TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 361.823 | Formula: C18H20ClN3O3
H donors: 1 H acceptors: 2 LogP: 4.5 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: COc1c(OC)c(OC)cc2c1c(ncn2)Nc1ccc(cc1)C.Cl
InChi: 1S/C18H19N3O3.ClH/c1-11-5-7-12(8-6-11)21-18-15-13(19-10-20-18)9-14(22-2)16(23-3)17(15)24-4;/h5-10H,1-4H3,(H,19,20,21);1H
InChiKey: QRCBKJGWHZSSLM-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.049	0.1288	0.1288
Loa Loa (eye worm)	hypothetical protein	0.049	0.1288	0.1288
Echinococcus multilocularis	orexin receptor type 2	0.049	0.1288	0.1278
Loa Loa (eye worm)	hypothetical protein	0.1971	0.5665	0.5665
Echinococcus multilocularis	rhodopsin orphan GPCR	0.049	0.1288	0.1278
Echinococcus granulosus	g protein coupled receptor	0.049	0.1288	0.1278
Toxoplasma gondii	phosphoglycerate mutase family protein	0.0058	0.0012	0.5
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.049	0.1288	0.1278
Echinococcus multilocularis	neuropeptide receptor	0.049	0.1288	0.1278
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.049	0.1288	0.1278
Plasmodium vivax	phosphoglycerate mutase, putative	0.0058	0.0012	0.5
Loa Loa (eye worm)	hypothetical protein	0.049	0.1288	0.1288
Loa Loa (eye worm)	hypothetical protein	0.049	0.1288	0.1288
Onchocerca volvulus		0.049	0.1288	0.1278
Echinococcus multilocularis	serotonin receptor	0.049	0.1288	0.1278
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.049	0.1288	0.1278
Onchocerca volvulus		0.049	0.1288	0.1278
Loa Loa (eye worm)	hypothetical protein	0.049	0.1288	0.1288
Brugia malayi	G-protein coupled receptor	0.049	0.1288	1
Loa Loa (eye worm)	hypothetical protein	0.049	0.1288	0.1288
Echinococcus granulosus	neuropeptides capa receptor	0.049	0.1288	0.1278
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.049	0.1288	0.1278
Toxoplasma gondii	phosphoglycerate mutase	0.0058	0.0012	0.5
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0058	0.0012	0.002
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.049	0.1288	0.1278
Echinococcus granulosus	alpha 1A adrenergic receptor	0.049	0.1288	0.1278
Schistosoma mansoni	hypothetical protein	0.0058	0.0012	0.0001
Mycobacterium leprae	PROBABLE PHOSPHOGLYCERATE MUTASE 1 GPM1 (PHOSPHOGLYCEROMUTASE) (PGAM) (BPG-DEPENDENT PGAM)	0.0058	0.0012	0.5
Echinococcus multilocularis	g protein coupled receptor	0.049	0.1288	0.1278
Onchocerca volvulus		0.049	0.1288	0.1278
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.049	0.1288	0.1278
Schistosoma mansoni	amine GPCR	0.049	0.1288	0.1278
Brugia malayi	hypothetical protein	0.049	0.1288	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.049	0.1288	0.1278
Echinococcus multilocularis	neuropeptide receptor	0.049	0.1288	0.1278
Echinococcus granulosus	neuropeptide s receptor	0.049	0.1288	0.1278
Loa Loa (eye worm)	hypothetical protein	0.049	0.1288	0.1288
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.049	0.1288	1
Onchocerca volvulus		0.049	0.1288	0.1278
Echinococcus multilocularis	rhodopsin orphan GPCR	0.049	0.1288	0.1278
Schistosoma mansoni	phosphoglycerate mutase	0.0058	0.0012	0.0001
Loa Loa (eye worm)	hypothetical protein	0.049	0.1288	0.1288
Loa Loa (eye worm)	hypothetical protein	0.049	0.1288	0.1288
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.049	0.1288	0.1288
Onchocerca volvulus		0.049	0.1288	0.1278
Loa Loa (eye worm)	hypothetical protein	0.049	0.1288	0.1288
