Detailed information for compound 1772782

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 451.858 | Formula: C20H22ClN3O7
  • H donors: 2 H acceptors: 4 LogP: 4.15 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(C(=O)O)c(cc1OC)Nc1ncnc2c1c(OC)c(c(c2)OC)OC.Cl
  • InChi: 1S/C20H21N3O7.ClH/c1-26-13-6-10(20(24)25)11(7-14(13)27-2)23-19-16-12(21-9-22-19)8-15(28-3)17(29-4)18(16)30-5;/h6-9H,1-5H3,(H,24,25)(H,21,22,23);1H
  • InChiKey: PNOWYYJIKPRSGJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0041 0.0093 0.0093
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0093 0.0325
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0261 0.1049 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0056 0.016 0.0582
Trypanosoma brucei phosphoglycerate mutase protein, putative 0.0039 0.0086 0.0078
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0041 0.0093 0.0814
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.099 0.4219 0.4214
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0086 0.0298
Trypanosoma brucei 6-phosphofructo-2-kinase 2 0.2282 0.983 0.983
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0157 0.0569
Onchocerca volvulus 0.0041 0.0093 0.0007
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0049 0.013 1
Giardia lamblia Hypothetical protein 0.137 0.5867 1
Brugia malayi acetyltransferase, GNAT family protein 0.0161 0.0616 0.2328
Brugia malayi phosphoglycerate mutase family protein 0.0039 0.0086 0.0298
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.2321 1 1
Brugia malayi hypothetical protein 0.0267 0.1075 0.409
Chlamydia trachomatis 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 0.0039 0.0086 0.5
Trypanosoma brucei Serine/threonine-protein phosphatase PGAM5, mitochondrial, putative 0.0039 0.0086 0.0078
Echinococcus multilocularis phosphoglycerate mutase 0.0039 0.0086 0.0086
Leishmania major glycerolphosphate mutase, putative 0.0039 0.0086 0.0078
Brugia malayi Bromodomain containing protein 0.0089 0.0302 0.1125
Echinococcus multilocularis phosphoglycerate mutase 0.0039 0.0086 0.0086
Trichomonas vaginalis phosphoglycerate mutase, putative 0.0039 0.0086 0.0298
Loa Loa (eye worm) hypothetical protein 0.0056 0.016 0.016
Trypanosoma cruzi Histidine phosphatase superfamily (branch 1), putative 0.0039 0.0086 0.0078
Mycobacterium ulcerans hydrolase MutT1 0.0039 0.0086 0.0133
Trichomonas vaginalis CAMK family protein kinase 0.0622 0.2617 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0133 0.0133
Echinococcus granulosus phosphoglycerate mutase 0.0039 0.0086 0.0086
Trypanosoma cruzi phosphoglycerate mutase, putative 0.0039 0.0086 0.0078
Leishmania major phosphoglycerate mutase, putative 0.0039 0.0086 0.0078
Trypanosoma cruzi glycerolphosphate mutase, putative 0.0039 0.0086 0.0078
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.0227 0.0227
Plasmodium vivax phosphoglucomutase-2, putative 0.0039 0.0086 0.6394
Loa Loa (eye worm) hypothetical protein 0.1331 0.5697 0.5697
Echinococcus multilocularis zinc finger protein 0.0026 0.0029 0.0029
Mycobacterium tuberculosis Probable esterase LipL 0.0041 0.0093 0.0814
Trypanosoma cruzi glycerolphosphate mutase, putative 0.0039 0.0086 0.0078
Mycobacterium leprae Probable lipase LipE 0.0041 0.0093 1
Schistosoma mansoni hypothetical protein 0.0039 0.0086 0.0086
Trypanosoma brucei 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.099 0.4219 0.4214
Mycobacterium ulcerans lipase LipD 0.0041 0.0093 0.0145
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0157 0.0157
Echinococcus granulosus dual specificity serine:threonine tyrosine 0.0622 0.2617 0.2617
Schistosoma mansoni hypothetical protein 0.0039 0.0086 0.0086
Toxoplasma gondii phosphoglycerate mutase 0.0039 0.0086 0.6394
Mycobacterium ulcerans hypothetical protein 0.137 0.5867 1
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0093 0.0085
