TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 451.858 | Formula: C20H22ClN3O7
H donors: 2 H acceptors: 4 LogP: 4.15 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc(C(=O)O)c(cc1OC)Nc1ncnc2c1c(OC)c(c(c2)OC)OC.Cl
InChi: 1S/C20H21N3O7.ClH/c1-26-13-6-10(20(24)25)11(7-14(13)27-2)23-19-16-12(21-9-22-19)8-15(28-3)17(29-4)18(16)30-5;/h6-9H,1-5H3,(H,24,25)(H,21,22,23);1H
InChiKey: PNOWYYJIKPRSGJ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	phosphoglycerate mutase family member 5, putative	0.0039	0.0086	0.0078
Echinococcus granulosus	geminin	0.0191	0.0747	0.0747
Loa Loa (eye worm)	acetyltransferase	0.0161	0.0616	0.0616
Trypanosoma cruzi	Histidine phosphatase superfamily (branch 1), putative	0.0039	0.0086	0.0078
Mycobacterium tuberculosis	Glucosyl-3-phosphoglycerate phosphatase GpgP	0.0039	0.0086	0.0746
Trichomonas vaginalis	esterase, putative	0.0041	0.0093	0.0325
Loa Loa (eye worm)	TTK protein kinase	0.0622	0.2617	0.2617
Echinococcus multilocularis	serine:threonine protein phosphatase PGAM5	0.0039	0.0086	0.0086
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0157	0.0157
Trypanosoma brucei	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.099	0.4219	0.4214
Mycobacterium ulcerans	lipoprotein LpqD	0.0039	0.0086	0.0133
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	0.0157	0.0157
Trypanosoma brucei	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.2321	1	1
Echinococcus multilocularis	serine:threonine protein phosphatase PGAM5	0.0039	0.0086	0.0086
Trypanosoma brucei	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative	0.0039	0.0086	0.0078
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0157	0.0157
Giardia lamblia	Hypothetical protein	0.137	0.5867	1
Brugia malayi	UBASH3A protein homolog	0.0039	0.0086	0.0298
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0021	0.0009	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0169	0.0648	0.0648
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0021	0.0009	0.0009
Loa Loa (eye worm)	beta-lactamase	0.0041	0.0093	0.0093
Mycobacterium tuberculosis	Possible phosphoglycerate mutase Gpm2 (phosphoglyceromutase) (PGAM) (BPG-dependent PGAM)	0.0039	0.0086	0.0746
Mycobacterium ulcerans	hypothetical protein	0.0041	0.0093	0.0145
Trypanosoma brucei	phosphoglycerate mutase protein, putative	0.0039	0.0086	0.0078
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0072	0.0227	0.0227
Schistosoma mansoni	hypothetical protein	0.0023	0.0018	0.0018
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0041	0.0093	0.0093
Mycobacterium ulcerans	phosphoglyceromutase	0.0039	0.0086	0.0133
Giardia lamblia	Histone acetyltransferase GCN5	0.0043	0.0102	0.0159
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0143	0.0143
Mycobacterium ulcerans	phosphoglycerate mutase	0.0039	0.0086	0.0133
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0056	0.016	0.0582
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0021	0.0009	0.5
Brugia malayi	Protein kinase domain containing protein	0.0622	0.2617	1
Trypanosoma cruzi	Histidine phosphatase superfamily (branch 1), putative	0.0039	0.0086	0.0078
Mycobacterium tuberculosis	Probable lipase LipE	0.0041	0.0093	0.0814
Toxoplasma gondii	phosphoglycerate mutase PGMII	0.0039	0.0086	0.6394
Trichomonas vaginalis	penicillin-binding protein, putative	0.0041	0.0093	0.0325
Echinococcus granulosus	survival motor neuron protein 1	0.0267	0.1075	0.1075
Toxoplasma gondii	ABC1 family protein	0.0041	0.0093	0.6974
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0105	0.0105
Trichomonas vaginalis	conserved hypothetical protein	0.0244	0.0977	0.3712
Leishmania major	fructose-6-phosphate2-kinase/fructose-2,6-bisph os phatase-likeprotein	0.0039	0.0086	0.0078
Schistosoma mansoni	ap endonuclease	0.0021	0.0009	0.0009
Schistosoma mansoni	hypothetical protein	0.0038	0.0083	0.0083
Entamoeba histolytica	phosphoglycerate mutase family protein, putative	0.0039	0.0086	0.0133