Echinococcus granulosus	phosphoglycerate mutase	0.0058	0.0012	0.0001
Loa Loa (eye worm)	hypothetical protein	0.049	0.1288	0.1288
Mycobacterium ulcerans	bifunctional RNase H/acid phosphatase	0.0058	0.0012	0.0002
Brugia malayi	follicle stimulating hormone receptor	0.049	0.1288	1
Loa Loa (eye worm)	hypothetical protein	0.049	0.1288	0.1288
Plasmodium vivax	phosphoglucomutase-2, putative	0.0058	0.0012	0.5
Brugia malayi	hypothetical protein	0.049	0.1288	1
Schistosoma mansoni	hypothetical protein	0.0171	0.0345	0.0334
Mycobacterium ulcerans	acid phosphatase	0.0058	0.0012	0.0002
Echinococcus granulosus	rhodopsin orphan GPCR	0.049	0.1288	0.1278
Brugia malayi	hypothetical protein	0.049	0.1288	1
Mycobacterium tuberculosis	Possible phosphoglycerate mutase Gpm2 (phosphoglyceromutase) (PGAM) (BPG-dependent PGAM)	0.0058	0.0012	0.002
Mycobacterium ulcerans	phosphoglyceromutase	0.0058	0.0012	0.0002
Schistosoma mansoni	hypothetical protein	0.049	0.1288	0.1278
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.049	0.1288	0.1288
Schistosoma mansoni	hypothetical protein	0.049	0.1288	0.1278
Brugia malayi	neuropeptide F receptor	0.049	0.1288	1
Brugia malayi	sulfakinin receptor protein	0.049	0.1288	1
Echinococcus granulosus	tm gpcr rhodopsin	0.049	0.1288	0.1278
Echinococcus multilocularis	neuropeptides capa receptor	0.049	0.1288	0.1278
Echinococcus multilocularis	phosphoglycerate mutase	0.0058	0.0012	0.0001
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.3438	1	1
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0164	0.0325	0.0325
Onchocerca volvulus		0.049	0.1288	0.1278
Toxoplasma gondii	phosphoglycerate mutase PGMII	0.0058	0.0012	0.5
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0241	0.0241
Loa Loa (eye worm)	hypothetical protein	0.049	0.1288	0.1288
Onchocerca volvulus		0.0095	0.0121	0.0109
Leishmania major	hypothetical protein, conserved	0.0058	0.0012	0.0001
Echinococcus granulosus	dro:myosuppressin receptor	0.049	0.1288	0.1278
Treponema pallidum	phosphoglyceromutase	0.0058	0.0012	0.5
Loa Loa (eye worm)	hypothetical protein	0.049	0.1288	0.1288
Loa Loa (eye worm)	hypothetical protein	0.049	0.1288	0.1288
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.049	0.1288	0.1278
Loa Loa (eye worm)	hypothetical protein	0.049	0.1288	0.1288
Loa Loa (eye worm)	hypothetical protein	0.338	0.9828	0.9828
Onchocerca volvulus		0.049	0.1288	0.1278
Brugia malayi	G protein-coupled receptor F59B2.13	0.049	0.1288	1
Echinococcus granulosus	orexin receptor type 2	0.049	0.1288	0.1278
Echinococcus multilocularis	g protein coupled receptor	0.049	0.1288	0.1278
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.049	0.1288	1
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0012	0.0012
Loa Loa (eye worm)	hypothetical protein	0.049	0.1288	0.1288
Brugia malayi	AKH receptor	0.049	0.1288	1
Schistosoma mansoni	amine GPCR	0.049	0.1288	0.1278
Brugia malayi	hypothetical protein	0.049	0.1288	1
Loa Loa (eye worm)	hypothetical protein	0.049	0.1288	0.1288
Mycobacterium ulcerans	hypothetical protein	0.0058	0.0012	0.0002
Loa Loa (eye worm)	hypothetical protein	0.049	0.1288	0.1288
Trypanosoma cruzi	6-phosphofructo-2-kinase 1	0.338	0.9828	0.9828
Schistosoma mansoni	neuropeptide receptor	0.049	0.1288	0.1278
Mycobacterium leprae	conserved hypothetical protein	0.0058	0.0012	0.5