Plasmodium falciparum histone acetyltransferase GCN5 0.0043 0.0102 1
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0093 0.0325
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.0093 0.0085
Mycobacterium tuberculosis Conserved protein 0.0039 0.0086 0.0746
Mycobacterium tuberculosis Conserved protein 0.0041 0.0093 0.0814
Mycobacterium ulcerans hypothetical protein 0.0039 0.0086 0.0133
Echinococcus multilocularis phosphoglycerate mutase 0.0039 0.0086 0.0086
Schistosoma mansoni hypothetical protein 0.0039 0.0086 0.0086
Echinococcus granulosus serine:threonine protein phosphatase PGAM5 0.0039 0.0086 0.0086
Leishmania major hypothetical protein, conserved 0.0041 0.0093 0.0085
Trypanosoma cruzi 6-phosphofructo-2-kinase 1 0.2282 0.983 0.983
Toxoplasma gondii phosphoglycerate mutase family protein 0.0039 0.0086 0.6394
Mycobacterium ulcerans phosphoglyceromutase 0.0039 0.0086 0.0133
Loa Loa (eye worm) hypothetical protein 0.0041 0.0093 0.0093
Loa Loa (eye worm) phosphoglycerate mutase 0.0039 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0041 0.0093 0.0093
Echinococcus granulosus survival motor neuron protein 1 0.0267 0.1075 0.1075
Trypanosoma cruzi phosphoglycerate mutase family member 5, putative 0.0039 0.0086 0.0078
Trypanosoma cruzi 6-phosphofructo-2-kinase 1 0.2282 0.983 0.983
Schistosoma mansoni survival motor neuron protein 0.0054 0.0153 0.0153
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0161 0.0616 0.0616
Onchocerca volvulus Dual specificity protein kinase TTK homolog 0.0622 0.2617 0.2553
Leishmania major hypothetical protein, conserved 0.0039 0.0086 0.0078
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-1-like protein 0.099 0.4219 0.4214
Trypanosoma brucei Histidine phosphatase superfamily (branch 1), putative 0.0039 0.0086 0.0078
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0049 0.013 0.0465
Onchocerca volvulus 0.2321 1 1
Loa Loa (eye worm) TTK protein kinase 0.0622 0.2617 0.2617
Toxoplasma gondii phosphoglycerate mutase PGMII 0.0039 0.0086 0.6394
Loa Loa (eye worm) hypothetical protein 0.0039 0.0086 0.0086
Schistosoma mansoni hypothetical protein 0.0038 0.0083 0.0083
Schistosoma mansoni hypothetical protein 0.0039 0.0086 0.0086
Mycobacterium ulcerans esterase/lipase LipP 0.0041 0.0093 0.0145
Echinococcus multilocularis phosphoglycerate mutase 0.0039 0.0086 0.0086
Plasmodium falciparum phosphoglycerate mutase, putative 0.0039 0.0086 0.8356
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0009 0.0009
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0157 0.0157
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0157 0.0157
Loa Loa (eye worm) hypothetical protein 0.2321 1 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0049 0.013 1
Entamoeba histolytica acetyltransferase, GNAT family 0.0043 0.0102 0.0159
Onchocerca volvulus 0.0041 0.0093 0.0007
Trypanosoma brucei 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.2321 1 1
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0026 0.0027 0.0027
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0056 0.016 0.016
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0041 0.0093 0.0814
Mycobacterium ulcerans hypothetical protein 0.0039 0.0086 0.0133
Schistosoma mansoni zinc finger protein 0.0026 0.0029 0.0029
Brugia malayi Bromodomain containing protein 0.0047 0.0121 0.0433
Loa Loa (eye worm) hypothetical protein 0.0041 0.0093 0.0093
Giardia lamblia Hypothetical protein 0.137 0.5867 1
Brugia malayi phosphoglycerate mutase family protein 0.0039 0.0086 0.0298
Mycobacterium leprae conserved hypothetical protein 0.0041 0.0093 1
Leishmania major hypothetical protein, conserved 0.0039 0.0086 0.0078
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0009 0.0009
Trypanosoma cruzi Histidine phosphatase superfamily (branch 1), putative 0.0039 0.0086 0.0078
Mycobacterium tuberculosis Probable lipase LipD 0.0041 0.0093 0.0814
