TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 996.153 | Formula: C57H65N5O11
H donors: 3 H acceptors: 6 LogP: 6.27 Rotable bonds: 16
Rule of 5 violations (Lipinski): 2
SMILES: CCC1=C[C@@H]2CN(C1)/C(=C(\Cc1c([C@@](C2)(C(=O)OC)c2cc3c(cc2OC)N([C@@H]2[C@@]43CCN3[C@H]4[C@@]([C@H]([C@]2(O)C(=O)OC)OC(=O)C)(CC)C=CC3)C)[nH]c2c1cccc2)/C(=O)OC)/C(=O)NCc1ccccc1
InChi: 1S/C57H65N5O11/c1-9-34-25-36-29-56(52(66)71-7,46-38(37-19-14-15-20-42(37)59-46)26-39(48(65)70-6)45(62(31-34)32-36)47(64)58-30-35-17-12-11-13-18-35)41-27-40-43(28-44(41)69-5)60(4)50-55(40)22-24-61-23-16-21-54(10-2,49(55)61)51(73-33(3)63)57(50,68)53(67)72-8/h11-21,25,27-28,36,49-51,59,68H,9-10,22-24,26,29-32H2,1-8H3,(H,58,64)/b45-39+/t36-,49-,50+,51+,54+,55+,56-,57-/m0/s1
InChiKey: JYNSQZYXYMMRCR-KCAACJCTSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	tyrosine kinase	0.0303	0.9872	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0188	0.3867	0.3917
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0188	0.3867	0.3917
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0303	0.9872	1
Schistosoma mansoni	tyrosine kinase	0.0303	0.9872	1
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0188	0.3867	0.3917
Echinococcus multilocularis	N chimaerin	0.0188	0.3867	0.3917
Loa Loa (eye worm)	hypothetical protein	0.0188	0.3867	0.3917
Echinococcus multilocularis	signal transduction protein lnk realted	0.0188	0.3867	0.3917
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0115	0	0.5
Plasmodium falciparum	protein kinase, putative	0.0115	0	0.5
Loa Loa (eye worm)	SH2 domain-containing protein	0.0188	0.3867	0.3917
Loa Loa (eye worm)	hypothetical protein	0.0188	0.3867	0.3917
Loa Loa (eye worm)	hypothetical protein	0.0188	0.3867	0.3917
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0188	0.3867	0.3917
Plasmodium falciparum	protein kinase, putative	0.0115	0	0.5
Echinococcus granulosus	tensin	0.0188	0.3867	0.3917
Loa Loa (eye worm)	hypothetical protein	0.0188	0.3867	0.3917
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0303	0.9872	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0303	0.9872	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0303	0.9872	1
Toxoplasma gondii	protein kinase domain-containing protein	0.0115	0	0.5
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0305	1	1
Echinococcus multilocularis	NCK adaptor protein	0.0188	0.3867	0.3917
Echinococcus multilocularis	SH2 motif	0.0188	0.3867	0.3917
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0188	0.3867	0.3917
Echinococcus granulosus	hypothetical protein	0.0188	0.3867	0.3917
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0303	0.9872	1
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0188	0.3867	0.3917
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0115	0	0.5
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0188	0.3867	0.3917
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0188	0.3867	0.3917
Brugia malayi	SH2 domain containing protein	0.0303	0.9872	1
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0115	0	0.5
Entamoeba histolytica	SH2 domain containing protein	0.0188	0.3867	0.3867
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0303	0.9872	1
Loa Loa (eye worm)	hypothetical protein	0.0188	0.3867	0.3917
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0188	0.3867	0.3917
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0188	0.3867	0.3917
Brugia malayi	SH2 domain containing protein	0.0188	0.3867	0.3917
Schistosoma mansoni	shc transforming protein	0.0188	0.3867	0.3917
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0115	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0188	0.3867	0.3917
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0303	0.9872	1
Brugia malayi	Protein kinase domain containing protein	0.0303	0.9872	1
Brugia malayi	protein-tyrosine kinase	0.0303	0.9872	1
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0149	0.1813	0.5
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0188	0.3867	0.3917