Leishmania major	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-1-like protein	0.1467	0.4176	0.4169
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.049	0.1288	0.1278
Echinococcus multilocularis	somatostatin receptor	0.049	0.1288	0.1278
Echinococcus multilocularis	6 phosphofructo 2 kinase:fructose 2	0.3438	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.049	0.1288	0.1278
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.049	0.1288	0.1278
Leishmania major	phosphoglycerate mutase protein, putative	0.0058	0.0012	0.0001
Echinococcus multilocularis	rhodopsin orphan GPCR	0.049	0.1288	0.1278
Onchocerca volvulus		0.049	0.1288	0.1278
Brugia malayi	GnHR receptor homolog	0.049	0.1288	1
Brugia malayi	G protein-coupled receptor	0.049	0.1288	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.049	0.1288	0.1278
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.049	0.1288	0.1278
Echinococcus multilocularis	phosphoglycerate mutase	0.0058	0.0012	0.0001
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.049	0.1288	0.1278
Onchocerca volvulus	Neuropeptide F receptor homolog	0.049	0.1288	0.1278
Onchocerca volvulus		0.049	0.1288	0.1278
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.3438	1	1
Schistosoma mansoni	neuropeptide receptor	0.049	0.1288	0.1278
Echinococcus granulosus	g protein coupled receptor	0.049	0.1288	0.1278
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.049	0.1288	0.1278
Schistosoma mansoni	hypothetical protein	0.0058	0.0012	0.0001
Onchocerca volvulus		0.049	0.1288	0.1278
Echinococcus granulosus	allatostatin A receptor	0.049	0.1288	0.1278
Mycobacterium tuberculosis	Conserved protein	0.0058	0.0012	0.002
Echinococcus granulosus	rhodopsin orphan GPCR	0.049	0.1288	0.1278
Leishmania major	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.338	0.9828	0.9828
Mycobacterium ulcerans	hypothetical protein	0.2029	0.5837	1
Plasmodium falciparum	phosphoglycerate mutase, putative	0.0058	0.0012	0.5
Mycobacterium tuberculosis	Glucosyl-3-phosphoglycerate phosphatase GpgP	0.0058	0.0012	0.002
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.049	0.1288	0.1278
Echinococcus multilocularis	G-protein coupled receptor, putative	0.049	0.1288	0.1278
Mycobacterium tuberculosis	Conserved protein	0.0058	0.0012	0.002
Loa Loa (eye worm)	hypothetical protein	0.049	0.1288	0.1288
Echinococcus multilocularis	muscleblind protein 1	0.0135	0.0241	0.0229
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.049	0.1288	0.1278
Echinococcus multilocularis	neuropeptides capa receptor	0.049	0.1288	0.1278
Echinococcus multilocularis	fmrfamide receptor	0.049	0.1288	0.1278
Leishmania major	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.3438	1	1
Echinococcus multilocularis	neuropeptide Y receptor	0.049	0.1288	0.1278
Schistosoma mansoni	amine GPCR	0.049	0.1288	0.1278
Loa Loa (eye worm)	hypothetical protein	0.049	0.1288	0.1288
Brugia malayi	Serotonin receptor	0.049	0.1288	1
Loa Loa (eye worm)	hypothetical protein	0.049	0.1288	0.1288
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0241	0.0241
Brugia malayi	phosphoglycerate mutase family protein	0.0058	0.0012	0.0007
Echinococcus granulosus	phosphoglycerate mutase	0.0058	0.0012	0.0001
Schistosoma mansoni	opsin-like receptor	0.049	0.1288	0.1278
Schistosoma mansoni	hypothetical protein	0.0058	0.0012	0.0001
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.049	0.1288	0.1278