Trypanosoma cruzi Histidine phosphatase superfamily (branch 1), putative 0.0039 0.0086 0.0078
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.2321 1 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.0227 0.0227
Schistosoma mansoni phosphoglycerate mutase 0.0039 0.0086 0.0086
Schistosoma mansoni hypothetical protein 0.0191 0.0747 0.0747
Trypanosoma brucei Histidine phosphatase superfamily (branch 1), putative 0.0039 0.0086 0.0078
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0093 0.0325
Loa Loa (eye worm) hypothetical protein 0.0169 0.0648 0.0648
Echinococcus granulosus phosphoglycerate mutase 0.0039 0.0086 0.0086
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0157 0.0157
Loa Loa (eye worm) hypothetical protein 0.0041 0.0093 0.0093
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.0027 0.0027
Echinococcus multilocularis dual specificity serine:threonine tyrosine 0.0622 0.2617 0.2617
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0049 0.013 1
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0086 0.0298
Echinococcus multilocularis geminin 0.0191 0.0747 0.0747
Trichomonas vaginalis CAMK family protein kinase 0.0622 0.2617 1
Echinococcus granulosus phosphoglycerate mutase 0.0039 0.0086 0.0086
Mycobacterium ulcerans beta-lactamase 0.0041 0.0093 0.0145
Schistosoma mansoni dual specificity serine/threonine tyrosine kinase 0.0622 0.2617 0.2617
Leishmania major fructose-6-phosphate2-kinase/fructose-2,6-bisph os phatase-likeprotein 0.0039 0.0086 0.0078
Trichomonas vaginalis phosphoglycerate mutase, putative 0.0039 0.0086 0.0298
Mycobacterium ulcerans acid phosphatase 0.0039 0.0086 0.0133
Schistosoma mansoni hypothetical protein 0.0054 0.0153 0.0153
Loa Loa (eye worm) hypothetical protein 0.008 0.0264 0.0264
Echinococcus multilocularis muscleblind protein 0.0169 0.0648 0.0648
Schistosoma mansoni phosphoglycerate mutase 0.0039 0.0086 0.0086
Echinococcus granulosus beta LACTamase domain containing family member 0.0041 0.0093 0.0093
Mycobacterium tuberculosis Conserved protein 0.0039 0.0086 0.0746
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.099 0.4219 0.4214
Leishmania major phosphoglycerate mutase family member 5, putative 0.0039 0.0086 0.0078
Loa Loa (eye worm) hypothetical protein 0.2282 0.983 0.983
Brugia malayi Protein kinase domain containing protein 0.0622 0.2617 1
Mycobacterium ulcerans phosphoglycerate mutase 0.0039 0.0086 0.0133
Echinococcus multilocularis phosphoglycerate mutase 0.0039 0.0086 0.0086
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0157 0.0157
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0251 0.1007 0.3826
Schistosoma mansoni ap endonuclease 0.0021 0.0009 0.0009
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative 0.0039 0.0086 0.0078
Echinococcus multilocularis serine:threonine protein phosphatase PGAM5 0.0039 0.0086 0.0086
Mycobacterium tuberculosis Conserved protein 0.0041 0.0093 0.0814
Mycobacterium ulcerans lipoprotein LpqD 0.0039 0.0086 0.0133
Schistosoma mansoni hypothetical protein 0.0039 0.0086 0.0086
Mycobacterium tuberculosis Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase) 0.0039 0.0086 0.0746
Mycobacterium tuberculosis Possible phosphoglycerate mutase Gpm2 (phosphoglyceromutase) (PGAM) (BPG-dependent PGAM) 0.0039 0.0086 0.0746
Echinococcus granulosus zinc finger protein 0.0026 0.0029 0.0029
Mycobacterium tuberculosis Probable lipase LipE 0.0041 0.0093 0.0814
Trypanosoma cruzi phosphoglycerate mutase, putative 0.0039 0.0086 0.0078
Brugia malayi beta-lactamase family protein 0.0041 0.0093 0.0325
Entamoeba histolytica phosphoglycerate mutase family protein, putative 0.137 0.5867 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0056 0.016 0.0582
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0093 0.0325
Giardia lamblia Kinase, TTK 0.0622 0.2617 0.4452