Loa Loa (eye worm)	bromodomain containing protein	0.0024	0.002	0.002
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0041	0.0093	0.0325
Echinococcus granulosus	zinc finger protein	0.0026	0.0029	0.0029
Toxoplasma gondii	phosphoglycerate mutase family protein	0.0039	0.0086	0.6394
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.2321	1	1
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0041	0.0093	0.0814
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0056	0.016	0.0582
Leishmania major	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.2321	1	1
Brugia malayi	Bromodomain containing protein	0.0047	0.0121	0.0433
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative	0.0039	0.0086	0.0078
Trichomonas vaginalis	CAMK family protein kinase	0.0622	0.2617	1
Schistosoma mansoni	hypothetical protein	0.0039	0.0086	0.0086
Mycobacterium ulcerans	fructose-2,6-bisphosphatase GpmB	0.137	0.5867	1
Loa Loa (eye worm)	hypothetical protein	0.0343	0.1405	0.1405
Loa Loa (eye worm)	hypothetical protein	0.005	0.0133	0.0133
Mycobacterium tuberculosis	Conserved protein	0.0039	0.0086	0.0746
Trichomonas vaginalis	phosphoglycerate mutase, putative	0.0039	0.0086	0.0298
Mycobacterium ulcerans	hydrolase MutT1	0.0039	0.0086	0.0133
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0161	0.0616	0.0616
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative	0.0039	0.0086	0.0078
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0083	0.0083
Schistosoma mansoni	hypothetical protein	0.0191	0.0747	0.0747
Loa Loa (eye worm)	hypothetical protein	0.0056	0.016	0.016
Onchocerca volvulus		0.0343	0.1405	0.133
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0157	0.0157
Mycobacterium ulcerans	lipase LipD	0.0041	0.0093	0.0145
Schistosoma mansoni	hypothetical protein	0.0054	0.0153	0.0153
Onchocerca volvulus		0.0054	0.0153	0.0067
Trypanosoma cruzi	Histidine phosphatase superfamily (branch 1), putative	0.0039	0.0086	0.0078
Entamoeba histolytica	phosphoglycerate mutase family protein, putative	0.137	0.5867	1
Mycobacterium ulcerans	bifunctional RNase H/acid phosphatase	0.0039	0.0086	0.0133
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0157	0.0157
Mycobacterium tuberculosis	Probable esterase LipL	0.0041	0.0093	0.0814
Leishmania major	hypothetical protein, conserved	0.0039	0.0086	0.0078
Mycobacterium tuberculosis	Possible hydrolase MutT1	0.0039	0.0086	0.0746
Loa Loa (eye worm)	hypothetical protein	0.008	0.0264	0.0264
Brugia malayi	hypothetical protein	0.0343	0.1405	0.5352
Echinococcus multilocularis	phosphoglycerate mutase	0.0039	0.0086	0.0086
Schistosoma mansoni	survival motor neuron protein	0.0054	0.0153	0.0153
Mycobacterium tuberculosis	Probable lipase LipD	0.0041	0.0093	0.0814
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0093	0.0093
Trichomonas vaginalis	phosphoglycerate mutase, putative	0.0039	0.0086	0.0298
Trichomonas vaginalis	D-aminoacylase, putative	0.0041	0.0093	0.0325
Echinococcus multilocularis	muscleblind protein	0.0169	0.0648	0.0648
Trypanosoma cruzi	6-phosphofructo-2-kinase 1	0.2282	0.983	0.983
Leishmania major	phosphoglycerate mutase family member 5, putative	0.0039	0.0086	0.0078
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0026	0.0027	0.0027
Trypanosoma cruzi	glycerolphosphate mutase, putative	0.0039	0.0086	0.0078
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.099	0.4219	0.4214
Entamoeba histolytica	phosphoglycerate mutase family protein. putative	0.0039	0.0086	0.0133
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0041	0.0093	0.0093
Schistosoma mansoni	phosphoglycerate mutase	0.0039	0.0086	0.0086
Mycobacterium leprae	conserved hypothetical protein	0.0041	0.0093	1
Echinococcus granulosus	phosphoglycerate mutase	0.0039	0.0086	0.0086
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0049	0.013	1
Trypanosoma brucei	Histidine phosphatase superfamily (branch 1), putative	0.0039	0.0086	0.0078
Trichomonas vaginalis	phosphoglycerate mutase, putative	0.0039	0.0086	0.0298