Leishmania major	hypothetical protein, conserved	0.0058	0.0012	0.0001
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.049	0.1288	0.1278
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.049	0.1288	1
Schistosoma mansoni	lipoxygenase	0.0103	0.0145	0.0133
Loa Loa (eye worm)	hypothetical protein	0.049	0.1288	0.1288
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.049	0.1288	0.1278
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.049	0.1288	1
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0012	0.0012
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0174	0.0356	0.0345
Loa Loa (eye worm)	hypothetical protein	0.049	0.1288	0.1288
Echinococcus multilocularis	allatostatin A receptor	0.049	0.1288	0.1278
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.049	0.1288	0.1278
Toxoplasma gondii	phosphoglycerate mutase family protein	0.0058	0.0012	0.5
Schistosoma mansoni	amine GPCR	0.049	0.1288	0.1278
Loa Loa (eye worm)	phosphoglycerate mutase	0.0058	0.0012	0.0012
Schistosoma mansoni	phosphoglycerate mutase	0.0058	0.0012	0.0001
Brugia malayi	phosphoglycerate mutase family protein	0.0058	0.0012	0.0007
Brugia malayi	glutaminase DH11.1	0.0248	0.0572	0.4393
Onchocerca volvulus	Huntingtin homolog	0.0123	0.0205	0.0193
Loa Loa (eye worm)	hypothetical protein	0.049	0.1288	0.1288
Echinococcus granulosus	neuropeptide FF receptor 2	0.049	0.1288	0.1278
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.049	0.1288	0.1278
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.049	0.1288	0.1278
Schistosoma mansoni	hypothetical protein	0.0058	0.0012	0.0001
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.049	0.1288	0.1278
Onchocerca volvulus		0.049	0.1288	0.1278
Schistosoma mansoni	biogenic amine receptor	0.049	0.1288	0.1278
Echinococcus multilocularis	g protein coupled receptor	0.049	0.1288	0.1278
Echinococcus multilocularis	serotonin receptor	0.049	0.1288	0.1278
Echinococcus granulosus	serine:threonine protein phosphatase PGAM5	0.0058	0.0012	0.0001
Giardia lamblia	Hypothetical protein	0.2029	0.5837	0.5
Brugia malayi	Tachykinin-like peptides receptor 99D	0.049	0.1288	1
Schistosoma mansoni	alpha-1 adrenergic receptor	0.049	0.1288	0.1278
Echinococcus granulosus	peptide allatostatin:somatostatin	0.049	0.1288	0.1278
Echinococcus multilocularis	phosphoglycerate mutase	0.0058	0.0012	0.0001
Brugia malayi	ORL1-like opioid receptor	0.049	0.1288	1
Brugia malayi	Melatonin receptor type 1A	0.049	0.1288	1
Brugia malayi	hypothetical protein	0.049	0.1288	1
Loa Loa (eye worm)	DnaJ domain-containing protein	0.0062	0.0023	0.0023
Trypanosoma brucei	6-phosphofructo-2-kinase 2	0.338	0.9828	0.9828
Mycobacterium leprae	probable isochorismate synthase EntC	0.0058	0.0012	0.5
Loa Loa (eye worm)	TYRA-2 protein	0.049	0.1288	0.1288
Loa Loa (eye worm)	hypothetical protein	0.049	0.1288	0.1288
Leishmania major	glycerolphosphate mutase, putative	0.0058	0.0012	0.0001
Brugia malayi	hypothetical protein	0.049	0.1288	1
Echinococcus multilocularis	muscleblind protein	0.0135	0.0241	0.0229
Echinococcus granulosus	7tm_1 domain containing protein	0.049	0.1288	0.1278
Loa Loa (eye worm)	glutaminase 2	0.0248	0.0572	0.0572
Mycobacterium ulcerans	hypothetical protein	0.0058	0.0012	0.0002
Chlamydia trachomatis	2,3-bisphosphoglycerate-dependent phosphoglycerate mutase	0.0058	0.0012	0.5
Loa Loa (eye worm)	hypothetical protein	0.049	0.1288	0.1288
