Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.2425 | 0.5 | 0.5 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.2425 | 0.5 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.2425 | 0.5 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase | 0.2425 | 0.5 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.2425 | 0.5 | 0.5 |
Trypanosoma brucei | protein kinase, putative | 0.2425 | 0.5 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.2425 | 0.5 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.2425 | 0.5 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.2425 | 0.5 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.2425 | 0.5 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.2425 | 0.5 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.2425 | 0.5 | 0.5 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.2425 | 0.5 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.2425 | 0.5 | 0.5 |
Giardia lamblia | Kinase, CMGC MAPK | 0.2425 | 0.5 | 0.5 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.2425 | 0.5 | 0.5 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.2425 | 0.5 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.2425 | 0.5 | 0.5 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.2425 | 0.5 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.2425 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ID50 (functional) | = 65 nM | In vitro concentration of the compound required to reduce the murine L1210 leukemia cells in cultures to 50% after a period of 72 hr. | ChEMBL. | 6546590 |
ID50 (functional) | = 65 nM | In vitro concentration of the compound required to reduce the murine L1210 leukemia cells in cultures to 50% after a period of 72 hr. | ChEMBL. | 6546590 |
ILS (functional) | = 48 % | In vivo antitumor activity of the compound in mice bearing P388 leukemia cells at an optimal dose of 100 mg/kg given on days 1,5,9. | ChEMBL. | 6546590 |
ILS (functional) | = 48 % | In vivo antitumor activity of the compound in mice bearing P388 leukemia cells at an optimal dose of 100 mg/kg given on days 1,5,9. | ChEMBL. | 6546590 |
ILS (functional) | = 99 % | In vivo antitumor activity of the compound in mice bearing P388 leukemia cells at an optimal dose of 45 mg/kg given on days 1,5,9 | ChEMBL. | 6546590 |
ILS (functional) | = 99 % | In vivo antitumor activity of the compound in mice bearing P388 leukemia cells at an optimal dose of 45 mg/kg given on days 1,5,9 | ChEMBL. | 6546590 |
Log 1/D50 (functional) | = 4.76 | Drug concentration in mole/kg/day providing 50% extension of life in intraperitoneally implanted leukemia L1210 mice. | ChEMBL. | 7069706 |
Log 1/LD10 (ADMET) | = 4.74 | Compound concentration in mole/kg/day lethal to 10% of mice | ChEMBL. | 7069706 |
Log K (binding) | = 6.32 | DNA binding affinity as log K value | ChEMBL. | 6546590 |
Log K (binding) | = 6.4 | DNA binding affinity as log K value | ChEMBL. | 6546590 |
pKa (ADMET) | = 6.9 | Compound was evaluated for its rate of absorption from the intestine and pKa value was determined , lower value indicate high absorption from gastrointestinal tract . | ChEMBL. | 6546590 |
pKa | = 6.9 | Ionization constant (pKa) | ChEMBL. | 7069706 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.