Echinococcus granulosus	serine:threonine protein phosphatase PGAM5	0.0039	0.0086	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0267	0.1075	0.1075
Brugia malayi	acetyltransferase, GNAT family protein	0.0161	0.0616	0.2328
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0041	0.0093	0.0814
Trichomonas vaginalis	phosphoglycerate mutase, putative	0.0039	0.0086	0.0298
Schistosoma mansoni	6-phosphofructokinase	0.2321	1	1
Leishmania major	hypothetical protein, conserved	0.0039	0.0086	0.0078
Trichomonas vaginalis	penicillin-binding protein, putative	0.0041	0.0093	0.0325
Echinococcus multilocularis	zinc finger protein	0.0026	0.0029	0.0029
Trypanosoma cruzi	phosphoglycerate mutase, putative	0.0039	0.0086	0.0078
Trypanosoma brucei	Histidine phosphatase superfamily (branch 1), putative	0.0039	0.0086	0.0078
Echinococcus multilocularis	phosphoglycerate mutase	0.0039	0.0086	0.0086
Mycobacterium tuberculosis	Conserved protein	0.0041	0.0093	0.0814
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.099	0.4219	0.4214
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0049	0.013	0.0465
Mycobacterium ulcerans	phosphoglycerate mutase	0.0039	0.0086	0.0133
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.0086	0.0298
Echinococcus granulosus	phosphoglycerate mutase	0.0039	0.0086	0.0086
Schistosoma mansoni	bromodomain containing protein	0.0076	0.0244	0.0244
Echinococcus granulosus	dual specificity serine:threonine tyrosine	0.0622	0.2617	0.2617
Mycobacterium tuberculosis	Conserved protein	0.0041	0.0093	0.0814
Echinococcus granulosus	phosphoglycerate mutase	0.0039	0.0086	0.0086
Mycobacterium tuberculosis	Probable conserved lipoprotein LpqD	0.0039	0.0086	0.0746
Loa Loa (eye worm)	hypothetical protein	0.0251	0.1007	0.1007
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0086	0.0086
Mycobacterium tuberculosis	PE-PGRS family protein PE_PGRS11	0.0039	0.0086	0.0746
Schistosoma mansoni	hypothetical protein	0.0039	0.0086	0.0086
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0161	0.0616	0.0616
Trichomonas vaginalis	phosphoglycerate mutase, putative	0.0039	0.0086	0.0298
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0157	0.0157
Trypanosoma brucei	glycerolphosphate mutase, putative	0.0039	0.0086	0.0078
Echinococcus granulosus	phosphoglycerate mutase	0.0039	0.0086	0.0086
Echinococcus multilocularis	muscleblind protein 1	0.0169	0.0648	0.0648
Leishmania major	phosphoglycerate mutase protein, putative	0.0039	0.0086	0.0078
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0056	0.016	0.016
Plasmodium vivax	hypothetical protein, conserved	0.0041	0.0093	0.6974
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0086	0.0086
Leishmania major	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.2282	0.983	0.983
Trypanosoma cruzi	phosphoglycerate mutase, putative	0.0039	0.0086	0.0078
Echinococcus multilocularis	survival motor neuron protein 1	0.0267	0.1075	0.1075
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0041	0.0093	0.0814
Brugia malayi	hypothetical protein	0.0267	0.1075	0.409
Mycobacterium ulcerans	acid phosphatase	0.0039	0.0086	0.0133
Brugia malayi	phosphoglycerate mutase family protein	0.0039	0.0086	0.0298
Chlamydia trachomatis	2,3-bisphosphoglycerate-dependent phosphoglycerate mutase	0.0039	0.0086	0.5
Trypanosoma brucei	phosphoglycerate mutase, putative	0.0039	0.0086	0.0078
Echinococcus multilocularis	6 phosphofructo 2 kinase:fructose 2	0.2321	1	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0086	0.0086
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0055	0.0157	0.0569
Trypanosoma cruzi	phosphoglycerate mutase protein, putative	0.0039	0.0086	0.0078
Loa Loa (eye worm)	PHD-finger family protein	0.0023	0.0018	0.0018
Trypanosoma cruzi	phosphoglycerate mutase family member 5, putative	0.0039	0.0086	0.0078
Mycobacterium leprae	Probable lipase LipE	0.0041	0.0093	1
Brugia malayi	Muscleblind-like protein	0.0169	0.0648	0.2453