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.049	0.1288	0.1278
Brugia malayi	Serotonin receptor	0.049	0.1288	1
Loa Loa (eye worm)	hypothetical protein	0.049	0.1288	0.1288
Giardia lamblia	Hypothetical protein	0.2029	0.5837	0.5
Schistosoma mansoni	opsin-like receptor	0.049	0.1288	0.1278
Trypanosoma brucei	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.3438	1	1
Echinococcus granulosus	neuropeptide Y receptor	0.049	0.1288	0.1278
Brugia malayi	hypothetical protein	0.049	0.1288	1
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0012	0.0012
Loa Loa (eye worm)	hypothetical protein	0.049	0.1288	0.1288
Brugia malayi	UBASH3A protein homolog	0.0058	0.0012	0.0007
Echinococcus granulosus	neuropeptide Y receptor	0.049	0.1288	0.1278
Echinococcus multilocularis	neuropeptide FF receptor 2	0.049	0.1288	0.1278
Loa Loa (eye worm)	neuropeptide F receptor	0.049	0.1288	0.1288
Leishmania major	fructose-6-phosphate2-kinase/fructose-2,6-bisph os phatase-likeprotein	0.0058	0.0012	0.0001
Brugia malayi	Dopamine receptor protein 1	0.049	0.1288	1
Schistosoma mansoni	adenoreceptor	0.049	0.1288	0.1278
Brugia malayi	putative neuropeptide receptor	0.049	0.1288	1
Onchocerca volvulus		0.3438	1	1
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.049	0.1288	0.1278
Echinococcus granulosus	phosphoglycerate mutase	0.0058	0.0012	0.0001
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.049	0.1288	0.1278
Echinococcus granulosus	g-protein coupled receptor	0.049	0.1288	0.1278
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.049	0.1288	0.1278
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0174	0.0356	0.0345
Loa Loa (eye worm)	hypothetical protein	0.049	0.1288	0.1288
Schistosoma mansoni	lipoxygenase	0.0174	0.0356	0.0345
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.049	0.1288	0.1288
Echinococcus granulosus	hypothetical protein	0.049	0.1288	0.1278
Brugia malayi	Dopamine receptor protein 2	0.049	0.1288	1
Loa Loa (eye worm)	hypothetical protein	0.049	0.1288	0.1288
Brugia malayi	hypothetical protein	0.0123	0.0205	0.1517
Onchocerca volvulus		0.049	0.1288	0.1278
Loa Loa (eye worm)	hypothetical protein	0.049	0.1288	0.1288
Loa Loa (eye worm)	G-protein coupled receptor	0.049	0.1288	0.1288
Schistosoma mansoni	neuropeptide F-like receptor	0.049	0.1288	0.1278
Loa Loa (eye worm)	hypothetical protein	0.049	0.1288	0.1288
Echinococcus granulosus	biogenic amine 5HT receptor	0.049	0.1288	0.1278
Echinococcus granulosus	neuropeptide receptor A26	0.049	0.1288	0.1278
Schistosoma mansoni	glutaminase	0.0248	0.0572	0.0562
Onchocerca volvulus		0.049	0.1288	0.1278
Mycobacterium leprae	conserved hypothetical protein	0.0058	0.0012	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.049	0.1288	0.1278
Toxoplasma gondii	phosphoglycerate mutase family protein	0.0058	0.0012	0.5
Echinococcus granulosus	biogenic amine 5HT receptor	0.049	0.1288	0.1278
Schistosoma mansoni	amine GPCR	0.049	0.1288	0.1278
Echinococcus multilocularis	sex peptide receptor	0.049	0.1288	0.1278
Schistosoma mansoni	myosin xvIII	0.049	0.1288	0.1278
Brugia malayi	hypothetical protein	0.049	0.1288	1
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.049	0.1288	0.1278
Schistosoma mansoni	neuropeptide receptor	0.049	0.1288	0.1278
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.049	0.1288	0.1278
Brugia malayi	neuropeptide F receptor	0.049	0.1288	1