Echinococcus multilocularis	SH2 domain containing protein 7	0.0188	0.3867	0.3917
Loa Loa (eye worm)	hypothetical protein	0.0188	0.3867	0.3917
Trypanosoma brucei	protein kinase, putative	0.0115	0	0.5
Onchocerca volvulus		0.0303	0.9872	1
Echinococcus granulosus	SH2 motif	0.0188	0.3867	0.3917
Trypanosoma brucei	Pseudokinase, putative	0.0115	0	0.5
Loa Loa (eye worm)	SH2 domain-containing protein	0.0188	0.3867	0.3917
Loa Loa (eye worm)	TK/ABL protein kinase	0.0303	0.9872	1
Schistosoma mansoni	GTPase activating protein	0.0188	0.3867	0.3917
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0303	0.9872	0.9872
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0303	0.9872	1
Brugia malayi	SH2 domain containing protein	0.0188	0.3867	0.3917
Echinococcus multilocularis	tensin	0.0188	0.3867	0.3917
Echinococcus granulosus	tyrosine kinase	0.0303	0.9872	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0303	0.9872	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0305	1	1
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0188	0.3867	0.3917
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0188	0.3867	0.3917
Schistosoma mansoni	tensin	0.0188	0.3867	0.3917
Loa Loa (eye worm)	SH2 domain-containing protein	0.0188	0.3867	0.3917
Loa Loa (eye worm)	TK/FER protein kinase	0.0303	0.9872	1
Brugia malayi	Protein kinase domain containing protein	0.0303	0.9872	1
Onchocerca volvulus		0.0303	0.9872	1
Brugia malayi	Protein kinase domain containing protein	0.0303	0.9872	1
Loa Loa (eye worm)	hypothetical protein	0.0188	0.3867	0.3917
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0303	0.9872	1
Echinococcus granulosus	N chimaerin	0.0188	0.3867	0.3917
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0188	0.3867	0.3917
Loa Loa (eye worm)	TK/FER protein kinase	0.0303	0.9872	1
Brugia malayi	Sex muscle abnormal protein 5	0.0188	0.3867	0.3917
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0188	0.3867	0.3917
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0303	0.9872	1
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0188	0.3867	0.3917
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0305	1	1
Brugia malayi	SH2 domain containing protein	0.0188	0.3867	0.3917
Echinococcus multilocularis	tensin	0.0188	0.3867	0.3917
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0303	0.9872	1
Brugia malayi	SH2 domain containing protein	0.0188	0.3867	0.3917
Brugia malayi	Variant SH3 domain containing protein	0.0188	0.3867	0.3917
Brugia malayi	Tyrosine-protein kinase abl-1	0.0303	0.9872	1
Echinococcus granulosus	SH2 motif	0.0188	0.3867	0.3917
Onchocerca volvulus		0.0303	0.9872	1
Onchocerca volvulus		0.0188	0.3867	0.3917
Loa Loa (eye worm)	STAT protein	0.0188	0.3867	0.3917
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0305	1	1
Schistosoma mansoni	tyrosine kinase	0.0303	0.9872	1
Onchocerca volvulus		0.0303	0.9872	1
Echinococcus granulosus	SHC transforming protein 3	0.0188	0.3867	0.3917
Loa Loa (eye worm)	hypothetical protein	0.0188	0.3867	0.3917
Brugia malayi	Variant SH3 domain containing protein	0.0188	0.3867	0.3917
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0115	0	0.5
Schistosoma mansoni	tensin-related	0.0188	0.3867	0.3917
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0303	0.9872	1
Brugia malayi	Variant SH3 domain containing protein	0.0188	0.3867	0.3917
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0303	0.9872	1
Toxoplasma gondii	protein kinase	0.0115	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0303	0.9872	1
Schistosoma mansoni	signal transduction protein lnk-related	0.0188	0.3867	0.3917
Loa Loa (eye worm)	TK/FER protein kinase	0.0303	0.9872	1
Plasmodium falciparum	protein kinase, putative	0.0115	0	0.5
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0188	0.3867	0.3917
Echinococcus multilocularis	SHC transforming protein 3	0.0188	0.3867	0.3917
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0303	0.9872	1
Giardia lamblia	Fructose-bisphosphate aldolase	0.0305	1	1
Brugia malayi	SRC-1	0.0303	0.9872	1