Trichomonas vaginalis	CAMK family protein kinase	0.0622	0.2617	1
Echinococcus granulosus	beta LACTamase domain containing family member	0.0041	0.0093	0.0093
Brugia malayi	beta-lactamase family protein	0.0041	0.0093	0.0325
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0049	0.013	0.0465
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0041	0.0093	0.0093
Brugia malayi	Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog	0.0251	0.1007	0.3826
Echinococcus granulosus	muscleblind protein	0.0169	0.0648	0.0648
Plasmodium falciparum	histone acetyltransferase GCN5	0.0043	0.0102	1
Schistosoma mansoni	hypothetical protein	0.0039	0.0086	0.0086
Brugia malayi	phosphoglycerate mutase family protein	0.0039	0.0086	0.0298
Mycobacterium tuberculosis	Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase)	0.0039	0.0086	0.0746
Schistosoma mansoni	hypothetical protein	0.0191	0.0747	0.0747
Echinococcus multilocularis	phosphoglycerate mutase	0.0039	0.0086	0.0086
Entamoeba histolytica	phosphoglycerate mutase family protein, putative	0.0039	0.0086	0.0133
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0041	0.0093	0.0093
Trypanosoma brucei	hypothetical protein, conserved	0.0041	0.0093	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0093	0.0093
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0049	0.013	1
Loa Loa (eye worm)	phosphoglycerate mutase	0.0039	0.0086	0.0086
Trypanosoma cruzi	Histidine phosphatase superfamily (branch 1), putative	0.0039	0.0086	0.0078
Giardia lamblia	Kinase, TTK	0.0622	0.2617	0.4452
Schistosoma mansoni	zinc finger protein	0.0026	0.0029	0.0029
Brugia malayi	PHD-finger family protein	0.0032	0.0056	0.018
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0261	0.1049	1
Mycobacterium tuberculosis	Probable hydrolase	0.0041	0.0093	0.0814
Loa Loa (eye worm)	hypothetical protein	0.0169	0.0648	0.0648
Echinococcus multilocularis	dual specificity serine:threonine tyrosine	0.0622	0.2617	0.2617
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0093	0.0093
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0157	0.0157
Echinococcus multilocularis	phosphoglycerate mutase	0.0039	0.0086	0.0086
Trichomonas vaginalis	D-aminoacylase, putative	0.0041	0.0093	0.0325
Echinococcus granulosus	fetal alzheimer antigen falz	0.0026	0.0027	0.0027
Mycobacterium tuberculosis	Conserved protein	0.0039	0.0086	0.0746
Mycobacterium ulcerans	hypothetical protein	0.0039	0.0086	0.0133
Leishmania major	glycerolphosphate mutase, putative	0.0039	0.0086	0.0078
Onchocerca volvulus		0.0041	0.0093	0.0007
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0054	0.0153	0.0552
Loa Loa (eye worm)	hypothetical protein	0.1331	0.5697	0.5697
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0041	0.0093	0.0093
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0157	0.0157
Plasmodium vivax	phosphoglycerate mutase, putative	0.0039	0.0086	0.6394
Mycobacterium ulcerans	hypothetical protein	0.0039	0.0086	0.0133
Mycobacterium ulcerans	hypothetical protein	0.137	0.5867	1
Trypanosoma brucei	6-phosphofructo-2-kinase 2	0.2282	0.983	0.983
Treponema pallidum	phosphoglyceromutase	0.0039	0.0086	1
Schistosoma mansoni	hypothetical protein	0.0039	0.0086	0.0086
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0026	0.0027	0.0027
Leishmania major	hypothetical protein, unknown function	0.0039	0.0086	0.0078
Toxoplasma gondii	phosphoglycerate mutase family protein	0.0039	0.0086	0.6394
Onchocerca volvulus		0.0041	0.0093	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0093	0.0093
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0093	0.0093
Mycobacterium ulcerans	esterase/lipase LipP	0.0041	0.0093	0.0145
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.0086	0.0298
Trypanosoma brucei	Serine/threonine-protein phosphatase PGAM5, mitochondrial, putative	0.0039	0.0086	0.0078
Brugia malayi	Bromodomain containing protein	0.0089	0.0302	0.1125