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0205	0.0205
Loa Loa (eye worm)	hypothetical protein	0.049	0.1288	0.1288
Echinococcus multilocularis	serine:threonine protein phosphatase PGAM5	0.0058	0.0012	0.0001
Echinococcus multilocularis	rhodopsin orphan GPCR	0.049	0.1288	0.1278
Brugia malayi	RE15519p	0.049	0.1288	1
Loa Loa (eye worm)	G-protein coupled receptor	0.049	0.1288	0.1288
Mycobacterium leprae	Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase)	0.0058	0.0012	0.5
Entamoeba histolytica	phosphoglycerate mutase family protein, putative	0.2029	0.5837	1
Loa Loa (eye worm)	hypothetical protein	0.049	0.1288	0.1288
Schistosoma mansoni	hypothetical protein	0.049	0.1288	0.1278
Schistosoma mansoni	6-phosphofructokinase	0.3438	1	1
Echinococcus granulosus	serine:threonine protein phosphatase PGAM5	0.0058	0.0012	0.0001
Mycobacterium leprae	conserved hypothetical protein	0.0058	0.0012	0.5
Echinococcus granulosus	tachykinin peptides receptor 99D	0.049	0.1288	0.1278
Leishmania major	hypothetical protein, unknown function	0.0058	0.0012	0.0001
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.1467	0.4176	0.4169
Echinococcus granulosus	serotonin receptor	0.049	0.1288	0.1278
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.049	0.1288	0.1278
Loa Loa (eye worm)	hypothetical protein	0.049	0.1288	0.1288
Leishmania major	phosphoglycerate mutase family member 5, putative	0.0058	0.0012	0.0001
Echinococcus granulosus	rhodopsin orphan GPCR	0.049	0.1288	0.1278
Schistosoma mansoni	neuropeptide f receptor 76f	0.049	0.1288	0.1278
Schistosoma mansoni	hypothetical protein	0.0062	0.0023	0.0012
Brugia malayi	hypothetical protein	0.049	0.1288	1
Loa Loa (eye worm)	hypothetical protein	0.049	0.1288	0.1288
Mycobacterium ulcerans	glutaminase	0.0248	0.0572	0.0963
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.049	0.1288	0.1278
Echinococcus multilocularis	G protein coupled receptor 139	0.049	0.1288	0.1278
Loa Loa (eye worm)	neuropeptide F receptor	0.049	0.1288	0.1288
Loa Loa (eye worm)	glutaminase	0.0248	0.0572	0.0572
Echinococcus multilocularis	serine:threonine protein phosphatase PGAM5	0.0058	0.0012	0.0001
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.049	0.1288	0.1278
Brugia malayi	Muscleblind-like protein	0.0135	0.0241	0.1795
Mycobacterium leprae	PROBABLE PHOSPHOGLYCERATE MUTASE (PHOSPHOGLYCEROMUTASE)	0.0058	0.0012	0.5
Brugia malayi	DnaJ domain containing protein	0.0062	0.0023	0.0091
Brugia malayi	larval opioid receptor	0.049	0.1288	1
Leishmania major	phosphoglycerate mutase, putative	0.0058	0.0012	0.0001
Brugia malayi	putative neuropeptide receptor NPR1	0.049	0.1288	1
Loa Loa (eye worm)	hypothetical protein	0.049	0.1288	0.1288
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.049	0.1288	0.1278
Mycobacterium tuberculosis	Possible hydrolase MutT1	0.0058	0.0012	0.002
Loa Loa (eye worm)	melatonin receptor type 1A	0.049	0.1288	0.1288
Echinococcus multilocularis	geminin	0.0171	0.0345	0.0334
Echinococcus multilocularis	phosphoglycerate mutase	0.0058	0.0012	0.0001
Loa Loa (eye worm)	hypothetical protein	0.049	0.1288	0.1288
Loa Loa (eye worm)	hypothetical protein	0.049	0.1288	0.1288
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.049	0.1288	1
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.049	0.1288	0.1278
Echinococcus multilocularis	g-protein coupled receptor	0.049	0.1288	0.1278