Trypanosoma cruzi	protein kinase, putative	0.0115	0	0.5
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0188	0.3867	0.3917
Schistosoma mansoni	tensin	0.0188	0.3867	0.3917
Loa Loa (eye worm)	SRC-1	0.0303	0.9872	1
Brugia malayi	SH2 domain containing protein	0.0188	0.3867	0.3917
Onchocerca volvulus		0.0188	0.3867	0.3917
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0188	0.3867	0.3917
Onchocerca volvulus		0.0188	0.3867	0.3917
Loa Loa (eye worm)	hypothetical protein	0.0303	0.9872	1
Entamoeba histolytica	protein kinase, putative	0.0188	0.3867	0.3867
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0188	0.3867	0.3867
Brugia malayi	Tensin	0.0188	0.3867	0.3917
Schistosoma mansoni	tensin	0.0188	0.3867	0.3917
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0115	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0188	0.3867	0.3917
Echinococcus multilocularis	tyrosine kinase	0.0303	0.9872	1
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0188	0.3867	0.3917
Schistosoma mansoni	suppressor of cytokine signaling	0.0188	0.3867	0.3917
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0188	0.3867	0.3917
Plasmodium falciparum	tyrosine kinase-like protein	0.0115	0	0.5
Echinococcus granulosus	SH2 domain containing protein 7	0.0188	0.3867	0.3917
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0188	0.3867	0.3917
Brugia malayi	hypothetical protein	0.0188	0.3867	0.3917
Schistosoma mansoni	tyrosine kinase	0.0303	0.9872	1
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0303	0.9872	1
Loa Loa (eye worm)	hypothetical protein	0.0188	0.3867	0.3917
Brugia malayi	SH2 domain containing protein	0.0188	0.3867	0.3917
Leishmania major	protein kinase, putative	0.0115	0	0.5
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0303	0.9872	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0188	0.3867	0.3917
Onchocerca volvulus		0.0303	0.9872	1
Brugia malayi	Variant SH3 domain containing protein	0.0188	0.3867	0.3917
Loa Loa (eye worm)	hypothetical protein	0.0188	0.3867	0.3917
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0303	0.9872	1
Schistosoma mansoni	vav2	0.0188	0.3867	0.3917
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0303	0.9872	1
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0303	0.9872	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0188	0.3867	0.3917
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0303	0.9872	1
Loa Loa (eye worm)	hypothetical protein	0.0188	0.3867	0.3917
Schistosoma mansoni	hypothetical protein	0.0188	0.3867	0.3917
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0303	0.9872	1
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0115	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0303	0.9872	1
Onchocerca volvulus		0.0188	0.3867	0.3917
Echinococcus granulosus	tyrosine protein kinase Blk	0.0303	0.9872	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0303	0.9872	1
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0115	0	0.5
Onchocerca volvulus		0.0303	0.9872	1
Brugia malayi	Protein kinase domain containing protein	0.0303	0.9872	1
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0188	0.3867	0.3917
Loa Loa (eye worm)	hypothetical protein	0.0188	0.3867	0.3917
Trypanosoma cruzi	protein kinase, putative	0.0115	0	0.5
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0303	0.9872	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0305	1	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0305	1	1
Plasmodium falciparum	tyrosine kinase-like protein	0.0115	0	0.5
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0303	0.9872	1
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0188	0.3867	0.3917
Schistosoma mansoni	tyrosine kinase	0.0303	0.9872	1
Loa Loa (eye worm)	hypothetical protein	0.0188	0.3867	0.3917
Schistosoma mansoni	suppressor of cytokine signaling	0.0188	0.3867	0.3917
Schistosoma mansoni	tensin-related	0.0188	0.3867	0.3917
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0305	1	1
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0188	0.3867	0.3917
