receptor | 0.0038 | 0.0144 | 0.0331 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0175 | 0.4357 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.2667 | 0.612 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0111 | 0.2383 | 0.5471 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0175 | 0.4357 | 1 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.012 | 0.2667 | 0.612 |
Echinococcus granulosus | 6 phosphofructo 2 kinase:fructose 2 | 0.0175 | 0.4357 | 1 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0359 | 1 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0175 | 0.4357 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0048 | 0.0427 | 0.0981 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.0103 | 0.2145 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0175 | 0.4357 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0082 | 0.1482 | 0.3402 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.0333 | 0.9223 | 0.5 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0098 | 0.1971 | 1 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0082 | 0.1482 | 0.3402 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0075 | 0.1263 | 0.2898 |
Giardia lamblia | Hypothetical protein | 0.0103 | 0.2145 | 0.5 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0034 | 0 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0175 | 0.4357 | 1 |
Giardia lamblia | Hypothetical protein | 0.0103 | 0.2145 | 0.5 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0082 | 0.1482 | 0.3402 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.2054 | 0.4714 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 0.4266 | 0.9791 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.0175 | 0.4357 | 1 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.012 | 0.2667 | 0.612 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0034 | 0 | 0.5 |
Loa Loa (eye worm) | glutamate receptor | 0.0098 | 0.1971 | 0.4523 |
Mycobacterium ulcerans | hypothetical protein | 0.0103 | 0.2145 | 0.2145 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.0172 | 0.4266 | 0.9791 |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.0172 | 0.4266 | 0.9791 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0075 | 0.1263 | 0.2898 |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.0103 | 0.2145 | 0.2145 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0089 | 0.1688 | 0.8563 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0172 | 0.4266 | 0.9791 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.0045 uM | Inhibition of human recombinant MAO-B expressed in insect Hi5 cells using kynuramine as substrate | ChEMBL. | 23856046 |
IC50 (binding) | = 0.0346 uM | Negative allosteric modulation of mGluR5 in differentiated rat primary astrocytes assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation treated 5 mins before L-quisqualate addition by FLIPR assay | ChEMBL. | 23856046 |
IC50 (binding) | = 0.0831 uM | Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation treated 5 mins before L-quisqualate addition by FLIPR assay | ChEMBL. | 23856046 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.