Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.4477 | 0.9818 | 0.9706 |
Entamoeba histolytica | protein kinase, putative | 0.0326 | 0.0015 | 0.0027 |
Entamoeba histolytica | p21-activated kinase | 0.0768 | 0.1058 | 0.1892 |
Loa Loa (eye worm) | hypothetical protein | 0.0761 | 0.1043 | 0.1043 |
Loa Loa (eye worm) | STE/STE20/PAKA protein kinase | 0.0448 | 0.0304 | 0.0304 |
Schistosoma mansoni | serine/threonine protein kinase | 0.2155 | 0.4335 | 0.4335 |
Brugia malayi | p21/Cdc42/Rac1-activated kinase | 0.0448 | 0.0304 | 0.0731 |
Mycobacterium ulcerans | hypothetical protein | 0.2688 | 0.5593 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.4477 | 0.9818 | 0.9818 |
Brugia malayi | Protein kinase domain | 0.0768 | 0.1058 | 0.2546 |
Giardia lamblia | Hypothetical protein | 0.2688 | 0.5593 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.0768 | 0.1058 | 0.1058 |
Entamoeba histolytica | protein kinase, putative | 0.0768 | 0.1058 | 0.1892 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.4477 | 0.9818 | 0.9706 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0761 | 0.1043 | 0.9857 |
Loa Loa (eye worm) | STE/STE20/PAKA protein kinase | 0.0448 | 0.0304 | 0.0304 |
Echinococcus multilocularis | PAK box P21 Rho binding | 0.0326 | 0.0015 | 0.0015 |
Trichomonas vaginalis | STE family protein kinase | 0.0768 | 0.1058 | 1 |
Schistosoma mansoni | protein kinase | 0.0768 | 0.1058 | 0.1058 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.4554 | 1 | 1 |
Loa Loa (eye worm) | raf kinase | 0.2145 | 0.431 | 0.431 |
Schistosoma mansoni | protein kinase | 0.0326 | 0.0015 | 0.0015 |
Brugia malayi | serine/threonine-protein kinase PAK 7 | 0.0326 | 0.0015 | 0.0036 |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.2688 | 0.5593 | 0.5 |
Schistosoma mansoni | 6-phosphofructokinase | 0.4554 | 1 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.4554 | 1 | 1 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.4554 | 1 | 1 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.4554 | 1 | 1 |
Echinococcus granulosus | serine:threonine protein kinase PAK 3 | 0.0768 | 0.1058 | 0.1058 |
Giardia lamblia | Hypothetical protein | 0.2688 | 0.5593 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1943 | 0.3834 | 0.3641 |
Echinococcus multilocularis | raf serine:threonine protein kinase | 0.2155 | 0.4335 | 0.4335 |
Trichomonas vaginalis | STE family protein kinase | 0.0768 | 0.1058 | 1 |
Trichomonas vaginalis | mitogen-activated protein kinase kinase kinase 3, MAPKKK3, MEKK3, putative | 0.0448 | 0.0304 | 0.2768 |
Onchocerca volvulus | 0.4554 | 1 | 0.5 | |
Loa Loa (eye worm) | TKL/RAF/RAF protein kinase | 0.1222 | 0.2131 | 0.2131 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.0768 | 0.1058 | 0.1058 |
Echinococcus granulosus | raf serine:threonine protein kinase | 0.2155 | 0.4335 | 0.4335 |
Echinococcus granulosus | serine:threonine protein kinase PAK 1 | 0.0442 | 0.0289 | 0.0289 |
Loa Loa (eye worm) | hypothetical protein | 0.4554 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0326 | 0.0015 | 0.0027 |
Echinococcus granulosus | serine:threonine protein kinase PAK 3 | 0.0768 | 0.1058 | 0.1058 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.4477 | 0.9818 | 0.9813 |
Echinococcus granulosus | p21 activated protein kinase 1 Dpak1 | 0.0768 | 0.1058 | 0.1058 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.4477 | 0.9818 | 0.9813 |
Brugia malayi | Raf kinase | 0.208 | 0.4157 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.033 | 0.0025 | 0.0025 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0448 | 0.0304 | 0.0304 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.2688 | 0.5593 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.033 | 0.0025 | 0.0025 |
Echinococcus multilocularis | p21 activated protein kinase 1 Dpak1 | 0.0768 | 0.1058 | 0.1058 |
Trichomonas vaginalis | STE family protein kinase | 0.0768 | 0.1058 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1943 | 0.3834 | 0.3641 |
Entamoeba histolytica | protein kinase, putative | 0.0326 | 0.0015 | 0.0027 |
Schistosoma mansoni | protein kinase | 0.0768 | 0.1058 | 0.1058 |
Loa Loa (eye worm) | hypothetical protein | 0.2611 | 0.5411 | 0.5411 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0448 | 0.0304 | 0.0304 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.4554 | 1 | 1 |
Loa Loa (eye worm) | STE/STE20/PAKB protein kinase | 0.0326 | 0.0015 | 0.0015 |
Trichomonas vaginalis | STE family protein kinase | 0.0768 | 0.1058 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.