Echinococcus multilocularis	SH2 motif	0.0188	0.3867	0.3917
Schistosoma mansoni	SH2A	0.0188	0.3867	0.3917
Echinococcus granulosus	signal transduction protein lnk realted	0.0188	0.3867	0.3917
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0303	0.9872	1
Toxoplasma gondii	STE kinase	0.0115	0	0.5
Echinococcus multilocularis	c src tyrosine kinase	0.0303	0.9872	1
Brugia malayi	SH2 domain containing protein	0.0188	0.3867	0.3917
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0149	0.1813	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0303	0.9872	1
Echinococcus multilocularis	SH2 motif	0.0188	0.3867	0.3917
Leishmania major	hypothetical protein, conserved	0.0115	0	0.5
Echinococcus granulosus	tyrosine kinase	0.0303	0.9872	1
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0115	0	0.5
Plasmodium vivax	protein kinase, putative	0.0115	0	0.5
Schistosoma mansoni	nck2/grb4	0.0188	0.3867	0.3917
Schistosoma mansoni	hypothetical protein	0.0188	0.3867	0.3917
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0188	0.3867	0.3917
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0303	0.9872	1
Schistosoma mansoni	adapter molecule crk	0.0188	0.3867	0.3917
Echinococcus multilocularis		0.0188	0.3867	0.3917
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0188	0.3867	0.3917
Loa Loa (eye worm)	TK/FER protein kinase	0.0303	0.9872	1
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0303	0.9872	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0305	1	1
Brugia malayi	SH2 domain containing protein	0.0303	0.9872	1
Echinococcus granulosus	growth factor receptor bound protein 2	0.0188	0.3867	0.3917
Leishmania major	protein kinase, putative	0.0115	0	0.5
Brugia malayi	hypothetical protein	0.0303	0.9872	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0303	0.9872	1
Echinococcus granulosus	c src tyrosine kinase	0.0303	0.9872	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0305	1	1
Schistosoma mansoni	tyrosine kinase	0.0303	0.9872	1
Brugia malayi	Protein kinase domain containing protein	0.0303	0.9872	1
Brugia malayi	RhoGAP domain containing protein	0.0188	0.3867	0.3917
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0188	0.3867	0.3917
Onchocerca volvulus		0.0188	0.3867	0.3917
Loa Loa (eye worm)	TK protein kinase	0.0303	0.9872	1
Echinococcus granulosus	expressed conserved protein	0.0188	0.3867	0.3917
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0188	0.3867	0.3917
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0115	0	0.5
Treponema pallidum	fructose-bisphosphate aldolase	0.0305	1	0.5
Echinococcus multilocularis	tyrosine protein kinase shark	0.0303	0.9872	1
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0188	0.3867	0.3917
Onchocerca volvulus		0.0188	0.3867	0.3917
Loa Loa (eye worm)	TK/FER protein kinase	0.0303	0.9872	1
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0188	0.3867	0.3917
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0188	0.3867	0.3917
Schistosoma mansoni	growth factor receptor-bound protein	0.0188	0.3867	0.3917
Echinococcus granulosus	NCK adaptor protein	0.0188	0.3867	0.3917
Schistosoma mansoni	growth factor receptor-bound protein	0.0188	0.3867	0.3917
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0303	0.9872	1
Echinococcus granulosus	tyrosine protein kinase shark	0.0303	0.9872	1
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0303	0.9872	1
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0188	0.3867	0.3917
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0149	0.1813	0.5
Echinococcus granulosus	tyrosine protein kinase Srms	0.0303	0.9872	1
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0188	0.3867	0.3917

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (ADMET)	= 40 nM	Cytotoxicity against HUVEC after 72 hrs by resazurin assay	ChEMBL.	23822556

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	23822556

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2407576

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1772877