Trypanosoma brucei 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative 0.0039 0.0086 0.0078
Trichomonas vaginalis phosphoglycerate mutase, putative 0.0039 0.0086 0.0298
Schistosoma mansoni bromodomain containing protein 0.0076 0.0244 0.0244
Brugia malayi UBASH3A protein homolog 0.0039 0.0086 0.0298
Loa Loa (eye worm) hypothetical protein 0.0041 0.0093 0.0093
Loa Loa (eye worm) acetyltransferase 0.0161 0.0616 0.0616
Plasmodium vivax phosphoglycerate mutase, putative 0.0039 0.0086 0.6394
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0093 0.6974
Echinococcus multilocularis beta LACTamase domain containing family member 0.0041 0.0093 0.0093
Echinococcus granulosus geminin 0.0191 0.0747 0.0747
Leishmania major hypothetical protein, unknown function 0.0039 0.0086 0.0078
Toxoplasma gondii phosphoglycerate mutase family protein 0.0039 0.0086 0.6394
Mycobacterium ulcerans fructose-2,6-bisphosphatase GpmB 0.137 0.5867 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0038 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.0343 0.1405 0.1405
Treponema pallidum phosphoglyceromutase 0.0039 0.0086 1
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative 0.0039 0.0086 0.0078
Loa Loa (eye worm) hypothetical protein 0.0251 0.1007 0.1007
Onchocerca volvulus 0.0054 0.0153 0.0067
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0161 0.0616 0.0616
Echinococcus multilocularis muscleblind protein 1 0.0169 0.0648 0.0648
Mycobacterium tuberculosis Probable hydrolase 0.0041 0.0093 0.0814
Schistosoma mansoni ap endonuclease 0.0021 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0043 0.0105 0.0105
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0093 0.0093
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0093 0.0085
Giardia lamblia Histone acetyltransferase GCN5 0.0043 0.0102 0.0159
Onchocerca volvulus 0.0041 0.0093 0.0007
Echinococcus multilocularis serine:threonine protein phosphatase PGAM5 0.0039 0.0086 0.0086
Echinococcus granulosus phosphoglycerate mutase 0.0039 0.0086 0.0086
Trichomonas vaginalis bromodomain-containing protein, putative 0.0049 0.013 0.0465
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0083 0.0286
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0041 0.0093 0.0814
Mycobacterium ulcerans phosphoglycerate mutase 0.0039 0.0086 0.0133
Entamoeba histolytica phosphoglycerate mutase family protein, putative 0.0039 0.0086 0.0133
Entamoeba histolytica phosphoglycerate mutase family protein. putative 0.0039 0.0086 0.0133
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0041 0.0093 0.0145
Leishmania major hypothetical protein, conserved 0.0039 0.0086 0.0078
Echinococcus granulosus histone acetyltransferase KAT2B 0.0154 0.0585 0.0585
Onchocerca volvulus 0.0343 0.1405 0.133
Trypanosoma brucei phosphoglycerate mutase, putative 0.0039 0.0086 0.0078
Echinococcus granulosus histone acetyltransferase KAT2B 0.0049 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.0041 0.0093 0.0093
Trypanosoma cruzi phosphoglycerate mutase family member 5, putative 0.0039 0.0086 0.0078
Trichomonas vaginalis esterase, putative 0.0041 0.0093 0.0325
Toxoplasma gondii ABC1 family protein 0.0041 0.0093 0.6974
Toxoplasma gondii phosphoglycerate mutase family protein 0.0039 0.0086 0.6394
Loa Loa (eye worm) hypothetical protein 0.0169 0.0648 0.0648
Loa Loa (eye worm) PHD-finger family protein 0.0023 0.0018 0.0018
Echinococcus multilocularis survival motor neuron protein 1 0.0267 0.1075 0.1075
Schistosoma mansoni hypothetical protein 0.0023 0.0018 0.0018
Schistosoma mansoni hypothetical protein 0.0191 0.0747 0.0747
Echinococcus granulosus fetal alzheimer antigen falz 0.0026 0.0027 0.0027
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0041 0.0093 0.0093
Mycobacterium tuberculosis Glucosyl-3-phosphoglycerate phosphatase GpgP 0.0039 0.0086 0.0746
Echinococcus granulosus phosphoglycerate mutase 0.0039 0.0086 0.0086