Plasmodium falciparum	phosphoglucomutase-2	0.0039	0.0086	0.8356
Trypanosoma cruzi	Histidine phosphatase superfamily (branch 1), putative	0.0039	0.0086	0.0078
Brugia malayi	latrophilin 2 splice variant baaae	0.0038	0.0083	0.0286
Trypanosoma brucei	Histidine phosphatase superfamily (branch 1), putative	0.0039	0.0086	0.0078
Onchocerca volvulus	Dual specificity protein kinase TTK homolog	0.0622	0.2617	0.2553
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0041	0.0093	0.0145
Trypanosoma cruzi	phosphoglycerate mutase protein, putative	0.0039	0.0086	0.0078
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0086	0.0086
Schistosoma mansoni	ap endonuclease	0.0021	0.0009	0.0009
Mycobacterium ulcerans	phosphohistidine phosphatase SixA	0.0039	0.0086	0.0133
Echinococcus multilocularis	geminin	0.0191	0.0747	0.0747
Leishmania major	phosphoglycerate mutase, putative	0.0039	0.0086	0.0078
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0049	0.013	0.013
Leishmania major	hypothetical protein, conserved	0.0039	0.0086	0.0078
Echinococcus multilocularis	phosphoglycerate mutase	0.0039	0.0086	0.0086
Leishmania major	hypothetical protein, conserved	0.0041	0.0093	0.0085
Schistosoma mansoni	hypothetical protein	0.0039	0.0086	0.0086
Echinococcus multilocularis	phosphoglycerate mutase	0.0039	0.0086	0.0086
Onchocerca volvulus		0.2321	1	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0041	0.0093	0.0085
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0154	0.0585	0.0585
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0072	0.0227	0.0227
Brugia malayi	beta-lactamase family protein	0.0041	0.0093	0.0325
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0021	0.0009	0.0009
Loa Loa (eye worm)	hypothetical protein	0.2282	0.983	0.983
Giardia lamblia	Hypothetical protein	0.137	0.5867	1
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0049	0.013	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0093	0.0093
Echinococcus granulosus	phosphoglycerate mutase	0.0039	0.0086	0.0086
Trichomonas vaginalis	D-aminoacylase, putative	0.0041	0.0093	0.0325
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.2321	1	1
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0041	0.0093	0.0093
Toxoplasma gondii	phosphoglycerate mutase family protein	0.0039	0.0086	0.6394
Mycobacterium ulcerans	beta-lactamase	0.0041	0.0093	0.0145
Trypanosoma cruzi	hypothetical protein, conserved	0.0041	0.0093	0.0085
Trypanosoma cruzi	glycerolphosphate mutase, putative	0.0039	0.0086	0.0078
Onchocerca volvulus		0.0041	0.0093	0.0007
Schistosoma mansoni	hypothetical protein	0.0039	0.0086	0.0086
Mycobacterium tuberculosis	Conserved protein	0.0041	0.0093	0.0814
Plasmodium vivax	phosphoglucomutase-2, putative	0.0039	0.0086	0.6394
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0039	0.0086	0.0746
Leishmania major	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-1-like protein	0.099	0.4219	0.4214
Entamoeba histolytica	acetyltransferase, GNAT family	0.0043	0.0102	0.0159
Brugia malayi	beta-lactamase	0.0041	0.0093	0.0325
Loa Loa (eye worm)	hypothetical protein	0.2321	1	1
Schistosoma mansoni	dual specificity serine/threonine tyrosine kinase	0.0622	0.2617	0.2617
Trypanosoma cruzi	6-phosphofructo-2-kinase 1	0.2282	0.983	0.983
Echinococcus granulosus	serine:threonine protein phosphatase PGAM5	0.0039	0.0086	0.0086
Toxoplasma gondii	phosphoglycerate mutase	0.0039	0.0086	0.6394
Schistosoma mansoni	phosphoglycerate mutase	0.0039	0.0086	0.0086
Toxoplasma gondii	phosphoglycerate mutase family protein	0.0039	0.0086	0.6394
Plasmodium falciparum	phosphoglycerate mutase, putative	0.0039	0.0086	0.8356

Activities

Activity type	Activity value	Assay description	Source	Reference
GI (functional)	= 40.9 %	Growth inhibition of human Bcap37 cells at 1 uM after 72 hrs by MTT assay relative to control	ChEMBL.	23811258

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL2409814

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1772782