Onchocerca volvulus	Huntingtin homolog	0.0123	0.0205	0.0193
Echinococcus multilocularis	rhodopsin orphan GPCR	0.049	0.1288	0.1278
Echinococcus granulosus	rhodopsin orphan GPCR	0.049	0.1288	0.1278
Brugia malayi	hypothetical protein	0.049	0.1288	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.049	0.1288	0.1278
Schistosoma mansoni	biogenic amine (5HT) receptor	0.049	0.1288	0.1278
Brugia malayi	Dopamine receptor	0.049	0.1288	1
Schistosoma mansoni	neuropeptide F-like receptor	0.049	0.1288	0.1278
Echinococcus multilocularis	rhodopsin orphan GPCR	0.049	0.1288	0.1278
Echinococcus granulosus	neuropeptide receptor	0.049	0.1288	0.1278
Trypanosoma brucei	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.1467	0.4176	0.4169
Trichomonas vaginalis	protein kinase inhibitor, putative	0.0062	0.0023	0.019
Echinococcus multilocularis	neuropeptide Y receptor	0.049	0.1288	0.1278
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.049	0.1288	0.1278
Loa Loa (eye worm)	hypothetical protein	0.3438	1	1
Echinococcus granulosus	muscleblind protein	0.0135	0.0241	0.0229
Schistosoma mansoni	biogenic amine (5HT) receptor	0.049	0.1288	0.1278
Onchocerca volvulus		0.049	0.1288	0.1278
Brugia malayi	G-protein coupled receptor	0.049	0.1288	1
Loa Loa (eye worm)	hypothetical protein	0.049	0.1288	0.1288
Mycobacterium tuberculosis	Probable conserved lipoprotein LpqD	0.0058	0.0012	0.002
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0205	0.0205
Schistosoma mansoni	growth hormone secretagogue receptor	0.049	0.1288	0.1278
Mycobacterium leprae	POSSIBLE HYDROLASE MUTT1	0.0058	0.0012	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.049	0.1288	0.1278
Echinococcus granulosus	lysosomal alpha glucosidase	0.0164	0.0325	0.0314
Toxoplasma gondii	phosphoglycerate mutase family protein	0.0058	0.0012	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.049	0.1288	0.1278
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.049	0.1288	0.1278
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.049	0.1288	0.1278
Echinococcus granulosus	G protein coupled receptor 139	0.049	0.1288	0.1278
Loa Loa (eye worm)	hypothetical protein	0.049	0.1288	0.1288
Trichomonas vaginalis	glutaminase, putative	0.0248	0.0572	1
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0208	0.0456	1
Echinococcus multilocularis	phosphoglycerate mutase	0.0058	0.0012	0.0001
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.1467	0.4176	0.4169
Echinococcus granulosus	phosphoglycerate mutase	0.0058	0.0012	0.0001
Onchocerca volvulus		0.049	0.1288	0.1278
Schistosoma mansoni	biogenic amine receptor	0.049	0.1288	0.1278
Echinococcus multilocularis	dnaJ subfamily C 6	0.0062	0.0023	0.0012
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.049	0.1288	0.1278
Echinococcus multilocularis	fmrfamide receptor	0.049	0.1288	0.1278
Echinococcus granulosus	7TM GPCR rhodopsin	0.049	0.1288	0.1278
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0164	0.0325	0.0314
Mycobacterium ulcerans	phosphoglycerate mutase	0.0058	0.0012	0.0002
Echinococcus granulosus	rhodopsin orphan GPCR	0.049	0.1288	0.1278
Schistosoma mansoni	histamine h1 receptor	0.049	0.1288	0.1278
Schistosoma mansoni	alpha-glucosidase	0.0141	0.0258	0.0247
Plasmodium falciparum	phosphoglucomutase-2	0.0058	0.0012	0.5
Schistosoma mansoni	hypothetical protein	0.049	0.1288	0.1278
Mycobacterium ulcerans	phosphohistidine phosphatase SixA	0.0058	0.0012	0.0002