Mycobacterium tuberculosis Conserved hypothetical protein 0.0039 0.0086 0.0746
Toxoplasma gondii phosphoglycerate mutase family protein 0.0039 0.0086 0.6394
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0041 0.0093 0.0325
Mycobacterium tuberculosis PE-PGRS family protein PE_PGRS11 0.0039 0.0086 0.0746
Mycobacterium tuberculosis Possible hydrolase MutT1 0.0039 0.0086 0.0746
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0041 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0039 0.0086 0.0086
Echinococcus multilocularis phosphoglycerate mutase 0.0039 0.0086 0.0086
Echinococcus granulosus serine:threonine protein phosphatase PGAM5 0.0039 0.0086 0.0086
Mycobacterium ulcerans bifunctional RNase H/acid phosphatase 0.0039 0.0086 0.0133
Mycobacterium tuberculosis Conserved protein 0.0041 0.0093 0.0814
Loa Loa (eye worm) hypothetical protein 0.0267 0.1075 0.1075
Trichomonas vaginalis conserved hypothetical protein 0.0244 0.0977 0.3712
Trypanosoma cruzi Histidine phosphatase superfamily (branch 1), putative 0.0039 0.0086 0.0078
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0157 0.0157
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.2321 1 1
Trypanosoma brucei glycerolphosphate mutase, putative 0.0039 0.0086 0.0078
Trichomonas vaginalis phosphoglycerate mutase, putative 0.0039 0.0086 0.0298
Brugia malayi Muscleblind-like protein 0.0169 0.0648 0.2453
Brugia malayi beta-lactamase 0.0041 0.0093 0.0325
Loa Loa (eye worm) bromodomain containing protein 0.0024 0.002 0.002
Echinococcus multilocularis 6 phosphofructo 2 kinase:fructose 2 0.2321 1 1
Trichomonas vaginalis phosphoglycerate mutase, putative 0.0039 0.0086 0.0298
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0157 0.0157
Leishmania major phosphoglycerate mutase protein, putative 0.0039 0.0086 0.0078
Entamoeba histolytica phosphoglycerate mutase family protein, putative 0.0039 0.0086 0.0133
Mycobacterium ulcerans hypothetical protein 0.0041 0.0093 0.0145
Loa Loa (eye worm) hypothetical protein 0.0039 0.0086 0.0086
Echinococcus granulosus muscleblind protein 0.0169 0.0648 0.0648
Schistosoma mansoni hypothetical protein 0.0039 0.0086 0.0086
Brugia malayi PHD-finger family protein 0.0032 0.0056 0.018
Brugia malayi hypothetical protein 0.0343 0.1405 0.5352
Mycobacterium ulcerans phosphohistidine phosphatase SixA 0.0039 0.0086 0.0133
Loa Loa (eye worm) hypothetical protein 0.0052 0.0143 0.0143
Schistosoma mansoni 6-phosphofructokinase 0.2321 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0157 0.0157
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.0009 0.5
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0054 0.0153 0.0552
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0093 0.0093
Brugia malayi beta-lactamase family protein 0.0041 0.0093 0.0325
Plasmodium falciparum phosphoglucomutase-2 0.0039 0.0086 0.8356
Loa Loa (eye worm) hypothetical protein 0.0039 0.0086 0.0086
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0093 0.0325
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.2282 0.983 0.983
Loa Loa (eye worm) beta-lactamase 0.0041 0.0093 0.0093
Mycobacterium tuberculosis Probable conserved lipoprotein LpqD 0.0039 0.0086 0.0746
Trypanosoma cruzi phosphoglycerate mutase protein, putative 0.0039 0.0086 0.0078
Trypanosoma cruzi phosphoglycerate mutase protein, putative 0.0039 0.0086 0.0078
Trypanosoma brucei Histidine phosphatase superfamily (branch 1), putative 0.0039 0.0086 0.0078
Trypanosoma cruzi Histidine phosphatase superfamily (branch 1), putative 0.0039 0.0086 0.0078

Activities

Activity type Activity value Assay description Source Reference
GI (functional) = 40.9 % Growth inhibition of human Bcap37 cells at 1 uM after 72 hrs by MTT assay relative to control ChEMBL. 23811258

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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