Schistosoma mansoni	neuropeptide receptor	0.049	0.1288	0.1278
Onchocerca volvulus		0.049	0.1288	0.1278
Echinococcus multilocularis	neuropeptide receptor A26	0.049	0.1288	0.1278
Mycobacterium ulcerans	hydrolase MutT1	0.0058	0.0012	0.0002
Trypanosoma cruzi	6-phosphofructo-2-kinase 1	0.338	0.9828	0.9828
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.049	0.1288	0.1288
Mycobacterium tuberculosis	Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase)	0.0058	0.0012	0.002
Mycobacterium ulcerans	lipoprotein LpqD	0.0058	0.0012	0.0002
Echinococcus multilocularis	neuropeptide s receptor	0.049	0.1288	0.1278
Echinococcus granulosus	tm gpcr rhodopsin	0.049	0.1288	0.1278
Echinococcus multilocularis	dro:myosuppressin receptor	0.049	0.1288	0.1278
Loa Loa (eye worm)	hypothetical protein	0.049	0.1288	0.1288
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0164	0.0325	0.2458
Echinococcus granulosus	somatostatin receptor	0.049	0.1288	0.1278
Schistosoma mansoni	alpha-glucosidase	0.0141	0.0258	0.0247
Echinococcus granulosus	sex peptide receptor	0.049	0.1288	0.1278
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0012	0.0012
Echinococcus granulosus	dnaJ subfamily C 6	0.0062	0.0023	0.0012
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.049	0.1288	0.1278
Schistosoma mansoni	hypothetical protein	0.0058	0.0012	0.0001
Schistosoma mansoni	hypothetical protein	0.0171	0.0345	0.0334
Echinococcus multilocularis	phosphoglycerate mutase	0.0058	0.0012	0.0001
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.049	0.1288	0.1278
Echinococcus granulosus	geminin	0.0171	0.0345	0.0334
Schistosoma mansoni	hypothetical protein	0.0058	0.0012	0.0001
Mycobacterium tuberculosis	PE-PGRS family protein PE_PGRS11	0.0058	0.0012	0.002
Onchocerca volvulus		0.049	0.1288	0.1278
Echinococcus granulosus	neuropeptide receptor	0.049	0.1288	0.1278
Schistosoma mansoni	biogenic amine receptor	0.049	0.1288	0.1278
Mycobacterium ulcerans	fructose-2,6-bisphosphatase GpmB	0.2029	0.5837	1
Loa Loa (eye worm)	hypothetical protein	0.049	0.1288	0.1288
Leishmania major	hypothetical protein, conserved	0.0058	0.0012	0.0001
Echinococcus granulosus	neuropeptides capa receptor	0.049	0.1288	0.1278
Schistosoma mansoni	opsin-like receptor	0.049	0.1288	0.1278
Echinococcus granulosus	fmrfamide receptor	0.049	0.1288	0.1278
Loa Loa (eye worm)	hypothetical protein	0.049	0.1288	0.1288
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.049	0.1288	0.1278
Mycobacterium ulcerans	phosphoglycerate mutase	0.0058	0.0012	0.0002
Echinococcus granulosus	tm gpcr rhodopsin	0.049	0.1288	0.1278
Loa Loa (eye worm)	hypothetical protein	0.049	0.1288	0.1288
Mycobacterium leprae	Possible phosphoglycerate mutase	0.0058	0.0012	0.5
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0164	0.0325	0.0314
Echinococcus granulosus	g protein coupled receptor	0.049	0.1288	0.1278
Echinococcus granulosus	phosphoglycerate mutase	0.0058	0.0012	0.0001
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.049	0.1288	0.1278

Activities

Activity type	Activity value	Assay description	Source	Reference
GI (functional)	= 11.1 %	Growth inhibition of human Bcap37 cells at 10 uM after 72 hrs by MTT assay relative to control	ChEMBL.	23811258

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2409819

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1772787